Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.

abstract：:Some cortical neurons receive highly selective thalamocortical (TC) input, but others do not. Here, we examine connectivity of single thalamic neurons (lateral geniculate nucleus, LGN) onto putative fast-spike inhibitory interneurons in layer 4 of rabbit visual cortex. We show that three 'rules' regulate this connecti...

journal_title：eLife

authors： Bereshpolova Y,Hei X,Alonso JM,Swadlow HA

更新日期：2020-12-08 00:00:00

abstract：:TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif of Pygo proteins. ...

journal_title：eLife

authors： Fiedler M,Graeb M,Mieszczanek J,Rutherford TJ,Johnson CM,Bienz M

更新日期：2015-08-27 00:00:00

abstract：:The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literat...

journal_title：eLife

authors： Guthman EM,Garcia JD,Ma M,Chu P,Baca SM,Smith KR,Restrepo D,Huntsman MM

更新日期：2020-01-09 00:00:00

abstract：:The loss of previously adaptive traits is typically linked to relaxation in selection, yet the molecular steps leading to such repeated losses are rarely known. Molecular studies of loss have tended to focus on gene sequences alone, but overlooking other aspects of protein expression might underestimate phenotypic div...

journal_title：eLife

authors： Sadier A,Davies KT,Yohe LR,Yun K,Donat P,Hedrick BP,Dumont ER,Dávalos LM,Rossiter SJ,Sears KE

更新日期：2018-12-18 00:00:00

abstract：:Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two 'PPXY' motifs, that direct it to degra...

journal_title：eLife

authors： Yue S,Tang LY,Tang Y,Tang Y,Shen QH,Ding J,Chen Y,Zhang Z,Yu TT,Zhang YE,Cheng SY

更新日期：2014-06-12 00:00:00

abstract：:Brain connectivity maps display a delicate balance between individual variation and stereotypy, suggesting the existence of dedicated mechanisms that simultaneously permit and limit individual variation. We show that during the development of the Drosophila central nervous system, mutual inhibition among groups of nei...

journal_title：eLife

authors： Langen M,Koch M,Yan J,De Geest N,Erfurth ML,Pfeiffer BD,Schmucker D,Moreau Y,Hassan BA

更新日期：2013-03-05 00:00:00

abstract：:Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion of HR in G1 cells can lead to the loss-of-heterozygosity (LOH), whic...

journal_title：eLife

authors： Choi YE,Pan Y,Park E,Konstantinopoulos P,De S,D'Andrea A,Chowdhury D

更新日期：2014-04-30 00:00:00

abstract：:Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB o...

journal_title：eLife

authors： Manzano Nieves G,Bravo M,Baskoylu S,Bath KG

更新日期：2020-07-21 00:00:00

abstract：:Eliminating malaria from a defined region involves draining the endemic parasite reservoir and minimizing local malaria transmission around imported malaria infections . In the last phases of malaria elimination, as universal interventions reap diminishing marginal returns, national resources must become increasingly ...

journal_title：eLife

authors： Reiner RC,Le Menach A,Kunene S,Ntshalintshali N,Hsiang MS,Perkins TA,Greenhouse B,Tatem AJ,Cohen JM,Smith DL

更新日期：2015-12-29 00:00:00

abstract：:Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed ea...

journal_title：eLife

authors： Burfeind KG,Zhu X,Norgard MA,Levasseur PR,Huisman C,Buenafe AC,Olson B,Michaelis KA,Torres ER,Jeng S,McWeeney S,Raber J,Marks DL

更新日期：2020-05-11 00:00:00

abstract：:WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain protein...

journal_title：eLife

authors： Lin Z,Yang Z,Xie R,Ji Z,Guan K,Zhang M

更新日期：2019-09-05 00:00:00

abstract：:Determining the etiologic basis of the mutations that are responsible for cancer is one of the fundamental challenges in modern cancer research. Different mutational processes induce different types of DNA mutations, providing 'mutational signatures' that have led to key insights into cancer etiology. The most widely ...

journal_title：eLife

authors： Afsari B,Kuo A,Zhang Y,Li L,Lahouel K,Danilova L,Favorov A,Rosenquist TA,Grollman AP,Kinzler KW,Cope L,Vogelstein B,Tomasetti C

更新日期：2021-01-25 00:00:00

abstract：:Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties. Their evolution i...

journal_title：eLife

authors： Phillips AM,Gonzalez LO,Nekongo EE,Ponomarenko AI,McHugh SM,Butty VL,Levine SS,Lin YS,Mirny LA,Shoulders MD

更新日期：2017-09-26 00:00:00

abstract：:Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the ze...

journal_title：eLife

authors： Pelliccia JL,Jindal GA,Burdine RD

更新日期：2017-11-15 00:00:00

abstract：:Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors such as 53BP1 and BRCA1 on the chromatin flanking the break site. RNF1...

journal_title：eLife

authors： Kitevski-LeBlanc J,Fradet-Turcotte A,Kukic P,Wilson MD,Portella G,Yuwen T,Panier S,Duan S,Canny MD,van Ingen H,Arrowsmith CH,Rubinstein JL,Vendruscolo M,Durocher D,Kay LE

更新日期：2017-04-13 00:00:00

abstract：:Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications. We develop a coarse-grained model of capsid proteins and NAs with which we investigate assembly dynamics and thermodynamics. In contra...

journal_title：eLife

authors： Perlmutter JD,Qiao C,Hagan MF

更新日期：2013-06-14 00:00:00

abstract：:Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include tra...

journal_title：eLife

authors： Kim K,Shin W,Kang M,Lee S,Kim D,Kang R,Jung Y,Cho Y,Yang E,Kim H,Bae YC,Kim E

更新日期：2020-03-06 00:00:00

abstract：:Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013). Here we show that mouse embryonic fibroblasts deficient in Bax/Bak...

journal_title：eLife

authors： Karch J,Schips TG,Maliken BD,Brody MJ,Sargent MA,Kanisicak O,Molkentin JD

更新日期：2017-11-17 00:00:00

abstract：:How producers of public goods persist in microbial communities is a major question in evolutionary biology. Cooperation is evolutionarily unstable, since cheating strains can reproduce quicker and take over. Spatial structure has been shown to be a robust mechanism for the evolution of cooperation. Here we study how s...

journal_title：eLife

authors： Uppal G,Vural DC

更新日期：2018-05-22 00:00:00

abstract：:Improving the peer review process, overcoming the limitations of print journals and providing open access to the very best work in the life and biomedical sciences are three highlights of our first year. ...

journal_title：eLife

authors： Schekman R,Watt FM,Weigel D

更新日期：2013-10-15 00:00:00

abstract：:Differentiation of cellular lineages is facilitated by asymmetric segregation of fate determinants between dividing cells. In budding yeast, various aging factors segregate to the aging (mother)-lineage, with poorly understood consequences. In this study, we show that yeast mother cells form a protein aggregate during...

journal_title：eLife

authors： Saarikangas J,Barral Y

更新日期：2015-11-06 00:00:00

abstract：:The integration of direct bottom-up inputs with contextual information is a core feature of neocortical circuits. In area V1, neurons may reduce their firing rates when their receptive field input can be predicted by spatial context. Gamma-synchronized (30-80 Hz) firing may provide a complementary signal to rates, ref...

journal_title：eLife

authors： Peter A,Uran C,Klon-Lipok J,Roese R,van Stijn S,Barnes W,Dowdall JR,Singer W,Fries P,Vinck M

更新日期：2019-02-04 00:00:00

abstract：:The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes th...

journal_title：eLife

authors： Li Z,Hao MM,Van den Haute C,Baekelandt V,Boesmans W,Vanden Berghe P

更新日期：2019-02-12 00:00:00

abstract：:Understanding how fungi specialize on their plant host is crucial for developing sustainable disease control. A traditional, centuries-old rice agro-system of the Yuanyang terraces was used as a model to show that virulence effectors of the rice blast fungus Magnaporthe oryzaeh play a key role in its specialization on...

journal_title：eLife

authors： Liao J,Huang H,Meusnier I,Adreit H,Ducasse A,Bonnot F,Pan L,He X,Kroj T,Fournier E,Tharreau D,Gladieux P,Morel JB

更新日期：2016-12-23 00:00:00

abstract：:Aeromonas bacteria living in the gut of zebrafish produce a specific molecule to pacify the immune system of their host. ...

journal_title：eLife

authors： Matos RC,Leulier F

更新日期：2018-11-06 00:00:00

abstract：:We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with quantitative analysis of deletion mutants of H2A-H2B suggests that the N...

journal_title：eLife

authors： Padavannil A,Sarkar P,Kim SJ,Cagatay T,Jiou J,Brautigam CA,Tomchick DR,Sali A,D'Arcy S,Chook YM

更新日期：2019-03-11 00:00:00

abstract：Background:Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-establishe...

journal_title：eLife

authors： Reuling IJ,van de Schans LA,Coffeng LE,Lanke K,Meerstein-Kessel L,Graumans W,van Gemert GJ,Teelen K,Siebelink-Stoter R,van de Vegte-Bolmer M,de Mast Q,van der Ven AJ,Ivinson K,Hermsen CC,de Vlas S,Bradley J,Collins KA,O

更新日期：2018-02-27 00:00:00

abstract：:Increasing evidence highlights the important roles of microRNAs in mediating p53's tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein i...

journal_title：eLife

authors： Cao B,Wang K,Liao JM,Zhou X,Liao P,Zeng SX,He M,Chen L,He Y,Li W,Lu H

更新日期：2016-07-07 00:00:00

abstract：:In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opp...

journal_title：eLife

authors： van der Wijst M,de Vries DH,Groot HE,Trynka G,Hon CC,Bonder MJ,Stegle O,Nawijn MC,Idaghdour Y,van der Harst P,Ye CJ,Powell J,Theis FJ,Mahfouz A,Heinig M,Franke L

更新日期：2020-03-09 00:00:00

abstract：:Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fea...

journal_title：eLife

authors： Inoue R,Abdou K,Hayashi-Tanaka A,Muramatsu SI,Mino K,Inokuchi K,Mori H

更新日期：2018-06-26 00:00:00