Abstract:
:How producers of public goods persist in microbial communities is a major question in evolutionary biology. Cooperation is evolutionarily unstable, since cheating strains can reproduce quicker and take over. Spatial structure has been shown to be a robust mechanism for the evolution of cooperation. Here we study how spatial assortment might emerge from native dynamics and show that fluid flow shear promotes cooperative behavior. Social structures arise naturally from our advection-diffusion-reaction model as self-reproducing Turing patterns. We computationally study the effects of fluid advection on these patterns as a mechanism to enable or enhance social behavior. Our central finding is that flow shear enables and promotes social behavior in microbes by increasing the group fragmentation rate and thereby limiting the spread of cheating strains. Regions of the flow domain with higher shear admit high cooperativity and large population density, whereas low shear regions are devoid of life due to opportunistic mutations.
journal_name
Elifejournal_title
eLifeauthors
Uppal G,Vural DCdoi
10.7554/eLife.34862subject
Has Abstractpub_date
2018-05-22 00:00:00issn
2050-084Xpii
34862journal_volume
7pub_type
杂志文章相关文献
eLife文献大全abstract::Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corollary discharge sign...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44032
更新日期:2019-03-14 00:00:00
abstract::We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique peptidoglycan comp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45343
更新日期:2019-04-10 00:00:00
abstract::The importance of cultural processes to behavioural diversity in our closest living relatives is central to revealing the evolutionary origins of human culture. However, the bonobo is often overlooked as a candidate model. Further, a prominent critique to many examples of proposed animal cultures is premature exclusio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59191
更新日期:2020-09-01 00:00:00
abstract::Animals host multi-species microbial communities (microbiomes) whose properties may result from inter-species interactions; however, current understanding of host-microbiome interactions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult. In exploring how Drosophila melanogas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18855
更新日期:2017-01-09 00:00:00
abstract::Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation of oscillatory activity might contribute to WM by enabling the coordination of long-range processes. However, causal evidence for the way oscillatory activity shapes network dynamics and behavio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22001
更新日期:2017-03-14 00:00:00
abstract::We studied the role of the synaptic ribbon for sound encoding at the synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in mice lacking RIBEYE (RBEKO/KO). Electron and immunofluorescence microscopy revealed a lack of synaptic ribbons and an assembly of several small active zones (AZs) at each ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29275
更新日期:2018-01-12 00:00:00
abstract::Social rank differentially influences how male and female mice respond to chronic stress. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63996
更新日期:2020-11-20 00:00:00
abstract::B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.25375
更新日期:2017-03-30 00:00:00
abstract::Bacterial cells utilize monitoring substrates, which undergo force-sensitive translation elongation arrest, to feedback-regulate a Sec-related gene. Vibrio alginolyticus VemP controls the expression of SecD/F that stimulates a late step of translocation by undergoing export-regulated elongation arrest. Here, we attemp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62623
更新日期:2020-12-15 00:00:00
abstract::Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51063
更新日期:2019-12-23 00:00:00
abstract::The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here, we traced the whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55585
更新日期:2020-09-17 00:00:00
abstract::KdpFABC is an ATP-dependent K+ pump that ensures bacterial survival in K+-deficient environments. Whereas transcriptional activation of kdpFABC expression is well studied, a mechanism for down-regulation when K+ levels are restored has not been described. Here, we show that KdpFABC is inhibited when cells return to a ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55480
更新日期:2020-09-21 00:00:00
abstract::Generating recombinant monoclonal antibodies (R-mAbs) from mAb-producing hybridomas offers numerous advantages that increase the effectiveness, reproducibility, and transparent reporting of research. We report here the generation of a novel resource in the form of a library of recombinant R-mAbs validated for neurosci...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43322
更新日期:2019-01-22 00:00:00
abstract::bicoid mRNA localises to the Drosophila oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at stage 9 reveals that bicoid mRNA particles undergo rapid Dynein-dependent movements near the oocyte anterior, but with no directional bias. Fu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17537
更新日期:2016-10-28 00:00:00
abstract::The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41036
更新日期:2019-02-08 00:00:00
abstract::Rising and more variable global temperatures pose a challenge for biodiversity, with reproduction and fertility being especially sensitive to heat. Here, we assessed the potential for thermal adaptation in sperm and egg function using Tribolium flour beetles, a warm-temperate-tropical insect model. Following temperatu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49452
更新日期:2019-10-01 00:00:00
abstract::Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles. Aside from the virus itself, important molecular players involved in virus entry ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44345
更新日期:2019-05-20 00:00:00
abstract::A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell responses in the intesti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12444
更新日期:2016-02-24 00:00:00
abstract::Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51735
更新日期:2020-06-09 00:00:00
abstract::Non-segmented negative-strand RNA viruses, such as measles, ebola and Newcastle disease viruses (NDV), encapsidate viral genomic RNAs into helical nucleocapsids, which serve as the template for viral replication and transcription. Here, the clam-shaped nucleocapsid structure, where the NDV viral genome is sequestered,...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45057
更新日期:2019-07-10 00:00:00
abstract::Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the acti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49315
更新日期:2019-11-01 00:00:00
abstract::Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays. We purified N-terminally tagged recombinant Wnt3a secreted from cells and accidenta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11621
更新日期:2016-02-23 00:00:00
abstract::Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in part been limit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25174
更新日期:2017-05-19 00:00:00
abstract::Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins' functions as ion channels. This question remains unsolved largely because polycystins localize to the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33183
更新日期:2018-02-14 00:00:00
abstract::Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08362
更新日期:2015-09-03 00:00:00
abstract::Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01119
更新日期:2013-12-24 00:00:00
abstract::One of the major unanswered questions in evolutionary biology is when and how the transition between diderm (two membranes) and monoderm (one membrane) cell envelopes occurred in Bacteria. The Negativicutes and the Halanaerobiales belong to the classically monoderm Firmicutes, but possess outer membranes with lipopoly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14589
更新日期:2016-08-31 00:00:00
abstract::Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part of several macromolecular complexes such as INO80, SWR1, and R2TP. Interesti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63042
更新日期:2020-11-18 00:00:00
abstract::Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog, ECT-2, functions through the conserved RAS/ERK MAP kinase signaling...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12039
更新日期:2016-02-27 00:00:00
abstract::Clinical trials are currently underway to assess the efficacy of forniceal deep brain stimulation (DBS) for improvement of memory in Alzheimer's patients, and forniceal DBS has been shown to improve learning and memory in a mouse model of Rett syndrome (RTT), an intellectual disability disorder caused by loss-of-funct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34031
更新日期:2018-03-23 00:00:00