ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly.

abstract：:B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...

journal_title：eLife

authors： Bálint Š,Dustin ML

更新日期：2017-03-30 00:00:00

abstract：:The COVID-19 pandemic has resulted in school closures and distancing requirements that have disrupted both work and family life for many. Concerns exist that these disruptions caused by the pandemic may not have influenced men and women researchers equally. Many medical journals have published papers on the pandemic, ...

journal_title：eLife

authors： Andersen JP,Nielsen MW,Simone NL,Lewiss RE,Jagsi R

更新日期：2020-06-15 00:00:00

abstract：:During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2, and Neuropilin1 (NRP1), are targeted in therapeutic strategies for ...

journal_title：eLife

authors： Gelfand MV,Hagan N,Tata A,Oh WJ,Lacoste B,Kang KT,Kopycinska J,Bischoff J,Wang JH,Gu C

更新日期：2014-09-22 00:00:00

abstract：:While the dynamin GTPase Drp1 plays a critical role during mitochondrial fission, mechanisms controlling its recruitment to fission sites are unclear. A current assumption is that cytosolic Drp1 is recruited directly to fission sites immediately prior to fission. Using live-cell microscopy, we find evidence for a diff...

journal_title：eLife

authors： Ji WK,Hatch AL,Merrill RA,Strack S,Higgs HN

更新日期：2015-11-26 00:00:00

abstract：:A major puzzle in biology is how mammalian sperm maintain the correct swimming direction during various phases of the sexual reproduction process. Whilst chemotaxis may dominate near the ovum, it is unclear which cues guide spermatozoa on their long journey towards the egg. Hypothesized mechanisms range from peristalt...

journal_title：eLife

authors： Kantsler V,Dunkel J,Blayney M,Goldstein RE

更新日期：2014-05-27 00:00:00

abstract：:The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes th...

journal_title：eLife

authors： Li Z,Hao MM,Van den Haute C,Baekelandt V,Boesmans W,Vanden Berghe P

更新日期：2019-02-12 00:00:00

abstract：:Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the acti...

journal_title：eLife

authors： Stalnaker TA,Howard JD,Takahashi YK,Gershman SJ,Kahnt T,Schoenbaum G

更新日期：2019-11-01 00:00:00

abstract：:Peroxiredoxins are H2O2 scavenging enzymes that also carry out H2O2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H2O2 and extending lifespan upon caloric restriction. We show here that Tsa1 effects both these functions not by scavengi...

journal_title：eLife

authors： Roger F,Picazo C,Reiter W,Libiad M,Asami C,Hanzén S,Gao C,Lagniel G,Welkenhuysen N,Labarre J,Nyström T,Grøtli M,Hartl M,Toledano MB,Molin M

更新日期：2020-07-14 00:00:00

abstract：:Pathological metabolic conditions such as ischemia induce the rupture of the mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death. At the onset of this process, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due to the opening of a non-sel...

journal_title：eLife

authors： Zhou W,Marinelli F,Nief C,Faraldo-Gómez JD

更新日期：2017-02-10 00:00:00

abstract：:A new study reveals that a protein called talin forms a vital link between microtubules and focal adhesions at the surface of cells. ...

journal_title：eLife

authors： Armitage SK,Plotnikov SV

更新日期：2016-08-23 00:00:00

abstract：:Striatal dysfunction plays an important role in dystonia, but the striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate that conditional deletion of the DYT1 dystonia protein torsinA in embryonic progenitors of forebrain cholinergic and GABAergic neurons causes dystonic-like twis...

journal_title：eLife

authors： Pappas SS,Darr K,Holley SM,Cepeda C,Mabrouk OS,Wong JM,LeWitt TM,Paudel R,Houlden H,Kennedy RT,Levine MS,Dauer WT

更新日期：2015-06-08 00:00:00

abstract：:Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habi...

journal_title：eLife

authors： O'Hare JK,Li H,Kim N,Gaidis E,Ade K,Beck J,Yin H,Calakos N

更新日期：2017-09-05 00:00:00

abstract：:Claims that magnetic fields can be used to manipulate biological systems contradict some basic laws of physics. ...

journal_title：eLife

authors： Anikeeva P,Jasanoff A

更新日期：2016-09-08 00:00:00

abstract：:Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental mechanism of this lattice structure. We found that this structure emerged early during axon...

journal_title：eLife

authors： Zhong G,He J,Zhou R,Lorenzo D,Babcock HP,Bennett V,Zhuang X

更新日期：2014-12-23 00:00:00

abstract：:Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo. We generate...

journal_title：eLife

authors： Bulley S,Fernández-Peña C,Hasan R,Leo MD,Muralidharan P,Mackay CE,Evanson KW,Moreira-Junior L,Mata-Daboin A,Burris SK,Wang Q,Kuruvilla KP,Jaggar JH

更新日期：2018-12-04 00:00:00

abstract：:Improving the peer review process, overcoming the limitations of print journals and providing open access to the very best work in the life and biomedical sciences are three highlights of our first year. ...

journal_title：eLife

authors： Schekman R,Watt FM,Weigel D

更新日期：2013-10-15 00:00:00

abstract：:During sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals. ...

journal_title：eLife

authors： Williams SD,Lewis LD

更新日期：2020-12-23 00:00:00

abstract：:Evolutionary changes in transcription networks are an important source of diversity across species, yet the quantitative consequences of network evolution have rarely been studied. Here we consider the transcriptional 'rewiring' of the three GAL genes that encode the enzymes needed for cells to convert galactose to gl...

journal_title：eLife

authors： Dalal CK,Zuleta IA,Mitchell KF,Andes DR,El-Samad H,Johnson AD

更新日期：2016-09-10 00:00:00

abstract：:As the staff of the MRC Laboratory of Molecular Biology settle into their new building in Cambridge, its director Hugh Pelham explains the challenges of living up to its prestigious past. ...

journal_title：eLife

authors： Pelham H

更新日期：2013-05-28 00:00:00

abstract：:Neurons coding for head-direction are crucial for spatial navigation. Here we explored the cellular basis of head-direction coding in the rat dorsal presubiculum (PreS). We found that layer2 is composed of two principal cell populations (calbindin-positive and calbindin-negative neurons) which targeted the contralater...

journal_title：eLife

authors： Preston-Ferrer P,Coletta S,Frey M,Burgalossi A

更新日期：2016-06-10 00:00:00

abstract：:The axolotl can regenerate multiple organs, including the brain. It remains, however, unclear whether neuronal diversity, intricate tissue architecture, and axonal connectivity can be regenerated; yet, this is critical for recovery of function and a central aim of cell replacement strategies in the mammalian central n...

journal_title：eLife

authors： Amamoto R,Huerta VG,Takahashi E,Dai G,Grant AK,Fu Z,Arlotta P

更新日期：2016-05-09 00:00:00

abstract：:WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain protein...

journal_title：eLife

authors： Lin Z,Yang Z,Xie R,Ji Z,Guan K,Zhang M

更新日期：2019-09-05 00:00:00

abstract：:Notch signaling plays a crucial role in controling the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis, but its regulation is incompletely understood. BLOS2, encoded by the Bloc1s2 gene, is a shared subunit of two lysosomal trafficking complexes, biogenesis of lysos...

journal_title：eLife

authors： Zhou W,He Q,Zhang C,He X,Cui Z,Liu F,Li W

更新日期：2016-10-10 00:00:00

abstract：:Correct neuronal development requires tailored neurite outgrowth. Neurite outgrowth is driven in part by microtubule-sliding - the transport of microtubules along each other. We have recently demonstrated that a 'mitotic' kinesin-6 (Pavarotti in Drosophila) effectively inhibits microtubule-sliding and neurite outgrowt...

journal_title：eLife

authors： Norkett R,Del Castillo U,Lu W,Gelfand VI

更新日期：2020-02-05 00:00:00

abstract：:The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...

journal_title：eLife

authors： Kim KW,Tang NH,Piggott CA,Andrusiak MG,Park S,Zhu M,Kurup N,Cherra SJ 3rd,Wu Z,Chisholm AD,Jin Y

更新日期：2018-11-21 00:00:00

abstract：:How different helicase families with a conserved catalytic 'helicase core' evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear. In this study, we used Mss116, a yeast DEAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and mechanism. Ou...

journal_title：eLife

authors： Mallam AL,Sidote DJ,Lambowitz AM

更新日期：2014-12-12 00:00:00

abstract：:The internal brain dynamics that link sensation and action are arguably better studied during natural animal behaviors. Here, we report on a novel volume imaging and 3D tracking technique that monitors whole brain neural activity in freely swimming larval zebrafish (Danio rerio). We demonstrated the capability of our ...

journal_title：eLife

authors： Cong L,Wang Z,Chai Y,Hang W,Shang C,Yang W,Bai L,Du J,Wang K,Wen Q

更新日期：2017-09-20 00:00:00

abstract：:TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosomal membranes throug...

journal_title：eLife

authors： Chia KH,Fukuda T,Sofyantoro F,Matsuda T,Amai T,Shiozaki K

更新日期：2017-12-04 00:00:00

abstract：:Some DNA viruses overcome plant defenses by producing a suppressor protein that blocks the silencing of viral genes. ...

journal_title：eLife

authors： Ré DA,Manavella PA

更新日期：2015-10-16 00:00:00

abstract：:The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter's mechanism. Stoichiometry is known for a wide array ...

journal_title：eLife

authors： Fitzgerald GA,Mulligan C,Mindell JA

更新日期：2017-01-25 00:00:00