Abstract:
:Animals host multi-species microbial communities (microbiomes) whose properties may result from inter-species interactions; however, current understanding of host-microbiome interactions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult. In exploring how Drosophila melanogaster acquires its microbiome, we found that a microbial community influences Drosophila olfactory and egg-laying behaviors differently than individual members. Drosophila prefers a Saccharomyces-Acetobacter co-culture to the same microorganisms grown individually and then mixed, a response mainly due to the conserved olfactory receptor, Or42b. Acetobacter metabolism of Saccharomyces-derived ethanol was necessary, and acetate and its metabolic derivatives were sufficient, for co-culture preference. Preference correlated with three emergent co-culture properties: ethanol catabolism, a distinct volatile profile, and yeast population decline. Egg-laying preference provided a context-dependent fitness benefit to larvae. We describe a molecular mechanism by which a microbial community affects animal behavior. Our results support a model whereby emergent metabolites signal a beneficial multispecies microbiome.
journal_name
Elifejournal_title
eLifeauthors
Fischer CN,Trautman EP,Crawford JM,Stabb EV,Handelsman J,Broderick NAdoi
10.7554/eLife.18855subject
Has Abstractpub_date
2017-01-09 00:00:00issn
2050-084Xjournal_volume
6pub_type
杂志文章相关文献
eLife文献大全abstract::The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37202
更新日期:2018-09-07 00:00:00
abstract::A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.24238
更新日期:2017-01-31 00:00:00
abstract::Atopic Dermatitis (AD) is a T cell-mediated chronic skin disease and is associated with altered skin barrier integrity. Infants with mutations in genes involved in tissue barrier fitness are predisposed towards inflammatory diseases, but most do not develop or sustain the diseases, suggesting that there exist regulato...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51188
更新日期:2020-02-17 00:00:00
abstract::The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing protocol. We observe most TCR sequences only once, consistent wi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49900
更新日期:2020-03-18 00:00:00
abstract::Experiments in which monkeys have to select or estimate the location of a target are revealing more about the role of the dorsal premotor cortex in decision making. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.18721
更新日期:2016-07-15 00:00:00
abstract::The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37357
更新日期:2018-07-25 00:00:00
abstract::Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a stro...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.20975
更新日期:2017-02-14 00:00:00
abstract::Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular process contributes to tube formation in different developmental conte...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22235
更新日期:2017-03-06 00:00:00
abstract::Successful fertilization in angiosperms depends on the proper trajectory of pollen tubes through the pistil tissues to reach the ovules. Pollen tubes first grow within the cell wall of the papilla cells, applying pressure to the cell. Mechanical forces are known to play a major role in plant cell shape by controlling ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57282
更新日期:2020-09-01 00:00:00
abstract::The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstruc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53470
更新日期:2020-06-04 00:00:00
abstract::Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that effici...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02630
更新日期:2014-06-24 00:00:00
abstract::A major puzzle in biology is how mammalian sperm maintain the correct swimming direction during various phases of the sexual reproduction process. Whilst chemotaxis may dominate near the ovum, it is unclear which cues guide spermatozoa on their long journey towards the egg. Hypothesized mechanisms range from peristalt...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02403
更新日期:2014-05-27 00:00:00
abstract::The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41036
更新日期:2019-02-08 00:00:00
abstract::Many postdoctoral researchers apply for faculty positions knowing relatively little about the hiring process or what is needed to secure a job offer. To address this lack of knowledge about the hiring process we conducted a survey of applicants for faculty positions: the survey ran between May 2018 and May 2019, and r...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54097
更新日期:2020-06-12 00:00:00
abstract::Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.38748
更新日期:2018-07-09 00:00:00
abstract::The application of current channelrhodopsin-based optogenetic tools is limited by the lack of strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared (NIR) tissue transmissible range. Here we present an NIR-stimulable optogenetic platform (termed 'Opto-CRAC') that selectively ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10024
更新日期:2015-12-08 00:00:00
abstract::Positive-strand RNA viruses, the largest genetic class of viruses, include numerous important pathogens such as Zika virus. These viruses replicate their RNA genomes in novel, membrane-bounded mini-organelles, but the organization of viral proteins and RNAs in these compartments has been largely unknown. We used cryo-...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25940
更新日期:2017-06-27 00:00:00
abstract::Human pluripotent stem cell (hPSC)-derived neural organoids display unprecedented emergent properties. Yet in contrast to the singular neuroepithelial tube from which the entire central nervous system (CNS) develops in vivo, current organoid protocols yield tissues with multiple neuroepithelial units, a.k.a. neural ro...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37549
更新日期:2018-10-29 00:00:00
abstract::Glucocorticoid receptors (GR) have diverse functions relevant to maintenance of homeostasis and adaptation to environmental challenges. Understanding the importance of tissue-specific GR function in physiology and behavior has been hampered by near-ubiquitous localization in brain and body. Here we use CRISPR/Cas9 gen...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44672
更新日期:2019-07-22 00:00:00
abstract::Animals and humans replay neural patterns encoding trajectories through their environment, both whilst they solve decision-making tasks and during rest. Both on-task and off-task replay are believed to contribute to flexible decision making, though how their relative contributions differ remains unclear. We investigat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56911
更新日期:2020-06-17 00:00:00
abstract::Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole e...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39865
更新日期:2018-12-03 00:00:00
abstract::Altered insulin signaling has been linked to widespread nervous system dysfunction including cognitive dysfunction, neuropathy and susceptibility to neurodegenerative disease. However, knowledge of the cellular mechanisms underlying the effects of insulin on neuronal function is incomplete. Here, we show that cell aut...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.16807
更新日期:2016-08-15 00:00:00
abstract::The mechanisms generating epileptic neuronal networks following insults such as severe seizures are unknown. We have previously shown that interfering with the function of the neuron-restrictive silencer factor (NRSF/REST), an important transcription factor that influences neuronal phenotype, attenuated development of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01267
更新日期:2014-08-12 00:00:00
abstract::The sequential activation of neurons has been observed in various areas of the brain, but in no case is the underlying network structure well understood. Here we examined the circuit anatomy of zebra finch HVC, a cortical region that generates sequences underlying the temporal progression of the song. We combined seri...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24364
更新日期:2017-03-27 00:00:00
abstract::The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through posttranslational m...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04883
更新日期:2015-03-10 00:00:00
abstract::How different helicase families with a conserved catalytic 'helicase core' evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear. In this study, we used Mss116, a yeast DEAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and mechanism. Ou...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04630
更新日期:2014-12-12 00:00:00
abstract::Mood and anxiety disorders are the most prevalent psychiatric conditions and are exacerbated by stress. Recent studies have suggested cyclooxygenase-2 (COX-2) inhibition could represent a novel treatment approach or augmentation strategy for affective disorders including anxiety disorders and major depression. We show...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14137
更新日期:2016-05-10 00:00:00
abstract::The spinal cord has the capacity to coordinate motor activities such as locomotion. Following spinal transection, functional activity can be regained, to a degree, following motor training. To identify microcircuits involved in this recovery, we studied a population of mouse spinal interneurons known to receive direct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21715
更新日期:2016-12-15 00:00:00
abstract::Microtubules are nucleated from specific locations at precise times in the cell cycle. However, the factors that constitute these microtubule nucleation pathways and their mode of action still need to be identified. Using purified Xenopus laevis proteins we biochemically reconstitute branching microtubule nucleation, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49797
更新日期:2020-01-14 00:00:00
abstract::Bacillus subtilis can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54244
更新日期:2020-01-24 00:00:00