The single-cell eQTLGen consortium.

abstract：:Whether neurons encode information through their spike rates, their activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed of the same two components delivered in rapid succession in either one tempor...

journal_title：eLife

authors： Perl O,Nahum N,Belelovsky K,Haddad R

更新日期：2020-02-07 00:00:00

abstract：:Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm. Here, we tested the ability of single and multiple motors to bypass synthetic obstacles on MTs in vitro....

journal_title：eLife

authors： Ferro LS,Can S,Turner MA,ElShenawy MM,Yildiz A

更新日期：2019-09-09 00:00:00

abstract：:Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for targeted therapies....

journal_title：eLife

authors： McCauley HA,Chevrier V,Birnbaum D,Guasch G

更新日期：2017-02-21 00:00:00

abstract：:Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections. However, the influence of SOR on T cell immunity remains uncharacterized. Here we show the detrimental effect of h...

journal_title：eLife

authors： Saragovi A,Abramovich I,Omar I,Arbib E,Toker O,Gottlieb E,Berger M

更新日期：2020-11-23 00:00:00

abstract：:Although seasonality is widespread and can cause fluctuations in the intensity and direction of natural selection, we have little information about the consequences of seasonal fitness trade-offs for population dynamics. Here we exposed populations of Drosophila melanogaster to repeated seasonal changes in resources a...

journal_title：eLife

authors： Betini GS,McAdam AG,Griswold CK,Norris DR

更新日期：2017-02-06 00:00:00

abstract：:Genetic analyses of 15 species of yeast have shed new light on the divergence of gene regulation during evolution, with significant changes occurring after an event in which a whole genome was duplicated. ...

journal_title：eLife

authors： Ragan MA

更新日期：2013-06-18 00:00:00

abstract：:Cavin-3 regulates metabolism and cell proliferation by coordinating the activities of growth factor signalling cascades. ...

journal_title：eLife

authors： Whitmarsh AJ

更新日期：2013-09-24 00:00:00

abstract：:Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocy...

journal_title：eLife

authors： Manzoni G,Marinach C,Topçu S,Briquet S,Grand M,Tolle M,Gransagne M,Lescar J,Andolina C,Franetich JF,Zeisel MB,Huby T,Rubinstein E,Snounou G,Mazier D,Nosten F,Baumert TF,Silvie O

更新日期：2017-05-16 00:00:00

abstract：:Bacterial flagella mediate host-microbe interactions through tissue tropism during colonization, as well as by activating immune responses. The flagellar shaft of some bacteria, including several human pathogens, is encased in a membranous sheath of unknown function. While it has been hypothesized that the sheath may ...

journal_title：eLife

authors： Brennan CA,Hunt JR,Kremer N,Krasity BC,Apicella MA,McFall-Ngai MJ,Ruby EG

更新日期：2014-03-04 00:00:00

abstract：:The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence of ATPγS and a DNA duplex bearing a 3' single-stranded tail. The struc...

journal_title：eLife

authors： Costa A,Renault L,Swuec P,Petojevic T,Pesavento JJ,Ilves I,MacLellan-Gibson K,Fleck RA,Botchan MR,Berger JM

更新日期：2014-08-12 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics. Combining differential lncRNA expression during neuronal lineage induction with copy number variation morbidity maps of a cohort of children with autism sp...

journal_title：eLife

authors： Ang CE,Ma Q,Wapinski OL,Fan S,Flynn RA,Lee QY,Coe B,Onoguchi M,Olmos VH,Do BT,Dukes-Rimsky L,Xu J,Tanabe K,Wang L,Elling U,Penninger JM,Zhao Y,Qu K,Eichler EE,Srivastava A,Wernig M,Chang HY

更新日期：2019-01-10 00:00:00

abstract：:Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic investigation. RNA prof...

journal_title：eLife

authors： Bunker BD,Nellimoottil TT,Boileau RM,Classen AK,Bilder D

更新日期：2015-02-26 00:00:00

abstract：:How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real time. Mtb infection induced a quiescent energy phenotype in human monocyte-derive...

journal_title：eLife

authors： Cumming BM,Addicott KW,Adamson JH,Steyn AJ

更新日期：2018-11-16 00:00:00

abstract：:Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson's disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although autop...

journal_title：eLife

authors： Yamano K,Wang C,Sarraf SA,Münch C,Kikuchi R,Noda NN,Hizukuri Y,Kanemaki MT,Harper W,Tanaka K,Matsuda N,Youle RJ

更新日期：2018-01-23 00:00:00

abstract：:Manipulating gene function cell type-specifically is a common experimental goal in Drosophila research and has been central to studies of neural development, circuit computation, and behavior. However, current cell type-specific gene disruption techniques in flies often reduce gene activity incompletely or rely on cel...

journal_title：eLife

authors： Fisher YE,Yang HH,Isaacman-Beck J,Xie M,Gohl DM,Clandinin TR

更新日期：2017-02-17 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β-lactams showed mycobactericidal activity in combination with β-lactamase inhibitor, clavulanate (Clav). However, the mechanistic aspects of ho...

journal_title：eLife

authors： Mishra S,Shukla P,Bhaskar A,Anand K,Baloni P,Jha RK,Mohan A,Rajmani RS,Nagaraja V,Chandra N,Singh A

更新日期：2017-05-26 00:00:00

abstract：:It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that macrophages and microglia respond immediately upon oncogene activation in the brai...

journal_title：eLife

authors： Chia K,Mazzolini J,Mione M,Sieger D

更新日期：2018-02-21 00:00:00

abstract：:Slo2 potassium channels play important roles in neuronal function, and their mutations in humans may cause epilepsies and cognitive defects. However, it is largely unknown how Slo2 is regulated by other proteins. Here we show that the function of C. elegans Slo2 (SLO-2) depends on adr-1, a gene important to RNA editin...

journal_title：eLife

authors： Niu LG,Liu P,Wang ZW,Chen B

更新日期：2020-04-21 00:00:00

abstract：:The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive ...

journal_title：eLife

authors： Ignatius MS,Hayes MN,Moore FE,Tang Q,Garcia SP,Blackburn PR,Baxi K,Wang L,Jin A,Ramakrishnan A,Reeder S,Chen Y,Nielsen GP,Chen EY,Hasserjian RP,Tirode F,Ekker SC,Langenau DM

更新日期：2018-09-07 00:00:00

abstract：:The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any behavioral effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propos...

journal_title：eLife

authors： Barrett DG,Denève S,Machens CK

更新日期：2016-12-09 00:00:00

abstract：:The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph involving only two am...

journal_title：eLife

authors： Wu NC,Dai L,Olson CA,Lloyd-Smith JO,Sun R

更新日期：2016-07-08 00:00:00

abstract：:Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these ageing processes re...

journal_title：eLife

authors： Baran-Gale J,Morgan MD,Maio S,Dhalla F,Calvo-Asensio I,Deadman ME,Handel AE,Maynard A,Chen S,Green F,Sit RV,Neff NF,Darmanis S,Tan W,May AP,Marioni JC,Ponting CP,Holländer GA

更新日期：2020-08-25 00:00:00

abstract：:Sex-optimal diets have different effects on gene expression in female and male flies. ...

journal_title：eLife

authors： Flatt T

更新日期：2019-10-01 00:00:00

abstract：:During sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals. ...

journal_title：eLife

authors： Williams SD,Lewis LD

更新日期：2020-12-23 00:00:00

abstract：:Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing ...

journal_title：eLife

authors： Kolasinski J,Makin TR,Logan JP,Jbabdi S,Clare S,Stagg CJ,Johansen-Berg H

更新日期：2016-12-30 00:00:00

abstract：:The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical intrinsic and synaptic mechanisms, associated with the putative action of acetylcholine (ACh), G...

journal_title：eLife

authors： Krishnan GP,Chauvette S,Shamie I,Soltani S,Timofeev I,Cash SS,Halgren E,Bazhenov M

更新日期：2016-11-16 00:00:00

abstract：:Heterochromatin exerts a heritable form of eukaryotic gene repression and contributes to chromosome segregation fidelity and genome stability. However, to date there has been no quantitative evaluation of the stability of heterochromatic gene repression. We designed a genetic strategy to capture transient losses of ge...

journal_title：eLife

authors： Dodson AE,Rine J

更新日期：2015-01-12 00:00:00

abstract：:Nutritional regulation by ants emerges from a distributed process: food is collected by a small fraction of workers, stored within the crops of individuals, and spread via local ant-to-ant interactions. The precise individual-level underpinnings of this collective regulation have remained unclear mainly due to difficu...

journal_title：eLife

authors： Greenwald EE,Baltiansky L,Feinerman O

更新日期：2018-03-06 00:00:00

abstract：:Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is coupled to the presence of the cargo is unclear. Here we show that the...

journal_title：eLife

authors： Fracchiolla D,Sawa-Makarska J,Zens B,Ruiter A,Zaffagnini G,Brezovich A,Romanov J,Runggatscher K,Kraft C,Zagrovic B,Martens S

更新日期：2016-11-23 00:00:00

abstract：:Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathemati...

journal_title：eLife

authors： Doebeli M,Ispolatov Y,Simon B

更新日期：2017-02-15 00:00:00