The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

abstract：:Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic t...

journal_title：eLife

authors： Dolan MJ,Frechter S,Bates AS,Dan C,Huoviala P,Roberts RJ,Schlegel P,Dhawan S,Tabano R,Dionne H,Christoforou C,Close K,Sutcliffe B,Giuliani B,Li F,Costa M,Ihrke G,Meissner GW,Bock DD,Aso Y,Rubin GM,Jefferis GS

更新日期：2019-05-21 00:00:00

abstract：:The spinal cord has the capacity to coordinate motor activities such as locomotion. Following spinal transection, functional activity can be regained, to a degree, following motor training. To identify microcircuits involved in this recovery, we studied a population of mouse spinal interneurons known to receive direct...

journal_title：eLife

authors： Bui TV,Stifani N,Akay T,Brownstone RM

更新日期：2016-12-15 00:00:00

abstract：:Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circulatory system and pr...

journal_title：eLife

authors： Gawrys-Kopczynska M,Konop M,Maksymiuk K,Kraszewska K,Derzsi L,Sozanski K,Holyst R,Pilz M,Samborowska E,Dobrowolski L,Jaworska K,Mogilnicka I,Ufnal M

更新日期：2020-06-08 00:00:00

abstract：:Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoenc...

journal_title：eLife

authors： Dijkstra N,Mostert P,Lange FP,Bosch S,van Gerven MA

更新日期：2018-05-29 00:00:00

abstract：:The neural correlates of consciousness are typically sought by comparing the overall brain responses to perceived and unperceived stimuli. However, this comparison may be contaminated by non-specific attention, alerting, performance, and reporting confounds. Here, we pursue a novel approach, tracking the neuronal codi...

journal_title：eLife

authors： Salti M,Monto S,Charles L,King JR,Parkkonen L,Dehaene S

更新日期：2015-05-21 00:00:00

abstract：:The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because ...

journal_title：eLife

authors： Christensen RP,Bokinsky A,Santella A,Wu Y,Marquina-Solis J,Guo M,Kovacevic I,Kumar A,Winter PW,Tashakkori N,McCreedy E,Liu H,McAuliffe M,Mohler W,Colón-Ramos DA,Bao Z,Shroff H

更新日期：2015-12-03 00:00:00

abstract：:Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentified temperature-sensing domain. Here we report that the homologous...

journal_title：eLife

authors： Yang F,Zheng J

更新日期：2014-07-16 00:00:00

abstract：:Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly dependent on membrane volta...

journal_title：eLife

authors： Zhang X,Chen W,Li P,Calvo R,Southall N,Hu X,Bryant-Genevier M,Feng X,Geng Q,Gao C,Yang M,Tang K,Ferrer M,Marugan JJ,Xu H

更新日期：2019-12-11 00:00:00

abstract：:XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet their mechanism remains unknown. Here, we describe the biochemical and structural basis for TOG arrays in recruiting and polymerizing tubulins. Alp14 binds four tu...

journal_title：eLife

authors： Nithianantham S,Cook BD,Beans M,Guo F,Chang F,Al-Bassam J

更新日期：2018-11-13 00:00:00

abstract：:Despite employing diverse molecular mechanisms, many different cell signaling systems avoid losing information by transmitting it in a linear manner. ...

journal_title：eLife

authors： Andrews SS,Brent R,Balázsi G

更新日期：2018-10-25 00:00:00

abstract：:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investi...

journal_title：eLife

authors： Rabinowitz NC,Goris RL,Cohen M,Simoncelli EP

更新日期：2015-11-02 00:00:00

abstract：:The characteristics of goal-directed actions tend to resemble those of previously executed actions, but it is unclear whether such effects depend strictly on action history, or also reflect context-dependent processes related to predictive motor planning. Here we manipulated the time available to initiate movements af...

journal_title：eLife

authors： Marinovic W,Poh E,de Rugy A,Carroll TJ

更新日期：2017-10-23 00:00:00

abstract：:Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...

journal_title：eLife

authors： Serra-Marques A,Dumont S

更新日期：2018-07-09 00:00:00

abstract：:Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI effectiveness. We sh...

journal_title：eLife

authors： Theard PL,Sheffels E,Sealover NE,Linke AJ,Pratico DJ,Kortum RL

更新日期：2020-09-08 00:00:00

abstract：:Rats exhibit 'empathy' making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA ...

journal_title：eLife

authors： Lichtenberg NT,Lee B,Kashtelyan V,Chappa BS,Girma HT,Green EA,Kantor S,Lagowala DA,Myers MA,Potemri D,Pecukonis MG,Tesfay RT,Walters MS,Zhao AC,Blair RJR,Cheer JF,Roesch MR

更新日期：2018-11-28 00:00:00

abstract：:Cerebral cortical architecture at birth encodes regionally differential dendritic arborization and synaptic formation. It underlies behavioral emergence of 2-year-olds. Brain changes in 0-2 years are most dynamic across the lifespan. Effective prediction of future behavior with brain microstructure at birth will revea...

journal_title：eLife

authors： Ouyang M,Peng Q,Jeon T,Heyne R,Chalak L,Huang H

更新日期：2020-12-22 00:00:00

abstract：:Mood and anxiety disorders are the most prevalent psychiatric conditions and are exacerbated by stress. Recent studies have suggested cyclooxygenase-2 (COX-2) inhibition could represent a novel treatment approach or augmentation strategy for affective disorders including anxiety disorders and major depression. We show...

journal_title：eLife

authors： Gamble-George JC,Baldi R,Halladay L,Kocharian A,Hartley N,Silva CG,Roberts H,Haymer A,Marnett LJ,Holmes A,Patel S

更新日期：2016-05-10 00:00:00

abstract：:Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for targeted therapies....

journal_title：eLife

authors： McCauley HA,Chevrier V,Birnbaum D,Guasch G

更新日期：2017-02-21 00:00:00

abstract：:Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors, generating a positive feedback of GTPase activation and membrane ...

journal_title：eLife

authors： Cezanne A,Lauer J,Solomatina A,Sbalzarini IF,Zerial M

更新日期：2020-06-08 00:00:00

abstract：:Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level. ...

journal_title：eLife

authors： Komondor KM,Carlson AE

更新日期：2020-12-02 00:00:00

abstract：: ...

journal_title：eLife

authors： Hayasaka N,Hirano A,Miyoshi Y,Tokuda IT,Yoshitane H,Matsuda J,Fukada Y

更新日期：2021-01-25 00:00:00

abstract：:Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites. These ATPases are ...

journal_title：eLife

authors： Çamdere G,Guacci V,Stricklin J,Koshland D

更新日期：2015-11-19 00:00:00

abstract：:The Hippo-YAP pathway is a central regulator of cell contact inhibition, proliferation and death. There are conflicting reports regarding the role of Angiomotin (Amot) in regulating this pathway. While some studies suggest a YAP-inhibitory function other studies indicate Amot is required for YAP activity. Here, we des...

journal_title：eLife

authors： Moleirinho S,Hoxha S,Mandati V,Curtale G,Troutman S,Ehmer U,Kissil JL

更新日期：2017-05-03 00:00:00

abstract：:Pioneer factors such as Zelda (Zld) help initiate zygotic transcription in Drosophila early embryos, but whether other factors support this dynamic process is unclear. Odd-paired (Opa), a zinc-finger transcription factor expressed at cellularization, controls the transition of genes from pair-rule to segmental pattern...

journal_title：eLife

authors： Koromila T,Gao F,Iwasaki Y,He P,Pachter L,Gergen JP,Stathopoulos A

更新日期：2020-07-23 00:00:00

abstract：:Processing bodies (PBs) are cytoplasmic mRNP granules that assemble via liquid-liquid phase separation and are implicated in the decay or storage of mRNAs. How PB assembly is regulated in cells remains unclear. Previously, we identified the ATPase activity of the DEAD-box protein Dhh1 as a key regulator of PB dynamics...

journal_title：eLife

authors： Sachdev R,Hondele M,Linsenmeier M,Vallotton P,Mugler CF,Arosio P,Weis K

更新日期：2019-01-16 00:00:00

abstract：:Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions including mood, learning and memory. However, mechanisms underlying neural stem/progenitor cells (NSPCs) proliferation are not well understood. We found that Agrin, a factor critical for neuromuscular junction formation, is ele...

journal_title：eLife

authors： Zhang H,Sathyamurthy A,Liu F,Li L,Zhang L,Dong Z,Cui W,Sun X,Zhao K,Wang H,Ho HH,Xiong WC,Mei L

更新日期：2019-07-03 00:00:00

abstract：:Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate. ...

journal_title：eLife

authors： Odom DT

更新日期：2016-02-11 00:00:00

abstract：:Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a transgenic mouse lin...

journal_title：eLife

authors： Ngodup T,Romero GE,Trussell LO

更新日期：2020-11-03 00:00:00

abstract：:Learning more about the cells that enable parasitic worms called schistosomes to reproduce inside snails could lead to new treatments that prevent these parasites from being transmitted to humans. ...

journal_title：eLife

authors： Sánchez Alvarado A

更新日期：2013-07-30 00:00:00

abstract：:Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles. Aside from the virus itself, important molecular players involved in virus entry ...

journal_title：eLife

authors： Mikuličić S,Finke J,Boukhallouk F,Wüstenhagen E,Sons D,Homsi Y,Reiss K,Lang T,Florin L

更新日期：2019-05-20 00:00:00