Abstract:
:Improving the peer review process, overcoming the limitations of print journals and providing open access to the very best work in the life and biomedical sciences are three highlights of our first year.
journal_name
Elifejournal_title
eLifeauthors
Schekman R,Watt FM,Weigel Ddoi
10.7554/eLife.01516subject
Has Abstractpub_date
2013-10-15 00:00:00pages
e01516issn
2050-084Xpii
01516journal_volume
2pub_type
杂志文章相关文献
eLife文献大全abstract::A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density inform this transcriptional program remain enigmatic. Here, we uncover a novel mechanism licensing tr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.06821
更新日期:2015-06-25 00:00:00
abstract::Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an in vivo tumor model expressing oncogenic Drosophila Homeodomain-interacting protein kinase (Hipk), tumor cells display elevated aerobic gly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46315
更新日期:2019-07-01 00:00:00
abstract::MFN2 encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication. MFN2 mutations cause axonal neuropathy, with associated lipodystrophy only occasionally noted, however homozygosity for the p.Arg707Trp mutation was recently associated with upper body adipose overgr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23813
更新日期:2017-04-19 00:00:00
abstract::Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26231
更新日期:2017-09-05 00:00:00
abstract::Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13238
更新日期:2016-05-24 00:00:00
abstract::Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan vil...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61562
更新日期:2020-11-06 00:00:00
abstract::Eukaryotic kinetochores connect spindlemicrotubules to chromosomal centromeres. A group of proteins called the Ctf19 complex (Ctf19c) in yeast and the constitutive centromere associated network (CCAN) in other organisms creates the foundation of a kinetochore. The Ctf19c/CCAN influences the timing of kinetochore assem...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44239
更新日期:2019-02-14 00:00:00
abstract::A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarde...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34122
更新日期:2018-03-26 00:00:00
abstract::The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis with regions of incompletely replicated DNA. These regions are processe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48686
更新日期:2019-09-23 00:00:00
abstract::Advances in DNA sequencing have revolutionized our ability to read genomes. However, even in the most well-studied of organisms, the bacterium Escherichia coli, for ≈65% of promoters we remain ignorant of their regulation. Until we crack this regulatory Rosetta Stone, efforts to read and write genomes will remain haph...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55308
更新日期:2020-09-21 00:00:00
abstract::The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca2+ release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively open. Previously, using on...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62772
更新日期:2020-11-30 00:00:00
abstract::The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays, we developed a mode...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36258
更新日期:2018-05-01 00:00:00
abstract::Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61271
更新日期:2020-12-02 00:00:00
abstract::Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for ful...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40039
更新日期:2018-10-22 00:00:00
abstract::The sense of ownership of one's body is important for survival, e.g., in defending the body against a threat. However, in addition to affecting behavior, it also affects perception of the world. In the case of visuospatial perception, it has been shown that the sense of ownership causes external space to be perceptual...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26022
更新日期:2017-08-17 00:00:00
abstract::Studies of the performance of individuals with dyslexia in perceptual tasks suggest that their implicit inference of sound statistics is impaired. Previously, using two-tone frequency discrimination, we found that the effect of previous trials' frequencies on the judgments of individuals with dyslexia decays faster th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30018
更新日期:2018-02-28 00:00:00
abstract::Pervasive expression of circular RNA is a recently discovered feature of eukaryotic gene expression programs, yet its function remains largely unknown. The presumed biogenesis of these RNAs involves a non-canonical 'backsplicing' event. Recent studies in mammalian cell culture posit that backsplicing is facilitated by...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07540
更新日期:2015-06-09 00:00:00
abstract::Bacillus subtilis can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54244
更新日期:2020-01-24 00:00:00
abstract::Humans can run without falling down, usually despite uneven terrain or occasional pushes. Even without such external perturbations, intrinsic sources like sensorimotor noise perturb the running motion incessantly, making each step variable. Here, using simple and generalizable models, we show that even such small step...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38371
更新日期:2019-03-19 00:00:00
abstract::Ribosomes are universally important in biology and their production is dysregulated by developmental disorders, cancer, and virus infection. Although presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-intrinsic immune responses remains untested. Surprisingly, we find t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49551
更新日期:2019-12-16 00:00:00
abstract::TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif of Pygo proteins. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09073
更新日期:2015-08-27 00:00:00
abstract::Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+, SUR1 increases the apparent affinity for nucleotide inhibition...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52775
更新日期:2020-01-07 00:00:00
abstract::Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circulatory system and pr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57028
更新日期:2020-06-08 00:00:00
abstract::Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44098
更新日期:2019-08-08 00:00:00
abstract::Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include tra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54224
更新日期:2020-03-06 00:00:00
abstract::Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct. However, discrepancies between confidence and accuracy suggest ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12192
更新日期:2016-02-01 00:00:00
abstract::Understanding how genetic variation contributes to phenotypic differences is a fundamental question in biology. Combining high-throughput gene function assays with mechanistic models of the impact of genetic variants is a promising alternative to genome-wide association studies. Here we have assembled a large panel of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31035
更新日期:2017-12-27 00:00:00
abstract::Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome. Here, we show that Srsf10 expression is controlled through an autoregulated minor intron, tightly co...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56075
更新日期:2020-04-27 00:00:00
abstract::How different helicase families with a conserved catalytic 'helicase core' evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear. In this study, we used Mss116, a yeast DEAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and mechanism. Ou...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04630
更新日期:2014-12-12 00:00:00
abstract::Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthesis of hybrid and complex N-glycans. However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether GnT1IP-L inhibits other N-glycan...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08916
更新日期:2015-09-15 00:00:00