Abstract:
:Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior.
journal_name
Elifejournal_title
eLifeauthors
O'Hare JK,Li H,Kim N,Gaidis E,Ade K,Beck J,Yin H,Calakos Ndoi
10.7554/eLife.26231subject
Has Abstractpub_date
2017-09-05 00:00:00issn
2050-084Xpii
26231journal_volume
6pub_type
杂志文章相关文献
eLife文献大全abstract::Human lung adenocarcinoma exhibits a propensity for de-differentiation, complicating diagnosis and treatment, and predicting poorer patient survival. In genetically engineered mouse models of lung cancer, expression of the BRAFV600E oncoprotein kinase initiates the growth of benign tumors retaining characteristics of ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43668
更新日期:2019-08-27 00:00:00
abstract::The light environment greatly impacts human alertness, mood, and cognition by both acute regulation of physiology and indirect alignment of circadian rhythms. These processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), but the relevant downstream brain areas involved...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44358
更新日期:2019-07-23 00:00:00
abstract::Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β-lactams showed mycobactericidal activity in combination with β-lactamase inhibitor, clavulanate (Clav). However, the mechanistic aspects of ho...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25624
更新日期:2017-05-26 00:00:00
abstract::The ability to flexibly navigate an environment relies on a hippocampal-dependent cognitive map. External space can be internally mapped at different spatial resolutions. However, whether hippocampal spatial coding resolution can rapidly adapt to local features of an environment remains unclear. To explore this possib...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44487
更新日期:2019-03-01 00:00:00
abstract::Cells respond to changes in their environment through signaling networks that modulate cytoskeleton and membrane organization to coordinate cell-cycle progression, polarized cell growth and multicellular development. Here, we define a novel regulatory mechanism by which the motor activity and function of the fission y...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51150
更新日期:2019-09-30 00:00:00
abstract::Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) subunits GluA2, GluA3...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28080
更新日期:2017-06-13 00:00:00
abstract::In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes matter a priori. H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43318
更新日期:2019-04-25 00:00:00
abstract::Centering and decentering of cellular components is essential for internal organization of cells and their ability to perform basic cellular functions such as division and motility. How cells achieve proper localization of their organelles is still not well-understood, especially in large cells such as oocytes. Here, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55368
更新日期:2020-04-21 00:00:00
abstract::Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a transcription factor to its own promoter. Here, we report a novel mechan...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58836
更新日期:2020-08-03 00:00:00
abstract::Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08362
更新日期:2015-09-03 00:00:00
abstract::Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved the 4.2 Å resoluti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31662
更新日期:2018-01-18 00:00:00
abstract::Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therap...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48890
更新日期:2019-12-24 00:00:00
abstract::A study of 3,500 children in the UK shows that data on socioeconomic background and previous educational achievements can better predict how students will perform at school than genetic data. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55720
更新日期:2020-03-13 00:00:00
abstract::TFIID-a complex of TATA-binding protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter recognition apparatus. Recent studies have revealed significant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adipocytes. Here, we report that TBP prot...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08536
更新日期:2015-09-22 00:00:00
abstract::Many primary sensory cilia exhibit unique architectures that are critical for transduction of specific sensory stimuli. Although basic ciliogenic mechanisms are well described, how complex ciliary structures are generated remains unclear. Seminal work performed several decades ago provided an initial but incomplete de...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01948
更新日期:2014-03-25 00:00:00
abstract::Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively. Recently, we demonstrated that ferroportin is also found in cardiomyocytes, and that its cardiac-spe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19804
更新日期:2016-11-29 00:00:00
abstract::Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge this covalently closed macromolecule during growth, but how these autolytic enzymes are regulated remains poorly understood. Bacillus s...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52088
更新日期:2019-12-06 00:00:00
abstract::Previously, we found that in the mammalian retina, inhibitory inputs onto starburst amacrine cells (SACs) are required for robust direction selectivity of On-Off direction-selective ganglion cells (On-Off DSGCs) against noisy backgrounds (Chen et al., 2016). However, the source of the inhibitory inputs to SACs and how...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62618
更新日期:2020-12-03 00:00:00
abstract::Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, we identified extensive afferent synaptic inputs to OPCs residing in secondary m...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49291
更新日期:2019-10-18 00:00:00
abstract::Transposable elements (TEs), the movement of which can damage the genome, are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in the sperm companion cell - vegetative cell (VC) - of the flowering plant Arabidopsis thaliana. However, the extent and mechanism of this activation are unknown. Here w...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42530
更新日期:2019-05-28 00:00:00
abstract::The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41036
更新日期:2019-02-08 00:00:00
abstract::The loss of previously adaptive traits is typically linked to relaxation in selection, yet the molecular steps leading to such repeated losses are rarely known. Molecular studies of loss have tended to focus on gene sequences alone, but overlooking other aspects of protein expression might underestimate phenotypic div...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37412
更新日期:2018-12-18 00:00:00
abstract::How mammalian tissues maintain their architecture and tissue-specificity is poorly understood. Previously, we documented both the indispensable role of the extracellular matrix (ECM) protein, laminin-111 (LN1), in the formation of normal breast acini, and the phenotypic reversion of cancer cells to acini-like structur...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26148
更新日期:2018-03-21 00:00:00
abstract::Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome,...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62576
更新日期:2020-12-14 00:00:00
abstract::Although mRNAs are localized in the processes of excitatory neurons, it is still unclear whether interneurons also localize a large population of mRNAs. In addition, the variability in the localized mRNA population within and between cell types is unknown. Here we describe the unbiased transcriptomic characterization ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63092
更新日期:2021-01-06 00:00:00
abstract::A mathematical model shows how the shape of early multicellular organisms may have helped cells evolve specialized roles. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.63328
更新日期:2020-11-03 00:00:00
abstract::The neural control of sugar consumption is critical for normal metabolism. In contrast to sugar-sensing taste neurons that promote consumption, we identify a taste neuron that limits sucrose consumption in Drosophila. Silencing of the neuron increases sucrose feeding; optogenetic activation decreases it. The feeding i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24992
更新日期:2017-03-23 00:00:00
abstract::The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.04476
更新日期:2014-09-24 00:00:00
abstract::Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although the function of bactericidal macrophages is highly con...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50414
更新日期:2019-10-14 00:00:00
abstract::It is widely argued that personalized instruction based on individual differences in learning styles or genetic predispositions could improve learning outcomes. However, this proposition has resisted clear demonstration in human studies, where it is difficult to control experience and quantify outcomes. Here, we take ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47216
更新日期:2019-09-17 00:00:00