Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila.

abstract：:Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...

journal_title：eLife

authors： Wei XX,Prentice J,Balasubramanian V

更新日期：2015-09-03 00:00:00

abstract：:Segmentation of the axial skeleton in amniotes depends on the segmentation clock, which patterns the paraxial mesoderm and the sclerotome. While the segmentation clock clearly operates in teleosts, the role of the sclerotome in establishing the axial skeleton is unclear. We severely disrupt zebrafish paraxial segmenta...

journal_title：eLife

authors： Lleras Forero L,Narayanan R,Huitema LF,VanBergen M,Apschner A,Peterson-Maduro J,Logister I,Valentin G,Morelli LG,Oates AC,Schulte-Merker S

更新日期：2018-04-06 00:00:00

abstract：:Manipulating gene function cell type-specifically is a common experimental goal in Drosophila research and has been central to studies of neural development, circuit computation, and behavior. However, current cell type-specific gene disruption techniques in flies often reduce gene activity incompletely or rely on cel...

journal_title：eLife

authors： Fisher YE,Yang HH,Isaacman-Beck J,Xie M,Gohl DM,Clandinin TR

更新日期：2017-02-17 00:00:00

abstract：:Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in cortical porosity, and a...

journal_title：eLife

authors： Walker EC,Truong K,McGregor NE,Poulton IJ,Isojima T,Gooi JH,Martin TJ,Sims NA

更新日期：2020-05-27 00:00:00

abstract：:Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly dependent on membrane volta...

journal_title：eLife

authors： Zhang X,Chen W,Li P,Calvo R,Southall N,Hu X,Bryant-Genevier M,Feng X,Geng Q,Gao C,Yang M,Tang K,Ferrer M,Marugan JJ,Xu H

更新日期：2019-12-11 00:00:00

abstract：:The ability to flexibly navigate an environment relies on a hippocampal-dependent cognitive map. External space can be internally mapped at different spatial resolutions. However, whether hippocampal spatial coding resolution can rapidly adapt to local features of an environment remains unclear. To explore this possib...

journal_title：eLife

authors： Bourboulou R,Marti G,Michon FX,El Feghaly E,Nouguier M,Robbe D,Koenig J,Epsztein J

更新日期：2019-03-01 00:00:00

abstract：:While host immune receptors detect pathogen-associated molecular patterns to activate immunity, pathogens attempt to deregulate host immunity through secreted effectors. Fungi employ LysM effectors to prevent recognition of cell wall-derived chitin by host immune receptors, although the mechanism to compete for chitin...

journal_title：eLife

authors： Sánchez-Vallet A,Saleem-Batcha R,Kombrink A,Hansen G,Valkenburg DJ,Thomma BP,Mesters JR

更新日期：2013-07-02 00:00:00

abstract：:Human patients carrying PAPP-A2 inactivating mutations have low bone mineral density. The underlying mechanisms for this reduced calcification are poorly understood. Using a zebrafish model, we report that Papp-aa regulates bone calcification by promoting Ca2+-transporting epithelial cell (ionocyte) quiescence-prolife...

journal_title：eLife

authors： Liu C,Li S,Noer PR,Kjaer-Sorensen K,Juhl AK,Goldstein A,Ke C,Oxvig C,Duan C

更新日期：2020-04-16 00:00:00

abstract：:Ribosomes are universally important in biology and their production is dysregulated by developmental disorders, cancer, and virus infection. Although presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-intrinsic immune responses remains untested. Surprisingly, we find t...

journal_title：eLife

authors： Bianco C,Mohr I

更新日期：2019-12-16 00:00:00

abstract：:Microtubule dynamics facilitate neurite growth and establish morphology, but the role of minus-end binding proteins in these processes is largely unexplored. CAMSAP homologs associate with microtubule minus-ends, and are important for the stability of epithelial cell adhesions. In this study, we report morphological d...

journal_title：eLife

authors： Marcette JD,Chen JJ,Nonet ML

更新日期：2014-02-25 00:00:00

abstract：:Fruit fly neuroblasts can either self-renew, rest or take on a specialized form, depending on the levels of a protein called Prospero. ...

journal_title：eLife

authors： Pollarolo G,Gonzalez C

更新日期：2014-10-29 00:00:00

abstract：:Most funding agencies rely on peer review to evaluate grant applications and proposals, but research into the use of this process by funding agencies has been limited. Here we explore if two changes to the organization of peer review for proposals submitted to various funding actions by the European Union has an influ...

journal_title：eLife

authors： Pina DG,Buljan I,Hren D,Marušić A

更新日期：2021-01-13 00:00:00

abstract：:Feedback inhibitory motifs are thought to be important for pattern separation across species. How feedback circuits may implement pattern separation of biologically plausible, temporally structured input in mammals is, however, poorly understood. We have quantitatively determined key properties of netfeedback inhibiti...

journal_title：eLife

authors： Braganza O,Mueller-Komorowska D,Kelly T,Beck H

更新日期：2020-02-20 00:00:00

abstract：:A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured axons. DLK/Wnd is ...

journal_title：eLife

authors： Hao Y,Frey E,Yoon C,Wong H,Nestorovski D,Holzman LB,Giger RJ,DiAntonio A,Collins C

更新日期：2016-06-07 00:00:00

abstract：:Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adaptation. We tested if evolved bacterial resistance against host-target...

journal_title：eLife

authors： Rosener B,Sayin S,Oluoch PO,García González AP,Mori H,Walhout AJ,Mitchell A

更新日期：2020-11-30 00:00:00

abstract：:The diaphragm muscle is essential for breathing in mammals. Its asymmetric elevation during contraction correlates with morphological features suggestive of inherent left-right (L/R) asymmetry. Whether this asymmetry is due to L versus R differences in the muscle or in the phrenic nerve activity is unknown. Here, we h...

journal_title：eLife

authors： Charoy C,Dinvaut S,Chaix Y,Morlé L,Sanyas I,Bozon M,Kindbeiter K,Durand B,Skidmore JM,De Groef L,Seki M,Moons L,Ruhrberg C,Martin JF,Martin DM,Falk J,Castellani V

更新日期：2017-06-22 00:00:00

abstract：:Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This...

journal_title：eLife

authors： Sait LG,Sula A,Ghovanloo MR,Hollingworth D,Ruben PC,Wallace BA

更新日期：2020-10-22 00:00:00

abstract：:Experiments in which monkeys have to select or estimate the location of a target are revealing more about the role of the dorsal premotor cortex in decision making. ...

journal_title：eLife

authors： Stuphorn V

更新日期：2016-07-15 00:00:00

abstract：:Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentified temperature-sensing domain. Here we report that the homologous...

journal_title：eLife

authors： Yang F,Zheng J

更新日期：2014-07-16 00:00:00

abstract：:During outbreaks of high-consequence pathogens, airport screening programs have been deployed to curtail geographic spread of infection. The effectiveness of screening depends on several factors, including pathogen natural history and epidemiology, human behavior, and characteristics of the source epidemic. We develop...

journal_title：eLife

authors： Gostic KM,Kucharski AJ,Lloyd-Smith JO

更新日期：2015-02-19 00:00:00

abstract：:Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment and action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells, is well ...

journal_title：eLife

authors： Cornford JH,Mercier MS,Leite M,Magloire V,Häusser M,Kullmann DM

更新日期：2019-10-28 00:00:00

abstract：:A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs cells. ...

journal_title：eLife

authors： Amelio I,Melino G

更新日期：2016-05-23 00:00:00

abstract：:Even when we are at rest, our spinal cords show spontaneous, yet well organised, fluctuations of activity that might reflect sensory and motor networks. ...

journal_title：eLife

authors： Eippert F,Tracey I

更新日期：2014-08-05 00:00:00

abstract：:Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are triggered by environmental cues is poorly understood. To uncover how primary murine macrophages respond to bacterial pathogens, we globally assessed changes in post-translatio...

journal_title：eLife

authors： Budzik JM,Swaney DL,Jimenez-Morales D,Johnson JR,Garelis NE,Repasy T,Roberts AW,Popov LM,Parry TJ,Pratt D,Ideker T,Krogan NJ,Cox JS

更新日期：2020-01-17 00:00:00

abstract：:Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is coupled to the presence of the cargo is unclear. Here we show that the...

journal_title：eLife

authors： Fracchiolla D,Sawa-Makarska J,Zens B,Ruiter A,Zaffagnini G,Brezovich A,Romanov J,Runggatscher K,Kraft C,Zagrovic B,Martens S

更新日期：2016-11-23 00:00:00

abstract：:Huntington disease (HD) is a neurological disorder caused by polyglutamine expansions in mutated Huntingtin (mHtt) proteins, rendering them prone to form inclusion bodies (IB). We report that in yeast, such IB formation is a factor-dependent process subjected to age-related decline. A genome-wide, high-content imaging...

journal_title：eLife

authors： Yang J,Hao X,Cao X,Liu B,Nyström T

更新日期：2016-04-01 00:00:00

abstract：:Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP amyloid formation and link their properties to induction of rat IN...

journal_title：eLife

authors： Abedini A,Plesner A,Cao P,Ridgway Z,Zhang J,Tu LH,Middleton CT,Chao B,Sartori DJ,Meng F,Wang H,Wong AG,Zanni MT,Verchere CB,Raleigh DP,Schmidt AM

更新日期：2016-05-23 00:00:00

abstract：:In animal-based biomedical research, both the sex and the age of the animals studied affect disease phenotypes by modifying their susceptibility, presentation and response to treatment. The accurate reporting of experimental methods and materials, including the sex and age of animals, is essential so that other resear...

journal_title：eLife

authors： Flórez-Vargas O,Brass A,Karystianis G,Bramhall M,Stevens R,Cruickshank S,Nenadic G

更新日期：2016-03-03 00:00:00

abstract：:Advanced microscopy and labeling techniques reveal that bacteria localize mRNAs within their cells in a similar way to eukaryotes. ...

journal_title：eLife

authors： Jan CH

更新日期：2016-05-20 00:00:00

abstract：:Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and...

journal_title：eLife

authors： Wheaton WW,Weinberg SE,Hamanaka RB,Soberanes S,Sullivan LB,Anso E,Glasauer A,Dufour E,Mutlu GM,Budigner GS,Chandel NS

更新日期：2014-05-13 00:00:00