Quantitative differences, qualitative outcomes.

abstract：:It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that macrophages and microglia respond immediately upon oncogene activation in the brai...

journal_title：eLife

authors： Chia K,Mazzolini J,Mione M,Sieger D

更新日期：2018-02-21 00:00:00

abstract：:During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Ra...

journal_title：eLife

authors： Chen X,Shibata AC,Hendi A,Kurashina M,Fortes E,Weilinger NL,MacVicar BA,Murakoshi H,Mizumoto K

更新日期：2018-07-31 00:00:00

abstract：:Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to stu...

journal_title：eLife

authors： Matias S,Lottem E,Dugué GP,Mainen ZF

更新日期：2017-03-21 00:00:00

abstract：:In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by tissue strain. It triggers the increase of accessibility of the Y65...

journal_title：eLife

authors： Röper JC,Mitrossilis D,Stirnemann G,Waharte F,Brito I,Fernandez-Sanchez ME,Baaden M,Salamero J,Farge E

更新日期：2018-07-19 00:00:00

abstract：:Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This...

journal_title：eLife

authors： Sait LG,Sula A,Ghovanloo MR,Hollingworth D,Ruben PC,Wallace BA

更新日期：2020-10-22 00:00:00

abstract：:Two distinct mechanisms for primordial germ cell (PGC) specification are observed within Bilatera: early determination by maternal factors or late induction by zygotic cues. Here we investigate the molecular basis for PGC specification in Nematostella, a representative pre-bilaterian animal where PGCs arise as paired ...

journal_title：eLife

authors： Chen CY,McKinney SA,Ellington LR,Gibson MC

更新日期：2020-09-24 00:00:00

abstract：:Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage. Here, we examine the impact of brief periods of sleep deprivation on dendritic structure. In mice, we find that five hours o...

journal_title：eLife

authors： Havekes R,Park AJ,Tudor JC,Luczak VG,Hansen RT,Ferri SL,Bruinenberg VM,Poplawski SG,Day JP,Aton SJ,Radwańska K,Meerlo P,Houslay MD,Baillie GS,Abel T

更新日期：2016-08-23 00:00:00

abstract：:Gustatory pheromones play an essential role in shaping the behavior of many organisms. However, little is known about the processing of taste pheromones in higher order brain centers. Here, we describe a male-specific gustatory circuit in Drosophila that underlies the detection of the anti-aphrodisiac pheromone (3R,11...

journal_title：eLife

authors： Shankar S,Chua JY,Tan KJ,Calvert ME,Weng R,Ng WC,Mori K,Yew JY

更新日期：2015-06-17 00:00:00

abstract：:LAMP1 and LAMP2 proteins are highly abundant, ubiquitous, mammalian proteins that line the lysosome limiting membrane, and protect it from lysosomal hydrolase action. LAMP2 deficiency causes Danon's disease, an X-linked hypertrophic cardiomyopathy. LAMP2 is needed for chaperone-mediated autophagy, and its expression i...

journal_title：eLife

authors： Li J,Pfeffer SR

更新日期：2016-09-24 00:00:00

abstract：:A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease. ...

journal_title：eLife

authors： Waghray A,Rajagopal J

更新日期：2017-08-14 00:00:00

abstract：:Microtubules control different aspects of cell polarization. In cells with a radial microtubule system, a pivotal role in setting up asymmetry is attributed to the relative positioning of the centrosome and the nucleus. Here, we show that centrosome loss had no effect on the ability of endothelial cells to polarize an...

journal_title：eLife

authors： Martin M,Veloso A,Wu J,Katrukha EA,Akhmanova A

更新日期：2018-03-16 00:00:00

abstract：:Establishing a link between the nonsense-mediated decay pathway and a gene associated with programmed cell death could explain why this pathway is essential in most, but not all, eukaryotes. ...

journal_title：eLife

authors： Saveanu C,Jacquier A

更新日期：2016-04-27 00:00:00

abstract：:The β-catenin transcriptional coregulator is involved in various biological and pathological processes; however, its requirements in hematopoietic cells remain controversial. We re-targeted the Ctnnb1 gene locus to generate a true β-catenin-null mutant mouse strain. Ablation of β-catenin alone, or in combination with ...

journal_title：eLife

authors： Zhao X,Shao P,Gai K,Li F,Shan Q,Xue HH

更新日期：2020-08-21 00:00:00

abstract：:A mathematical model shows how the shape of early multicellular organisms may have helped cells evolve specialized roles. ...

journal_title：eLife

authors： Staps M,Tarnita C

更新日期：2020-11-03 00:00:00

abstract：:Why does a first pregnancy after age 35 increase the risk of breast cancer, and what can be done to combat this? ...

journal_title：eLife

authors： Chakravarthi BV,Varambally S

更新日期：2013-12-31 00:00:00

abstract：:Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the S...

journal_title：eLife

authors： Vogan AA,Ament-Velásquez SL,Granger-Farbos A,Svedberg J,Bastiaans E,Debets AJ,Coustou V,Yvanne H,Clavé C,Saupe SJ,Johannesson H

更新日期：2019-07-26 00:00:00

abstract：:Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities, intrinsic platinum resistance, and tumorsphere formation are here ass...

journal_title：eLife

authors： Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,K

更新日期：2019-09-03 00:00:00

abstract：:Two-component systems (TCS) are protein machineries that enable cells to respond to input signals. Histidine kinases (HK) are the sensory component, transferring information toward downstream response regulators (RR). HKs transfer phosphoryl groups to their specific RRs, but also dephosphorylate them, overall ensuring...

journal_title：eLife

authors： Trajtenberg F,Imelio JA,Machado MR,Larrieux N,Marti MA,Obal G,Mechaly AE,Buschiazzo A

更新日期：2016-12-12 00:00:00

abstract：:The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine kinking. Here, we identified a mutation in the kinase gene dstyk tha...

journal_title：eLife

authors： Bagwell J,Norman J,Ellis K,Peskin B,Hwang J,Ge X,Nguyen SV,McMenamin SK,Stainier DY,Bagnat M

更新日期：2020-01-29 00:00:00

abstract：:Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured microvascular endothelial cells, Piezo1 channel activation by either shear...

journal_title：eLife

authors： Caolo V,Debant M,Endesh N,Futers TS,Lichtenstein L,Bartoli F,Parsonage G,Jones EA,Beech DJ

更新日期：2020-06-02 00:00:00

abstract：:Journals are exploring new approaches to peer review in order to reduce bias, increase transparency and respond to author preferences. Funders are also getting involved. ...

journal_title：eLife

authors： Rodgers P

更新日期：2017-09-29 00:00:00

abstract：:TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif of Pygo proteins. ...

journal_title：eLife

authors： Fiedler M,Graeb M,Mieszczanek J,Rutherford TJ,Johnson CM,Bienz M

更新日期：2015-08-27 00:00:00

abstract：:The contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying complexity, non-speech ...

journal_title：eLife

authors： Woolnough O,Forseth KJ,Rollo PS,Tandon N

更新日期：2019-12-19 00:00:00

abstract：:Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each corresponded to a sp...

journal_title：eLife

authors： Yeo SK,Zhu X,Okamoto T,Hao M,Wang C,Lu P,Lu LJ,Guan JL

更新日期：2020-08-25 00:00:00

abstract：:Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites. These ATPases are ...

journal_title：eLife

authors： Çamdere G,Guacci V,Stricklin J,Koshland D

更新日期：2015-11-19 00:00:00

abstract：:Probabilistic models of adaptive immune repertoire sequence distributions can be used to infer the expansion of immune cells in response to stimulus, differentiate genetic from environmental factors that determine repertoire sharing, and evaluate the suitability of various target immune sequences for stimulation via v...

journal_title：eLife

authors： Davidsen K,Olson BJ,DeWitt WS 3rd,Feng J,Harkins E,Bradley P,Matsen FA 4th

更新日期：2019-09-05 00:00:00

abstract：:Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory ...

journal_title：eLife

authors： Wu Y,Funato Y,Meschi E,Jovanoski KD,Miki H,Waddell S

更新日期：2020-11-26 00:00:00

abstract：:The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates the higher-order structure of chromatin, and has important roles in the regulation of gene expression, DNA damage repair and cell differentiation. H...

journal_title：eLife

authors： Millard CJ,Varma N,Saleh A,Morris K,Watson PJ,Bottrill AR,Fairall L,Smith CJ,Schwabe JW

更新日期：2016-04-21 00:00:00

abstract：:New ages for flowstone, sediments and fossil bones from the Dinaledi Chamber are presented. We combined optically stimulated luminescence dating of sediments with U-Th and palaeomagnetic analyses of flowstones to establish that all sediments containing Homo naledi fossils can be allocated to a single stratigraphic ent...

journal_title：eLife

authors： Dirks PH,Roberts EM,Hilbert-Wolf H,Kramers JD,Hawks J,Dosseto A,Duval M,Elliott M,Evans M,Grün R,Hellstrom J,Herries AI,Joannes-Boyau R,Makhubela TV,Placzek CJ,Robbins J,Spandler C,Wiersma J,Woodhead J,Berger LR

更新日期：2017-05-09 00:00:00

abstract：:WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse thymocyte development. We find that WNK1 is required for the transitio...

journal_title：eLife

authors： Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

更新日期：2020-10-14 00:00:00