Abstract:
:Experiments in which monkeys have to select or estimate the location of a target are revealing more about the role of the dorsal premotor cortex in decision making.
journal_name
Elifejournal_title
eLifeauthors
Stuphorn Vdoi
10.7554/eLife.18721subject
Has Abstractpub_date
2016-07-15 00:00:00issn
2050-084Xjournal_volume
5pub_type
评论,杂志文章相关文献
eLife文献大全abstract::The incubation period for typhoid, polio, measles, leukemia and many other diseases follows a right-skewed, approximately lognormal distribution. Although this pattern was discovered more than sixty years ago, it remains an open question to explain its ubiquity. Here, we propose an explanation based on evolutionary dy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30212
更新日期:2017-12-21 00:00:00
abstract::Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate whole-brain gene delivery by retro-orbital injection of virus, but slow and sparse expression and the large injection volumes required make this approach cumbersom...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53639
更新日期:2020-05-18 00:00:00
abstract::The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here, we traced the whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55585
更新日期:2020-09-17 00:00:00
abstract::We present in vivo single-cell FRET measurements in the Escherichia coli chemotaxis system that reveal pervasive signaling variability, both across cells in isogenic populations and within individual cells over time. We quantify cell-to-cell variability of adaptation, ligand response, as well as steady-state output le...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27455
更新日期:2017-12-12 00:00:00
abstract::WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain protein...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49439
更新日期:2019-09-05 00:00:00
abstract::SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walku...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52656
更新日期:2020-01-15 00:00:00
abstract::Different coding strategies are used to represent odor information at various stages of the mammalian olfactory system. A temporal latency code represents odor identity in olfactory bulb (OB), but this temporal information is discarded in piriform cortex (PCx) where odor identity is instead encoded through ensemble me...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34831
更新日期:2018-03-29 00:00:00
abstract::The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overexpression increases ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23242
更新日期:2017-05-03 00:00:00
abstract::Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms to prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via RasV12-overexpression in the postmitotic salivary glands of Drosophila larvae, we overrode the glands adap...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.64919
更新日期:2020-12-30 00:00:00
abstract::Calcineurin is responsible for mediating a wide variety of cellular processes in response to dynamic calcium (Ca(2+)) signals, yet the precise mechanisms involved in the spatiotemporal control of calcineurin signaling are poorly understood. Here, we use genetically encoded fluorescent biosensors to directly probe the ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03765
更新日期:2014-07-23 00:00:00
abstract::The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that a daughter centriole-associated ciliopathy protein, Cep120, play...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35439
更新日期:2018-05-09 00:00:00
abstract::Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013). Here we show that mouse embryonic fibroblasts deficient in Bax/Bak...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30543
更新日期:2017-11-17 00:00:00
abstract::The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells. It has remained controversial, however, whether mammalian and yeast IRE1 use a common mechanism for ER stress sensing. Here, we...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30700
更新日期:2017-10-03 00:00:00
abstract::The number of de novo mutations (DNMs) found in an offspring's genome increases with both paternal and maternal age. But does the rate of mutation accumulation in human gametes differ across families? Using sequencing data from 33 large, three-generation CEPH families, we observed significant variability in parental a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46922
更新日期:2019-09-24 00:00:00
abstract::The sense of ownership of one's body is important for survival, e.g., in defending the body against a threat. However, in addition to affecting behavior, it also affects perception of the world. In the case of visuospatial perception, it has been shown that the sense of ownership causes external space to be perceptual...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26022
更新日期:2017-08-17 00:00:00
abstract::Some DNA viruses overcome plant defenses by producing a suppressor protein that blocks the silencing of viral genes. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11509
更新日期:2015-10-16 00:00:00
abstract::Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities, intrinsic platinum resistance, and tumorsphere formation are here ass...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47327
更新日期:2019-09-03 00:00:00
abstract::AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to neuropsychiatric d...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56630
更新日期:2020-12-16 00:00:00
abstract::Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50855
更新日期:2019-11-05 00:00:00
abstract::The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.37552
更新日期:2018-05-24 00:00:00
abstract::Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome. Here, we show that Srsf10 expression is controlled through an autoregulated minor intron, tightly co...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56075
更新日期:2020-04-27 00:00:00
abstract::Dengue Virus (DENV), a flavivirus spread by mosquito vectors, can cause vascular leakage and hemorrhaging. However, the processes that underlie increased vascular permeability and pathological plasma leakage during viral hemorrhagic fevers are largely unknown. Mast cells (MCs) are activated in vivo during DENV infecti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00481
更新日期:2013-04-30 00:00:00
abstract::Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27744
更新日期:2017-07-27 00:00:00
abstract::The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested at a whole transcriptomic scale and their downstream networks remain unidentified. By combin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55526
更新日期:2020-06-09 00:00:00
abstract::Neurons coding for head-direction are crucial for spatial navigation. Here we explored the cellular basis of head-direction coding in the rat dorsal presubiculum (PreS). We found that layer2 is composed of two principal cell populations (calbindin-positive and calbindin-negative neurons) which targeted the contralater...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14592
更新日期:2016-06-10 00:00:00
abstract::Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathemati...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23804
更新日期:2017-02-15 00:00:00
abstract::Adhesion molecules hold cells together but also couple cell membranes to a contractile actomyosin network, which limits the expansion of cell contacts. Despite their fundamental role in tissue morphogenesis and tissue homeostasis, how adhesion molecules control cell shapes and cell patterns in tissues remains unclear....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22796
更新日期:2017-05-24 00:00:00
abstract::Most cellular features have a range of states, but understanding the mechanisms responsible for interspecific divergence is a challenge for evolutionary cell biology. Models are developed for the distribution of mean phenotypes likely to evolve under the joint forces of mutation and genetic drift in the face of consta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34820
更新日期:2018-06-21 00:00:00
abstract::We previously showed in Drosophila melanogaster embryos that low-affinity Ultrabithorax (Ubx)-responsive shavenbaby (svb) enhancers drive expression using localized transcriptional environments and that active svb enhancers on different chromosomes tended to colocalize (Tsai et al., 2017). Here, we test the hypothesis...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45325
更新日期:2019-07-11 00:00:00
abstract::Transient receptor potential (TRP) ion channels in peripheral sensory neurons are functionally regulated by hydrolysis of the phosphoinositide PI(4,5)P2 and changes in the level of protein kinase mediated phosphorylation following activation of various G protein coupled receptors. We now show that the activity of TRPM...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26138
更新日期:2017-08-15 00:00:00