A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells.

abstract：:The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis with regions of incompletely replicated DNA. These regions are processe...

journal_title：eLife

authors： Sonneville R,Bhowmick R,Hoffmann S,Mailand N,Hickson ID,Labib K

更新日期：2019-09-23 00:00:00

abstract：:Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodontal disease, and treatment is generally restricted to preventive mea...

journal_title：eLife

authors： An JY,Kerns KA,Ouellette A,Robinson L,Morris HD,Kaczorowski C,Park SI,Mekvanich T,Kang A,McLean JS,Cox TC,Kaeberlein M

更新日期：2020-04-28 00:00:00

abstract：:The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. ...

journal_title：eLife

authors： Okabe Y,Medzhitov R

更新日期：2014-09-24 00:00:00

abstract：:Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB o...

journal_title：eLife

authors： Manzano Nieves G,Bravo M,Baskoylu S,Bath KG

更新日期：2020-07-21 00:00:00

abstract：:The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function re...

journal_title：eLife

authors： Xie X,Tabuchi M,Brown MP,Mitchell SP,Wu MN,Kolodkin AL

更新日期：2017-06-20 00:00:00

abstract：:Hybrid sterility is one of the reproductive isolation mechanisms leading to speciation. Prdm9, the only known vertebrate hybrid-sterility gene, causes failure of meiotic chromosome synapsis and infertility in male hybrids that are the offspring of two mouse subspecies. Within species, Prdm9 determines the sites of pro...

journal_title：eLife

authors： Gregorova S,Gergelits V,Chvatalova I,Bhattacharyya T,Valiskova B,Fotopulosova V,Jansa P,Wiatrowska D,Forejt J

更新日期：2018-03-14 00:00:00

abstract：:Animals and humans replay neural patterns encoding trajectories through their environment, both whilst they solve decision-making tasks and during rest. Both on-task and off-task replay are believed to contribute to flexible decision making, though how their relative contributions differ remains unclear. We investigat...

journal_title：eLife

authors： Eldar E,Lièvre G,Dayan P,Dolan RJ

更新日期：2020-06-17 00:00:00

abstract：:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investi...

journal_title：eLife

authors： Rabinowitz NC,Goris RL,Cohen M,Simoncelli EP

更新日期：2015-11-02 00:00:00

abstract：:Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities, intrinsic platinum resistance, and tumorsphere formation are here ass...

journal_title：eLife

authors： Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,K

更新日期：2019-09-03 00:00:00

abstract：:Perturbation of neuronal activity is key to understanding the brain's functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target n...

journal_title：eLife

authors： Sadeh S,Clopath C

更新日期：2020-02-19 00:00:00

abstract：:How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platelet oxidoreductase, E...

journal_title：eLife

authors： Passam F,Chiu J,Ju L,Pijning A,Jahan Z,Mor-Cohen R,Yeheskel A,Kolšek K,Thärichen L,Aponte-Santamaría C,Gräter F,Hogg PJ

更新日期：2018-06-22 00:00:00

abstract：:Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang et al., 2014), we de...

journal_title：eLife

authors： Siegenthaler KD,Pareja KA,Wang J,Sevier CS

更新日期：2017-03-03 00:00:00

abstract：:Visual perception and behavior are mediated by cortical areas that have been distinguished using architectonic and retinotopic criteria. We employed fluorescence imaging and GCaMP6 reporter mice to generate retinotopic maps, revealing additional regions of retinotopic organization that extend into barrel and retrosple...

journal_title：eLife

authors： Zhuang J,Ng L,Williams D,Valley M,Li Y,Garrett M,Waters J

更新日期：2017-01-06 00:00:00

abstract：:Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery of behavioral and neurophysiological deficits using GABAAR antagonists led to hypothesize an excessive activity of inhibitory circuits in this condition. Nonetheless, whether over-inhibition is present in DS and whether t...

journal_title：eLife

authors： Zorrilla de San Martin J,Donato C,Peixoto J,Aguirre A,Choudhary V,De Stasi AM,Lourenço J,Potier MC,Bacci A

更新日期：2020-08-12 00:00:00

abstract：:Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a transgenic mouse lin...

journal_title：eLife

authors： Ngodup T,Romero GE,Trussell LO

更新日期：2020-11-03 00:00:00

abstract：:To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be label...

journal_title：eLife

authors： Tan D,Li Q,Zhang MJ,Liu C,Ma C,Zhang P,Ding YH,Fan SB,Tao L,Yang B,Li X,Ma S,Liu J,Feng B,Liu X,Wang HW,He SM,Gao N,Ye K,Dong MQ,Lei X

更新日期：2016-03-08 00:00:00

abstract：:The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed that the eliminatio...

journal_title：eLife

authors： Murase S,Lantz CL,Quinlan EM

更新日期：2017-09-06 00:00:00

abstract：:Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...

journal_title：eLife

authors： Tikhonov M

更新日期：2016-06-16 00:00:00

abstract：:The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any behavioral effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propos...

journal_title：eLife

authors： Barrett DG,Denève S,Machens CK

更新日期：2016-12-09 00:00:00

abstract：:Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level. ...

journal_title：eLife

authors： Komondor KM,Carlson AE

更新日期：2020-12-02 00:00:00

abstract：:C-type inactivation of potassium channels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism that is mediated by a hydrogen bond network in the channels' selectively filter. Previously, we used nonsense suppression to highlight the role of the conserved Trp434-Asp447 indole hyd...

journal_title：eLife

authors： Lueck JD,Mackey AL,Infield DT,Galpin JD,Li J,Roux B,Ahern CA

更新日期：2016-10-06 00:00:00

abstract：:Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan vil...

journal_title：eLife

authors： Easton A,Gao S,Lawton SP,Bennuru S,Khan A,Dahlstrom E,Oliveira RG,Kepha S,Porcella SF,Webster J,Anderson R,Grigg ME,Davis RE,Wang J,Nutman TB

更新日期：2020-11-06 00:00:00

abstract：:The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...

journal_title：eLife

authors： Kim KW,Tang NH,Piggott CA,Andrusiak MG,Park S,Zhu M,Kurup N,Cherra SJ 3rd,Wu Z,Chisholm AD,Jin Y

更新日期：2018-11-21 00:00:00

abstract：:Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find that the rate of decrease is adjusted to accommodate variation in the time of onset of darkness and starch content, such that reserves last al...

journal_title：eLife

authors： Scialdone A,Mugford ST,Feike D,Skeffington A,Borrill P,Graf A,Smith AM,Howard M

更新日期：2013-06-25 00:00:00

abstract：:Translesion DNA synthesis (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage. Human TLS involves the conjugation of ubiquitin to PCNA clamps encircling damaged DNA and the role of this post-translational modificati...

journal_title：eLife

authors： Hedglin M,Pandey B,Benkovic SJ

更新日期：2016-10-22 00:00:00

abstract：:In the retina, synaptic transmission between photoreceptors and downstream ON-bipolar neurons (ON-BCs) is mediated by a GPCR pathway, which plays an essential role in vision. However, the mechanisms that control signal transmission at this synapse and its relevance to behavior remain poorly understood. In this study w...

journal_title：eLife

authors： Sarria I,Pahlberg J,Cao Y,Kolesnikov AV,Kefalov VJ,Sampath AP,Martemyanov KA

更新日期：2015-04-16 00:00:00

abstract：:Activation of systemic acquired resistance in plants is associated with transcriptome reprogramming induced by the unstable coactivator NPR1. Immune-induced ubiquitination and proteasomal degradation of NPR1 are thought to facilitate continuous delivery of active NPR1 to target promoters, thereby maximising gene expre...

journal_title：eLife

authors： Skelly MJ,Furniss JJ,Grey H,Wong KW,Spoel SH

更新日期：2019-10-07 00:00:00

abstract：:Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences and reflect tumor microenvironment. By in vivo super-enhanc...

journal_title：eLife

authors： Yang H,Schramek D,Adam RC,Keyes BE,Wang P,Zheng D,Fuchs E

更新日期：2015-11-21 00:00:00

abstract：:The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. We measured BLA ACh signaling and activity of neurons expressing CaMKIIα (a marker for glutamatergic principal cells) in mice during...

journal_title：eLife

authors： Crouse RB,Kim K,Batchelor HM,Girardi EM,Kamaletdinova R,Chan J,Rajebhosale P,Pittenger ST,Role LW,Talmage DA,Jing M,Li Y,Gao XB,Mineur YS,Picciotto MR

更新日期：2020-09-18 00:00:00

abstract：:Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in ...

journal_title：eLife

authors： Breckwoldt MO,Bode J,Kurz FT,Hoffmann A,Ochs K,Ott M,Deumelandt K,Krüwel T,Schwarz D,Fischer M,Helluy X,Milford D,Kirschbaum K,Solecki G,Chiblak S,Abdollahi A,Winkler F,Wick W,Platten M,Heiland S,Bendszus M,Tews

更新日期：2016-02-02 00:00:00