Combinations of Spok genes create multiple meiotic drivers in Podospora.

Abstract:

:Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the Spok gene family underlies the Psks. The combination of Spok genes at different chromosomal locations defines the spore killer types and creates a killing hierarchy within a population. We identify two novel Spok homologs located within a large (74-167 kbp) region (the Spok block) that resides in different chromosomal locations in different strains. We confirm that the SPOK protein performs both killing and resistance functions and show that these activities are dependent on distinct domains, a predicted nuclease and kinase domain. Genomic and phylogenetic analyses across ascomycetes suggest that the Spok genes disperse through cross-species transfer, and evolve by duplication and diversification within lineages.

journal_name

Elife

journal_title

eLife

authors

Vogan AA,Ament-Velásquez SL,Granger-Farbos A,Svedberg J,Bastiaans E,Debets AJ,Coustou V,Yvanne H,Clavé C,Saupe SJ,Johannesson H

doi

10.7554/eLife.46454

subject

Has Abstract

pub_date

2019-07-26 00:00:00

issn

2050-084X

pii

46454

journal_volume

8

pub_type

杂志文章

相关文献

eLife文献大全
  • RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.

    abstract::In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the physical properties and organizing principles that define G body formation are unclear. We d...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.48480

    authors: Fuller GG,Han T,Freeberg MA,Moresco JJ,Ghanbari Niaki A,Roach NP,Yates JR 3rd,Myong S,Kim JK

    更新日期:2020-04-16 00:00:00

  • FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.

    abstract::CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator complex. We discov...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.37084

    authors: Dimitrova E,Kondo T,Feldmann A,Nakayama M,Koseki Y,Konietzny R,Kessler BM,Koseki H,Klose RJ

    更新日期:2018-05-29 00:00:00

  • How cells kill a "killer" messenger.

    abstract::Establishing a link between the nonsense-mediated decay pathway and a gene associated with programmed cell death could explain why this pathway is essential in most, but not all, eukaryotes. ...

    journal_title:eLife

    pub_type: 评论,杂志文章

    doi:10.7554/eLife.16076

    authors: Saveanu C,Jacquier A

    更新日期:2016-04-27 00:00:00

  • Uncovering the functional anatomy of the human insula during speech.

    abstract::The contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying complexity, non-speech ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.53086

    authors: Woolnough O,Forseth KJ,Rollo PS,Tandon N

    更新日期:2019-12-19 00:00:00

  • Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice.

    abstract::Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fiel...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.27069

    authors: Munshi R,Qadri SM,Zhang Q,Castellanos Rubio I,Del Pino P,Pralle A

    更新日期:2017-08-15 00:00:00

  • Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

    abstract::Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole e...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.39865

    authors: Pettinati I,Grzechnik P,Ribeiro de Almeida C,Brem J,McDonough MA,Dhir S,Proudfoot NJ,Schofield CJ

    更新日期:2018-12-03 00:00:00

  • Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo.

    abstract::Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sen...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.50345

    authors: Xie K,Wang N,Lin X,Wang Z,Zhao X,Fang P,Yue H,Kim J,Luo J,Cui S,Yan F,Shi P

    更新日期:2020-02-11 00:00:00

  • Diagnostic potential of tumor DNA from ovarian cyst fluid.

    abstract::We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were foun...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.15175

    authors: Wang Y,Sundfeldt K,Mateoiu C,Shih IeM,Kurman RJ,Schaefer J,Silliman N,Kinde I,Springer S,Foote M,Kristjansdottir B,James N,Kinzler KW,Papadopoulos N,Diaz LA,Vogelstein B

    更新日期:2016-07-15 00:00:00

  • An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.

    abstract::A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured axons. DLK/Wnd is ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.14048

    authors: Hao Y,Frey E,Yoon C,Wong H,Nestorovski D,Holzman LB,Giger RJ,DiAntonio A,Collins C

    更新日期:2016-06-07 00:00:00

  • TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium.

    abstract::Cells respond to changes in their environment through signaling networks that modulate cytoskeleton and membrane organization to coordinate cell-cycle progression, polarized cell growth and multicellular development. Here, we define a novel regulatory mechanism by which the motor activity and function of the fission y...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.51150

    authors: Baker K,Gyamfi IA,Mashanov GI,Molloy JE,Geeves MA,Mulvihill DP

    更新日期:2019-09-30 00:00:00

  • Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.

    abstract::Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved the 4.2 Å resoluti...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.31662

    authors: Spaulding CN,Schreiber HL 4th,Zheng W,Dodson KW,Hazen JE,Conover MS,Wang F,Svenmarker P,Luna-Rico A,Francetic O,Andersson M,Hultgren S,Egelman EH

    更新日期:2018-01-18 00:00:00

  • CHIP as a membrane-shuttling proteostasis sensor.

    abstract::Cells respond to protein misfolding and aggregation in the cytosol by adjusting gene transcription and a number of post-transcriptional processes. In parallel to functional reactions, cellular structure changes as well; however, the mechanisms underlying the early adaptation of cellular compartments to cytosolic prote...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.29388

    authors: Kopp Y,Lang WH,Schuster TB,Martínez-Limón A,Hofbauer HF,Ernst R,Calloni G,Vabulas RM

    更新日期:2017-11-01 00:00:00

  • Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast.

    abstract::Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that effici...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.02630

    authors: Zanders SE,Eickbush MT,Yu JS,Kang JW,Fowler KR,Smith GR,Malik HS

    更新日期:2014-06-24 00:00:00

  • Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.

    abstract::Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis with elusive mechanism; GLS1 promotes tumorigenesis, whereas GLS2 exhibits a tumor-suppressive function. In this study, we found that GLS2 but not GLS1 binds ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.10727

    authors: Zhang C,Liu J,Zhao Y,Yue X,Zhu Y,Wang X,Wu H,Blanco F,Li S,Bhanot G,Haffty BG,Hu W,Feng Z

    更新日期:2016-01-11 00:00:00

  • Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex.

    abstract::Rodents are emerging as increasingly popular models of visual functions. Yet, evidence that rodent visual cortex is capable of advanced visual processing, such as object recognition, is limited. Here we investigate how neurons located along the progression of extrastriate areas that, in the rat brain, run laterally to...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.22794

    authors: Tafazoli S,Safaai H,De Franceschi G,Rosselli FB,Vanzella W,Riggi M,Buffolo F,Panzeri S,Zoccolan D

    更新日期:2017-04-11 00:00:00

  • Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.

    abstract::Meiotic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs). Unlike yeast and plants, where DSBs are generated near gene promoters, in many vertebrates DSBs are enriched at hotspots determined by the DNA binding activity of the rapidly evolving zinc finger array of PRDM9 (PR domain zinc ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.53360

    authors: Mahgoub M,Paiano J,Bruno M,Wu W,Pathuri S,Zhang X,Ralls S,Cheng X,Nussenzweig A,Macfarlan TS

    更新日期:2020-04-30 00:00:00

  • The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.

    abstract::A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell responses in the intesti...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.12444

    authors: Kabat AM,Harrison OJ,Riffelmacher T,Moghaddam AE,Pearson CF,Laing A,Abeler-Dörner L,Forman SP,Grencis RK,Sattentau Q,Simon AK,Pott J,Maloy KJ

    更新日期:2016-02-24 00:00:00

  • Developmental mechanism of the periodic membrane skeleton in axons.

    abstract::Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental mechanism of this lattice structure. We found that this structure emerged early during axon...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.04581

    authors: Zhong G,He J,Zhou R,Lorenzo D,Babcock HP,Bennett V,Zhuang X

    更新日期:2014-12-23 00:00:00

  • Control of entropy in neural models of environmental state.

    abstract::Humans and animals construct internal models of their environment in order to select appropriate courses of action. The representation of uncertainty about the current state of the environment is a key feature of these models that controls the rate of learning as well as directly affecting choice behaviour. To maintai...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.39404

    authors: Muller TH,Mars RB,Behrens TE,O'Reilly JX

    更新日期:2019-02-28 00:00:00

  • One-shot learning and behavioral eligibility traces in sequential decision making.

    abstract::In many daily tasks, we make multiple decisions before reaching a goal. In order to learn such sequences of decisions, a mechanism to link earlier actions to later reward is necessary. Reinforcement learning (RL) theory suggests two classes of algorithms solving this credit assignment problem: In classic temporal-diff...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.47463

    authors: Lehmann MP,Xu HA,Liakoni V,Herzog MH,Gerstner W,Preuschoff K

    更新日期:2019-11-11 00:00:00

  • Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons.

    abstract::In Drosophila larvae, Class IV sensory neurons respond to noxious thermal stimuli and provoke heat avoidance behavior. Previously, we showed that the activated neurons displayed characteristic fluctuations of firing rates, which consisted of repetitive high-frequency spike trains and subsequent pause periods, and we p...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.29754

    authors: Onodera K,Baba S,Murakami A,Uemura T,Usui T

    更新日期:2017-10-16 00:00:00

  • Genetic specification of left-right asymmetry in the diaphragm muscles and their motor innervation.

    abstract::The diaphragm muscle is essential for breathing in mammals. Its asymmetric elevation during contraction correlates with morphological features suggestive of inherent left-right (L/R) asymmetry. Whether this asymmetry is due to L versus R differences in the muscle or in the phrenic nerve activity is unknown. Here, we h...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.18481

    authors: Charoy C,Dinvaut S,Chaix Y,Morlé L,Sanyas I,Bozon M,Kindbeiter K,Durand B,Skidmore JM,De Groef L,Seki M,Moons L,Ruhrberg C,Martin JF,Martin DM,Falk J,Castellani V

    更新日期:2017-06-22 00:00:00

  • SynEM, automated synapse detection for connectomics.

    abstract::Nerve tissue contains a high density of chemical synapses, about 1 per µm3 in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the focus of connectomic data analysis has been on neurite reconstru...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.26414

    authors: Staffler B,Berning M,Boergens KM,Gour A,Smagt PV,Helmstaedter M

    更新日期:2017-07-14 00:00:00

  • How biological attention mechanisms improve task performance in a large-scale visual system model.

    abstract::How does attentional modulation of neural activity enhance performance? Here we use a deep convolutional neural network as a large-scale model of the visual system to address this question. We model the feature similarity gain model of attention, in which attentional modulation is applied according to neural stimulus ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.38105

    authors: Lindsay GW,Miller KD

    更新日期:2018-10-01 00:00:00

  • Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.

    abstract::We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture pas...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.58042

    authors: Díaz-Alonso J,Morishita W,Incontro S,Simms J,Holtzman J,Gill M,Mucke L,Malenka RC,Nicoll RA

    更新日期:2020-08-24 00:00:00

  • Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels.

    abstract::Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological hallmark of Alzheimer's Disease (AD). Cerebral vessels play a major role in AD, as Aβ is cleared from the brain by pathways involving the cerebrovasculature, most AD patients have cerebrovascular amyloid (cerebral amyloid angiopathy (C...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.29595

    authors: Robert J,Button EB,Yuen B,Gilmour M,Kang K,Bahrabadi A,Stukas S,Zhao W,Kulic I,Wellington CL

    更新日期:2017-10-10 00:00:00

  • CDK9-dependent RNA polymerase II pausing controls transcription initiation.

    abstract::Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription i...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.29736

    authors: Gressel S,Schwalb B,Decker TM,Qin W,Leonhardt H,Eick D,Cramer P

    更新日期:2017-10-10 00:00:00

  • CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity.

    abstract::The knirps (kni) locus encodes transcription factors required for induction of the L2 wing vein in Drosophila. Here, we employ diverse CRISPR/Cas9 genome editing tools to generate a series of targeted lesions within the endogenous cis-regulatory module (CRM) required for kni expression in the L2 vein primordium. Pheno...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.30281

    authors: Xu XS,Gantz VM,Siomava N,Bier E

    更新日期:2017-12-23 00:00:00

  • Pattern regulation in a regenerating jellyfish.

    abstract::Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, notably by efficient restoration ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.54868

    authors: Sinigaglia C,Peron S,Eichelbrenner J,Chevalier S,Steger J,Barreau C,Houliston E,Leclère L

    更新日期:2020-09-07 00:00:00

  • Sensing the load.

    abstract::How does the skeleton detect and adapt to changes in the mechanical load it has to carry? ...

    journal_title:eLife

    pub_type: 评论,杂志文章

    doi:10.7554/eLife.50210

    authors: Haelterman N,Lim J

    更新日期:2019-10-07 00:00:00