Abstract:
:The expression of E-Cadherin, a protein best known for its role in cell adhesion, regulates the onset of embryonic differentiation.
journal_name
Elifejournal_title
eLifeauthors
Sancho M,Rodríguez TAdoi
10.7554/eLife.01839subject
Has Abstractpub_date
2013-12-17 00:00:00pages
e01839issn
2050-084Xpii
2/0/e01839journal_volume
2pub_type
评论,杂志文章相关文献
eLife文献大全abstract::To understand the neural origins of rhythmic behavior one must characterize the central pattern generator circuit and quantify the population size needed to sustain functionality. Breathing-related interneurons of the brainstem pre-Bötzinger complex (preBötC) that putatively comprise the core respiratory rhythm genera...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03427
更新日期:2014-07-15 00:00:00
abstract::Heterochromatin exerts a heritable form of eukaryotic gene repression and contributes to chromosome segregation fidelity and genome stability. However, to date there has been no quantitative evaluation of the stability of heterochromatic gene repression. We designed a genetic strategy to capture transient losses of ge...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05007
更新日期:2015-01-12 00:00:00
abstract::Viral replicase recruitment and long-range RNA interactions are essential for RNA virus replication, yet the mechanism of their interplay remains elusive. Flaviviruses include numerous important human pathogens, e.g., dengue virus (DENV) and Zika virus (ZIKV). Here, we revealed a highly conserved, conformation-tunable...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17636
更新日期:2016-10-01 00:00:00
abstract::Axonal conduction velocity can change substantially during ongoing activity, thus modifying spike interval structures and, potentially, temporal coding. We used a biophysical model to unmask mechanisms underlying the history-dependence of conduction. The model replicates activity in the unmyelinated axon of the crusta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25382
更新日期:2017-07-10 00:00:00
abstract::Circadian rhythms are biological oscillations that schedule daily changes in physiology. Outside the laboratory, circadian clocks do not generally free-run but are driven by daily cues whose timing varies with the seasons. The principles that determine how circadian clocks align to these external cycles are not well u...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23539
更新日期:2017-07-07 00:00:00
abstract::Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50240
更新日期:2020-03-11 00:00:00
abstract::The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two m...
journal_title:eLife
pub_type:
doi:10.7554/eLife.25835
更新日期:2017-07-06 00:00:00
abstract::Many pathogens possess the capacity for sex through outcrossing, despite being able to reproduce also asexually and/or via selfing. Given that sex is assumed to come at a cost, these mixed reproductive strategies typical of pathogens have remained puzzling. While the ecological and evolutionary benefits of outcrossing...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47091
更新日期:2019-06-18 00:00:00
abstract::The CRISPR-Cas9 bacterial surveillance system has become a versatile tool for genome editing and gene regulation in eukaryotic cells, yet how CRISPR-Cas9 contends with the barriers presented by eukaryotic chromatin is poorly understood. Here we investigate how the smallest unit of chromatin, a nucleosome, constrains t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13450
更新日期:2016-04-28 00:00:00
abstract::Individual recognition (IR) is essential for maintaining various social interactions in a group, and face recognition is one of the most specialised cognitive abilities in IR. We used both a mating preference system and an electric shock conditioning experiment to test IR ability in medaka, and found that signals near...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24728
更新日期:2017-07-11 00:00:00
abstract::Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18459
更新日期:2017-07-04 00:00:00
abstract::During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2, and Neuropilin1 (NRP1), are targeted in therapeutic strategies for ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03720
更新日期:2014-09-22 00:00:00
abstract::Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures; this seizure protection is mediated by ATP-sensitive potassium (KAT...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32721
更新日期:2018-01-25 00:00:00
abstract::Rhythmic events recruit neuronal activity in the basal ganglia and cerebellum, but their roles remain elusive. In monkeys attempting to detect a single omission of isochronous visual stimulus, we found that neurons in the caudate nucleus showed increased activity for each stimulus in sequence, while those in the cereb...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48702
更新日期:2019-09-06 00:00:00
abstract::Bacillus subtilis can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54244
更新日期:2020-01-24 00:00:00
abstract::Myosins play essential roles in the development and function of auditory organs and multiple myosin genes are associated with hereditary forms of deafness. Using a forward genetic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essential gene for auditory organ development. Ubr3 negatively regulates the ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15258
更新日期:2016-06-22 00:00:00
abstract::Our understanding of nonlinear stimulus transformations by neural circuits is hindered by the lack of comprehensive yet interpretable computational modeling frameworks. Here, we propose a data-driven approach based on deep neural networks to directly model arbitrarily nonlinear stimulus-response mappings. Reformulatin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53445
更新日期:2020-06-26 00:00:00
abstract::Interactions between membrane protein interfaces in lipid bilayers play an important role in membrane protein folding but quantification of the strength of these interactions has been challenging. Studying dimerization of ClC-type transporters offers a new approach to the problem, as individual subunits adopt a stable...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17438
更新日期:2016-08-03 00:00:00
abstract::Synonymous codon usage (SCU) varies widely among human genes. In particular, genes involved in different functional categories display a distinct codon usage, which was interpreted as evidence that SCU is adaptively constrained to optimize translation efficiency in distinct cellular states. We demonstrate here that SC...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27344
更新日期:2017-08-15 00:00:00
abstract::We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with quantitative analysis of deletion mutants of H2A-H2B suggests that the N...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43630
更新日期:2019-03-11 00:00:00
abstract::Rats exhibit 'empathy' making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38090
更新日期:2018-11-28 00:00:00
abstract::Microtubules control different aspects of cell polarization. In cells with a radial microtubule system, a pivotal role in setting up asymmetry is attributed to the relative positioning of the centrosome and the nucleus. Here, we show that centrosome loss had no effect on the ability of endothelial cells to polarize an...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33864
更新日期:2018-03-16 00:00:00
abstract::Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44098
更新日期:2019-08-08 00:00:00
abstract::CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator complex. We discov...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37084
更新日期:2018-05-29 00:00:00
abstract::Segmentation of the axial skeleton in amniotes depends on the segmentation clock, which patterns the paraxial mesoderm and the sclerotome. While the segmentation clock clearly operates in teleosts, the role of the sclerotome in establishing the axial skeleton is unclear. We severely disrupt zebrafish paraxial segmenta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33843
更新日期:2018-04-06 00:00:00
abstract::A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.33035
更新日期:2017-11-21 00:00:00
abstract::The speed at which a cell fate decision in nematode worms evolves is due to the number of genes that control the decision, rather than to a high mutation rate. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.62689
更新日期:2020-10-14 00:00:00
abstract::The actomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its filament organization and the mechanism of contractility is not well understood. We quantified actin filament order in human cells using fluorescence polarization microscopy and found that cleavage furrow ingression...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30867
更新日期:2017-11-06 00:00:00
abstract::Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison of ion channel models with one another and with experimental dat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22152
更新日期:2017-03-06 00:00:00
abstract::The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10070
更新日期:2015-12-03 00:00:00