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Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.

Abstract：

:Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-five lean and twenty-two overweight and obese participants underwent functional magnetic resonance imaging, on two separate days, before and after intranasal insulin or placebo application. Insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. The change in hippocampal functional connectivity significantly correlated with visceral adipose tissue and the change in subjective feeling of hunger after intranasal insulin. Mediation analysis revealed that the intranasal insulin induced hippocampal functional connectivity increase served as a mediator, suppressing the relationship between visceral adipose tissue and hunger. The insulin-induced hypothalamic functional connectivity change showed a significant interaction with peripheral insulin sensitivity. Only participants with high peripheral insulin sensitivity showed a boost in hypothalamic functional connectivity. Hence, brain insulin action may regulate eating behavior and facilitate weight loss by modifying brain functional connectivity within and between cognitive and homeostatic brain regions.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kullmann S,Heni M,Veit R,Scheffler K,Machann J,Häring HU,Fritsche A,Preissl H

doi

10.1038/s41598-017-01907-w

subject

Has Abstract

pub_date

2017-05-09 00:00:00

pages

1627

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01907-w

journal_volume

7

pub_type

临床试验,杂志文章

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