当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The BMP2 nuclear variant, nBMP2, is expressed in mouse hippocampus and impacts memory.

The BMP2 nuclear variant, nBMP2, is expressed in mouse hippocampus and impacts memory.

Abstract：

:The novel nuclear protein nBMP2 is synthesized from the BMP2 gene by translational initiation at an alternative start codon. We generated a targeted mutant mouse, nBmp2NLStm, in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of nBMP2 while still allowing the normal synthesis and secretion of the BMP2 growth factor. These mice exhibit abnormal muscle function due to defective Ca2+ transport in skeletal muscle. We hypothesized that neurological function, which also depends on intracellular Ca2+ transport, could be affected by the loss of nBMP2. Age-matched nBmp2NLStm and wild type mice were analyzed by immunohistochemistry, behavioral tests, and electrophysiology to assess nBMP2 expression and neurological function. Immunohistochemical staining of the hippocampus detected nBMP2 in the nuclei of CA1 neurons in wild type but not mutant mice, consistent with nBMP2 playing a role in the hippocampus. Mutant mice showed deficits in the novel object recognition task, suggesting hippocampal dysfunction. Electrophysiology experiments showed that long-term potentiation (LTP) in the hippocampus, which is dependent on intracellular Ca2+ transport and is thought to be the cellular equivalent of learning and memory, was impaired. Together, these results suggest that nBMP2 in the hippocampus impacts memory formation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Cordner RD,Friend LN,Mayo JL,Badgley C,Wallmann A,Stallings CN,Young PL,Miles DR,Edwards JG,Bridgewater LC

doi

10.1038/srep46464

subject

Has Abstract

pub_date

2017-04-18 00:00:00

pages

46464

issn

2045-2322

pii

srep46464

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Comparative analysis of rhizosphere soil physiochemical characteristics and microbial communities between rusty and healthy ginseng root.

    abstract：:Ginseng rusty root (GRR) symptom is one of the primary diseases of ginseng. There has been a problem of ginseng rusty root, leading to a severe decline in the quality of ginseng. To clarify the relationship between root symptoms of ginseng rust and soil, the physical and chemical properties, enzyme activity, community...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71024-8

    authors： Bian X,Xiao S,Zhao Y,Xu Y,Yang H,Zhang L

    更新日期：2020-09-25 00:00:00

  • Erratum: miR-2478 inhibits TGFβ1 expression by targeting the transcriptional activation region downstream of the TGFβ1 promoter in dairy goats.

    abstract：:This corrects the article DOI: 10.1038/srep42627. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/srep46966

    authors： Li Z,Lan X,Han R,Wang J,Huang Y,Sun J,Guo W,Chen H

    更新日期：2018-04-06 00:00:00

  • UPLC-Tandem Mass Spectrometry for Quantification of Busulfan in Human Plasma: Application to Therapeutic Drug Monitoring.

    abstract：:Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65919-9

    authors： Matar KM,Alshemmari SH,Refaat S,Anwar A

    更新日期：2020-06-02 00:00:00

  • Fast and accurate automated cell boundary determination for fluorescence microscopy.

    abstract：:Detailed measurement of cell phenotype information from digital fluorescence images has the potential to greatly advance biomedicine in various disciplines such as patient diagnostics or drug screening. Yet, the complexity of cell conformations presents a major barrier preventing effective determination of cell bounda...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02266

    authors： Arce SH,Wu PH,Tseng Y

    更新日期：2013-01-01 00:00:00

  • Bufonid herpesvirus 1 (BfHV1) associated dermatitis and mortality in free ranging common toads (Bufo bufo) in Switzerland.

    abstract：:Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at differen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32841-0

    authors： Origgi FC,Schmidt BR,Lohmann P,Otten P,Meier RK,Pisano SRR,Moore-Jones G,Tecilla M,Sattler U,Wahli T,Gaschen V,Stoffel MH

    更新日期：2018-10-03 00:00:00

  • MRI of the cervical spinal cord predicts respiratory dysfunction in ALS.

    abstract：:For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19938-2

    authors： Grolez G,Kyheng M,Lopes R,Moreau C,Timmerman K,Auger F,Kuchcinski G,Duhamel A,Jissendi-Tchofo P,Besson P,Laloux C,Petrault M,Devedjian JC,Pérez T,Pradat PF,Defebvre L,Bordet R,Danel-Brunaud V,Devos D

    更新日期：2018-01-29 00:00:00

  • Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis.

    abstract：:It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00431-1

    authors： Yu ZJ,Zeng L,Luo XQ,Geng XR,Xu R,Chen K,Yang G,Luo X,Liu ZQ,Liu ZG,Liu DB,Yang PC,Li HB

    更新日期：2017-04-03 00:00:00

  • Acute and chronic gregarisation are associated with distinct DNA methylation fingerprints in desert locusts.

    abstract：:Desert locusts (Schistocerca gregaria) show a dramatic form of socially induced phenotypic plasticity known as phase polyphenism. In the absence of conspecifics, locusts occur in a shy and cryptic solitarious phase. Crowding with conspecifics drives a behavioural transformation towards gregariousness that occurs withi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35608

    authors： Mallon EB,Amarasinghe HE,Ott SR

    更新日期：2016-10-18 00:00:00

  • Evaluation of permeability applicability based on continuum mechanics law in fluid flow through graphene membrane.

    abstract：:Graphene is expected to be used in separation applications such as desalination. However, it is difficult to predict the flow phenomena at the nanoscale using the conventional continuum law. Particularly at a Knudsen number (Kn) of >0.1, which is applied in filtration, it has been reported that not even slip boundary ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49131-y

    authors： Yamada T,Matsuzaki R

    更新日期：2019-09-03 00:00:00

  • Human responses to unfairness with primary rewards and their biological limits.

    abstract：:Humans bargaining over money tend to reject unfair offers, whilst chimpanzees bargaining over primary rewards of food do not show this same motivation to reject. Whether such reciprocal fairness represents a predominantly human motivation has generated considerable recent interest. We induced either moderate or severe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00593

    authors： Wright ND,Hodgson K,Fleming SM,Symmonds M,Guitart-Masip M,Dolan RJ

    更新日期：2012-01-01 00:00:00

  • Evaluation of nutritional and elemental compositions of green and red cultivars of roselle: Hibiscus sabdariffa L.

    abstract：:Roselle-Hibiscus sabdariffa L. leaves at different stages of growth, calyces and seeds were analyzed for nutritional and anti-nutritional factors. All the treatments contained a good but varied proportion of carbohydrate in a range of 26.93-54.13%, crude protein from 5.7 to 27.06%, crude fat 1.16-13.09%, crude fibre 1...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80433-8

    authors： Salami SO,Afolayan AJ

    更新日期：2021-01-13 00:00:00

  • Enhanced optoelectronic performances of vertically aligned hexagonal boron nitride nanowalls-nanocrystalline diamond heterostructures.

    abstract：:Field electron emission (FEE) properties of vertically aligned hexagonal boron nitride nanowalls (hBNNWs) grown on Si have been markedly enhanced through the use of nitrogen doped nanocrystalline diamond (nNCD) films as an interlayer. The FEE properties of hBNNWs-nNCD heterostructures show a low turn-on field of 15.2 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29444

    authors： Sankaran KJ,Hoang DQ,Kunuku S,Korneychuk S,Turner S,Pobedinskas P,Drijkoningen S,Van Bael MK,D' Haen J,Verbeeck J,Leou KC,Lin IN,Haenen K

    更新日期：2016-07-11 00:00:00

  • Community phylogenetic structure reveals the imprint of dispersal-related dynamics and environmental filtering by nutrient availability in freshwater diatoms.

    abstract：:Despite important progress, uncertainty persists regarding the ecological forces driving microbial community assembly. Here, we present the first study to use phylogenetic information to interpret the structure and diversity of diatom communities. We examined local phylogenetic divergence and beta- phylogenetic divers...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48125-0

    authors： Keck F,Kahlert M

    更新日期：2019-08-12 00:00:00

  • Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats.

    abstract：:The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59411-7

    authors： Tang L,Li K,Zhang Y,Li H,Li A,Xu Y,Wei B

    更新日期：2020-02-12 00:00:00

  • Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1β signaling.

    abstract：:Adolescent alcohol exposure may increase anxiety-like behaviors by altering central monoaminergic functions and other important neuronal pathways. The present study was designed to investigate the anxiolytic effect of 0.5% γ-oryzanol (GORZ) and its neurochemical and molecular mechanisms under chronic 10% ethanol consu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67689-w

    authors： Akter S,Uddin KR,Sasaki H,Lyu Y,Shibata S

    更新日期：2020-06-30 00:00:00

  • Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.

    abstract：:Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives may antagonize these actions. The effect of three antagonists, tetraiodoacetic a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16593-x

    authors： Shinderman-Maman E,Cohen K,Moskovich D,Hercbergs A,Werner H,Davis PJ,Ellis M,Ashur-Fabian O

    更新日期：2017-11-28 00:00:00

  • Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour.

    abstract：:Histamine is an important neurotransmitter that contributes to various processes, including the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated through histamine H1-H4 receptors. Gene knockout and pharmacological studies have revealed the importance of H1 receptors in learning and me...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52623-6

    authors： Kárpáti A,Yoshikawa T,Naganuma F,Matsuzawa T,Kitano H,Yamada Y,Yokoyama M,Futatsugi A,Mikoshiba K,Yanai K

    更新日期：2019-11-11 00:00:00

  • HIV cause-specific deaths, mortality, risk factors, and the combined influence of HAART and late diagnosis in Zhejiang, China, 2006-2013.

    abstract：:To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42366

    authors： Chen L,Pan X,Ma Q,Yang J,Xu Y,Zheng J,Wang H,Zhou X,Jiang T,Jiang J,He L,Jiang J

    更新日期：2017-02-15 00:00:00

  • Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue.

    abstract：:The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31270-3

    authors： Lee JS,Kim HG,Lee DS,Son CG

    更新日期：2018-08-27 00:00:00

  • Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney.

    abstract：:We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-dia...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43218-2

    authors： Ghosh A,Zhao S,Lo CS,Maachi H,Chenier I,Lateef MA,Abdo S,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

    更新日期：2019-04-30 00:00:00

  • In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET.

    abstract：:Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15015-2

    authors： Yamasaki T,Fujinaga M,Mori W,Zhang Y,Wakizaka H,Nengaki N,Xie L,Hatori A,Zhang MR

    更新日期：2017-11-02 00:00:00

  • Author Correction: Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-33284-3

    authors： Carregari VC,Rosa-Fernandes L,Baldasso P,Bydlowski SP,Marangoni S,Larsen MR,Palmisano G

    更新日期：2018-10-23 00:00:00

  • Comparison Between Performances of In2O3 and In2TiO5-Based EIS Biosensors Using Post Plasma CF4 Treatment Applied in Glucose and Urea Sensing.

    abstract：:In this study, the effect of post-deposition tetrafluoromethane (CF4) plasma treatment on the physical and electrical characteristics of an In2TiO5 based electrolyte-insulator-semiconductor (EIS) sensor was investigated. Post-deposition CF4 plasma treatment typically improved the crystalline structure and repaired dan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39012-9

    authors： Lin CF,Kao CH,Lin CY,Liu CS,Liu YW

    更新日期：2019-02-28 00:00:00

  • Spatially modulated structural colour in bird feathers.

    abstract：:Eurasian Jay (Garrulus glandarius) feathers display periodic variations in the reflected colour from white through light blue, dark blue and black. We find the structures responsible for the colour are continuous in their size and spatially controlled by the degree of spinodal phase separation in the corresponding reg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18317

    authors： Parnell AJ,Washington AL,Mykhaylyk OO,Hill CJ,Bianco A,Burg SL,Dennison AJ,Snape M,Cadby AJ,Smith A,Prevost S,Whittaker DM,Jones RA,Fairclough JP,Parker AR

    更新日期：2015-12-21 00:00:00

  • An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis.

    abstract：:Ulcerative colitis (UC) is a chronic relapsing-remitting form of inflammatory bowel disease (IBD) that increases the risk of colorectal cancer, the third most common malignancy in humans. Oxidative stress is a risk factor for the development of UC. The Keap1-Nrf2-ARE pathway is one of the most important defensive mech...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26585

    authors： Lu MC,Ji JA,Jiang YL,Chen ZY,Yuan ZW,You QD,Jiang ZY

    更新日期：2016-05-24 00:00:00

  • Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.

    abstract：:It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Post...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21931

    authors： Feng B,Tang Y,Chen B,Xu C,Wang Y,Dai Y,Wu D,Zhu J,Wang S,Zhou Y,Shi L,Hu W,Zhang X,Chen Z

    更新日期：2016-02-23 00:00:00

  • Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region.

    abstract：:The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the -10 promoter element and the transcription start site of the regu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27780-9

    authors： Tapscott T,Kim JS,Crawford MA,Fitzsimmons L,Liu L,Jones-Carson J,Vázquez-Torres A

    更新日期：2018-06-21 00:00:00

  • Global transcriptome analysis identifies differentially expressed genes related to lipid metabolism in Wagyu and Holstein cattle.

    abstract：:Fat deposition of beef cattle varies between breeds. However, the regulation mechanism is still not elucidated completely at molecular level. In the present study, we comparatively analyzed transcriptome of subcutaneous adipose tissue between Wagyu and Holstein cattle with a significant difference in fat deposition to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05702-5

    authors： Huang W,Guo Y,Du W,Zhang X,Li A,Miao X

    更新日期：2017-07-13 00:00:00

  • A humanized anti-DLL4 antibody promotes dysfunctional angiogenesis and inhibits breast tumor growth.

    abstract：:Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ0...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27985

    authors： Jia X,Wang W,Xu Z,Wang S,Wang T,Wang M,Wu M

    更新日期：2016-06-15 00:00:00

  • Impact of Comorbidities and Smoking on the Outcome in Aneurysmal Subarachnoid Hemorrhage.

    abstract：:The intention of this observational study is to show the significant impact of comorbidities and smoking on the outcome in aneurysmal subarachnoid hemorrhage (SAH). During this observational study 203 cases of treatment of ruptured intracranial aneurysms were analyzed. We examined and classified prospectively the 12 m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30878-9

    authors： Hammer A,Steiner A,Ranaie G,Yakubov E,Erbguth F,Hammer CM,Killer-Oberpfalzer M,Steiner H,Janssen H

    更新日期：2018-08-17 00:00:00