Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats.

abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...

journal_title：Scientific reports

authors： Levin E,Diekmann H,Fischer D

更新日期：2016-12-13 00:00:00

abstract：:The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced transcription and prote...

journal_title：Scientific reports

authors： Iyer RS,Chatham L,Sleigh R,Meek DW

更新日期：2017-06-15 00:00:00

abstract：:Maize (corn) is the dominant grain grown in the world. Total maize production in 2018 equaled 1.12 billion tons. Maize is used primarily as an animal feed in the production of eggs, dairy, pork and chicken. The US produces 32% of the world's maize followed by China at 22% and Brazil at 9% ( https://apps.fas.usda.gov/p...

journal_title：Scientific reports

authors： Jiang Z,Liu C,Ganapathysubramanian B,Hayes DJ,Sarkar S

更新日期：2020-09-11 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such "driver lncRNAs" are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. We h...

journal_title：Scientific reports

authors： Lanzós A,Carlevaro-Fita J,Mularoni L,Reverter F,Palumbo E,Guigó R,Johnson R

更新日期：2017-01-27 00:00:00

abstract：:Humans, like all organisms, are subject to fundamental biophysical laws. Van Valen predicted that, because of zero-sum dynamics, all populations of all species in a given environment flux the same amount of energy on average. Damuth's 'energetic equivalence rule' supported Van Valen´s conjecture by showing a tradeoff ...

journal_title：Scientific reports

authors： Burger JR,Weinberger VP,Marquet PA

更新日期：2017-03-02 00:00:00

abstract：:To understand the impact of PIK3CA mutations on clinical characteristics and treatment response to epidermal growth factor tyrosine kinase inhibitors (EGFR TKIs) of lung adenocarcinoma, we examined PIK3CA and EGFR mutations in lung adenocarcinoma patients, and analyzed their clinical outcomes. Surgically excised tumor...

journal_title：Scientific reports

authors： Wu SG,Chang YL,Yu CJ,Yang PC,Shih JY

更新日期：2016-10-13 00:00:00

abstract：:It is common to find in the literature different values for the working voltage window (WVW) range for aqueous-based supercapacitors. In many cases, even with the best intentions of the widening the operating voltage window, the measured current using the cyclic voltammetry (CV) technique includes a significant contri...

journal_title：Scientific reports

authors： Nunes WG,Freitas BGA,Beraldo RM,Filho RM,Da Silva LM,Zanin H

更新日期：2020-11-05 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in commercial arrays have often been discovered in a small number of samples from selected populations. This ascertainment skews patterns of nucleotide diversity and affects population genetic inferences. We propose a demographic inference pipeline that explicitly models the SNP ...

journal_title：Scientific reports

authors： Quinto-Cortés CD,Woerner AE,Watkins JC,Hammer MF

更新日期：2018-07-05 00:00:00

abstract：:In a previous study, we demonstrated that topical D-beta-hydroxybutyrate ameliorates corneal epithelial erosion and superficial punctate keratopathy in a rat model of dry eye disease. In the current investigation, we performed a prospective, randomized, multicentre, double-blind, placebo-controlled study to assess the...

journal_title：Scientific reports

authors： Kawakita T,Uchino M,Fukagawa K,Yoshino K,Shimazaki S,Toda I,Tanaka M,Arai H,Sakatani K,Hata S,Okano T,Tsubota K

更新日期：2016-02-11 00:00:00

abstract：:Climatic fluctuations largely affects species turnover and cause major shifts of terrestrial ecosystem. In the present study the five decade old herbarium specimens of lichens were compared with recent collection from Darjeeling district with respect to elements, PAHs accumulation and carbon isotope composition (δ(13)...

journal_title：Scientific reports

authors： Bajpai R,Mishra S,Dwivedi S,Upreti DK

更新日期：2016-08-09 00:00:00

abstract：:Epidemiological studies using saliva have revealed relationships between the oral microbiome and many oral and systemic diseases. However, when collecting from a large number of participants such as a large-scale cohort study, the time it takes to collect saliva can be a problem. Mouth-rinsed water, which is water tha...

journal_title：Scientific reports

authors： Jo R,Nishimoto Y,Umezawa K,Yama K,Aita Y,Ichiba Y,Murakami S,Kakizawa Y,Kumagai T,Yamada T,Fukuda S

更新日期：2019-11-06 00:00:00

abstract：:Cutaneous allodynia (CA) is a pain in response to non-nociceptive stimulation and a marker of central sensitisation. Probable migraine (PM) is a migraine subtype that fulfils all but one criterion of migraine. Headache intensity and the disability of individuals with PM are similar or lower than individuals with migra...

journal_title：Scientific reports

authors： Han SM,Kim KM,Cho SJ,Yang KI,Kim D,Yun CH,Chu MK

更新日期：2021-01-28 00:00:00

abstract：:Pyroclastic density currents are one of the most devastating volcanic hazards. Understanding their dynamics is a key to develop successful hazard mitigation strategies. The hazard associated with pyroclastic density currents is commonly investigated a posteriori from their deposits or a priori using analogue and numer...

journal_title：Scientific reports

authors： Scharff L,Hort M,Varley NR

更新日期：2019-05-14 00:00:00

abstract：:The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery. Seventy-one patients undergoing open thoracotomy were included in this study and randomly divided into three gro...

journal_title：Scientific reports

authors： Zeng X,Jiang J,Yang L,Ding W

更新日期：2017-06-21 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Shim CH,Parc YW,Kumar S,Ko IS,Kim DE

更新日期：2019-06-06 00:00:00

abstract：:By means of first principles calculation and experiments, a detailed mechanism is proposed to include the stages of slip, adjustment, and expansion for the HCP → FCC phase transformation with the prismatic relation of [Formula: see text] and [Formula: see text] in titanium. It is revealed that the formation of four FC...

journal_title：Scientific reports

authors： Yang JX,Zhao HL,Gong HR,Song M,Ren QQ

更新日期：2018-01-31 00:00:00

abstract：:Culturomics is a high-throughput culture approach that has dramatically contributed to the recent renewal of culture. While metagenomics enabled substantial advances in exploring the microbiota, culturomics significantly expanded our knowledge regarding the bacterial gut repertoire through the discovery and the descri...

journal_title：Scientific reports

authors： Diakite A,Dubourg G,Dione N,Afouda P,Bellali S,Ngom II,Valles C,Tall ML,Lagier JC,Raoult D

更新日期：2020-06-15 00:00:00

abstract：:When multiple information are spread on social networks, there may be Cooperation and Competition among these information. Based on a new spreading model of multiple information, we studied Cooperation and Competition in information spreading, and analyzed the influence of different factors on Cooperation and Competit...

journal_title：Scientific reports

authors： Zhu Z,Gao C,Zhang Y,Li H,Xu J,Zan Y,Li Z

更新日期：2020-07-22 00:00:00

abstract：:This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case-control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from...

journal_title：Scientific reports

authors： Li X,Wen JG,Shen T,Yang XQ,Peng SX,Wang XZ,Xie H,Wu XD,Du YK

更新日期：2020-09-01 00:00:00

abstract：:Present study aimed to estimate the incidence of recurrent SARS-CoV-2 RNA positivity after recovery from COVID-19 and to determine the factors associated with recurrent positivity. We searched the PubMed, MedRxiv, BioRxiv, the Cochrane Library, ClinicalTrials.gov, and the World Health Organization International Clinic...

journal_title：Scientific reports

authors： Azam M,Sulistiana R,Ratnawati M,Fibriana AI,Bahrudin U,Widyaningrum D,Aljunid SM

更新日期：2020-11-26 00:00:00

abstract：:Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...

journal_title：Scientific reports

authors： Kuwatani T,Nagata K,Okada M,Watanabe T,Ogawa Y,Komai T,Tsuchiya N

更新日期：2014-11-17 00:00:00

abstract：:Stabilization exercise (SE) is evident for the management of chronic non-specific low back pain (LBP). The optimal dose-response-relationship for the utmost treatment success is, thus, still unknown. The purpose is to systematically review the dose-response-relationship of stabilisation exercises on pain and disabilit...

journal_title：Scientific reports

authors： Mueller J,Niederer D

更新日期：2020-10-09 00:00:00

abstract：:We report on a novel electrically tunable hybrid graphene-gold Fano resonator. The proposed metamaterial consists of a square graphene patch and a square gold frame. The destructive interference between the narrow- and broadband dipolar surface plasmons, which are induced respectively on the surfaces of the graphene p...

journal_title：Scientific reports

authors： Amin M,Farhat M,Baǧcı H

更新日期：2013-01-01 00:00:00

abstract：:Global warming is projected to continue, leading to intense fluctuations in precipitation and heat waves and thereby affecting the productivity and the relevant biological processes of grassland ecosystems. Here, we determined the functional responses to warming and altered precipitation in both typical and desert ste...

journal_title：Scientific reports

authors： Xu Z,Hou Y,Zhang L,Liu T,Zhou G

更新日期：2016-10-10 00:00:00

abstract：:We study a three-mode (i.e., a clockwise mode, a counterclockwise mode, and a mechanical mode) coherent coupling regime of the optical whispering-gallery-mode (WGM) microresonator optomechanical system by considering a pair of counterpropagating modes in a general case. The WGM microresonator is coherently driven by a...

journal_title：Scientific reports

authors： Zhang S,Li J,Yu R,Wang W,Wu Y

更新日期：2017-01-03 00:00:00

abstract：:Real-valued functions of complex arguments violate the Cauchy-Riemann conditions and, consequently, do not have Taylor series expansion. Therefore, optimization methods based on derivatives cannot be directly applied to this class of functions. This is circumvented by mapping the problem to the field of the real numbe...

journal_title：Scientific reports

authors： Utreras-Alarcón A,Rivera-Tapia M,Niklitschek S,Delgado A

更新日期：2019-11-06 00:00:00

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits. Mutual interactions of these subunits constitute the basal architecture of the SMC complexes. In addition, binding of ATP molecules to the SMC subunits and their hydrolysis dri...

journal_title：Scientific reports

authors： Vondrova L,Kolesar P,Adamus M,Nociar M,Oliver AW,Palecek JJ

更新日期：2020-06-16 00:00:00

abstract：:C-phycocyanin (C-PC) pigment, as a natural blue dye, has particular applications in various fields. It is a water-soluble protein which has anticancer, antioxidant and anti-inflammatory properties. Here, we introduce an efficient procedure for the purification of C-PC pigment, followed by conducting a comprehensive in...

journal_title：Scientific reports

authors： Safaei M,Maleki H,Soleimanpour H,Norouzy A,Zahiri HS,Vali H,Noghabi KA

更新日期：2019-07-01 00:00:00

abstract：:We investigated the extent to which pre-pregnancy obesity mediates the association between maternal place of birth and severe pre-eclampsia in the PreCARE cohort of pregnant women in Paris (n = 9,579). Adjusted path analysis logistic regression models were used to assess the role of pre-pregnancy obesity as a mediator...

journal_title：Scientific reports

authors： Siddiqui A,Deneux-Tharaux C,Luton D,Schmitz T,Mandelbrot L,Estellat C,Howell EA,Khoshnood B,Bertille N,Azria E

更新日期：2020-03-23 00:00:00