Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats.

Abstract:

:The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegylated liposomes (PEGL) and pegylated quercetin liposomes (Q-PEGL). A group of healthy rats served as the normal control. The fasting blood glucose (FBG), body weights (BWs), renal hypertrophy index (rHI), serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments. Que and Q-PEGL significantly improved DN biochemistry and pathological changes, although the treated rats still had some symptoms of DN. The therapeutic effect of Q-PEGL surpassed that of Que. Pegylated quercetin liposomes allow maintaining higher quercetin concentrations in plasma than non-encapsulated quercetin. In conclusion the use of quercetin liposomes allows to reduce disease symptoms in a rat model of DN.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tang L,Li K,Zhang Y,Li H,Li A,Xu Y,Wei B

doi

10.1038/s41598-020-59411-7

subject

Has Abstract

pub_date

2020-02-12 00:00:00

pages

2440

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59411-7

journal_volume

10

pub_type

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