Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum.

abstract：:Many chemoattractants cause chemotaxis of leukocytes by stimulating a structurally distinct class of G protein-coupled receptors. To identify receptor functions required for chemotaxis, we studied chemotaxis in HEK293 cells transfected with receptors for nonchemokine ligands or for interleukin 8 (IL-8), a classical ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neptune ER,Bourne HR

更新日期：1997-12-23 00:00:00

abstract：:This work argues that, in a polarized environment, scientists can minimize the likelihood that the audience's biased processing will lead to rejection of their message if they not only eschew advocacy but also, convey that they are sharers of knowledge faithful to science's way of knowing and respectful of the audienc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamieson KH,Hardy BW

更新日期：2014-09-16 00:00:00

abstract：:The cell-surface antigen detected by the monoclonal antibody JONES is expressed in the retina and a number of other central nervous system regions of the rat during the latter part of embryonic development and the early postnatal period. In addition to the expression on certain neuroblast populations it is found on so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blum AS,Barnstable CJ

更新日期：1987-12-01 00:00:00

abstract：:The recently characterized corticosteroid receptor on amphibian neuronal membranes appears to mediate rapid, stress-induced changes in male reproductive behaviors. Because the transduction mechanisms associated with this receptor are unknown, we performed radioligand binding studies to determine whether this steroid r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orchinik M,Murray TF,Franklin PH,Moore FL

更新日期：1992-05-01 00:00:00

abstract：:S-Adenosylhomocysteine hydrolase (SAHH) is a key enzyme in transmethylation reactions that use S-adenosylmethionine as the methyl donor. Because of the importance of SAHH in a number of S-adenosylmethionine-dependent transmethylation reactions, particularly the 5' capping of mRNA during viral replication, SAHH has bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masuta C,Tanaka H,Uehara K,Kuwata S,Koiwai A,Noma M

更新日期：1995-06-20 00:00:00

abstract：:Seed development in plants involves the coordinated growth of the embryo, endosperm, and maternal tissue. Several genes have been identified that influence seed size by acting maternally, such as AUXIN RESPONSE FACTOR2, APETALA2, and DA1. However, given the lack of gain-of-function effects of these genes on seed size,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adamski NM,Anastasiou E,Eriksson S,O'Neill CM,Lenhard M

更新日期：2009-11-24 00:00:00

abstract：:Two deletion-substitution mutations of phage lambda, spi-113 and spi-274, are shown to remove about half of the rightward operator OR. Physiological studies show that spi-113 is still repressible. Thus, the 50 or so nucleotides of OR deleted in this mutant are not absolutely essential for repression. prm-116, which in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith GR,Eisen H,Reichardt L,Hedgepeth J

更新日期：1976-03-01 00:00:00

abstract：:Tyrosine hydroxylase (EC 1.14.16.2), the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis, was localized by electron microscopy within noradrenergic neurons of the nucleus locus coeruleus of the rat brain with a specific antibody to tyrosine hydroxylase labeled by the peroxidase-antiperoxidase im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickel VM,Joh TH,Reis DJ

更新日期：1975-02-01 00:00:00

abstract：:Human-caused environmental changes are creating regional combinations of environmental conditions that, within the next 50 to 100 years, may fall outside the envelope within which many of the terrestrial plants of a region evolved. These environmental modifications might become a greater cause of global species extinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D,Lehman C

更新日期：2001-05-08 00:00:00

abstract：:The neu gene is distantly related to the erbB gene and encodes a cell surface protein that appears to function as a growth factor receptor. To study the mechanisms that caused the conversion of the normal neu gene to an oncogenic allele, we have isolated molecular clones of the neu oncogene as well as a clone of the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hung MC,Schechter AL,Chevray PY,Stern DF,Weinberg RA

更新日期：1986-01-01 00:00:00

abstract：:High social status reduces stress responses in numerous species, but the stress-buffering effect of status may dissipate or even reverse during times of hierarchical instability. In an experimental test of this hypothesis, 118 participants (57.3% female) were randomly assigned to a high- or low-status position in a st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knight EL,Mehta PH

更新日期：2017-01-03 00:00:00

abstract：:To understand molecular interactions that organize developing myofibrils, we examined the biosynthesis and interaction of titin and myosin heavy chain in cultures of developing muscle. Use of pulse-labeling, immunoprecipitation, and a reversible cross-linking procedure demonstrates that within minutes of synthesis, ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isaacs WB,Kim IS,Struve A,Fulton AB

更新日期：1992-08-15 00:00:00

abstract：:Transcription initiation is a dynamic process in which RNA polymerase (RNAP) and promoter DNA act as partners, changing in response to one another, to produce a polymerase/promoter open complex (RPo) competent for transcription. In Escherichia coli RNAP, region 1.1, the N-terminal 100 residues of sigma(70), is thought...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hook-Barnard IG,Hinton DM

更新日期：2009-01-20 00:00:00

abstract：:Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by early pre-B phenotype (CD10(-)/CD19(+)) and poor treatment outcome. The t(4;11), creating MLL-AF4 chimeric transcripts, is the predominant 11q23 chromosome translocation in infant ALL and is associated with extremely poor progno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taki T,Kano H,Taniwaki M,Sako M,Yanagisawa M,Hayashi Y

更新日期：1999-12-07 00:00:00

abstract：:Friend murine leukemia virus (F-MuLV) is a replication-competent retrovirus that induces a rapidly fetal leukemia in susceptible mice (stage I disease). Leukemia cells obtained from these animals do not grow in cell culture using standard tissue culture conditions. However, in the presence of WEHI-3 cell-conditioned m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliff A,Oliff I,Schmidt B,Famulari N

更新日期：1984-09-01 00:00:00

abstract：:The satellite RNA of tobacco ringspot virus depends upon tobacco ringspot virus for its replication and source of coat protein. The satellite RNA reduces virus accumulation and the severity of virus-induced symptoms. Repetitive sequence, dimeric, and higher forms of the satellite RNA are known to autolytically process...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buzayan JM,Gerlach WL,Bruening G

更新日期：1986-12-01 00:00:00

abstract：:Neurofibromin gene (NF1) mutation causes neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocytes causes myelin decompaction and increases oligodendrocyte nitric oxide (NO) levels...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asleh J,Shofty B,Cohen N,Kavushansky A,López-Juárez A,Constantini S,Ratner N,Kahn I

更新日期：2020-09-08 00:00:00

abstract：:Inflammation is a hallmark of many diseases, such as atherosclerosis, chronic obstructive pulmonary disease, arthritis, infectious diseases, and cancer. Although steroids and cyclooxygenase inhibitors are effective antiinflammatory therapeutical agents, they may cause serious side effects. Therefore, developing unique...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeon KI,Xu X,Aizawa T,Lim JH,Jono H,Kwon DS,Abe J,Berk BC,Li JD,Yan C

更新日期：2010-05-25 00:00:00

abstract：:Population expansion in space, or range expansion, is widespread in nature and in clinical settings. Space competition among heterogeneous subpopulations during range expansion is essential to population ecology, and it may involve the interplay of multiple factors, primarily growth and motility of individuals. Struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuo W,Wu Y

更新日期：2020-03-03 00:00:00

abstract：:Infection is a major complication of implantable medical devices, which provide a scaffold for biofilm formation, thereby reducing susceptibility to antibiotics and complicating treatment. Hematogenous implant-related infections following bacteremia are particularly problematic because they can occur at any time in a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Cheng LI,Helfer DR,Ashbaugh AG,Miller RJ,Tzomides AJ,Thompson JM,Ortines RV,Tsai AS,Liu H,Dillen CA,Archer NK,Cohen TS,Tkaczyk C,Stover CK,Sellman BR,Miller LS

更新日期：2017-06-27 00:00:00

abstract：:DNA toroids produced by the condensation of lambda phage DNA with hexammine cobalt (III) have been investigated by cryoelectron microscopy. Image resolution obtained by this technique has allowed unprecedented views of DNA packing within toroidal condensates. Toroids oriented coplanar with the microscope image plane e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hud NV,Downing KH

更新日期：2001-12-18 00:00:00

abstract：:Circulating exosomal microRNA (miR) represents a new class of blood-based biomarkers for cancer liquid biopsy. The detection of miR at a very low concentration and with single-base discrimination without the need for sophisticated equipment, large volumes, or elaborate sample processing is a challenge. To address this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canady TD,Li N,Smith LD,Lu Y,Kohli M,Smith AM,Cunningham BT

更新日期：2019-09-24 00:00:00

abstract：:The trans-synaptic induction of tyrosine hydroxylase [tyrosine 3-monooxygenase; EC 1.14.16.2, L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating)] in adrenal medulla and sympathetic ganglia by short-term (1-2 hr) cold stress (4 degrees) exhibits a circadian rhythm which seems to be causally relate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Otten U,Thoenen H

更新日期：1975-04-01 00:00:00

abstract：:Spontaneous liposome formation is predicted in binary mixtures of fluid phase phospholipids and poly(n)ethylene oxide (PEO)-bearing lipids by using single chain mean field theory. The range of stability of the spontaneous liposomes is determined as a function of percentage of PEO-conjugated lipids and polymer molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szleifer I,Gerasimov OV,Thompson DH

更新日期：1998-02-03 00:00:00

abstract：:Tubulin cofactor B (TCoB) plays an important role in microtubule dynamics by facilitating the dimerization of alpha- and beta-tubulin. Recent evidence suggests that p21-activated kinase 1 (Pak1), a major signaling nodule in eukaryotic cells, phosphorylates TCoB on Ser-65 and Ser-128 and plays an essential role in micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayala SK,Martin E,Sharina IG,Molli PR,Wang X,Jacobson R,Murad F,Kumar R

更新日期：2007-12-04 00:00:00

abstract：:The accumulation of metal ions and amyloid-β (Aβ) aggregates found in the brain of patients with Alzheimer's disease (AD) has been suggested to be involved in AD pathogenesis. To investigate metal-Aβ-associated pathways in AD, development of chemical tools to target metal-Aβ species is desired. Only a few efforts, how...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JS,Braymer JJ,Nanga RP,Ramamoorthy A,Lim MH

更新日期：2010-12-21 00:00:00

abstract：:Previous research and theory suggest that two stable personality dimensions, extroversion and neuroticism, differentially influence emotional reactivity to a variety of pleasurable phenomena. Here, we use event-related functional MRI to address the putative neural and behavioral associations between humor appreciation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mobbs D,Hagan CC,Azim E,Menon V,Reiss AL

更新日期：2005-11-08 00:00:00

abstract：:The central limit theorem is applied to group foraging to show an automatic and universal benefit to group living. This may explain the paradoxical inverse correlation between group size and per capita brood production in primitively eusocial insects and why only one of the five major lineages of social insects contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wenzel JW,Pickering J

更新日期：1991-01-01 00:00:00

abstract：:Fifty cats with feline leukemia virus (FeLV) infection and leukemia-lymphoma complex were treated by ex vivo immunoadsorption with Staphylococcus protein A-bound filters. Most cats responded to therapy. Twelve showed tumor regression, including disappearance of tumor cells, but died later of other complications. Three...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu WT,Engelman RW,Trang LQ,Hau K,Good RA,Day NK

更新日期：1984-06-01 00:00:00

abstract：:The activity of Drosophila melanogaster DNA polymerase alpha on DNA-primed single-stranded DNA templates has been examined. The DNA templates contain a 1471-nucleotide sequence from the heavy-strand origin region of mouse mtDNA inserted into the single-stranded bacteriophage vector M13Gori1. Preferred sites for pausin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaguni LS,Clayton DA

更新日期：1982-02-01 00:00:00