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Pregnancy rate is significantly higher in in vitro fertilization procedure with spermatozoa isolated from nonliquefying semen in which liquefaction is induced by alpha-amylase.

Abstract：

:In 115 patients (group I) in which normal liquefaction of semen occurred, the fertilization rate of the yielded oocytes was 71.2% after standard in vitro fertilization procedure, and the viable pregnancy rate per patient per cycle was 13.0%. In a comparable group of 26 patients (group II), in which semen liquefaction did not occur spontaneously, alpha-amylase was added in order to liquefy the semen. In this group, the fertilization rate was 86.7% of the yielded oocytes, and the viable pregnancy rate per patient per cycle was 26.9% (P less than 0.05). It is concluded that alpha-amylase can be of use to liquefy nonliquefying semen, and that the resultant spermatozoa have a positive effect on pregnancy results.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Vermeiden JP,Bernardus RE,ten Brug CS,Statema-Lohmeijer CH,Willemsen-Brugma AM,Schoemaker J

doi

10.1016/s0015-0282(16)60444-2

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

149-52

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)60444-2

journal_volume

51

pub_type

杂志文章

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