Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

abstract：:Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophys...

journal_title：Vascular pharmacology

authors： Gorla R,Erbel R,Eagle KA,Bossone E

更新日期：2018-04-12 00:00:00

abstract：:Elevated plasma levels of factor VII and fibrinogen are risk factors for cardiovascular disease, especially arterial thrombosis. Oral contraceptive use increases factor VII and fibrinogen plasma levels. It has been described that DNA polymorphisms are associated with the plasma levels of hemostatic variables and their...

journal_title：Vascular pharmacology

authors： Bloemenkamp KW,de Maat MP,Dersjant-Roorda MC,Helmerhorst FM,Kluft C

更新日期：2002-08-01 00:00:00

abstract：:Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apo...

journal_title：Vascular pharmacology

authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Malý J,Kramer HJ,Dvorák P,Cervenka L

更新日期：2009-08-01 00:00:00

abstract：:Intra-aortic balloon pump (IABP) counterpulsation has been the most widely used left ventricular assist device for nearly five decades. Due to diastolic inflation and systolic deflation, coronary blood flow is increased and afterload decreased translating into augmentation of oxygen supply and lowering of oxygen deman...

journal_title：Vascular pharmacology

authors： de Waha S,Desch S,Eitel I,Fuernau G,Lurz P,Sandri M,Schuler G,Thiele H

更新日期：2014-02-01 00:00:00

abstract：:Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stabl...

journal_title：Vascular pharmacology

authors： Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

更新日期：2019-01-01 00:00:00

abstract：:In systemic sclerosis, microvascular injury often precedes the development of fibrosis. Whereas the development of digital ulcers and skin fibrosis causes high morbidity, the affection of internal organs, in particular complications such as interstitial lung disease and pulmonary (arterial) hypertension, account for t...

journal_title：Vascular pharmacology

authors： Maurer B,Distler JH,Distler O

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Tissue Factor (TF) plays a pivotal role in coronary thrombosis. Oxidized low-density lipoproteins (oxLDL) are crucial in development of atherosclerosclerosis. Moreover, oxLDL are known to induce TF expression on several cell types including endothelial cells. The lectin-type oxidized LDL receptor 1 (LOX-1) r...

journal_title：Vascular pharmacology

authors： Cimmino G,Conte S,Morello A,Pellegrino G,Marra L,Calì G,Golino P,Cirillo P

更新日期：2020-11-21 00:00:00

abstract：:Angiogenesis has become an attractive target for the treatment of certain diseases such as cancer and rheumatoid arthritis. Our previous studies demonstrated that the saponin fraction from Gleditsia sinensis fruits had anti-angiogenic potential, and Gleditsiosides B (GB) was probably the main active constituent. In th...

journal_title：Vascular pharmacology

authors： Tong B,Lu D,Wei Z,Wang T,Xia Y,Dai Y

更新日期：2013-01-01 00:00:00

abstract：:We have previously reported that prolonged exposure of porcine coronary arteries to adenosine agonists upregulates protein kinase C (PKC) through the activation of adenosine A1 receptor-coupled to pertussis toxin sensitive G-protein(s) [Am. J. Physiol. 264 (1993) H1465; Am. J. Physiol. 269 (1995) H1619]. The mechanism...

journal_title：Vascular pharmacology

authors： Nayeem MA,Mustafa SJ

更新日期：2002-07-01 00:00:00

abstract：:Poorly controlled diabetes in pregnancy, characterized by hypo- and hyperglycemia, is associated with adverse outcomes. We hypothesized that aberrant glucose levels affect vascular function in pregnancy. The effects of glucose concentration on constriction and endothelium-dependent relaxation in uterine arteries of no...

journal_title：Vascular pharmacology

authors： Chirayath HH,Wareing M,Taggart MJ,Baker PN

更新日期：2007-02-01 00:00:00

abstract：INTRODUCTION:Growth factor therapy provides a therapeutic alternative for "no option" patients with coronary disease. Fibroblast Growth Factor-2 (FGF-2) predominantly stimulates angiogenesis, the growth of new capillaries, whereas Monocyte Chemoattractant Protein-1 (MCP-1) is considered an arteriogenic agent. We hypoth...

journal_title：Vascular pharmacology

authors： Heilmann C,Kostic C,Giannone B,Grawitz AB,Armbruster W,Lutter G,Beyersdorf F,Göbel H

更新日期：2006-05-01 00:00:00

abstract：:Neurokinin(3) (NK(3)) receptors may regulate the airways primarily through actions on the nerves. In the periphery, airway parasympathetic ganglia neurons are depolarized following NK(3) receptor activation resulting subsequently in the facilitation of synaptic transmission. Such an effect may account for the excessiv...

journal_title：Vascular pharmacology

authors： Canning BJ

更新日期：2006-10-01 00:00:00

abstract：:Thalidomide is an antiangiogenic drug and is clinically useful in a number of cancers. However, the molecular mechanism by which thalidomide exerts its antitumor effects is poorly understood. This study was designed to clarify the relationship between antiangiogenesis and antitumor effects of thalidomide and to explor...

journal_title：Vascular pharmacology

authors： Du GJ,Lin HH,Xu QT,Wang MW

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Vascular calcification (VC) is associated with the high morbidity and mortality of cardiovascular diseases in dialysis patients and is a process in which vascular smooth muscle cells (VSMCs) actively differentiate into osteoblast-like cells. Reticulocalbin-2 (RCN2) is involved in the process of osteogenic di...

journal_title：Vascular pharmacology

authors： Zhao J,Liu Z,Chang Z

更新日期：2021-02-01 00:00:00

abstract：:Cardiac muscle extends into mammalian pulmonary veins for variable distances according to species. This study has addressed the autonomic control of electrically paced cardiac muscle of the pulmonary vein of the rat. Contractile responses of Wistar rat pulmonary veins were investigated under isometric conditions in vi...

journal_title：Vascular pharmacology

authors： Sweeney CM,Jones JF,Bund SJ

更新日期：2007-03-01 00:00:00

abstract：:Impaired endothelial function is recognised as one of the earliest events of atherogenesis. Endothelium-dependent vasomotion has been the principal method to assess endothelial function. In this article, we will discuss the clinical value of the different techniques to evaluate endothelium-dependent vasomotion. To dat...

journal_title：Vascular pharmacology

authors： Asselbergs FW,van der Harst P,Jessurun GA,Tio RA,van Gilst WH

更新日期：2005-02-01 00:00:00

abstract：AIM:Local levels of angiotensin peptides depend on their rates of production and degradation, which induce proatherogenic or atheroprotective effects. Here, we reveal the kinetics of Angiotensin-I metabolism in paired early and advanced atherosclerotic lesions. METHODS:Lesions were spiked with labeled Ang-I* and super...

journal_title：Vascular pharmacology

authors： Nehme A,Marcelo P,Nasser R,Kobeissy F,Bricca G,Zibara K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE(-/-)) mice, and examined its effects on endothelial function. METHODS AND ...

journal_title：Vascular pharmacology

authors： Salim HM,Fukuda D,Higashikuni Y,Tanaka K,Hirata Y,Yagi S,Soeki T,Shimabukuro M,Sata M

更新日期：2016-04-01 00:00:00

abstract：:Phosphorylation of proteins on tyrosine acts as a reversible and specific trigger mechanism, forming or disrupting regulatory connections between proteins. Tyrosine kinases and phosphatases participate in multiple cellular processes, and considerable evidence now supports a role for tyrosine phosphorylation in vascula...

journal_title：Vascular pharmacology

authors： Bogatcheva NV,Garcia JG,Verin AD

更新日期：2002-11-01 00:00:00

abstract：:To investigate the vasorelaxant effect of fasudil mesylate (FM) in vivo and in vitro. The relaxation effect of FM was studied using cerebral vasospasm (CVS) model in vivo and isolated aortic rings in vitro. FM (0.35, 1.2, 3.5 mg·kg⁻¹) increased cerebrovascular flow (CVF) and femoral blood flow (FBF) dose-dependently i...

journal_title：Vascular pharmacology

authors： Li Q,Chen Y,Sun L,Fu G,Guo L

更新日期：2011-11-01 00:00:00

abstract：:Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

journal_title：Vascular pharmacology

authors： Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

更新日期：2018-11-01 00:00:00

abstract：:Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinet...

journal_title：Vascular pharmacology

authors： Ferland DJ,Darios ES,Neubig RR,Sjögren B,Truong N,Torres R,Dexheimer TS,Thompson JM,Watts SW

更新日期：2017-01-01 00:00:00

abstract：:Recent studies evidence that peroxynitrite is spontaneously formed when nitric oxide (NO) and superoxide coexist and suggest that it is likely to be involved in the destruction of the pancreatic beta cells. We examined whether drugs that inhibit nitric oxide synthase (NOS) or scavenge peroxynitrite could abrogate STZ-...

journal_title：Vascular pharmacology

authors： Rao VS,Santos FA,Silva RM,Teixiera MG

更新日期：2002-03-01 00:00:00

abstract：:Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

journal_title：Vascular pharmacology

authors： Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

更新日期：2017-12-01 00:00:00

abstract：:Since the discovery of the importance of nitric oxide (NO) to the human body three decades ago, numerous laboratory and clinical studies have been done to explore its potential therapeutic actions on many organs. In the cardiovascular system, NO works as a volatile signaling molecule regulating the vascular permeabili...

journal_title：Vascular pharmacology

authors： Ma S,Ma CC

更新日期：2014-11-01 00:00:00

abstract：:To investigate mechanisms of protective effects of fenofibrate on the diabetic kidney, male Wistar rats were divided into control, untreated diabetes, and fenofibrate-treated (32 mg kg(-1) d(-1), 8 weeks) diabetes groups. Diabetes induced by streptozotocin (25 mg/kg) and a high-fat diet was characterized by the disord...

journal_title：Vascular pharmacology

authors： Chen LL,Zhang JY,Wang BP

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

journal_title：Vascular pharmacology

authors： Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

更新日期：2003-02-01 00:00:00

abstract：:A small amount of adipose tissue associated with small arteries and arterioles is encountered both in mice and man. This perivascular adipose tissue (PVAT) has a paracrine effect on the vascular tone regulation. PVAT is expanded in obesity and in diabetes. This expansion not only involves enlargement of fat cells, but...

journal_title：Vascular pharmacology

authors： Eringa EC,Bakker W,van Hinsbergh VW

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population w...

journal_title：Vascular pharmacology

authors： Hollstein T,Vogt A,Grenkowitz T,Stojakovic T,März W,Laufs U,Bölükbasi B,Steinhagen-Thiessen E,Scharnagl H,Kassner U

更新日期：2019-05-01 00:00:00

abstract：:Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that PGE2 receptor signaling modulates angiotensin II (Ang II)-induced hypertension, but the interact...

journal_title：Vascular pharmacology

authors： Kraemer MP,Choi H,Reese J,Lamb FS,Breyer RM

更新日期：2016-09-01 00:00:00