The Fra-2 transgenic mouse model of systemic sclerosis.

abstract：BACKGROUND:Tissue Factor (TF) plays a pivotal role in coronary thrombosis. Oxidized low-density lipoproteins (oxLDL) are crucial in development of atherosclerosclerosis. Moreover, oxLDL are known to induce TF expression on several cell types including endothelial cells. The lectin-type oxidized LDL receptor 1 (LOX-1) r...

journal_title：Vascular pharmacology

authors： Cimmino G,Conte S,Morello A,Pellegrino G,Marra L,Calì G,Golino P,Cirillo P

更新日期：2020-11-21 00:00:00

abstract：:This study was designed to study the influence of Sacoglottis gabonensis stem bark extract on the metabolic and cytotoxic side effects of 2,4-dinitrophenyl hydrazine (2,4-DNPH) on the brain and blood using male weaving rats as the experimental model. This was after the effect of the bark extract and bergenin, its isol...

journal_title：Vascular pharmacology

authors： Maduka HC,Okoye ZS,Eje A

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Suboptimal platelet inhibition still represents an important challenge, especially for patients undergoing percutaneous coronary interventions (PCI). Chronic kidney disease (CKD) is a common comorbidity of patients with coronary artery disease, and may potentially influence platelet reactivity. So far only f...

journal_title：Vascular pharmacology

authors： Barbieri L,Pergolini P,Verdoia M,Rolla R,Nardin M,Marino P,Bellomo G,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2016-04-01 00:00:00

abstract：:Despite a large number of studies, the mechanism by which 3',5'-cyclic monophosphate (cAMP) induces vasorelaxation is not fully understood. The comparison between results obtained in different vessels or species has often been the source of conflicting reports. In order to shed more light onto this mechanism, we studi...

journal_title：Vascular pharmacology

authors： Cuíñas A,Elíes J,Orallo F,Campos-Toimil M

更新日期：2013-01-01 00:00:00

abstract：:Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stabl...

journal_title：Vascular pharmacology

authors： Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to investigate the relation between endothelial dysfunction and aspirin response in a young healthy population (102 men aged 18-40). Initial concentrations of the NO pathway metabolites (ADMA, l-arginine, SDMA), cardiovascular risk markers, oxidative stress markers (MDA, thiol index), sICAM1,...

journal_title：Vascular pharmacology

authors： Doroszko A,Szahidewicz-Krupska E,Janus A,Jakubowski M,Turek A,Ilnicka P,Szuba A,Mazur G,Derkacz A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

journal_title：Vascular pharmacology

authors： Star GP,Giovinazzo M,Langleben D

更新日期：2009-01-01 00:00:00

abstract：:The antiplatelet and antithrombotic activities of a newly synthesized CP201, 2-(3,5-di-tert-butyl-4-hydroxyl)-3-chloro-1,4-naphthoquinone on human platelet aggregation in vitro and murine pulmonary thrombosis in vivo were examined. In addition, the antiplatelet activity of CP201 involved in calcium-signaling cascade w...

journal_title：Vascular pharmacology

authors： Jin YR,Hwang KA,Cho MR,Kim SY,Kim JH,Ryu CK,Son DJ,Park YH,Yun YP

更新日期：2004-02-01 00:00:00

abstract：:Platelet adhesion to subendothelial types I and III collagens exposed upon vascular injury plays a crucial role in hemostasis and thrombosis. We previously identified a KOGEOGPK sequence (O for hydroxyproline) within type III collagen interacting with platelets, and demonstrated a strong inhibitory effect of the KOGEO...

journal_title：Vascular pharmacology

authors： Maurice P,Pires V,Amant C,Kauskot A,Da Nascimento S,Sonnet P,Rochette J,Legrand C,Fauvel-Lafeve F,Bonnefoy A

更新日期：2006-01-01 00:00:00

abstract：:Neurokinin(3) (NK(3)) receptors may regulate the airways primarily through actions on the nerves. In the periphery, airway parasympathetic ganglia neurons are depolarized following NK(3) receptor activation resulting subsequently in the facilitation of synaptic transmission. Such an effect may account for the excessiv...

journal_title：Vascular pharmacology

authors： Canning BJ

更新日期：2006-10-01 00:00:00

abstract：:Poorly controlled diabetes in pregnancy, characterized by hypo- and hyperglycemia, is associated with adverse outcomes. We hypothesized that aberrant glucose levels affect vascular function in pregnancy. The effects of glucose concentration on constriction and endothelium-dependent relaxation in uterine arteries of no...

journal_title：Vascular pharmacology

authors： Chirayath HH,Wareing M,Taggart MJ,Baker PN

更新日期：2007-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR)alpha, gamma and beta/delta belong to the nuclear receptor family of ligand-activated transcription factors. PPARs heterodimerize with the retinoid X receptor (RXR) and then act as transcription factors to modulate the function of many target genes. PPARalpha, gamma an...

journal_title：Vascular pharmacology

authors： Touyz RM,Schiffrin EL

更新日期：2006-07-01 00:00:00

abstract：:The antiatherosclerotic effects of the dihydropyridine-type calcium channel blocker, benidipine hydrochloride (benidipine), and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pravastatin sodium (pravastatin), were compared in hypercholesterolemic rabbits. Male, New Zealand white rabbits were fed a 0.5% cho...

journal_title：Vascular pharmacology

authors： Takayama M,Matsubara M,Arakawa E,Takada C,Ina Y,Hasegawa K,Yao K

更新日期：2007-04-01 00:00:00

abstract：:MicroRNAs (e.g., miRNAs), endogenously expressed small non-coding RNAs, control gene expression by regulating target messenger RNA at post-transcriptional level. Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. The zebrafish (Danio rerio) system is a ...

journal_title：Vascular pharmacology

authors： Santoro MM

更新日期：2011-10-01 00:00:00

abstract：:The early stages of invasion are characterized by the extracellular proteolysis and the accumulation of specialized extracellular matrix (ECM) scaffold, that are responsible for the development of vascular bed, endothelial cell proliferation and invasion of tumour cells. The ground substance of provisional matrix cons...

journal_title：Vascular pharmacology

authors： Mathivadhani P,Shanthi P,Sachdanandam P

更新日期：2007-06-01 00:00:00

abstract：:Propionyl-l-carnitine (PLC) is a natural short-chain derivative of l-carnitine (LC), a natural amino acid that plays an important role in fatty acid metabolism. Recent studies suggest that PLC has vascular protective effects. Because of the importance of endothelial nitric oxide synthase (eNOS) and its product, antiat...

journal_title：Vascular pharmacology

authors： Ning WH,Zhao K

更新日期：2013-09-01 00:00:00

abstract：:Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

journal_title：Vascular pharmacology

authors： Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

更新日期：2018-11-01 00:00:00

abstract：:The mechanisms of action involved in the vasorelaxant effect of gallic acid (GA) were examined in the isolated rat thoracic aorta. GA exerted a relaxant effect in the highest concentrations (0.4-10mM) in both endothelium-intact and endothelium-denuded aortic rings. Pre-incubation with L-NAME, ODQ, calmidazolium, TEA, ...

journal_title：Vascular pharmacology

authors： de Oliveira LM,de Oliveira TS,da Costa RM,de Souza Gil E,Costa EA,Passaglia Rde C,Filgueira FP,Ghedini PC

更新日期：2016-06-01 00:00:00

abstract：AIM:Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against cardiovascular diseases including atherosclerosis. The safe dose of selenium in the organism is very narrow, limiting the supplementation of selenium in diet. The aim of this study is to explore whet...

journal_title：Vascular pharmacology

authors： Zhu ML,Wang G,Wang H,Guo YM,Song P,Xu J,Li P,Wang S,Yang L

更新日期：2019-04-01 00:00:00

abstract：:Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein ...

journal_title：Vascular pharmacology

authors： Roth L,Van der Donckt C,Emini Veseli B,Van Dam D,De Deyn PP,Martinet W,Herman AG,De Meyer GRY

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

journal_title：Vascular pharmacology

authors： Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

更新日期：2003-02-01 00:00:00

abstract：:Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered regularly interspaced short palindromic repeats (CRISPR) editing h...

journal_title：Vascular pharmacology

authors： Miano JM,Long X,Lyu Q

更新日期：2019-03-01 00:00:00

abstract：:Recent evidence showed that 17 β-estradiol (E₂) decreased cytokine-induced expression of cell adhesion molecules (CAM). Changes in intracellular Ca²+ concentration ([Ca²+](i)) has been shown to be associated with CAM expression in endothelial cells. Here, the effects of E₂ (1 μM, 24 h) on the expression of intracellul...

journal_title：Vascular pharmacology

authors： Thor D,Zhang R,Anderson L,Bose DD,Dubé GP,Rahimian R

更新日期：2010-11-01 00:00:00

abstract：:Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascular smooth muscle cells (VSMCs) are involved in As. Hyperhomocysteinemia (HHcy) is an independent risk factor for As. The present study was designed to test our hypothesi...

journal_title：Vascular pharmacology

authors： Chen Y,Su X,Qin Q,Yu Y,Jia M,Kong L,Zhang H,Li H

更新日期：2020-01-01 00:00:00

abstract：:While brain-derived neurotrophic factor (BDNF) was previously reported to induce relaxation of conduit artery, whether the BDNF/TrkB (tropomyosin-related kinase) pathway is involved in the tone control of resistance arteries is not known. This study investigated TrkB receptors levels/localization and the vasomotor eff...

journal_title：Vascular pharmacology

authors： Totoson P,Pedard M,Marie C,Demougeot C

更新日期：2018-07-01 00:00:00

abstract：:Therapeutic modulation of angiogenesis is believed to be a prospective powerful treatment strategy to modulate the microcirculation and therefore help millions of patients with cardiovascular and cancer diseases. The often-frustrating results from late-stage clinical studies indicate an urgent need for improved assess...

journal_title：Vascular pharmacology

authors： Hlushchuk R,Haberthür D,Djonov V

更新日期：2019-01-01 00:00:00

abstract：:The endothelium synthesizes and releases nitric oxide (NO) to maintain homeostatic function. Under basal conditions, endothelium-derived NO maintains a nonthrombogenic surface, prohibits leukocyte attachment, and promotes vascular relaxation. In the setting of clinical syndromes associated with the development of athe...

journal_title：Vascular pharmacology

authors： Russo G,Leopold JA,Loscalzo J

更新日期：2002-05-01 00:00:00

abstract：:Cardiac muscle extends into mammalian pulmonary veins for variable distances according to species. This study has addressed the autonomic control of electrically paced cardiac muscle of the pulmonary vein of the rat. Contractile responses of Wistar rat pulmonary veins were investigated under isometric conditions in vi...

journal_title：Vascular pharmacology

authors： Sweeney CM,Jones JF,Bund SJ

更新日期：2007-03-01 00:00:00

abstract：:Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

journal_title：Vascular pharmacology

authors： Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

更新日期：2007-08-01 00:00:00

abstract：:Numerous studies of acetylcholine (ACh)-induced endothelium-dependent relaxation in arteries have been reported since the original description by Furchgott and Zawadzki (1980). ACh also produces endothelium-independent relaxation. However, it is still unknown whether ACh-induced AMP-activated protein kinase (AMPK) act...

journal_title：Vascular pharmacology

authors： Lee KY,Choi HC

更新日期：2013-09-01 00:00:00