当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis.

Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis.

Abstract：

:Thalidomide is an antiangiogenic drug and is clinically useful in a number of cancers. However, the molecular mechanism by which thalidomide exerts its antitumor effects is poorly understood. This study was designed to clarify the relationship between antiangiogenesis and antitumor effects of thalidomide and to explore the molecular mechanism for its antitumor activity. We evaluated the effects of thalidomide on the growth of human tumor cells expressing (MCF-7 and HL-60) or not expressing (HeLa and K562) COX-2 in vitro. We also studied the effects of thalidomide on COX-1, COX-2 or bcl-2 expression, TNFalpha, VEGF, GSH and cytochrome c in these cells. Thalidomide could inhibit tumor growth in a concentration-dependent manner in MCF-7 and HL-60; its IC50s for them were 18.36+/-2.34 and 22.14+/-2.15 microM, respectively, while this effect was not observed in HeLa and K562. Thalidomide reduced COX-2 expression accompanied by a decrease of bcl-2 protein, TNFalpha, VEGF, GSH and an increased cytochrome c, but had no effect on that of COX-1, in MCF-7 and HL-60. Moreover, cells not expressing COX-2 were insensitive to the growth-inhibitory and effects on cytokines of thalidomide. In our mouse xenograft model of OVCAR-3 and HCT-8, we found that thalidomide could decrease intratumoral microvessel density in both tumors; it exerted antitumor effects only on OVCAR-3 expressing COX-2 but did not on HCT-8 not expressing COX-2. Effect of thalidomide on COX-1 and COX-2 in vivo was consistent with that of in vitro. These results demonstrated that thalidomide might inhibit growth of tumors through COX-2 degradation independent of antiangiogenesis.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Du GJ,Lin HH,Xu QT,Wang MW

doi

10.1016/j.vph.2005.04.003

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

112-9

issue

2

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(05)00101-1

journal_volume

43

pub_type

杂志文章

相关文献

VASCULAR PHARMACOLOGY文献大全
  • Treatment with PCSK9 inhibitors reduces atherogenic VLDL remnants in a real-world study.

    abstract：BACKGROUND:Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population w...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.03.002

    authors： Hollstein T,Vogt A,Grenkowitz T,Stojakovic T,März W,Laufs U,Bölükbasi B,Steinhagen-Thiessen E,Scharnagl H,Kassner U

    更新日期：2019-05-01 00:00:00

  • An updated view on stem cell differentiation into smooth muscle cells.

    abstract：:Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2012.02.014

    authors： Zhang L,Zhou Y,Zhu J,Xu Q

    更新日期：2012-05-01 00:00:00

  • Mechanisms of endothelial cell protection by hydroxycinnamic acids.

    abstract：:An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as the...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.10.006

    authors： Fuentes E,Palomo I

    更新日期：2014-12-01 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract：:Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106601

    authors： Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期：2020-01-01 00:00:00

  • Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids.

    abstract：:Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor sub...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.06.017

    authors： de Souza Rossignoli P,Yamamoto FZ,Pereira OC,Chies AB

    更新日期：2015-09-01 00:00:00

  • Na(+)/H(+) exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2(+) mobilization.

    abstract：:The objective of this study was to determine the mechanism by which Na(+)/H(+) exchanger (NHE) inhibitors induce vasodilatation. The NHE inhibitors, 5-(N,N-dimethyl)-amiloride (DMA), cariporide, and amiloride, evoked endothelium-dependent relaxation in rat aortas with ED50 values of 16, 89, and 148μM, respectively, an...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.11.004

    authors： Sasahara T,Yayama K,Matsuzaki T,Tsutsui M,Okamoto H

    更新日期：2013-04-01 00:00:00

  • Paclitaxel chemotherapy and vascular toxicity as assessed by flow-mediated and nitrate-mediated vasodilatation.

    abstract：BACKGROUND:Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS:We studied 27 women treated with paclitaxel-containing combinations...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.05.002

    authors： Vassilakopoulou M,Mountzios G,Papamechael C,Protogerou AD,Aznaouridis K,Katsichti P,Venetsanou K,Dimopoulos MA,Ikonomidis I,Papadimitriou CA

    更新日期：2010-09-01 00:00:00

  • Regulation of atherosclerotic plaque growth and stability by testosterone and its receptor via influence of inflammatory reaction.

    abstract：BACKGROUND:Platelets play crucial roles in the development of arterial thrombosis and other pathophysiologies leading to clinical ischemic events. Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis. The purposes of the study are to determine whether atherosclerotic pl...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2008.03.004

    authors： Li S,Li X,Li Y

    更新日期：2008-07-01 00:00:00

  • Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats.

    abstract：:Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2017.09.007

    authors： Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

    更新日期：2017-12-01 00:00:00

  • Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1.

    abstract：:Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that PGE2 receptor signaling modulates angiotensin II (Ang II)-induced hypertension, but the interact...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.05.015

    authors： Kraemer MP,Choi H,Reese J,Lamb FS,Breyer RM

    更新日期：2016-09-01 00:00:00

  • Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?

    abstract：:Autoimmune rheumatic diseases are characterised by systemic inflammation and complex immunopathology, with an increased risk of cardiovascular disease, initiated by endothelial dysfunction in a chronic inflammatory environment. Endothelial microparticles (EMPs) are released into the circulation from activated endothel...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2016.05.016

    authors： McCarthy EM,Wilkinson FL,Parker B,Alexander MY

    更新日期：2016-11-01 00:00:00

  • Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia.

    abstract：:Hyperhomocysteinemia (HHcy) is a metabolic disorder marked by an excess amount of the amino acid homocysteine (Hcy) in the blood stream. Hcy is a H(2)S precursor-formed from the metabolism of methionine. Elevated Hcy levels have been associated with higher blood pressure. However, the precise contribution of H(2)S to ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.05.004

    authors： Sowmya S,Swathi Y,Yeo AL,Shoon ML,Moore PK,Bhatia M

    更新日期：2010-09-01 00:00:00

  • Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases.

    abstract：:Propionyl-l-carnitine (PLC) is a natural short-chain derivative of l-carnitine (LC), a natural amino acid that plays an important role in fatty acid metabolism. Recent studies suggest that PLC has vascular protective effects. Because of the importance of endothelial nitric oxide synthase (eNOS) and its product, antiat...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2013.07.001

    authors： Ning WH,Zhao K

    更新日期：2013-09-01 00:00:00

  • Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

    abstract：:Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.10.001

    authors： Sangartit W,Pakdeechote P,Kukongviriyapan V,Donpunha W,Shibahara S,Kukongviriyapan U

    更新日期：2016-12-01 00:00:00

  • Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats.

    abstract：:Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apo...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2009.06.001

    authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Malý J,Kramer HJ,Dvorák P,Cervenka L

    更新日期：2009-08-01 00:00:00

  • Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice.

    abstract：:Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.05.001

    authors： Roth L,Van der Donckt C,Emini Veseli B,Van Dam D,De Deyn PP,Martinet W,Herman AG,De Meyer GRY

    更新日期：2019-01-01 00:00:00

  • Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.

    abstract：BACKGROUND:Macrophages play a central role in atherosclerosis development and progression, hence, targeting macrophage activity is considered an attractive therapeutic. Recently, we documented nanomedicinal delivery of the anti-inflammatory compound prednisolone to atherosclerotic plaque macrophages in patients, which ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.04.006

    authors： Alaarg A,Zheng KH,van der Valk FM,da Silva AE,Versloot M,van Ufford LC,Schulte DM,Storm G,Metselaar JM,Stroes ES,Hamers AA

    更新日期：2016-07-01 00:00:00

  • Effects of 17 β-estradiol on lipopolysacharride-induced intracellular adhesion molecule-1 mRNA expression and Ca²+ homeostasis alteration in human endothelial cells.

    abstract：:Recent evidence showed that 17 β-estradiol (E₂) decreased cytokine-induced expression of cell adhesion molecules (CAM). Changes in intracellular Ca²+ concentration ([Ca²+](i)) has been shown to be associated with CAM expression in endothelial cells. Here, the effects of E₂ (1 μM, 24 h) on the expression of intracellul...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.09.001

    authors： Thor D,Zhang R,Anderson L,Bose DD,Dubé GP,Rahimian R

    更新日期：2010-11-01 00:00:00

  • Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: sodium nitroprusside and a new ruthenium complex.

    abstract：:We studied the mechanisms involved in the relaxation induced by nitric oxide (NO) donors, ruthenium complex ([Ru(terpy)(bdq)NO(+)](3+)-TERPY) and sodium nitroprusside (SNP) in denuded rat aorta. Both NO donors induced vascular relaxation independent of the agonist used in the pre-contraction. [Ru(terpy)(bdq)NO(+)](3+)...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.10.002

    authors： Bonaventura D,de Lima RG,Vercesi JA,da Silva RS,Bendhack LM

    更新日期：2007-03-01 00:00:00

  • β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

    abstract：:β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2014.04.003

    authors： Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

    更新日期：2014-05-01 00:00:00

  • Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1.

    abstract：:Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes releasing intracellular molecules called damage-associated molecular patterns. Overactive and prolonged immune responses are likely to be responsible for heart failure development and progression in patients survivi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.08.011

    authors： Tomczyk M,Kraszewska I,Dulak J,Jazwa-Kusior A

    更新日期：2019-01-01 00:00:00

  • Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with familial combined hyperlipidemia and/or metabolic syndrome.

    abstract：OBJECTIVE:In patients with familial combined hyperlipidemia (FCHL), without metabolic syndrome (MS), occurrence of non-alcoholic fatty liver disease (NAFLD) is related to a specific pro-inflammatory profile, influenced by genetic traits, involved in oxidative stress and adipokine secretion. Among FCHL or MS patients, h...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.04.004

    authors： Santilli F,Blardi P,Scapellato C,Bocchia M,Guazzi G,Terzuoli L,Tabucchi A,Silvietti A,Lucani B,Gioffrè WR,Scarpini F,Fazio F,Davì G,Puccetti L

    更新日期：2015-09-01 00:00:00

  • Anti-inflammatory influence of P-selectin on human mononuclear cells.

    abstract：:The purpose of this study was to determine if P-selectin, an adhesion molecule involved in the transendothelial movement of leukocytes, might also have a direct influence on the function of cells that come into contact with it. Human peripheral blood mononuclear cells were incubated on immobilized P-selectin or a cont...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.11.002

    authors： Sloan CL,Sloan GJ,Cannon JG

    更新日期：2006-03-01 00:00:00

  • Systemic inflammatory response syndromes in the era of interventional cardiology.

    abstract：:Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophys...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.04.003

    authors： Gorla R,Erbel R,Eagle KA,Bossone E

    更新日期：2018-04-12 00:00:00

  • The kinetics of angiotensin-I metabolism in human carotid atheroma: An emerging role for angiotensin (1-7).

    abstract：AIM:Local levels of angiotensin peptides depend on their rates of production and degradation, which induce proatherogenic or atheroprotective effects. Here, we reveal the kinetics of Angiotensin-I metabolism in paired early and advanced atherosclerotic lesions. METHODS:Lesions were spiked with labeled Ang-I* and super...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.08.001

    authors： Nehme A,Marcelo P,Nasser R,Kobeissy F,Bricca G,Zibara K

    更新日期：2016-10-01 00:00:00

  • The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries.

    abstract：:There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2008.11.002

    authors： Montes FR,Cabrera M,Delgadillo A,Salgar C,Echeverri D

    更新日期：2009-03-01 00:00:00

  • Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.

    abstract：:Elevated plasma levels of factor VII and fibrinogen are risk factors for cardiovascular disease, especially arterial thrombosis. Oral contraceptive use increases factor VII and fibrinogen plasma levels. It has been described that DNA polymorphisms are associated with the plasma levels of hemostatic variables and their...

    journal_title：Vascular pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1537-1891(02)00300-2

    authors： Bloemenkamp KW,de Maat MP,Dersjant-Roorda MC,Helmerhorst FM,Kluft C

    更新日期：2002-08-01 00:00:00

  • Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue.

    abstract：:A small amount of adipose tissue associated with small arteries and arterioles is encountered both in mice and man. This perivascular adipose tissue (PVAT) has a paracrine effect on the vascular tone regulation. PVAT is expanded in obesity and in diabetes. This expansion not only involves enlargement of fat cells, but...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2012.02.003

    authors： Eringa EC,Bakker W,van Hinsbergh VW

    更新日期：2012-05-01 00:00:00

  • The Fra-2 transgenic mouse model of systemic sclerosis.

    abstract：:In systemic sclerosis, microvascular injury often precedes the development of fibrosis. Whereas the development of digital ulcers and skin fibrosis causes high morbidity, the affection of internal organs, in particular complications such as interstitial lung disease and pulmonary (arterial) hypertension, account for t...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2012.12.001

    authors： Maurer B,Distler JH,Distler O

    更新日期：2013-03-01 00:00:00

  • Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.

    abstract：:Unresolved endoplasmic reticulum (ER) stress, with the subsequent persistent activation of the unfolded protein response (UPR) is a well-recognized mechanism of endothelial cell apoptosis with a major impact on the integrity of the endothelium during the course of cardiovascular diseases. As in other cell types, Ca(2+...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.07.011

    authors： Ampem PT,Smedlund K,Vazquez G

    更新日期：2016-01-01 00:00:00