Abstract：
:Phosphorylation of proteins on tyrosine acts as a reversible and specific trigger mechanism, forming or disrupting regulatory connections between proteins. Tyrosine kinases and phosphatases participate in multiple cellular processes, and considerable evidence now supports a role for tyrosine phosphorylation in vascular permeability. A semipermeable barrier between the vascular compartment and the interstitium is maintained by the integrity of endothelial monolayer, controlling movement of fluids, macromolecules and leucocytes. Barrier function is regulated by the adjustment of paracellular gaps between endothelial cells (ECs) by two antagonistic forces, centripetal cytoskeletal tension and opposing cell-cell and cell-matrix adhesion forces. Both cytoskeletal filaments and adhesion sites are intimately linked in complex machinery which is regulated by multiple signaling events including protein phosphorylation and/or protein translocation to specific intracellular positions. Tyrosine kinases occupy key positions in the mechanism controlling cell responses mediated through various cell surface receptors, which use tyrosine phosphorylation to transduce extracellular signal.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
Bogatcheva NV,Garcia JG,Verin ADdoi
10.1016/s1537-1891(03)00009-0keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
201-12issue
4-5eissn
1537-1891issn
1879-3649pii
S1537189103000090journal_volume
39pub_type
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更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-04-12 00:00:00
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journal_title：Vascular pharmacology
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更新日期：2009-01-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2005.01.003
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.03.005
更新日期：2005-06-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/s1537-1891(03)00042-9
更新日期：2002-12-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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doi：10.1016/j.vph.2019.05.001
更新日期：2019-01-01 00:00:00
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journal_title：Vascular pharmacology
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更新日期：2010-09-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
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更新日期：2007-04-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2013.07.007
更新日期：2013-09-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/s1537-1891(02)00203-3
更新日期：2002-06-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.08.022
更新日期：2005-11-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.vph.2009.10.004
更新日期：2010-03-01 00:00:00
abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...
journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.08.005
更新日期：2005-12-01 00:00:00
