Lipoic acid decreases exhaled nitric oxide concentrations in anesthetized endotoxemic rats.

Abstract:

:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no special treatment, endotoxin alone, or pretreatment with lipoic acid followed by endotoxin. After anesthetizing the rats and injecting them intraperitoneally with lipoic acid (100 mg/kg) at 4 h and again at 1 h before treatment, the rats then received either endotoxin (0.01 mg/kg) or its vehicle solution. Exhaled gas was sampled every 15 min and concentrations of nitric oxide in the samples were measured using a chemiluminescence analyzer. After 150 min of exposure to endotoxin, the lungs were harvested and snap-frozen in liquid nitrogen for subsequent analysis. Lipoic acid attenuated endotoxin-induced increases in exhaled nitric oxide concentrations (P<0.001) and iNOS (P<0.05). These findings support the hypothesis that lipoic acid inhibits endotoxin-stimulated formation of intrapulmonary nitric oxide.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

De Marco VG,Bosanquet JP,Rawlani VR,Skimming JW

doi

10.1016/j.vph.2005.08.005

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

404-10

issue

6

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(05)00168-0

journal_volume

43

pub_type

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