当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.

Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.

Abstract：

:This study examined the effects of a novel orally active 14,15-epoxyeicosatrienoic acid analog (EET-A) on blood pressure (BP) and myocardial infarct size (IS) in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats during sustained phase of hypertension. Between days 31 and 35 after clip placement the rats were treated with EET-A and BP was monitored by radiotelemetry; sham-operated normotensive rats were used as controls. Tissue concentrations of epoxyeicosatrienoic acids served as a marker of production of epoxygenase metabolites. The rats were subjected to acute myocardial ischemia/reperfusion (I/R) injury and IS was determined. We found that EET-A treatment did not lower BP in 2K1C rats and did not alter availability of biologically active epoxygenase metabolites in 2K1C or in sham-operated rats. The myocardial IS was significantly smaller in untreated 2K1C rats as compared with normotensive controls and EET-A reduced it in controls but not in 2K1C rats. Our findings suggest that during the phase of sustained hypertension 2K1C Goldblatt hypertensive rats exhibit increased cardiac tolerance to I/R injury as compared with normotensive controls, and that in this animal model of human renovascular hypertension short-term treatment with EET-A does not induce any antihypertensive and cardioprotective actions.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Alánová P,Husková Z,Kopkan L,Sporková A,Jíchová Š,Neckář J,Imig JD,Klevstig M,Kolář F,Rami Reddy N,Falck JR,Sadowski J,Nishiyama A,Kramer HJ,Melenovský V,Červenková L,Kujal P,Vernerová Z,Červenka L

doi

10.1016/j.vph.2015.08.013

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

45-56

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(15)00199-8

journal_volume

73

pub_type

杂志文章

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