听力与言语-语言病理学

行为科学

医学伦理学

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  • Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop.

    abstract:BACKGROUND:Vascular calcification (VC) is associated with the high morbidity and mortality of cardiovascular diseases in dialysis patients and is a process in which vascular smooth muscle cells (VSMCs) actively differentiate into osteoblast-like cells. Reticulocalbin-2 (RCN2) is involved in the process of osteogenic di...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2020.106821

    authors: Zhao J,Liu Z,Chang Z

    更新日期:2021-02-01 00:00:00

  • Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia.

    abstract::The present study investigates the potential of ozagrel, a thromboxane A2 (TXA2) synthase inhibitor, in bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water maze (MWM) test was employed on 7th day p...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2020.106827

    authors: Bhatia P,Kaur G,Singh N

    更新日期:2020-12-17 00:00:00

  • Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells.

    abstract:BACKGROUND:Tissue Factor (TF) plays a pivotal role in coronary thrombosis. Oxidized low-density lipoproteins (oxLDL) are crucial in development of atherosclerosclerosis. Moreover, oxLDL are known to induce TF expression on several cell types including endothelial cells. The lectin-type oxidized LDL receptor 1 (LOX-1) r...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2020.106822

    authors: Cimmino G,Conte S,Morello A,Pellegrino G,Marra L,Calì G,Golino P,Cirillo P

    更新日期:2020-11-21 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract::Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106601

    authors: Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期:2020-01-01 00:00:00

  • Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF-κB signaling pathway in vascular smooth muscle cells.

    abstract::Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascular smooth muscle cells (VSMCs) are involved in As. Hyperhomocysteinemia (HHcy) is an independent risk factor for As. The present study was designed to test our hypothesi...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106613

    authors: Chen Y,Su X,Qin Q,Yu Y,Jia M,Kong L,Zhang H,Li H

    更新日期:2020-01-01 00:00:00

  • Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.

    abstract::Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alp...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106577

    authors: Kamau F,Strijdom H,Mwangi P,Blackhurst D,Imperial E,Salie R

    更新日期:2019-10-01 00:00:00

  • Treatment with PCSK9 inhibitors reduces atherogenic VLDL remnants in a real-world study.

    abstract:BACKGROUND:Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population w...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.03.002

    authors: Hollstein T,Vogt A,Grenkowitz T,Stojakovic T,März W,Laufs U,Bölükbasi B,Steinhagen-Thiessen E,Scharnagl H,Kassner U

    更新日期:2019-05-01 00:00:00

  • Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition.

    abstract:AIM:Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against cardiovascular diseases including atherosclerosis. The safe dose of selenium in the organism is very narrow, limiting the supplementation of selenium in diet. The aim of this study is to explore whet...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.01.005

    authors: Zhu ML,Wang G,Wang H,Guo YM,Song P,Xu J,Li P,Wang S,Yang L

    更新日期:2019-04-01 00:00:00

  • CRISPR links to long noncoding RNA function in mice: A practical approach.

    abstract::Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered regularly interspaced short palindromic repeats (CRISPR) editing h...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2019.02.004

    authors: Miano JM,Long X,Lyu Q

    更新日期:2019-03-01 00:00:00

  • Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice.

    abstract::Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.05.001

    authors: Roth L,Van der Donckt C,Emini Veseli B,Van Dam D,De Deyn PP,Martinet W,Herman AG,De Meyer GRY

    更新日期:2019-01-01 00:00:00

  • Ex vivo microangioCT: Advances in microvascular imaging.

    abstract::Therapeutic modulation of angiogenesis is believed to be a prospective powerful treatment strategy to modulate the microcirculation and therefore help millions of patients with cardiovascular and cancer diseases. The often-frustrating results from late-stage clinical studies indicate an urgent need for improved assess...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.09.003

    authors: Hlushchuk R,Haberthür D,Djonov V

    更新日期:2019-01-01 00:00:00

  • Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1.

    abstract::Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes releasing intracellular molecules called damage-associated molecular patterns. Overactive and prolonged immune responses are likely to be responsible for heart failure development and progression in patients survivi...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.08.011

    authors: Tomczyk M,Kraszewska I,Dulak J,Jazwa-Kusior A

    更新日期:2019-01-01 00:00:00

  • SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification.

    abstract::The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 or phytate): 1. Inhibits induced calcification in cultured aortic valve interstitial cells (VIC) as an in vitro model of aortic valve stenosis and 2. Whether inhibition is different in VIC obtaine...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106583

    authors: Zabirnyk A,Ferrer MD,Bogdanova M,Pérez MM,Salcedo C,Kaljusto ML,Kvitting JP,Stensløkken KO,Perelló J,Vaage J

    更新日期:2019-01-01 00:00:00

  • Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis.

    abstract::Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stabl...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.06.014

    authors: Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

    更新日期:2019-01-01 00:00:00

  • B cells treated with CTB-p210 acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient mice.

    abstract:OBJECTIVE:Intranasal immunization with a fusion protein of the ApoB100-derived peptide p210 and the cholera toxin B subunit (CTB-p210) has previously been shown to induce mucosal tolerance and reduce atherosclerosis development, but the exact mode of action remains to be elucidated. Recent studies have indicated an imp...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2018.09.002

    authors: Rattik S,Mantani PT,Yao Mattisson I,Ljungcrantz I,Sundius L,Björkbacka H,Terrinoni M,Lebens M,Holmgren J,Nilsson J,Wigren M,Nordin Fredrikson G

    更新日期:2018-12-01 00:00:00

  • A novel method to isolate retinal and brain microvessels from individual rats: Microscopic and molecular biological characterization and application in hyperglycemic animals.

    abstract::Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2018.07.001

    authors: Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

    更新日期:2018-11-01 00:00:00

  • Activation of endothelial TrkB receptors induces relaxation of resistance arteries.

    abstract::While brain-derived neurotrophic factor (BDNF) was previously reported to induce relaxation of conduit artery, whether the BDNF/TrkB (tropomyosin-related kinase) pathway is involved in the tone control of resistance arteries is not known. This study investigated TrkB receptors levels/localization and the vasomotor eff...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2018.02.005

    authors: Totoson P,Pedard M,Marie C,Demougeot C

    更新日期:2018-07-01 00:00:00

  • Systemic inflammatory response syndromes in the era of interventional cardiology.

    abstract::Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophys...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.04.003

    authors: Gorla R,Erbel R,Eagle KA,Bossone E

    更新日期:2018-04-12 00:00:00

  • Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis.

    abstract::Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). This study aims to investigate the amelioration of chlorogenic acid (CGA) on proliferative DR (PDR) via focusing on inhibiting retinal neoangiogenesis. CGA reduced the increased cell proliferation, migration and tu...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2017.11.002

    authors: Mei X,Zhou L,Zhang T,Lu B,Sheng Y,Ji L

    更新日期:2018-02-01 00:00:00

  • Lactadherin: An unappreciated haemostasis regulator and potential therapeutic agent.

    abstract::Lactadherin is a small (53-66kDa) multifunctional glycoprotein belonging to the secreted extracellular matrix protein family. It has a multi-domain structure and is involved in many biological and physiological processes, including phagocytosis, angiogenesis, atherosclerosis, tissue remodeling, and haemostasis regulat...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2017.11.006

    authors: Kamińska A,Enguita FJ,Stępień EŁ

    更新日期:2018-02-01 00:00:00

  • Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats.

    abstract::Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2017.09.007

    authors: Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

    更新日期:2017-12-01 00:00:00

  • Role of altered coagulation-fibrinolytic system in the pathophysiology of diabetic retinopathy.

    abstract::The implications of altered coagulation-fibrinolytic system in the pathophysiology of several vascular disorders, such as stroke and myocardial infarction, have been well researched upon and established. However, its role in the progression of diabetic retinopathy has not been explored much. Since a decade, it is know...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2017.03.005

    authors: Behl T,Velpandian T,Kotwani A

    更新日期:2017-05-01 00:00:00

  • Chemerin-induced arterial contraction is Gi- and calcium-dependent.

    abstract::Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinet...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.11.009

    authors: Ferland DJ,Darios ES,Neubig RR,Sjögren B,Truong N,Torres R,Dexheimer TS,Thompson JM,Watts SW

    更新日期:2017-01-01 00:00:00

  • Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

    abstract::Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.10.001

    authors: Sangartit W,Pakdeechote P,Kukongviriyapan V,Donpunha W,Shibahara S,Kukongviriyapan U

    更新日期:2016-12-01 00:00:00

  • Infliximab therapy restores adiponectin expression in perivascular adipose tissue and improves endothelial nitric oxide-mediated vasodilation in mice with type 1 diabetes.

    abstract::Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM by reducing adiponectin (Ad) synthesis and therefore impairing Ad-mediated activity in the contiguous blood vessel system. We evaluated whether in vivo treatment with the...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.08.007

    authors: Nacci C,Leo V,De Benedictis L,Potenza MA,Sgarra L,De Salvia MA,Quon MJ,Montagnani M

    更新日期:2016-12-01 00:00:00

  • Baroreflex deficiency aggravates atherosclerosis via α7 nicotinic acetylcholine receptor in mice.

    abstract:OBJECTIVE:Inflammation and oxidative stress play a key role in the initiation, propagation, and development of atherosclerosis. Arterial baroreflex (ABR) dysfunction induced by sinoaortic denervation (SAD) promoted the development of atherosclerosis in ApoE-/- mice. The present work was designed to examine whether ABR ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.08.008

    authors: Chen L,Liu DH,Zhang X,Zhang EH,Liu C,Su DF,Cai GJ

    更新日期:2016-12-01 00:00:00

  • Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?

    abstract::Autoimmune rheumatic diseases are characterised by systemic inflammation and complex immunopathology, with an increased risk of cardiovascular disease, initiated by endothelial dysfunction in a chronic inflammatory environment. Endothelial microparticles (EMPs) are released into the circulation from activated endothel...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2016.05.016

    authors: McCarthy EM,Wilkinson FL,Parker B,Alexander MY

    更新日期:2016-11-01 00:00:00

  • The kinetics of angiotensin-I metabolism in human carotid atheroma: An emerging role for angiotensin (1-7).

    abstract:AIM:Local levels of angiotensin peptides depend on their rates of production and degradation, which induce proatherogenic or atheroprotective effects. Here, we reveal the kinetics of Angiotensin-I metabolism in paired early and advanced atherosclerotic lesions. METHODS:Lesions were spiked with labeled Ang-I* and super...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.08.001

    authors: Nehme A,Marcelo P,Nasser R,Kobeissy F,Bricca G,Zibara K

    更新日期:2016-10-01 00:00:00

  • Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1.

    abstract::Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that PGE2 receptor signaling modulates angiotensin II (Ang II)-induced hypertension, but the interact...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.05.015

    authors: Kraemer MP,Choi H,Reese J,Lamb FS,Breyer RM

    更新日期:2016-09-01 00:00:00

  • PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells.

    abstract::Increasing evidences support that PGC-1α participates in regulating endothelial homeostasis, in part by mediating endothelial nitric oxide (NO) synthase (eNOS) activity and NO production. However, the molecular mechanisms by which PGC-1α regulates eNOS activity are not completely understood. In the present study, we i...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.05.005

    authors: Li J,Geng XY,Cong XL

    更新日期:2016-08-01 00:00:00

  • Blood pressure variability provokes vascular β-adrenoceptor desensitization in rats.

    abstract::Spontaneous variation in blood pressure is defined as 'blood pressure variability' (BPV). Sinoaortic denervation (SAD) is characterized by BPV without sustained hypertension. In the present study, we investigated whether BPV could be related to vascular β-adrenoceptor desensitization in rats. Three days after surgery ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.05.007

    authors: Rocha ML,Silva BR,Lunardi CN,Ramalho LN,Bendhack LM

    更新日期:2016-07-01 00:00:00

  • Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors.

    abstract::Schistosomiasis is caused by an intravascular parasite and linked to phenotypic changes in endothelial cells that favor inflammation. Endothelial cells express P2Y1 receptors (P2Y1R), and their activation by ADP favors leukocyte adhesion to the endothelial monolayer. We aimed to evaluate the influence of schistosomias...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.02.005

    authors: Oliveira SD,Oliveira NF,Meyer-Fernandes JR,Savio LE,Ornelas FG,Ferreira ZS,Coutinho-Silva R,Silva CL

    更新日期:2016-07-01 00:00:00

  • Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.

    abstract:BACKGROUND:Macrophages play a central role in atherosclerosis development and progression, hence, targeting macrophage activity is considered an attractive therapeutic. Recently, we documented nanomedicinal delivery of the anti-inflammatory compound prednisolone to atherosclerotic plaque macrophages in patients, which ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.04.006

    authors: Alaarg A,Zheng KH,van der Valk FM,da Silva AE,Versloot M,van Ufford LC,Schulte DM,Storm G,Metselaar JM,Stroes ES,Hamers AA

    更新日期:2016-07-01 00:00:00

  • Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events.

    abstract::Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during early development. Upon exposure to glucocorticoids, the fetus develops hypertension, and the of...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2016.02.002

    authors: Anwar MA,Saleh AI,Al Olabi R,Al Shehabi TS,Eid AH

    更新日期:2016-07-01 00:00:00

  • The vasorelaxant effect of gallic acid involves endothelium-dependent and -independent mechanisms.

    abstract::The mechanisms of action involved in the vasorelaxant effect of gallic acid (GA) were examined in the isolated rat thoracic aorta. GA exerted a relaxant effect in the highest concentrations (0.4-10mM) in both endothelium-intact and endothelium-denuded aortic rings. Pre-incubation with L-NAME, ODQ, calmidazolium, TEA, ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.10.010

    authors: de Oliveira LM,de Oliveira TS,da Costa RM,de Souza Gil E,Costa EA,Passaglia Rde C,Filgueira FP,Ghedini PC

    更新日期:2016-06-01 00:00:00

  • Acetylsalicylic acid desensitization in patients with coronary artery disease: A comprehensive overview of currently available protocols.

    abstract:BACKGROUND:Acetylsalicylic acid (ASA) represents the basis of pharmacological therapy for cardiovascular prevention. However, several patients are excluded from the benefits of ASA for hypersensitivity problems, and controversies still exist on their management. The aim of present study was to evaluate the safety and e...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.vph.2015.09.005

    authors: Verdoia M,Barbieri L,Schaffer A,Nardin M,Suryapranata H,De Luca G

    更新日期:2016-05-01 00:00:00

  • Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.

    abstract:BACKGROUND:Dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE(-/-)) mice, and examined its effects on endothelial function. METHODS AND ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.08.011

    authors: Salim HM,Fukuda D,Higashikuni Y,Tanaka K,Hirata Y,Yagi S,Soeki T,Shimabukuro M,Sata M

    更新日期:2016-04-01 00:00:00

  • Platelet reactivity in patients with impaired renal function receiving dual antiplatelet therapy with clopidogrel or ticagrelor.

    abstract:BACKGROUND:Suboptimal platelet inhibition still represents an important challenge, especially for patients undergoing percutaneous coronary interventions (PCI). Chronic kidney disease (CKD) is a common comorbidity of patients with coronary artery disease, and may potentially influence platelet reactivity. So far only f...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.10.006

    authors: Barbieri L,Pergolini P,Verdoia M,Rolla R,Nardin M,Marino P,Bellomo G,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

    更新日期:2016-04-01 00:00:00

  • Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.

    abstract::Unresolved endoplasmic reticulum (ER) stress, with the subsequent persistent activation of the unfolded protein response (UPR) is a well-recognized mechanism of endothelial cell apoptosis with a major impact on the integrity of the endothelium during the course of cardiovascular diseases. As in other cell types, Ca(2+...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.07.011

    authors: Ampem PT,Smedlund K,Vazquez G

    更新日期:2016-01-01 00:00:00

  • The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice.

    abstract::AMP-activated protein kinase (AMPK) is present in the arterial wall and is activated in response to cellular stressors that raise AMP relative to ADP/ATP. Activation of AMPK in vivo lowers blood pressure but the influence of hyperlipidemia on this response has not been studied. ApoE(-/-) mice on high fat diet for 6wee...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.07.010

    authors: Greig FH,Ewart MA,McNaughton E,Cooney J,Spickett CM,Kennedy S

    更新日期:2015-11-01 00:00:00

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