当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Thyroid hormone and chronically unloaded hearts.

Thyroid hormone and chronically unloaded hearts.

Abstract：

:The heart is subjected to chronic mechanical unloading during prolonged spaceflight and microgravity. The heart in patients with end-stage heart failure is also unloaded in prolonged duration after left ventricular assist devices (LVAD) are implanted. Heterotopic heart transplantation in rats is an established model of chronic cardiac unloading, and has been used to investigate the effects of chronic cardiac unloading on the heart. Observations that have been found using this experimental model are as follow. Chronic cardiac unloading induces time-dependent depressions of Ca2+ handling and myocyte contractility, which are associated with the shift of myosin heavy chain (MHC) isozymes and altered expressions of Ca2+ cycling-related proteins. Treatment with the physiological treatment dose of thyroid hormone restores the expression levels of Ca2+ cycling-related proteins, Ca2+ handling, and contractile function of cardiac myocytes in chronically unloaded hearts. Although future studies are required to determine precise mechanisms of the beneficial effects of thyroid hormone on chronically unloaded hearts, these observations may have clinical implications in the future for chronic cardiac unloading in the space industry as well as in the treatment of patients with end-stage heart failure supported by LVAD.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Ito K,Kagaya Y,Shimokawa H

doi

10.1016/j.vph.2009.10.004

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

138-41

issue

3-4

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(09)00124-4

journal_volume

52

pub_type

杂志文章,评审

相关文献

VASCULAR PHARMACOLOGY文献大全
  • Cyclopiazonic acid alters serotonin-induced responses in rat thoracic aorta.

    abstract：:We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade. Since seroton...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2014.03.008

    authors： Selli C,Erac Y,Tosun M

    更新日期：2014-05-01 00:00:00

  • PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges.

    abstract：:Hypercholesterolemia, is a prominent risk factor for cardiovascular disease (CVD). Undestanding of the biochemical mechanisms that regulate the expression of the low density lipoproteins receptor (LDLR) and the hepatic clearance of LDL cholesterol (LDL-C) paved the way to the statin therapy as the gold standard for CV...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.05.011

    authors： Norata GD,Tibolla G,Catapano AL

    更新日期：2014-08-01 00:00:00

  • Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.

    abstract：RATIONALE:We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. METHODS:Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC a...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.05.006

    authors： Beckles DL,Mascareno E,Siddiqui MA

    更新日期：2006-12-01 00:00:00

  • Prevention of neointima formation by taurine ingestion after carotid balloon injury.

    abstract：:The sulfur-containing amino acid, taurine, has been shown to ameliorate the vascular disorders. We examined the effects of taurine ingestion on intimal thickening following balloon injury. Balloon injury was induced in the left common carotid artery of Wistar rats. Taurine (3% (w/v)) was mixed in the drinking water fr...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.07.003

    authors： Murakami S,Sakurai T,Toda Y,Morito A,Sakono M,Fukuda N

    更新日期：2010-09-01 00:00:00

  • Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways.

    abstract：:Evidence from both clinical and experimental studies indicates that Di-peptidyl peptidase-IV (DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The objective of this study was to examine the acute effects of DPP-4 inhibition on vascular responses and to study the underlying mechanisms of al...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2011.03.001

    authors： Shah Z,Pineda C,Kampfrath T,Maiseyeu A,Ying Z,Racoma I,Deiuliis J,Xu X,Sun Q,Moffatt-Bruce S,Villamena F,Rajagopalan S

    更新日期：2011-07-01 00:00:00

  • Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis.

    abstract：:The endothelium synthesizes and releases nitric oxide (NO) to maintain homeostatic function. Under basal conditions, endothelium-derived NO maintains a nonthrombogenic surface, prohibits leukocyte attachment, and promotes vascular relaxation. In the setting of clinical syndromes associated with the development of athe...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1537-1891(02)00250-1

    authors： Russo G,Leopold JA,Loscalzo J

    更新日期：2002-05-01 00:00:00

  • "ApoptomiRs" in vascular cells: their role in physiological and pathological angiogenesis.

    abstract：:MicroRNAs (miRNAs) have emerged as crucial players regulating the magnitude of gene expression in a variety of organisms. This class of short (22 nucleotides) noncoding RNA molecules have been shown to participate in almost every cellular process investigated so far, and their deregulation is observed in different hum...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2011.07.004

    authors： Quintavalle C,Garofalo M,Croce CM,Condorelli G

    更新日期：2011-10-01 00:00:00

  • Epigenetic modulators mitigate angiogenesis through a complex transcriptomic network.

    abstract：:In this review, we summarize the knowledge pertaining to the role of epigenetics in the regulation of angiogenesis. In particular, we show that lysine acetylation and cytosine methylation are important transcriptional regulators of angiogenic genes in endothelial cells. Lysine acetylation and cytosine methylation inhi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.01.003

    authors： Shiva Shankar TV,Willems L

    更新日期：2014-02-01 00:00:00

  • Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors.

    abstract：:Schistosomiasis is caused by an intravascular parasite and linked to phenotypic changes in endothelial cells that favor inflammation. Endothelial cells express P2Y1 receptors (P2Y1R), and their activation by ADP favors leukocyte adhesion to the endothelial monolayer. We aimed to evaluate the influence of schistosomias...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.02.005

    authors： Oliveira SD,Oliveira NF,Meyer-Fernandes JR,Savio LE,Ornelas FG,Ferreira ZS,Coutinho-Silva R,Silva CL

    更新日期：2016-07-01 00:00:00

  • Involvement of tyrosine kinase pathway in acute hypoxic vasoconstriction in sheep isolated pulmonary vein.

    abstract：:Tyrosine kinase pathway has been shown to be involved in the effects of hypoxia in pulmonary arteries, but its role in pulmonary vein is not known. The aims of this study were to determine the effect of hypoxia in sheep isolated pulmonary veins and to identify the role of tyrosine kinase pathway in hypoxic response. G...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(03)00051-x

    authors： Uzun O,Tuncay Demiryürek A

    更新日期：2003-10-01 00:00:00

  • Vascular AMPK as an attractive target in the treatment of vascular complications of obesity.

    abstract：:The key for the survival of all organisms is the regulation and control of energy metabolism. Thus, several strategies have evolved in each tissue in order to balance nutrient supply with energy demand. Adenosine monophosphate-activated protein kinase (AMPK) is now recognized as a key participant in energy metabolism....

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2015.02.017

    authors： García-Prieto CF,Gil-Ortega M,Aránguez I,Ortiz-Besoain M,Somoza B,Fernández-Alfonso MS

    更新日期：2015-04-01 00:00:00

  • Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts.

    abstract：:Activation of ATP-sensitive K+ channels (K ATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal K ATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial K ATP channel blocker on cardiac fun...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.11.006

    authors： Gok S,Vural K,Sekuri C,Onur R,Tezcan A,Izanli A

    更新日期：2006-04-01 00:00:00

  • Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: sodium nitroprusside and a new ruthenium complex.

    abstract：:We studied the mechanisms involved in the relaxation induced by nitric oxide (NO) donors, ruthenium complex ([Ru(terpy)(bdq)NO(+)](3+)-TERPY) and sodium nitroprusside (SNP) in denuded rat aorta. Both NO donors induced vascular relaxation independent of the agonist used in the pre-contraction. [Ru(terpy)(bdq)NO(+)](3+)...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.10.002

    authors： Bonaventura D,de Lima RG,Vercesi JA,da Silva RS,Bendhack LM

    更新日期：2007-03-01 00:00:00

  • Differential effects of ouabain on the vasodilator actions of nitric oxide and S-nitrosothiols in vivo: relevance to the identity of EDRF/EDHF.

    abstract：OBJECTIVES:This study examined the role of Na+/K+-ATPase in the vasodilator actions of nitric oxide (NO), S-nitrosothiols and the endothelium-dependent agonist, acetylcholine. METHODS:The vasodilator responses elicited by intravenous injections of (i) the NO-donors, sodium nitroprusside and MAHMA NONOate, (ii) the S-n...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.06.008

    authors： Lewis SJ,Travis MD,Hashmi-Hill MP,Sandock K,Robertson TP,Bates JN

    更新日期：2006-12-01 00:00:00

  • Infliximab therapy restores adiponectin expression in perivascular adipose tissue and improves endothelial nitric oxide-mediated vasodilation in mice with type 1 diabetes.

    abstract：:Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM by reducing adiponectin (Ad) synthesis and therefore impairing Ad-mediated activity in the contiguous blood vessel system. We evaluated whether in vivo treatment with the...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.08.007

    authors： Nacci C,Leo V,De Benedictis L,Potenza MA,Sgarra L,De Salvia MA,Quon MJ,Montagnani M

    更新日期：2016-12-01 00:00:00

  • Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats.

    abstract：:Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2017.09.007

    authors： Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

    更新日期：2017-12-01 00:00:00

  • Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition.

    abstract：AIM:Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against cardiovascular diseases including atherosclerosis. The safe dose of selenium in the organism is very narrow, limiting the supplementation of selenium in diet. The aim of this study is to explore whet...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.01.005

    authors： Zhu ML,Wang G,Wang H,Guo YM,Song P,Xu J,Li P,Wang S,Yang L

    更新日期：2019-04-01 00:00:00

  • Role of tyrosine kinase signaling in endothelial cell barrier regulation.

    abstract：:Phosphorylation of proteins on tyrosine acts as a reversible and specific trigger mechanism, forming or disrupting regulatory connections between proteins. Tyrosine kinases and phosphatases participate in multiple cellular processes, and considerable evidence now supports a role for tyrosine phosphorylation in vascula...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1537-1891(03)00009-0

    authors： Bogatcheva NV,Garcia JG,Verin AD

    更新日期：2002-11-01 00:00:00

  • Doxorubicin selectively suppresses mRNA expression and production of endothelin-1 in endothelial cells.

    abstract：:Doxorubicin (DXR) is a widely used cytostatic agent, but its administration is limited by its cardiovascular side effects. The endothelium is one of the largest organs in the human body and due to its direct contact with blood; it is exposed to the toxic effects of DXR. The aim of this study was to investigate in endo...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.08.001

    authors： Keltai K,Cervenak L,Makó V,Doleschall Z,Zsáry A,Karádi I

    更新日期：2010-11-01 00:00:00

  • Differential effects of ET(A) and ET(B) receptor antagonism on oxidative stress in type 2 diabetes.

    abstract：:Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2007.05.006

    authors： Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

    更新日期：2007-08-01 00:00:00

  • Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1.

    abstract：:Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes releasing intracellular molecules called damage-associated molecular patterns. Overactive and prolonged immune responses are likely to be responsible for heart failure development and progression in patients survivi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.08.011

    authors： Tomczyk M,Kraszewska I,Dulak J,Jazwa-Kusior A

    更新日期：2019-01-01 00:00:00

  • Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis.

    abstract：:Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). This study aims to investigate the amelioration of chlorogenic acid (CGA) on proliferative DR (PDR) via focusing on inhibiting retinal neoangiogenesis. CGA reduced the increased cell proliferation, migration and tu...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2017.11.002

    authors： Mei X,Zhou L,Zhang T,Lu B,Sheng Y,Ji L

    更新日期：2018-02-01 00:00:00

  • Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.

    abstract：:Elevated plasma levels of factor VII and fibrinogen are risk factors for cardiovascular disease, especially arterial thrombosis. Oral contraceptive use increases factor VII and fibrinogen plasma levels. It has been described that DNA polymorphisms are associated with the plasma levels of hemostatic variables and their...

    journal_title：Vascular pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1537-1891(02)00300-2

    authors： Bloemenkamp KW,de Maat MP,Dersjant-Roorda MC,Helmerhorst FM,Kluft C

    更新日期：2002-08-01 00:00:00

  • Comparison of the antiatherosclerotic effects of dihydropyridine calcium channel blocker and HMG-CoA reductase inhibitor on hypercholesterolemic rabbits.

    abstract：:The antiatherosclerotic effects of the dihydropyridine-type calcium channel blocker, benidipine hydrochloride (benidipine), and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pravastatin sodium (pravastatin), were compared in hypercholesterolemic rabbits. Male, New Zealand white rabbits were fed a 0.5% cho...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.11.004

    authors： Takayama M,Matsubara M,Arakawa E,Takada C,Ina Y,Hasegawa K,Yao K

    更新日期：2007-04-01 00:00:00

  • Effects of 17 β-estradiol on lipopolysacharride-induced intracellular adhesion molecule-1 mRNA expression and Ca²+ homeostasis alteration in human endothelial cells.

    abstract：:Recent evidence showed that 17 β-estradiol (E₂) decreased cytokine-induced expression of cell adhesion molecules (CAM). Changes in intracellular Ca²+ concentration ([Ca²+](i)) has been shown to be associated with CAM expression in endothelial cells. Here, the effects of E₂ (1 μM, 24 h) on the expression of intracellul...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.09.001

    authors： Thor D,Zhang R,Anderson L,Bose DD,Dubé GP,Rahimian R

    更新日期：2010-11-01 00:00:00

  • Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells.

    abstract：:We have previously reported that prolonged exposure of porcine coronary arteries to adenosine agonists upregulates protein kinase C (PKC) through the activation of adenosine A1 receptor-coupled to pertussis toxin sensitive G-protein(s) [Am. J. Physiol. 264 (1993) H1465; Am. J. Physiol. 269 (1995) H1619]. The mechanism...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(02)00307-5

    authors： Nayeem MA,Mustafa SJ

    更新日期：2002-07-01 00:00:00

  • The vasorelaxant effect of gallic acid involves endothelium-dependent and -independent mechanisms.

    abstract：:The mechanisms of action involved in the vasorelaxant effect of gallic acid (GA) were examined in the isolated rat thoracic aorta. GA exerted a relaxant effect in the highest concentrations (0.4-10mM) in both endothelium-intact and endothelium-denuded aortic rings. Pre-incubation with L-NAME, ODQ, calmidazolium, TEA, ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.10.010

    authors： de Oliveira LM,de Oliveira TS,da Costa RM,de Souza Gil E,Costa EA,Passaglia Rde C,Filgueira FP,Ghedini PC

    更新日期：2016-06-01 00:00:00

  • Mechanisms of endothelial cell protection by hydroxycinnamic acids.

    abstract：:An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as the...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.10.006

    authors： Fuentes E,Palomo I

    更新日期：2014-12-01 00:00:00

  • Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells.

    abstract：BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2008.09.001

    authors： Star GP,Giovinazzo M,Langleben D

    更新日期：2009-01-01 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract：:Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106601

    authors： Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期：2020-01-01 00:00:00