Abstract：
:Tyrosine kinase pathway has been shown to be involved in the effects of hypoxia in pulmonary arteries, but its role in pulmonary vein is not known. The aims of this study were to determine the effect of hypoxia in sheep isolated pulmonary veins and to identify the role of tyrosine kinase pathway in hypoxic response. Genistein and tyrphostin were used as selective tyrosine kinase inhibitors, and sodium orthovanadate was administered for tyrosine kinase activation. Hypoxia (95% N(2) to 5% CO(2)) caused a vasoconstriction either under resting tone or in U46619-precontracted pulmonary veins. Genistein and tyrphostin inhibited hypoxia-induced vasoconstriction both under resting tone and in precontracted veins, while sodium orthovanadate increased these hypoxic contractions. Our findings suggest that tyrosine kinase pathway is involved in hypoxic pulmonary vasoconstriction in sheep isolated pulmonary vein rings.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
Uzun O,Tuncay Demiryürek Adoi
10.1016/s1537-1891(03)00051-xkeywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
175-81issue
3eissn
1537-1891issn
1879-3649pii
S153718910300051Xjournal_volume
40pub_type
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
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journal_title：Vascular pharmacology
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journal_title：Vascular pharmacology
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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