Propranolol-induced relaxation in the rat basilar artery.

abstract：:Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

journal_title：Vascular pharmacology

authors： Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

更新日期：2007-08-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is present in the arterial wall and is activated in response to cellular stressors that raise AMP relative to ADP/ATP. Activation of AMPK in vivo lowers blood pressure but the influence of hyperlipidemia on this response has not been studied. ApoE(-/-) mice on high fat diet for 6wee...

journal_title：Vascular pharmacology

authors： Greig FH,Ewart MA,McNaughton E,Cooney J,Spickett CM,Kennedy S

更新日期：2015-11-01 00:00:00

abstract：:Hypercholesterolemia, is a prominent risk factor for cardiovascular disease (CVD). Undestanding of the biochemical mechanisms that regulate the expression of the low density lipoproteins receptor (LDLR) and the hepatic clearance of LDL cholesterol (LDL-C) paved the way to the statin therapy as the gold standard for CV...

journal_title：Vascular pharmacology

authors： Norata GD,Tibolla G,Catapano AL

更新日期：2014-08-01 00:00:00

abstract：:Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

journal_title：Vascular pharmacology

authors： Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

更新日期：2017-12-01 00:00:00

abstract：:The early stages of invasion are characterized by the extracellular proteolysis and the accumulation of specialized extracellular matrix (ECM) scaffold, that are responsible for the development of vascular bed, endothelial cell proliferation and invasion of tumour cells. The ground substance of provisional matrix cons...

journal_title：Vascular pharmacology

authors： Mathivadhani P,Shanthi P,Sachdanandam P

更新日期：2007-06-01 00:00:00

abstract：:Small GTPase Rap1 has been extensively studied in vitro and shown to regulate multiple basic cellular processes. Until recently, the best studied aspect of Rap1 function in endothelial cells involved its role in regulation of cell-cell junction formation and remodeling. These in vitro studies have increased understand...

journal_title：Vascular pharmacology

authors： Chrzanowska-Wodnicka M

更新日期：2010-07-01 00:00:00

abstract：:Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

journal_title：Vascular pharmacology

authors： Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

更新日期：2018-11-01 00:00:00

abstract：:β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

journal_title：Vascular pharmacology

authors： Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

更新日期：2014-05-01 00:00:00

abstract：:Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs...

journal_title：Vascular pharmacology

authors： Zhang L,Zhou Y,Zhu J,Xu Q

更新日期：2012-05-01 00:00:00

abstract：:tert-Butyl hydroperoxide (t-BOOH), a membrane permeant oxidant, elicits enhanced vasoconstriction of perfused kidney and mesenteric arterial beds isolated from DOCA-salt-induced hypertensive rats. We hypothesize that enhanced vasoconstriction to t-BOOH during DOCA-salt hypertension involves free radical species and de...

journal_title：Vascular pharmacology

authors： Awe SO,Tsakadze NL,D'Souza SE,Adeagbo AS

更新日期：2003-01-01 00:00:00

abstract：:Four main vascular effects of hydrogen peroxide (H2O2) were studied in intact and rubbed aortic rings from WKY rats. In rings partially precontracted with phenylephrine: 1-30 microM H2O2 induced an increase of tone, 100 microM H2O2 produced a transient contraction followed by a fast-developing endothelium-independent ...

journal_title：Vascular pharmacology

authors： Gil-Longo J,González-Vázquez C

更新日期：2005-08-01 00:00:00

abstract：:LIGHT is known to act as a novel mediator for atherogenesis. Furthermore, it has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells. However, it is not known if emodin exerts anti-atherogenic effects in the human monocyte, THP-1, following treatment with LIGHT. I...

journal_title：Vascular pharmacology

authors： Heo SK,Yun HJ,Noh EK,Park SD

更新日期：2010-07-01 00:00:00

abstract：:Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascular smooth muscle cells (VSMCs) are involved in As. Hyperhomocysteinemia (HHcy) is an independent risk factor for As. The present study was designed to test our hypothesi...

journal_title：Vascular pharmacology

authors： Chen Y,Su X,Qin Q,Yu Y,Jia M,Kong L,Zhang H,Li H

更新日期：2020-01-01 00:00:00

abstract：:Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during early development. Upon exposure to glucocorticoids, the fetus develops hypertension, and the of...

journal_title：Vascular pharmacology

authors： Anwar MA,Saleh AI,Al Olabi R,Al Shehabi TS,Eid AH

更新日期：2016-07-01 00:00:00

abstract：:Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor sub...

journal_title：Vascular pharmacology

authors： de Souza Rossignoli P,Yamamoto FZ,Pereira OC,Chies AB

更新日期：2015-09-01 00:00:00

abstract：:Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein ...

journal_title：Vascular pharmacology

authors： Roth L,Van der Donckt C,Emini Veseli B,Van Dam D,De Deyn PP,Martinet W,Herman AG,De Meyer GRY

更新日期：2019-01-01 00:00:00

abstract：:Animal studies have identified monocyte chemoattractive protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) as critical mediators of arterial diameter enlargement in response to chronic increases in blood flow (arteriogenesis). Furthermore, cellular studies have shown that the shear stresses resulting from...

journal_title：Vascular pharmacology

authors： Cannon JG,Sabatier MJ,Marinik EL,Schwark EH,Haddow S,Cortez-Cooper M,Bergeron MF,Sloan GJ,McCully KK

更新日期：2009-03-01 00:00:00

abstract：:Cigarette smoking is implicated as a major risk factor in the development of cardiovascular and cerebrovascular diseases. Creatine kinase (CK) and its isoforms (CK-MM, MB, BB) have been advocated as sensitive markers in the assessment of cardiac and cerebral damage. Therefore, in the present study, we report the isoen...

journal_title：Vascular pharmacology

authors： Anbarasi K,Vani G,Balakrishna K,Devi CS

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:In patients with familial combined hyperlipidemia (FCHL), without metabolic syndrome (MS), occurrence of non-alcoholic fatty liver disease (NAFLD) is related to a specific pro-inflammatory profile, influenced by genetic traits, involved in oxidative stress and adipokine secretion. Among FCHL or MS patients, h...

journal_title：Vascular pharmacology

authors： Santilli F,Blardi P,Scapellato C,Bocchia M,Guazzi G,Terzuoli L,Tabucchi A,Silvietti A,Lucani B,Gioffrè WR,Scarpini F,Fazio F,Davì G,Puccetti L

更新日期：2015-09-01 00:00:00

abstract：:Recent evidence showed that 17 β-estradiol (E₂) decreased cytokine-induced expression of cell adhesion molecules (CAM). Changes in intracellular Ca²+ concentration ([Ca²+](i)) has been shown to be associated with CAM expression in endothelial cells. Here, the effects of E₂ (1 μM, 24 h) on the expression of intracellul...

journal_title：Vascular pharmacology

authors： Thor D,Zhang R,Anderson L,Bose DD,Dubé GP,Rahimian R

更新日期：2010-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as crucial players regulating the magnitude of gene expression in a variety of organisms. This class of short (22 nucleotides) noncoding RNA molecules have been shown to participate in almost every cellular process investigated so far, and their deregulation is observed in different hum...

journal_title：Vascular pharmacology

authors： Quintavalle C,Garofalo M,Croce CM,Condorelli G

更新日期：2011-10-01 00:00:00

abstract：:Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophys...

journal_title：Vascular pharmacology

authors： Gorla R,Erbel R,Eagle KA,Bossone E

更新日期：2018-04-12 00:00:00

abstract：:Ion channels control electrical excitability in living cells. In mammalian heart, the opposing actions of Na(+) and Ca(2+) ion influx, and K(+) ion efflux, through cardiac ion channels determine the morphology and duration of action potentials in cardiac myocytes, thus controlling the heartbeat. The last decade has se...

journal_title：Vascular pharmacology

authors： Roepke TK,Abbott GW

更新日期：2006-02-01 00:00:00

abstract：:Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM by reducing adiponectin (Ad) synthesis and therefore impairing Ad-mediated activity in the contiguous blood vessel system. We evaluated whether in vivo treatment with the...

journal_title：Vascular pharmacology

authors： Nacci C,Leo V,De Benedictis L,Potenza MA,Sgarra L,De Salvia MA,Quon MJ,Montagnani M

更新日期：2016-12-01 00:00:00

abstract：:Vasculopathy is common in patients with connective tissue disease and can be directly implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune multiorgan connective tissue disorder characterized by fibrosis of the skin and visceral organs and vascular disease. Micro- and macro-vessels are a ...

journal_title：Vascular pharmacology

authors： Kavian N,Batteux F

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Growth factor therapy provides a therapeutic alternative for "no option" patients with coronary disease. Fibroblast Growth Factor-2 (FGF-2) predominantly stimulates angiogenesis, the growth of new capillaries, whereas Monocyte Chemoattractant Protein-1 (MCP-1) is considered an arteriogenic agent. We hypoth...

journal_title：Vascular pharmacology

authors： Heilmann C,Kostic C,Giannone B,Grawitz AB,Armbruster W,Lutter G,Beyersdorf F,Göbel H

更新日期：2006-05-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a metabolic disorder marked by an excess amount of the amino acid homocysteine (Hcy) in the blood stream. Hcy is a H(2)S precursor-formed from the metabolism of methionine. Elevated Hcy levels have been associated with higher blood pressure. However, the precise contribution of H(2)S to ...

journal_title：Vascular pharmacology

authors： Sowmya S,Swathi Y,Yeo AL,Shoon ML,Moore PK,Bhatia M

更新日期：2010-09-01 00:00:00

abstract：:We have studied the therapeutic efficacy of the sodium alginate in experimental immune complex glomerulonephritis. Bovine serum albumin (BSA) nephritis was induced in rats by a subcutaneous immunization and daily intravenous administration of BSA. Sodium alginate at two different doses (25 and 50 mg/kg) was administer...

journal_title：Vascular pharmacology

authors： Mirshafiey A,Borzooy Z,Abhari RS,Razavi A,Tavangar M,Rehm BH

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. METHODS:Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC a...

journal_title：Vascular pharmacology

authors： Beckles DL,Mascareno E,Siddiqui MA

更新日期：2006-12-01 00:00:00

abstract：:Neurokinin(3) (NK(3)) receptors may regulate the airways primarily through actions on the nerves. In the periphery, airway parasympathetic ganglia neurons are depolarized following NK(3) receptor activation resulting subsequently in the facilitation of synaptic transmission. Such an effect may account for the excessiv...

journal_title：Vascular pharmacology

authors： Canning BJ

更新日期：2006-10-01 00:00:00