当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Characterization of four different effects elicited by H2O2 in rat aorta.

Characterization of four different effects elicited by H2O2 in rat aorta.

Abstract：

:Four main vascular effects of hydrogen peroxide (H2O2) were studied in intact and rubbed aortic rings from WKY rats. In rings partially precontracted with phenylephrine: 1-30 microM H2O2 induced an increase of tone, 100 microM H2O2 produced a transient contraction followed by a fast-developing endothelium-independent relaxation, and 0.3 mM H2O2 induced a fast-developing relaxation followed by a slow-developing endothelium-independent relaxation. Superoxide dismutase (SOD) or dimethyl sulfoxide (DMSO)/manitol did not significantly modify the H2O2 effects, while catalase suppressed them. Indomethacin abolished the increase of tone elicited by H2O2 and revealed a small endothelium-dependent relaxation, which was suppressed by N(G)-nitro-L-arginine (L-NA), high K+ or tetraethylammonium (TEA). TEA strongly inhibited the fast-developing relaxation while indomethacin, glybenclamide, 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), cafeic acid or eicosatriynoic acid (ETI) did not affect the relaxation. In rings precontracted with 70 mM KCl, 1-100 microM H2O2 induced a small increase of tone and 0.3 mM a slow-developing relaxation. Catalase or Fe2+-EDTA/vitamin C suppressed the slow-developing relaxation while deferoxamine did not modify it. In rings partially precontracted with arachidonic acid, 1-30 microM H2O2 induced higher contractile effects than in rings partially precontracted with phenylephrine. H2O2 at 0.3 mM for one hour induced a persistent impairment on the reactivity of the rings and the release of lactate dehydrogenase. In summary, H2O2 produces: (1) contractions mediated by direct activation of cyclooxygenase; 2) endothelium-dependent relaxations related to activation of endothelial K+ channels and NO synthesis; 3) reversible endothelium-independent relaxations mediated by activation of smooth muscle K+ channels; and 4) irreversible endothelium-independent relaxations related to cellular damage, caused by H2O2 but not by hydroxyl radicals.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Gil-Longo J,González-Vázquez C

doi

10.1016/j.vph.2005.06.001

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

128-38

issue

2

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(05)00119-9

journal_volume

43

pub_type

杂志文章

相关文献

VASCULAR PHARMACOLOGY文献大全
  • Cyclopiazonic acid alters serotonin-induced responses in rat thoracic aorta.

    abstract：:We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade. Since seroton...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2014.03.008

    authors： Selli C,Erac Y,Tosun M

    更新日期：2014-05-01 00:00:00

  • CRISPR links to long noncoding RNA function in mice: A practical approach.

    abstract：:Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered regularly interspaced short palindromic repeats (CRISPR) editing h...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2019.02.004

    authors： Miano JM,Long X,Lyu Q

    更新日期：2019-03-01 00:00:00

  • Chemerin-induced arterial contraction is Gi- and calcium-dependent.

    abstract：:Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinet...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.11.009

    authors： Ferland DJ,Darios ES,Neubig RR,Sjögren B,Truong N,Torres R,Dexheimer TS,Thompson JM,Watts SW

    更新日期：2017-01-01 00:00:00

  • Neurokinin3 receptor regulation of the airways.

    abstract：:Neurokinin(3) (NK(3)) receptors may regulate the airways primarily through actions on the nerves. In the periphery, airway parasympathetic ganglia neurons are depolarized following NK(3) receptor activation resulting subsequently in the facilitation of synaptic transmission. Such an effect may account for the excessiv...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2005.08.031

    authors： Canning BJ

    更新日期：2006-10-01 00:00:00

  • Mechanisms of endothelial cell protection by hydroxycinnamic acids.

    abstract：:An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as the...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.10.006

    authors： Fuentes E,Palomo I

    更新日期：2014-12-01 00:00:00

  • Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.

    abstract：RATIONALE:We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. METHODS:Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC a...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.05.006

    authors： Beckles DL,Mascareno E,Siddiqui MA

    更新日期：2006-12-01 00:00:00

  • Acetylsalicylic acid desensitization in patients with coronary artery disease: A comprehensive overview of currently available protocols.

    abstract：BACKGROUND:Acetylsalicylic acid (ASA) represents the basis of pharmacological therapy for cardiovascular prevention. However, several patients are excluded from the benefits of ASA for hypersensitivity problems, and controversies still exist on their management. The aim of present study was to evaluate the safety and e...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.vph.2015.09.005

    authors： Verdoia M,Barbieri L,Schaffer A,Nardin M,Suryapranata H,De Luca G

    更新日期：2016-05-01 00:00:00

  • The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.

    abstract：:Successful drug delivery to the central nervous system (CNS) is highly dependent on DMPK as well as physicochemical properties and it is therefore important to characterise these properties and take them into account when designing chemical lead series that act at CNS targets. Since the drug discovery/development proc...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(02)00203-3

    authors： Lundquist S,Renftel M

    更新日期：2002-06-01 00:00:00

  • Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.

    abstract：:The present study was undertaken to investigate endothelial function and epoxyeicosatrienoic acids (EETs), which is a cytochrome P-450 monooxygenase (CYP) metabolite and one of the candidates as an endothelium-derived hyperpolarizing factor (EDHF) in the renal artery isolated from short-term hypercholesterolemic rabbi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.03.005

    authors： Taniguchi J,Honda H,Shibusawa Y,Iwata T,Notoya Y

    更新日期：2005-06-01 00:00:00

  • Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF-κB signaling pathway in vascular smooth muscle cells.

    abstract：:Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascular smooth muscle cells (VSMCs) are involved in As. Hyperhomocysteinemia (HHcy) is an independent risk factor for As. The present study was designed to test our hypothesi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106613

    authors： Chen Y,Su X,Qin Q,Yu Y,Jia M,Kong L,Zhang H,Li H

    更新日期：2020-01-01 00:00:00

  • Oxidative metabolism of peripheral blood neutrophils in experimental acute hypercapnia in the mechanically ventilated rabbit.

    abstract：BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(02)00338-5

    authors： Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

    更新日期：2003-02-01 00:00:00

  • Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels.

    abstract：:In this study, we have investigated the actions of danshensu, an active, water-extractable component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 microM 5-hydroxytryptamine (5-HT) and its action compared to the water-extractable fraction of the herb. E...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.10.011

    authors： Lam FF,Yeung JH,Chan KM,Or PM

    更新日期：2007-04-01 00:00:00

  • Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?

    abstract：:Autoimmune rheumatic diseases are characterised by systemic inflammation and complex immunopathology, with an increased risk of cardiovascular disease, initiated by endothelial dysfunction in a chronic inflammatory environment. Endothelial microparticles (EMPs) are released into the circulation from activated endothel...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2016.05.016

    authors： McCarthy EM,Wilkinson FL,Parker B,Alexander MY

    更新日期：2016-11-01 00:00:00

  • Paclitaxel chemotherapy and vascular toxicity as assessed by flow-mediated and nitrate-mediated vasodilatation.

    abstract：BACKGROUND:Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS:We studied 27 women treated with paclitaxel-containing combinations...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.05.002

    authors： Vassilakopoulou M,Mountzios G,Papamechael C,Protogerou AD,Aznaouridis K,Katsichti P,Venetsanou K,Dimopoulos MA,Ikonomidis I,Papadimitriou CA

    更新日期：2010-09-01 00:00:00

  • Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats.

    abstract：:Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apo...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2009.06.001

    authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Malý J,Kramer HJ,Dvorák P,Cervenka L

    更新日期：2009-08-01 00:00:00

  • β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

    abstract：:β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2014.04.003

    authors： Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

    更新日期：2014-05-01 00:00:00

  • Propranolol-induced relaxation in the rat basilar artery.

    abstract：:Propranolol is a non-selective beta-adrenergic receptor blocker used in the treatment of cardiovascular diseases and migraine prophylaxis. Although it has been shown that propranolol dilates the peripheral arteries of rat, its action in the central nervous system vasculature has not been investigated. In this study, t...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.12.004

    authors： Cekic EG,Soydan G,Guler S,Babaoglu MO,Tuncer M

    更新日期：2013-04-01 00:00:00

  • Thyroid hormone and chronically unloaded hearts.

    abstract：:The heart is subjected to chronic mechanical unloading during prolonged spaceflight and microgravity. The heart in patients with end-stage heart failure is also unloaded in prolonged duration after left ventricular assist devices (LVAD) are implanted. Heterotopic heart transplantation in rats is an established model o...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2009.10.004

    authors： Ito K,Kagaya Y,Shimokawa H

    更新日期：2010-03-01 00:00:00

  • Adrenoceptor and cholinoceptor modulation of rat pulmonary vein cardiac muscle contractility.

    abstract：:Cardiac muscle extends into mammalian pulmonary veins for variable distances according to species. This study has addressed the autonomic control of electrically paced cardiac muscle of the pulmonary vein of the rat. Contractile responses of Wistar rat pulmonary veins were investigated under isometric conditions in vi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.09.005

    authors： Sweeney CM,Jones JF,Bund SJ

    更新日期：2007-03-01 00:00:00

  • Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.

    abstract：BACKGROUND:Macrophages play a central role in atherosclerosis development and progression, hence, targeting macrophage activity is considered an attractive therapeutic. Recently, we documented nanomedicinal delivery of the anti-inflammatory compound prednisolone to atherosclerotic plaque macrophages in patients, which ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.04.006

    authors： Alaarg A,Zheng KH,van der Valk FM,da Silva AE,Versloot M,van Ufford LC,Schulte DM,Storm G,Metselaar JM,Stroes ES,Hamers AA

    更新日期：2016-07-01 00:00:00

  • Endothelial injury in the initiation and progression of vascular disorders.

    abstract：:Endothelial cell dysfunction is considered to be an early event which subsequently leads to vascular wall disorders. Ultrastructural studies indicate that the endothelial cell changes involve membrane damage, increased permeability, swelling and necrosis. The endothelial cell loss of function could be as a result of c...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2006.11.005

    authors： Tesfamariam B,DeFelice AF

    更新日期：2007-04-01 00:00:00

  • Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell migration through preventing the activation of MMP-2 and FAK via inhibiting ERK and PI3K/AKT signaling pathways.

    abstract：:Angiogenesis has become an attractive target for the treatment of certain diseases such as cancer and rheumatoid arthritis. Our previous studies demonstrated that the saponin fraction from Gleditsia sinensis fruits had anti-angiogenic potential, and Gleditsiosides B (GB) was probably the main active constituent. In th...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.09.006

    authors： Tong B,Lu D,Wei Z,Wang T,Xia Y,Dai Y

    更新日期：2013-01-01 00:00:00

  • Lipoic acid decreases exhaled nitric oxide concentrations in anesthetized endotoxemic rats.

    abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.08.005

    authors： De Marco VG,Bosanquet JP,Rawlani VR,Skimming JW

    更新日期：2005-12-01 00:00:00

  • Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.

    abstract：:Endothelial cell dysfunction may play an important role in the development of various vascular diseases, including atherosclerosis. Here we investigated whether lithium chloride (LiCl), an inhibitor of glycogen synthase kinase-3β (GSK-3β), could counteract atherosclerosis induced by a high-fat diet in ApoE⁻/⁻ mice. Te...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.09.004

    authors： Choi SE,Jang HJ,Kang Y,Jung JG,Han SJ,Kim HJ,Kim DJ,Lee KW

    更新日期：2010-11-01 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract：:Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106601

    authors： Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期：2020-01-01 00:00:00

  • Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia.

    abstract：:The present study investigates the potential of ozagrel, a thromboxane A2 (TXA2) synthase inhibitor, in bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water maze (MWM) test was employed on 7th day p...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2020.106827

    authors： Bhatia P,Kaur G,Singh N

    更新日期：2020-12-17 00:00:00

  • The kinetics of angiotensin-I metabolism in human carotid atheroma: An emerging role for angiotensin (1-7).

    abstract：AIM:Local levels of angiotensin peptides depend on their rates of production and degradation, which induce proatherogenic or atheroprotective effects. Here, we reveal the kinetics of Angiotensin-I metabolism in paired early and advanced atherosclerotic lesions. METHODS:Lesions were spiked with labeled Ang-I* and super...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.08.001

    authors： Nehme A,Marcelo P,Nasser R,Kobeissy F,Bricca G,Zibara K

    更新日期：2016-10-01 00:00:00

  • Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

    abstract：:Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.10.001

    authors： Sangartit W,Pakdeechote P,Kukongviriyapan V,Donpunha W,Shibahara S,Kukongviriyapan U

    更新日期：2016-12-01 00:00:00

  • Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events.

    abstract：:Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during early development. Upon exposure to glucocorticoids, the fetus develops hypertension, and the of...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2016.02.002

    authors： Anwar MA,Saleh AI,Al Olabi R,Al Shehabi TS,Eid AH

    更新日期：2016-07-01 00:00:00

  • Regulation of atherosclerotic plaque growth and stability by testosterone and its receptor via influence of inflammatory reaction.

    abstract：BACKGROUND:Platelets play crucial roles in the development of arterial thrombosis and other pathophysiologies leading to clinical ischemic events. Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis. The purposes of the study are to determine whether atherosclerotic pl...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2008.03.004

    authors： Li S,Li X,Li Y

    更新日期：2008-07-01 00:00:00