Abstract：
:Our previous studies revealed that scopoletin, the main bioactive constituent of Erycibe obtusifolia Benth stems, exerted anti-arthritic activity in vivo partly by preventing synovial angiogenesis. Herein we further investigated the anti-angiogenic potential and related mechanisms of this coumarin compound in vivo and in vitro. On chick chorioallantoic membrane (CAM) model, scopoletin (10, 30, 100 nmol/egg) dose-dependently reduced the blood vessels that were quantified by counting the number of blood vessel branch points. In vitro, scopoletin at concentrations above 30 microM obviously inhibited the VEGF-induced tube formation, proliferation and migration of human umbilical vein endothelial cells (HUVECs). Furthermore, scopoletin was shown to block VEGF-induced autophosphorylation of VEGFR2 but not VEGFR1, and down-regulate the following activation of ERK1/2, p38 MAPK and endothelial nitric oxide synthase (eNOS) as well as the production of nitric oxide (NO) in HUVECs. In sum, our findings further support that scopoletin is a candidate of angiogenesis inhibitors, and it functions by interrupting the autophosphorylation of VEGF receptor 2 (VEGFR2) and the downstream signaling pathways.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
Pan R,Dai Y,Gao XH,Lu D,Xia YFdoi
10.1016/j.vph.2010.11.001subject
Has Abstractpub_date
2011-01-01 00:00:00pages
18-28issue
1-2eissn
1537-1891issn
1879-3649pii
S1537-1891(10)00153-9journal_volume
54pub_type
杂志文章abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...
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journal_title：Vascular pharmacology
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pub_type： 杂志文章,meta分析,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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更新日期：2014-11-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2009.09.001
更新日期：2009-11-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2003.09.002
更新日期：2003-12-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2008.09.001
更新日期：2009-01-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2014.04.003
更新日期：2014-05-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2015.02.001
更新日期：2015-04-01 00:00:00
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doi：10.1016/j.vph.2006.11.004
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doi：10.1016/j.vph.2006.09.005
更新日期：2007-03-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2007.05.006
更新日期：2007-08-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.vph.2011.08.224
更新日期：2011-10-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2003.08.003
更新日期：2004-01-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2018.02.005
更新日期：2018-07-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2011.04.001
更新日期：2011-07-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.03.005
更新日期：2005-06-01 00:00:00
abstract：:Propranolol is a non-selective beta-adrenergic receptor blocker used in the treatment of cardiovascular diseases and migraine prophylaxis. Although it has been shown that propranolol dilates the peripheral arteries of rat, its action in the central nervous system vasculature has not been investigated. In this study, t...
journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2012.12.004
更新日期：2013-04-01 00:00:00
