Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis.

Abstract:

:Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stable and a vulnerable, rupture-prone lesion. The need for plaque-stabilizing therapies is high, and for a long time the lack of a suitable animal model mimicking advanced human atherosclerotic plaques made it very difficult to make progress in this area. Evidence from human plaques indicates that intra-plaque (IP) angiogenesis promotes atherosclerosis and plaque destabilization. Although neovascularization has been widely investigated in cancer, studies on the pharmacological inhibition of this phenomenon in atherosclerosis are scarce, mainly due to the lack of an appropriate animal model. By using ApoE-/- Fbn1C1039G+/- mice, a novel model of vulnerable plaques, we were able to investigate the effect of pharmacological inhibition of various mechanisms of IP angiogenesis on plaque destabilization and atherogenesis. In the present review, we discuss the following potential pharmacological strategies to inhibit IP angiogenesis: (1) inhibition of vascular endothelial growth factor signalling, (2) inhibition of glycolytic flux, and (3) inhibition of fatty acid oxidation. On the long run, IP neovascularization might be applicable as a therapeutic target to induce plaque stabilization on top of lipid-lowering treatment.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

doi

10.1016/j.vph.2018.06.014

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

72-78

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(18)30113-7

journal_volume

112

pub_type

杂志文章,评审
  • Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.

    abstract::Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alp...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106577

    authors: Kamau F,Strijdom H,Mwangi P,Blackhurst D,Imperial E,Salie R

    更新日期:2019-10-01 00:00:00

  • An updated view on stem cell differentiation into smooth muscle cells.

    abstract::Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2012.02.014

    authors: Zhang L,Zhou Y,Zhu J,Xu Q

    更新日期:2012-05-01 00:00:00

  • Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis.

    abstract::Thalidomide is an antiangiogenic drug and is clinically useful in a number of cancers. However, the molecular mechanism by which thalidomide exerts its antitumor effects is poorly understood. This study was designed to clarify the relationship between antiangiogenesis and antitumor effects of thalidomide and to explor...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.04.003

    authors: Du GJ,Lin HH,Xu QT,Wang MW

    更新日期:2005-08-01 00:00:00

  • Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure.

    abstract::We characterized vascular reactivity to endothelin-1 (ET-1) in mesenteric vessels from DOCA-salt hypertensive and SHAM control mice and assessed the effect that endothelial-derived vasodilators have on ET-1-induced vasoconstriction. Changes in the diameter of unpressurized small mesenteric arteries and veins (100- to ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.02.014

    authors: Pérez-Rivera AA,Fink GD,Galligan JJ

    更新日期:2005-06-01 00:00:00

  • The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.

    abstract::Successful drug delivery to the central nervous system (CNS) is highly dependent on DMPK as well as physicochemical properties and it is therefore important to characterise these properties and take them into account when designing chemical lead series that act at CNS targets. Since the drug discovery/development proc...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1537-1891(02)00203-3

    authors: Lundquist S,Renftel M

    更新日期:2002-06-01 00:00:00

  • Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature.

    abstract::Although the vasorelaxing effects of testosterone (T) and various androgen metabolites have been observed in a variety of blood vessels and species, previous studies have not systematically compared the vasorelaxing effects of androgen metabolites in different vascular beds within the same species. Therefore, we studi...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2012.01.008

    authors: Perusquía M,Espinoza J,Montaño LM,Stallone JN

    更新日期:2012-03-01 00:00:00

  • Characterization of four different effects elicited by H2O2 in rat aorta.

    abstract::Four main vascular effects of hydrogen peroxide (H2O2) were studied in intact and rubbed aortic rings from WKY rats. In rings partially precontracted with phenylephrine: 1-30 microM H2O2 induced an increase of tone, 100 microM H2O2 produced a transient contraction followed by a fast-developing endothelium-independent ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.06.001

    authors: Gil-Longo J,González-Vázquez C

    更新日期:2005-08-01 00:00:00

  • Chemerin-induced arterial contraction is Gi- and calcium-dependent.

    abstract::Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinet...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.11.009

    authors: Ferland DJ,Darios ES,Neubig RR,Sjögren B,Truong N,Torres R,Dexheimer TS,Thompson JM,Watts SW

    更新日期:2017-01-01 00:00:00

  • Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.

    abstract::Peroxisome proliferator-activated receptors (PPAR)alpha, gamma and beta/delta belong to the nuclear receptor family of ligand-activated transcription factors. PPARs heterodimerize with the retinoid X receptor (RXR) and then act as transcription factors to modulate the function of many target genes. PPARalpha, gamma an...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2005.11.014

    authors: Touyz RM,Schiffrin EL

    更新日期:2006-07-01 00:00:00

  • Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice.

    abstract::Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.05.001

    authors: Roth L,Van der Donckt C,Emini Veseli B,Van Dam D,De Deyn PP,Martinet W,Herman AG,De Meyer GRY

    更新日期:2019-01-01 00:00:00

  • Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells.

    abstract:BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2008.09.001

    authors: Star GP,Giovinazzo M,Langleben D

    更新日期:2009-01-01 00:00:00

  • Effects of 17 β-estradiol on lipopolysacharride-induced intracellular adhesion molecule-1 mRNA expression and Ca²+ homeostasis alteration in human endothelial cells.

    abstract::Recent evidence showed that 17 β-estradiol (E₂) decreased cytokine-induced expression of cell adhesion molecules (CAM). Changes in intracellular Ca²+ concentration ([Ca²+](i)) has been shown to be associated with CAM expression in endothelial cells. Here, the effects of E₂ (1 μM, 24 h) on the expression of intracellul...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2010.09.001

    authors: Thor D,Zhang R,Anderson L,Bose DD,Dubé GP,Rahimian R

    更新日期:2010-11-01 00:00:00

  • Intra-aortic balloon counterpulsation - basic principles and clinical evidence.

    abstract::Intra-aortic balloon pump (IABP) counterpulsation has been the most widely used left ventricular assist device for nearly five decades. Due to diastolic inflation and systolic deflation, coronary blood flow is increased and afterload decreased translating into augmentation of oxygen supply and lowering of oxygen deman...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2013.12.003

    authors: de Waha S,Desch S,Eitel I,Fuernau G,Lurz P,Sandri M,Schuler G,Thiele H

    更新日期:2014-02-01 00:00:00

  • Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of Bacoside A.

    abstract::Cigarette smoking is implicated as a major risk factor in the development of cardiovascular and cerebrovascular diseases. Creatine kinase (CK) and its isoforms (CK-MM, MB, BB) have been advocated as sensitive markers in the assessment of cardiac and cerebral damage. Therefore, in the present study, we report the isoen...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.01.003

    authors: Anbarasi K,Vani G,Balakrishna K,Devi CS

    更新日期:2005-01-01 00:00:00

  • β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

    abstract::β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2014.04.003

    authors: Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

    更新日期:2014-05-01 00:00:00

  • Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins.

    abstract::Impaired endothelial function is recognised as one of the earliest events of atherogenesis. Endothelium-dependent vasomotion has been the principal method to assess endothelial function. In this article, we will discuss the clinical value of the different techniques to evaluate endothelium-dependent vasomotion. To dat...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2005.01.009

    authors: Asselbergs FW,van der Harst P,Jessurun GA,Tio RA,van Gilst WH

    更新日期:2005-02-01 00:00:00

  • Acetylsalicylic acid desensitization in patients with coronary artery disease: A comprehensive overview of currently available protocols.

    abstract:BACKGROUND:Acetylsalicylic acid (ASA) represents the basis of pharmacological therapy for cardiovascular prevention. However, several patients are excluded from the benefits of ASA for hypersensitivity problems, and controversies still exist on their management. The aim of present study was to evaluate the safety and e...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.vph.2015.09.005

    authors: Verdoia M,Barbieri L,Schaffer A,Nardin M,Suryapranata H,De Luca G

    更新日期:2016-05-01 00:00:00

  • The influence of sulindac on diabetic cardiomyopathy: a non-invasive evaluation by Doppler echocardiography in streptozotocin-induced diabetic rats.

    abstract::The aim of the present study was to investigate the cardioprotective activity of sulindac as an aldose reductase inhibitor in the development of cardiomyopathy by non-invasive techniques; M-mode and Doppler echocardiography. Diabetes was induced by streptozotocin (45 mg/kg, iv) in the Sprague-Dawley rats. Echocardiogr...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.02.012

    authors: Krishna KM,Gopal GS,Chalam CR,Madan K,Kumar VK,Prakash GJ,Annapurna A

    更新日期:2005-08-01 00:00:00

  • PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells.

    abstract::Increasing evidences support that PGC-1α participates in regulating endothelial homeostasis, in part by mediating endothelial nitric oxide (NO) synthase (eNOS) activity and NO production. However, the molecular mechanisms by which PGC-1α regulates eNOS activity are not completely understood. In the present study, we i...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.05.005

    authors: Li J,Geng XY,Cong XL

    更新日期:2016-08-01 00:00:00

  • Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling.

    abstract:BACKGROUND:Immunosuppressive agents are at the forefront of preventing organ rejection after transplantation. However, their effects on vascular smooth muscle cell-mediated intimal hyperplasia that occurs in post-transplant coronary artery disease are less well known. METHODS AND RESULTS:We investigated the in vitro e...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2004.10.002

    authors: Hafizi S,Mordi VN,Andersson KM,Chester AH,Yacoub MH

    更新日期:2004-05-01 00:00:00

  • The vasorelaxant effect of gallic acid involves endothelium-dependent and -independent mechanisms.

    abstract::The mechanisms of action involved in the vasorelaxant effect of gallic acid (GA) were examined in the isolated rat thoracic aorta. GA exerted a relaxant effect in the highest concentrations (0.4-10mM) in both endothelium-intact and endothelium-denuded aortic rings. Pre-incubation with L-NAME, ODQ, calmidazolium, TEA, ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.10.010

    authors: de Oliveira LM,de Oliveira TS,da Costa RM,de Souza Gil E,Costa EA,Passaglia Rde C,Filgueira FP,Ghedini PC

    更新日期:2016-06-01 00:00:00

  • Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia.

    abstract::Hyperhomocysteinemia (HHcy) is a metabolic disorder marked by an excess amount of the amino acid homocysteine (Hcy) in the blood stream. Hcy is a H(2)S precursor-formed from the metabolism of methionine. Elevated Hcy levels have been associated with higher blood pressure. However, the precise contribution of H(2)S to ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2010.05.004

    authors: Sowmya S,Swathi Y,Yeo AL,Shoon ML,Moore PK,Bhatia M

    更新日期:2010-09-01 00:00:00

  • Circulating endothelial progenitor cells: Do they live up to their name?

    abstract::Preclinical and clinical studies have suggested that specific subsets of cells isolated from the bone marrow or peripheral blood, collectively named endothelial progenitor cells (EPCs), play an essential role in neovascularization and are biomarkers of atherosclerosis, inversely related to the presence and progression...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2015.02.018

    authors: Madonna R,De Caterina R

    更新日期:2015-04-01 00:00:00

  • Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.

    abstract:BACKGROUND:Macrophages play a central role in atherosclerosis development and progression, hence, targeting macrophage activity is considered an attractive therapeutic. Recently, we documented nanomedicinal delivery of the anti-inflammatory compound prednisolone to atherosclerotic plaque macrophages in patients, which ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.04.006

    authors: Alaarg A,Zheng KH,van der Valk FM,da Silva AE,Versloot M,van Ufford LC,Schulte DM,Storm G,Metselaar JM,Stroes ES,Hamers AA

    更新日期:2016-07-01 00:00:00

  • Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.

    abstract:RATIONALE:We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. METHODS:Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC a...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2006.05.006

    authors: Beckles DL,Mascareno E,Siddiqui MA

    更新日期:2006-12-01 00:00:00

  • Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo.

    abstract::Angiogenesis consists in the growth of new blood vessels from pre-existing ones. Although anti-angiogenesis interventions have been shown to have therapeutic properties in human diseases such as cancer, their effect is only partial and the identification of novel modulators of angiogenesis is warranted. Recently, we r...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2011.04.001

    authors: Yu C,Sharma A,Trane A,Utokaparch S,Leung C,Bernatchez P

    更新日期:2011-07-01 00:00:00

  • Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1.

    abstract::Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes releasing intracellular molecules called damage-associated molecular patterns. Overactive and prolonged immune responses are likely to be responsible for heart failure development and progression in patients survivi...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.08.011

    authors: Tomczyk M,Kraszewska I,Dulak J,Jazwa-Kusior A

    更新日期:2019-01-01 00:00:00

  • Vasodilatation produced by fasudil mesylate in vivo and in vitro.

    abstract::To investigate the vasorelaxant effect of fasudil mesylate (FM) in vivo and in vitro. The relaxation effect of FM was studied using cerebral vasospasm (CVS) model in vivo and isolated aortic rings in vitro. FM (0.35, 1.2, 3.5 mg·kg⁻¹) increased cerebrovascular flow (CVF) and femoral blood flow (FBF) dose-dependently i...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2011.06.005

    authors: Li Q,Chen Y,Sun L,Fu G,Guo L

    更新日期:2011-11-01 00:00:00

  • Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.

    abstract::Elevated plasma levels of factor VII and fibrinogen are risk factors for cardiovascular disease, especially arterial thrombosis. Oral contraceptive use increases factor VII and fibrinogen plasma levels. It has been described that DNA polymorphisms are associated with the plasma levels of hemostatic variables and their...

    journal_title:Vascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1537-1891(02)00300-2

    authors: Bloemenkamp KW,de Maat MP,Dersjant-Roorda MC,Helmerhorst FM,Kluft C

    更新日期:2002-08-01 00:00:00

  • Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis.

    abstract::Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). This study aims to investigate the amelioration of chlorogenic acid (CGA) on proliferative DR (PDR) via focusing on inhibiting retinal neoangiogenesis. CGA reduced the increased cell proliferation, migration and tu...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2017.11.002

    authors: Mei X,Zhou L,Zhang T,Lu B,Sheng Y,Ji L

    更新日期:2018-02-01 00:00:00