Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle.

abstract：:Platelet adhesion to subendothelial types I and III collagens exposed upon vascular injury plays a crucial role in hemostasis and thrombosis. We previously identified a KOGEOGPK sequence (O for hydroxyproline) within type III collagen interacting with platelets, and demonstrated a strong inhibitory effect of the KOGEO...

journal_title：Vascular pharmacology

authors： Maurice P,Pires V,Amant C,Kauskot A,Da Nascimento S,Sonnet P,Rochette J,Legrand C,Fauvel-Lafeve F,Bonnefoy A

更新日期：2006-01-01 00:00:00

abstract：:In systemic sclerosis, microvascular injury often precedes the development of fibrosis. Whereas the development of digital ulcers and skin fibrosis causes high morbidity, the affection of internal organs, in particular complications such as interstitial lung disease and pulmonary (arterial) hypertension, account for t...

journal_title：Vascular pharmacology

authors： Maurer B,Distler JH,Distler O

更新日期：2013-03-01 00:00:00

abstract：:Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor sub...

journal_title：Vascular pharmacology

authors： de Souza Rossignoli P,Yamamoto FZ,Pereira OC,Chies AB

更新日期：2015-09-01 00:00:00

abstract：:Phosphorylation of proteins on tyrosine acts as a reversible and specific trigger mechanism, forming or disrupting regulatory connections between proteins. Tyrosine kinases and phosphatases participate in multiple cellular processes, and considerable evidence now supports a role for tyrosine phosphorylation in vascula...

journal_title：Vascular pharmacology

authors： Bogatcheva NV,Garcia JG,Verin AD

更新日期：2002-11-01 00:00:00

abstract：:tert-Butyl hydroperoxide (t-BOOH), a membrane permeant oxidant, elicits enhanced vasoconstriction of perfused kidney and mesenteric arterial beds isolated from DOCA-salt-induced hypertensive rats. We hypothesize that enhanced vasoconstriction to t-BOOH during DOCA-salt hypertension involves free radical species and de...

journal_title：Vascular pharmacology

authors： Awe SO,Tsakadze NL,D'Souza SE,Adeagbo AS

更新日期：2003-01-01 00:00:00

abstract：:We characterized vascular reactivity to endothelin-1 (ET-1) in mesenteric vessels from DOCA-salt hypertensive and SHAM control mice and assessed the effect that endothelial-derived vasodilators have on ET-1-induced vasoconstriction. Changes in the diameter of unpressurized small mesenteric arteries and veins (100- to ...

journal_title：Vascular pharmacology

authors： Pérez-Rivera AA,Fink GD,Galligan JJ

更新日期：2005-06-01 00:00:00

abstract：:The sulfur-containing amino acid, taurine, has been shown to ameliorate the vascular disorders. We examined the effects of taurine ingestion on intimal thickening following balloon injury. Balloon injury was induced in the left common carotid artery of Wistar rats. Taurine (3% (w/v)) was mixed in the drinking water fr...

journal_title：Vascular pharmacology

authors： Murakami S,Sakurai T,Toda Y,Morito A,Sakono M,Fukuda N

更新日期：2010-09-01 00:00:00

abstract：:In addition to its role as a vasoconstrictor, angiotensin II also acts as a potent growth factor by activating several tyrosine kinases, including Jak2. Interestingly, Jak2 has been linked to similar cardiovascular pathologies as have been previously linked to the renin-angiotensin system. Identifying the downstream t...

journal_title：Vascular pharmacology

authors： Wallace TA,Xia SL,Sayeski PP

更新日期：2005-11-01 00:00:00

abstract：:Macrophages are important participants in the development of atherosclerotic lesions, in cholesterol accumulation, as mediators of the immune response, and as sources of secreted enzymes and growth factors. Besides potentially contributing to local oxidation of lesion lipoproteins, many aspects of macrophage function ...

journal_title：Vascular pharmacology

authors： Jessup W,Wilson P,Gaus K,Kritharides L

更新日期：2002-04-01 00:00:00

abstract：:Tyrosine kinase pathway has been shown to be involved in the effects of hypoxia in pulmonary arteries, but its role in pulmonary vein is not known. The aims of this study were to determine the effect of hypoxia in sheep isolated pulmonary veins and to identify the role of tyrosine kinase pathway in hypoxic response. G...

journal_title：Vascular pharmacology

authors： Uzun O,Tuncay Demiryürek A

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

journal_title：Vascular pharmacology

authors： Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

更新日期：2003-02-01 00:00:00

abstract：:Numerous studies of acetylcholine (ACh)-induced endothelium-dependent relaxation in arteries have been reported since the original description by Furchgott and Zawadzki (1980). ACh also produces endothelium-independent relaxation. However, it is still unknown whether ACh-induced AMP-activated protein kinase (AMPK) act...

journal_title：Vascular pharmacology

authors： Lee KY,Choi HC

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to investigate the cardioprotective activity of sulindac as an aldose reductase inhibitor in the development of cardiomyopathy by non-invasive techniques; M-mode and Doppler echocardiography. Diabetes was induced by streptozotocin (45 mg/kg, iv) in the Sprague-Dawley rats. Echocardiogr...

journal_title：Vascular pharmacology

authors： Krishna KM,Gopal GS,Chalam CR,Madan K,Kumar VK,Prakash GJ,Annapurna A

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Suboptimal platelet inhibition still represents an important challenge, especially for patients undergoing percutaneous coronary interventions (PCI). Chronic kidney disease (CKD) is a common comorbidity of patients with coronary artery disease, and may potentially influence platelet reactivity. So far only f...

journal_title：Vascular pharmacology

authors： Barbieri L,Pergolini P,Verdoia M,Rolla R,Nardin M,Marino P,Bellomo G,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2016-04-01 00:00:00

abstract：:Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

journal_title：Vascular pharmacology

authors： Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

更新日期：2018-11-01 00:00:00

abstract：:Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascular smooth muscle cells (VSMCs) are involved in As. Hyperhomocysteinemia (HHcy) is an independent risk factor for As. The present study was designed to test our hypothesi...

journal_title：Vascular pharmacology

authors： Chen Y,Su X,Qin Q,Yu Y,Jia M,Kong L,Zhang H,Li H

更新日期：2020-01-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) system is important for several biological processes that call for extracellular proteolysis, fibrinolysis, cell migration, proliferation and angiogenesis. The current study highlights the fibrinolytic and wound healing potential of emodin, an anthraquinone, with relevance to the ...

journal_title：Vascular pharmacology

authors： Radha KS,Madhyastha HK,Nakajima Y,Omura S,Maruyama M

更新日期：2008-04-01 00:00:00

abstract：:The aim of this study was to investigate the relation between endothelial dysfunction and aspirin response in a young healthy population (102 men aged 18-40). Initial concentrations of the NO pathway metabolites (ADMA, l-arginine, SDMA), cardiovascular risk markers, oxidative stress markers (MDA, thiol index), sICAM1,...

journal_title：Vascular pharmacology

authors： Doroszko A,Szahidewicz-Krupska E,Janus A,Jakubowski M,Turek A,Ilnicka P,Szuba A,Mazur G,Derkacz A

更新日期：2015-04-01 00:00:00

abstract：AIM:Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against cardiovascular diseases including atherosclerosis. The safe dose of selenium in the organism is very narrow, limiting the supplementation of selenium in diet. The aim of this study is to explore whet...

journal_title：Vascular pharmacology

authors： Zhu ML,Wang G,Wang H,Guo YM,Song P,Xu J,Li P,Wang S,Yang L

更新日期：2019-04-01 00:00:00

abstract：:Ghrelin, a 28-amino acid peptide, known to exist in both acylated and des-acylated varieties, was identified as the first endogenous ligand of growth hormone secretagogue receptor in 1999. Various arteries are known to express ghrelin receptors, but the direct action of ghrelin on blood vessels has been unclear. In th...

journal_title：Vascular pharmacology

authors： Dimitrova DZ,Mihov DN,Wang R,Hristov KL,Rizov LI,Bolton TB,Duridanova DB

更新日期：2007-07-01 00:00:00

abstract：:β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

journal_title：Vascular pharmacology

authors： Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

更新日期：2014-05-01 00:00:00

abstract：:This study was designed to study the influence of Sacoglottis gabonensis stem bark extract on the metabolic and cytotoxic side effects of 2,4-dinitrophenyl hydrazine (2,4-DNPH) on the brain and blood using male weaving rats as the experimental model. This was after the effect of the bark extract and bergenin, its isol...

journal_title：Vascular pharmacology

authors： Maduka HC,Okoye ZS,Eje A

更新日期：2002-12-01 00:00:00

abstract：:The present study was undertaken to investigate endothelial function and epoxyeicosatrienoic acids (EETs), which is a cytochrome P-450 monooxygenase (CYP) metabolite and one of the candidates as an endothelium-derived hyperpolarizing factor (EDHF) in the renal artery isolated from short-term hypercholesterolemic rabbi...

journal_title：Vascular pharmacology

authors： Taniguchi J,Honda H,Shibusawa Y,Iwata T,Notoya Y

更新日期：2005-06-01 00:00:00

abstract：:Increasing evidences support that PGC-1α participates in regulating endothelial homeostasis, in part by mediating endothelial nitric oxide (NO) synthase (eNOS) activity and NO production. However, the molecular mechanisms by which PGC-1α regulates eNOS activity are not completely understood. In the present study, we i...

journal_title：Vascular pharmacology

authors： Li J,Geng XY,Cong XL

更新日期：2016-08-01 00:00:00

abstract：:Endothelial cell dysfunction is considered to be an early event which subsequently leads to vascular wall disorders. Ultrastructural studies indicate that the endothelial cell changes involve membrane damage, increased permeability, swelling and necrosis. The endothelial cell loss of function could be as a result of c...

journal_title：Vascular pharmacology

authors： Tesfamariam B,DeFelice AF

更新日期：2007-04-01 00:00:00

abstract：:Neurokinin(3) (NK(3)) receptors may regulate the airways primarily through actions on the nerves. In the periphery, airway parasympathetic ganglia neurons are depolarized following NK(3) receptor activation resulting subsequently in the facilitation of synaptic transmission. Such an effect may account for the excessiv...

journal_title：Vascular pharmacology

authors： Canning BJ

更新日期：2006-10-01 00:00:00

abstract：:Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during early development. Upon exposure to glucocorticoids, the fetus develops hypertension, and the of...

journal_title：Vascular pharmacology

authors： Anwar MA,Saleh AI,Al Olabi R,Al Shehabi TS,Eid AH

更新日期：2016-07-01 00:00:00

abstract：:Hypercholesterolemia, is a prominent risk factor for cardiovascular disease (CVD). Undestanding of the biochemical mechanisms that regulate the expression of the low density lipoproteins receptor (LDLR) and the hepatic clearance of LDL cholesterol (LDL-C) paved the way to the statin therapy as the gold standard for CV...

journal_title：Vascular pharmacology

authors： Norata GD,Tibolla G,Catapano AL

更新日期：2014-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as crucial players regulating the magnitude of gene expression in a variety of organisms. This class of short (22 nucleotides) noncoding RNA molecules have been shown to participate in almost every cellular process investigated so far, and their deregulation is observed in different hum...

journal_title：Vascular pharmacology

authors： Quintavalle C,Garofalo M,Croce CM,Condorelli G

更新日期：2011-10-01 00:00:00

abstract：:Our previous studies revealed that scopoletin, the main bioactive constituent of Erycibe obtusifolia Benth stems, exerted anti-arthritic activity in vivo partly by preventing synovial angiogenesis. Herein we further investigated the anti-angiogenic potential and related mechanisms of this coumarin compound in vivo and...

journal_title：Vascular pharmacology

authors： Pan R,Dai Y,Gao XH,Lu D,Xia YF

更新日期：2011-01-01 00:00:00