Oxidized lipoproteins and macrophages.

Abstract:

:Macrophages are important participants in the development of atherosclerotic lesions, in cholesterol accumulation, as mediators of the immune response, and as sources of secreted enzymes and growth factors. Besides potentially contributing to local oxidation of lesion lipoproteins, many aspects of macrophage function can be affected by interaction with oxidized lipoproteins. Here we review macrophage responses to oxidized lipoproteins and provide novel data on the effects of a major oxidation product, 7-ketocholesterol, on high-density lipoprotein (HDL) function in cholesterol removal from macrophages.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Jessup W,Wilson P,Gaus K,Kritharides L

doi

10.1016/s1537-1891(02)00174-x

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

239-48

issue

4

eissn

1537-1891

issn

1879-3649

pii

S153718910200174X

journal_volume

38

pub_type

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