Platelet reactivity in patients with impaired renal function receiving dual antiplatelet therapy with clopidogrel or ticagrelor.

Abstract:

BACKGROUND:Suboptimal platelet inhibition still represents an important challenge, especially for patients undergoing percutaneous coronary interventions (PCI). Chronic kidney disease (CKD) is a common comorbidity of patients with coronary artery disease, and may potentially influence platelet reactivity. So far only few studies have assessed the role of CKD on response to dual antiplatelet therapy (DAPT) with conflicting results. Therefore, the aim of our study was to evaluate the impact of CKD on platelet function in patients treated with DAPT after a recent acute coronary syndrome (ACS) or PCI. METHODS:Patients treated with DAPT, acetylsalicylic acid (ASA)+adenosine diphosphate antagonist (ADP-antagonist) such as clopidogrel or ticagrelor, for ACS or elective patients undergoing PCI were scheduled for platelet function assessment at 30-90 days post-discharge. Platelet function was assessed by whole blood impedance aggregometry (Multiplate®- Roche Diagnostics AG), high residual platelet reactivity (HRPR) was considered for ASPI test >862 AU*min (for ASA) and ADP test values ≥ 417 AU*min (for ADP-antagonists). Chronic renal failure was defined as an estimated glomerular filtration rate of 60 mol/min/1.73 m(2) or less, calculated by applying MDRD (Modification of Diet in renal Disease) formula. RESULTS:Our population included a total of 537 patients of which 308 (57.3%) received ASA and clopidogrel and 229 (42.6%) received ASA and ticagrelor. Patients with renal failure at baseline (101 out of 537, 18.8%) were older, with higher prevalence of hypertension, previous myocardial infarction and coronary artery bypass graft surgery. Moreover, they had a lower ejection fraction at baseline and were more often in therapy with diuretics, but less often with statins at admission. They had lower haemoglobin and higher glycated haemoglobin. HRPR was observed in 1.5% of patients treated with ASA with no difference according to renal function (p=0.18). HRPR for ADP-antagonists was observed in 23.7% of patients, with no difference according to renal function (p=0.50). This result was confirmed either with clopidogrel (31.9% versus 38%, p=0.41) and ticagrelor (13.1% versus 10.8%, p=0.99), also after correction for all baseline confounders (clopidogrel: adjusted OR[95%CI]=1.26 [0.60-2.63], p=0.54) (ticagrelor: adjusted OR[95%CI]=0.95 [0.54-1.65], p=0.84). The absence of association between renal function and platelet reactivity was confirmed at linear regression analysis both with clopidogrel (r=-0.04, p=0.52) and ticagrelor (r=0.006, p=0.92). CONCLUSION:In patients receiving DAPT, chronic renal failure did not influence ADP-mediated platelet reactivity, with both ticagrelor or clopidogrel. No influence of chronic renal failure was found on the effectiveness of ASA.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Barbieri L,Pergolini P,Verdoia M,Rolla R,Nardin M,Marino P,Bellomo G,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

doi

10.1016/j.vph.2015.10.006

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

11-15

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(15)00223-2

journal_volume

79

pub_type

杂志文章
  • Acetylcholine-induced AMP-activated protein kinase activation attenuates vasoconstriction through an LKB1-dependent mechanism in rat aorta.

    abstract::Numerous studies of acetylcholine (ACh)-induced endothelium-dependent relaxation in arteries have been reported since the original description by Furchgott and Zawadzki (1980). ACh also produces endothelium-independent relaxation. However, it is still unknown whether ACh-induced AMP-activated protein kinase (AMPK) act...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2013.07.007

    authors: Lee KY,Choi HC

    更新日期:2013-09-01 00:00:00

  • Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia.

    abstract::The present study investigates the potential of ozagrel, a thromboxane A2 (TXA2) synthase inhibitor, in bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water maze (MWM) test was employed on 7th day p...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2020.106827

    authors: Bhatia P,Kaur G,Singh N

    更新日期:2020-12-17 00:00:00

  • Oxidative metabolism of peripheral blood neutrophils in experimental acute hypercapnia in the mechanically ventilated rabbit.

    abstract:BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1537-1891(02)00338-5

    authors: Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

    更新日期:2003-02-01 00:00:00

  • Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.

    abstract:BACKGROUND:Macrophages play a central role in atherosclerosis development and progression, hence, targeting macrophage activity is considered an attractive therapeutic. Recently, we documented nanomedicinal delivery of the anti-inflammatory compound prednisolone to atherosclerotic plaque macrophages in patients, which ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.04.006

    authors: Alaarg A,Zheng KH,van der Valk FM,da Silva AE,Versloot M,van Ufford LC,Schulte DM,Storm G,Metselaar JM,Stroes ES,Hamers AA

    更新日期:2016-07-01 00:00:00

  • "Fishing" for endothelial microRNA functions and dysfunction.

    abstract::MicroRNAs (e.g., miRNAs), endogenously expressed small non-coding RNAs, control gene expression by regulating target messenger RNA at post-transcriptional level. Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. The zebrafish (Danio rerio) system is a ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2011.08.224

    authors: Santoro MM

    更新日期:2011-10-01 00:00:00

  • Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

    abstract::Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.10.001

    authors: Sangartit W,Pakdeechote P,Kukongviriyapan V,Donpunha W,Shibahara S,Kukongviriyapan U

    更新日期:2016-12-01 00:00:00

  • The influence of sulindac on diabetic cardiomyopathy: a non-invasive evaluation by Doppler echocardiography in streptozotocin-induced diabetic rats.

    abstract::The aim of the present study was to investigate the cardioprotective activity of sulindac as an aldose reductase inhibitor in the development of cardiomyopathy by non-invasive techniques; M-mode and Doppler echocardiography. Diabetes was induced by streptozotocin (45 mg/kg, iv) in the Sprague-Dawley rats. Echocardiogr...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.02.012

    authors: Krishna KM,Gopal GS,Chalam CR,Madan K,Kumar VK,Prakash GJ,Annapurna A

    更新日期:2005-08-01 00:00:00

  • Call for a reference model of chronic hind limb ischemia to investigate therapeutic angiogenesis.

    abstract::A large number of studies utilize animal models to investigate therapeutic angiogenesis. However, the lack of a standardized experimental model leaves the comparison of different studies problematic. To establish a reference model of prolonged moderate tissue ischemia, we created unilateral hind limb ischemia in athym...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2009.07.001

    authors: Yang Z,von Ballmoos MW,Diehm N,Baumgartner I,Kalka C,Di Santo S

    更新日期:2009-10-01 00:00:00

  • Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids.

    abstract::Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor sub...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.06.017

    authors: de Souza Rossignoli P,Yamamoto FZ,Pereira OC,Chies AB

    更新日期:2015-09-01 00:00:00

  • Anti-inflammatory influence of P-selectin on human mononuclear cells.

    abstract::The purpose of this study was to determine if P-selectin, an adhesion molecule involved in the transendothelial movement of leukocytes, might also have a direct influence on the function of cells that come into contact with it. Human peripheral blood mononuclear cells were incubated on immobilized P-selectin or a cont...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.11.002

    authors: Sloan CL,Sloan GJ,Cannon JG

    更新日期:2006-03-01 00:00:00

  • Regulation of angiogenesis by a small GTPase Rap1.

    abstract::Small GTPase Rap1 has been extensively studied in vitro and shown to regulate multiple basic cellular processes. Until recently, the best studied aspect of Rap1 function in endothelial cells involved its role in regulation of cell-cell junction formation and remodeling. These in vitro studies have increased understand...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2010.03.003

    authors: Chrzanowska-Wodnicka M

    更新日期:2010-07-01 00:00:00

  • Na(+)/H(+) exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2(+) mobilization.

    abstract::The objective of this study was to determine the mechanism by which Na(+)/H(+) exchanger (NHE) inhibitors induce vasodilatation. The NHE inhibitors, 5-(N,N-dimethyl)-amiloride (DMA), cariporide, and amiloride, evoked endothelium-dependent relaxation in rat aortas with ED50 values of 16, 89, and 148μM, respectively, an...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2012.11.004

    authors: Sasahara T,Yayama K,Matsuzaki T,Tsutsui M,Okamoto H

    更新日期:2013-04-01 00:00:00

  • Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis.

    abstract::The endothelium synthesizes and releases nitric oxide (NO) to maintain homeostatic function. Under basal conditions, endothelium-derived NO maintains a nonthrombogenic surface, prohibits leukocyte attachment, and promotes vascular relaxation. In the setting of clinical syndromes associated with the development of athe...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1537-1891(02)00250-1

    authors: Russo G,Leopold JA,Loscalzo J

    更新日期:2002-05-01 00:00:00

  • Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.

    abstract:BACKGROUND:Dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE(-/-)) mice, and examined its effects on endothelial function. METHODS AND ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.08.011

    authors: Salim HM,Fukuda D,Higashikuni Y,Tanaka K,Hirata Y,Yagi S,Soeki T,Shimabukuro M,Sata M

    更新日期:2016-04-01 00:00:00

  • Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo.

    abstract::Angiogenesis consists in the growth of new blood vessels from pre-existing ones. Although anti-angiogenesis interventions have been shown to have therapeutic properties in human diseases such as cancer, their effect is only partial and the identification of novel modulators of angiogenesis is warranted. Recently, we r...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2011.04.001

    authors: Yu C,Sharma A,Trane A,Utokaparch S,Leung C,Bernatchez P

    更新日期:2011-07-01 00:00:00

  • Cyclopiazonic acid alters serotonin-induced responses in rat thoracic aorta.

    abstract::We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade. Since seroton...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2014.03.008

    authors: Selli C,Erac Y,Tosun M

    更新日期:2014-05-01 00:00:00

  • Treatment with PCSK9 inhibitors reduces atherogenic VLDL remnants in a real-world study.

    abstract:BACKGROUND:Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population w...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.03.002

    authors: Hollstein T,Vogt A,Grenkowitz T,Stojakovic T,März W,Laufs U,Bölükbasi B,Steinhagen-Thiessen E,Scharnagl H,Kassner U

    更新日期:2019-05-01 00:00:00

  • Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells.

    abstract:BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2008.09.001

    authors: Star GP,Giovinazzo M,Langleben D

    更新日期:2009-01-01 00:00:00

  • Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors.

    abstract::Schistosomiasis is caused by an intravascular parasite and linked to phenotypic changes in endothelial cells that favor inflammation. Endothelial cells express P2Y1 receptors (P2Y1R), and their activation by ADP favors leukocyte adhesion to the endothelial monolayer. We aimed to evaluate the influence of schistosomias...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.02.005

    authors: Oliveira SD,Oliveira NF,Meyer-Fernandes JR,Savio LE,Ornelas FG,Ferreira ZS,Coutinho-Silva R,Silva CL

    更新日期:2016-07-01 00:00:00

  • Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.

    abstract::Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alp...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106577

    authors: Kamau F,Strijdom H,Mwangi P,Blackhurst D,Imperial E,Salie R

    更新日期:2019-10-01 00:00:00

  • Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.

    abstract::To investigate mechanisms of protective effects of fenofibrate on the diabetic kidney, male Wistar rats were divided into control, untreated diabetes, and fenofibrate-treated (32 mg kg(-1) d(-1), 8 weeks) diabetes groups. Diabetes induced by streptozotocin (25 mg/kg) and a high-fat diet was characterized by the disord...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2006.01.004

    authors: Chen LL,Zhang JY,Wang BP

    更新日期:2006-05-01 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract::Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106601

    authors: Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期:2020-01-01 00:00:00

  • Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats.

    abstract:OBJECTIVE:The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wine, in the rat after ischemia-reperfusion (I/R). DESIGN:The left coronary artery was in occlusion for 30 min followed by a 120 min reperfusion in anesthetized rats. Animals wer...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2006.04.002

    authors: Shen M,Jia GL,Wang YM,Ma H

    更新日期:2006-08-01 00:00:00

  • Ex vivo microangioCT: Advances in microvascular imaging.

    abstract::Therapeutic modulation of angiogenesis is believed to be a prospective powerful treatment strategy to modulate the microcirculation and therefore help millions of patients with cardiovascular and cancer diseases. The often-frustrating results from late-stage clinical studies indicate an urgent need for improved assess...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.09.003

    authors: Hlushchuk R,Haberthür D,Djonov V

    更新日期:2019-01-01 00:00:00

  • β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

    abstract::β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2014.04.003

    authors: Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

    更新日期:2014-05-01 00:00:00

  • Improvement of contractility accompanies angiogenesis rather than arteriogenesis in chronic myocardial ischemia.

    abstract:INTRODUCTION:Growth factor therapy provides a therapeutic alternative for "no option" patients with coronary disease. Fibroblast Growth Factor-2 (FGF-2) predominantly stimulates angiogenesis, the growth of new capillaries, whereas Monocyte Chemoattractant Protein-1 (MCP-1) is considered an arteriogenic agent. We hypoth...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2006.01.002

    authors: Heilmann C,Kostic C,Giannone B,Grawitz AB,Armbruster W,Lutter G,Beyersdorf F,Göbel H

    更新日期:2006-05-01 00:00:00

  • Antiplatelet and antithrombotic activities of CP201, a newly synthesized 1,4-naphthoquinone derivative.

    abstract::The antiplatelet and antithrombotic activities of a newly synthesized CP201, 2-(3,5-di-tert-butyl-4-hydroxyl)-3-chloro-1,4-naphthoquinone on human platelet aggregation in vitro and murine pulmonary thrombosis in vivo were examined. In addition, the antiplatelet activity of CP201 involved in calcium-signaling cascade w...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2004.04.001

    authors: Jin YR,Hwang KA,Cho MR,Kim SY,Kim JH,Ryu CK,Son DJ,Park YH,Yun YP

    更新日期:2004-02-01 00:00:00

  • Vasodilatation produced by fasudil mesylate in vivo and in vitro.

    abstract::To investigate the vasorelaxant effect of fasudil mesylate (FM) in vivo and in vitro. The relaxation effect of FM was studied using cerebral vasospasm (CVS) model in vivo and isolated aortic rings in vitro. FM (0.35, 1.2, 3.5 mg·kg⁻¹) increased cerebrovascular flow (CVF) and femoral blood flow (FBF) dose-dependently i...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2011.06.005

    authors: Li Q,Chen Y,Sun L,Fu G,Guo L

    更新日期:2011-11-01 00:00:00

  • A novel method to isolate retinal and brain microvessels from individual rats: Microscopic and molecular biological characterization and application in hyperglycemic animals.

    abstract::Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2018.07.001

    authors: Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

    更新日期:2018-11-01 00:00:00

  • Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways.

    abstract::Our previous studies revealed that scopoletin, the main bioactive constituent of Erycibe obtusifolia Benth stems, exerted anti-arthritic activity in vivo partly by preventing synovial angiogenesis. Herein we further investigated the anti-angiogenic potential and related mechanisms of this coumarin compound in vivo and...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2010.11.001

    authors: Pan R,Dai Y,Gao XH,Lu D,Xia YF

    更新日期:2011-01-01 00:00:00