Platelet reactivity in patients with impaired renal function receiving dual antiplatelet therapy with clopidogrel or ticagrelor.

Abstract:

BACKGROUND:Suboptimal platelet inhibition still represents an important challenge, especially for patients undergoing percutaneous coronary interventions (PCI). Chronic kidney disease (CKD) is a common comorbidity of patients with coronary artery disease, and may potentially influence platelet reactivity. So far only few studies have assessed the role of CKD on response to dual antiplatelet therapy (DAPT) with conflicting results. Therefore, the aim of our study was to evaluate the impact of CKD on platelet function in patients treated with DAPT after a recent acute coronary syndrome (ACS) or PCI. METHODS:Patients treated with DAPT, acetylsalicylic acid (ASA)+adenosine diphosphate antagonist (ADP-antagonist) such as clopidogrel or ticagrelor, for ACS or elective patients undergoing PCI were scheduled for platelet function assessment at 30-90 days post-discharge. Platelet function was assessed by whole blood impedance aggregometry (Multiplate®- Roche Diagnostics AG), high residual platelet reactivity (HRPR) was considered for ASPI test >862 AU*min (for ASA) and ADP test values ≥ 417 AU*min (for ADP-antagonists). Chronic renal failure was defined as an estimated glomerular filtration rate of 60 mol/min/1.73 m(2) or less, calculated by applying MDRD (Modification of Diet in renal Disease) formula. RESULTS:Our population included a total of 537 patients of which 308 (57.3%) received ASA and clopidogrel and 229 (42.6%) received ASA and ticagrelor. Patients with renal failure at baseline (101 out of 537, 18.8%) were older, with higher prevalence of hypertension, previous myocardial infarction and coronary artery bypass graft surgery. Moreover, they had a lower ejection fraction at baseline and were more often in therapy with diuretics, but less often with statins at admission. They had lower haemoglobin and higher glycated haemoglobin. HRPR was observed in 1.5% of patients treated with ASA with no difference according to renal function (p=0.18). HRPR for ADP-antagonists was observed in 23.7% of patients, with no difference according to renal function (p=0.50). This result was confirmed either with clopidogrel (31.9% versus 38%, p=0.41) and ticagrelor (13.1% versus 10.8%, p=0.99), also after correction for all baseline confounders (clopidogrel: adjusted OR[95%CI]=1.26 [0.60-2.63], p=0.54) (ticagrelor: adjusted OR[95%CI]=0.95 [0.54-1.65], p=0.84). The absence of association between renal function and platelet reactivity was confirmed at linear regression analysis both with clopidogrel (r=-0.04, p=0.52) and ticagrelor (r=0.006, p=0.92). CONCLUSION:In patients receiving DAPT, chronic renal failure did not influence ADP-mediated platelet reactivity, with both ticagrelor or clopidogrel. No influence of chronic renal failure was found on the effectiveness of ASA.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Barbieri L,Pergolini P,Verdoia M,Rolla R,Nardin M,Marino P,Bellomo G,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

doi

10.1016/j.vph.2015.10.006

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

11-15

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(15)00223-2

journal_volume

79

pub_type

杂志文章
  • Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling.

    abstract:BACKGROUND:Immunosuppressive agents are at the forefront of preventing organ rejection after transplantation. However, their effects on vascular smooth muscle cell-mediated intimal hyperplasia that occurs in post-transplant coronary artery disease are less well known. METHODS AND RESULTS:We investigated the in vitro e...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2004.10.002

    authors: Hafizi S,Mordi VN,Andersson KM,Chester AH,Yacoub MH

    更新日期:2004-05-01 00:00:00

  • Involvement of tyrosine kinase pathway in acute hypoxic vasoconstriction in sheep isolated pulmonary vein.

    abstract::Tyrosine kinase pathway has been shown to be involved in the effects of hypoxia in pulmonary arteries, but its role in pulmonary vein is not known. The aims of this study were to determine the effect of hypoxia in sheep isolated pulmonary veins and to identify the role of tyrosine kinase pathway in hypoxic response. G...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1537-1891(03)00051-x

    authors: Uzun O,Tuncay Demiryürek A

    更新日期:2003-10-01 00:00:00

  • Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production.

    abstract::LIGHT is known to act as a novel mediator for atherogenesis. Furthermore, it has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells. However, it is not known if emodin exerts anti-atherogenic effects in the human monocyte, THP-1, following treatment with LIGHT. I...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2010.03.002

    authors: Heo SK,Yun HJ,Noh EK,Park SD

    更新日期:2010-07-01 00:00:00

  • Pharmacogenetics: progress, pitfalls and clinical potential for coronary heart disease.

    abstract::Much has been written about the potential of pharmacogenetic testing to inform therapy based on an individual's genetic makeup, and to decide the most effective choice of available drugs, or to avoid dangerous side effects. Currently, there is little hard data for either in the field of cardiovascular disease. The usu...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2005.10.003

    authors: Humphries SE,Hingorani A

    更新日期:2006-02-01 00:00:00

  • Oxidative metabolism of peripheral blood neutrophils in experimental acute hypercapnia in the mechanically ventilated rabbit.

    abstract:BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1537-1891(02)00338-5

    authors: Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

    更新日期:2003-02-01 00:00:00

  • Chemerin-induced arterial contraction is Gi- and calcium-dependent.

    abstract::Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinet...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.11.009

    authors: Ferland DJ,Darios ES,Neubig RR,Sjögren B,Truong N,Torres R,Dexheimer TS,Thompson JM,Watts SW

    更新日期:2017-01-01 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract::Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2019.106601

    authors: Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期:2020-01-01 00:00:00

  • Adrenoceptor and cholinoceptor modulation of rat pulmonary vein cardiac muscle contractility.

    abstract::Cardiac muscle extends into mammalian pulmonary veins for variable distances according to species. This study has addressed the autonomic control of electrically paced cardiac muscle of the pulmonary vein of the rat. Contractile responses of Wistar rat pulmonary veins were investigated under isometric conditions in vi...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2006.09.005

    authors: Sweeney CM,Jones JF,Bund SJ

    更新日期:2007-03-01 00:00:00

  • Detection and implications of potassium channel alterations.

    abstract::Potassium channel dysfunction plays a role in the pathogenesis of a number of vascular diseases including pulmonary and systemic hypertension, diabetes, and complications of atherosclerosis. Two types of K+ channels that are known to be prevalent and contribute significantly to the repolarization of vascular smooth mu...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1537-1891(02)00121-0

    authors: Korovkina VP,England SK

    更新日期:2002-01-01 00:00:00

  • Aldosterone signaling modifies capillary formation by human bone marrow endothelial cells.

    abstract::We investigated the regulation of the epithelial sodium channel (ENaC) in human bone marrow endothelial cells (HBMEC) responding to mineralocorticoid hormones and other accessory effectors. The message for both the mineralocorticoid receptor (MCR) and the alpha subunit of ENaC was expressed in HBMEC as predicted bands...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2003.08.003

    authors: Chen W,Valamanesh F,Mirshahi T,Soria J,Tang R,Agarwal MK,Mirshahi M

    更新日期:2004-01-01 00:00:00

  • Differential effects of ET(A) and ET(B) receptor antagonism on oxidative stress in type 2 diabetes.

    abstract::Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2007.05.006

    authors: Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

    更新日期:2007-08-01 00:00:00

  • PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges.

    abstract::Hypercholesterolemia, is a prominent risk factor for cardiovascular disease (CVD). Undestanding of the biochemical mechanisms that regulate the expression of the low density lipoproteins receptor (LDLR) and the hepatic clearance of LDL cholesterol (LDL-C) paved the way to the statin therapy as the gold standard for CV...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2014.05.011

    authors: Norata GD,Tibolla G,Catapano AL

    更新日期:2014-08-01 00:00:00

  • Acetylcholine-induced AMP-activated protein kinase activation attenuates vasoconstriction through an LKB1-dependent mechanism in rat aorta.

    abstract::Numerous studies of acetylcholine (ACh)-induced endothelium-dependent relaxation in arteries have been reported since the original description by Furchgott and Zawadzki (1980). ACh also produces endothelium-independent relaxation. However, it is still unknown whether ACh-induced AMP-activated protein kinase (AMPK) act...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2013.07.007

    authors: Lee KY,Choi HC

    更新日期:2013-09-01 00:00:00

  • Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats.

    abstract::Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2017.09.007

    authors: Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

    更新日期:2017-12-01 00:00:00

  • Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?

    abstract::Autoimmune rheumatic diseases are characterised by systemic inflammation and complex immunopathology, with an increased risk of cardiovascular disease, initiated by endothelial dysfunction in a chronic inflammatory environment. Endothelial microparticles (EMPs) are released into the circulation from activated endothel...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2016.05.016

    authors: McCarthy EM,Wilkinson FL,Parker B,Alexander MY

    更新日期:2016-11-01 00:00:00

  • The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries.

    abstract::There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2008.11.002

    authors: Montes FR,Cabrera M,Delgadillo A,Salgar C,Echeverri D

    更新日期:2009-03-01 00:00:00

  • Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis.

    abstract::Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stabl...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2018.06.014

    authors: Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

    更新日期:2019-01-01 00:00:00

  • Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells.

    abstract:BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2008.09.001

    authors: Star GP,Giovinazzo M,Langleben D

    更新日期:2009-01-01 00:00:00

  • Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with familial combined hyperlipidemia and/or metabolic syndrome.

    abstract:OBJECTIVE:In patients with familial combined hyperlipidemia (FCHL), without metabolic syndrome (MS), occurrence of non-alcoholic fatty liver disease (NAFLD) is related to a specific pro-inflammatory profile, influenced by genetic traits, involved in oxidative stress and adipokine secretion. Among FCHL or MS patients, h...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2015.04.004

    authors: Santilli F,Blardi P,Scapellato C,Bocchia M,Guazzi G,Terzuoli L,Tabucchi A,Silvietti A,Lucani B,Gioffrè WR,Scarpini F,Fazio F,Davì G,Puccetti L

    更新日期:2015-09-01 00:00:00

  • Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis.

    abstract::Thalidomide is an antiangiogenic drug and is clinically useful in a number of cancers. However, the molecular mechanism by which thalidomide exerts its antitumor effects is poorly understood. This study was designed to clarify the relationship between antiangiogenesis and antitumor effects of thalidomide and to explor...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.04.003

    authors: Du GJ,Lin HH,Xu QT,Wang MW

    更新日期:2005-08-01 00:00:00

  • Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: a hypoxia specific mechanism of action.

    abstract::Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular endothelial cells (HMVEC-L) we...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2012.11.003

    authors: Radziwon-Balicka A,Ramer C,Moncada de la Rosa C,Zielnik-Drabik B,Jurasz P

    更新日期:2013-04-01 00:00:00

  • Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature.

    abstract::Although the vasorelaxing effects of testosterone (T) and various androgen metabolites have been observed in a variety of blood vessels and species, previous studies have not systematically compared the vasorelaxing effects of androgen metabolites in different vascular beds within the same species. Therefore, we studi...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2012.01.008

    authors: Perusquía M,Espinoza J,Montaño LM,Stallone JN

    更新日期:2012-03-01 00:00:00

  • Baroreflex deficiency aggravates atherosclerosis via α7 nicotinic acetylcholine receptor in mice.

    abstract:OBJECTIVE:Inflammation and oxidative stress play a key role in the initiation, propagation, and development of atherosclerosis. Arterial baroreflex (ABR) dysfunction induced by sinoaortic denervation (SAD) promoted the development of atherosclerosis in ApoE-/- mice. The present work was designed to examine whether ABR ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.08.008

    authors: Chen L,Liu DH,Zhang X,Zhang EH,Liu C,Su DF,Cai GJ

    更新日期:2016-12-01 00:00:00

  • Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats.

    abstract::Our previous studies in heterozygous Ren-2 transgenic rats (TGR) have shown that early treatment with selective endothelin (ET)(A) receptor blockade is superior to nonselective ET(A/B) receptor blockade. The aim of this study was to evaluate the role of the ET system in male heterozygous TGR with established hypertens...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2008.01.009

    authors: Vernerová Z,Kramer HJ,Bäcker A,Cervenka L,Opocenský M,Husková Z,Vanourková Z,Eis V,Chábová VC,Tesar V,Malý J,Vanecková I

    更新日期:2008-04-01 00:00:00

  • Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels.

    abstract::In this study, we have investigated the actions of danshensu, an active, water-extractable component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 microM 5-hydroxytryptamine (5-HT) and its action compared to the water-extractable fraction of the herb. E...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2006.10.011

    authors: Lam FF,Yeung JH,Chan KM,Or PM

    更新日期:2007-04-01 00:00:00

  • Paclitaxel chemotherapy and vascular toxicity as assessed by flow-mediated and nitrate-mediated vasodilatation.

    abstract:BACKGROUND:Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS:We studied 27 women treated with paclitaxel-containing combinations...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2010.05.002

    authors: Vassilakopoulou M,Mountzios G,Papamechael C,Protogerou AD,Aznaouridis K,Katsichti P,Venetsanou K,Dimopoulos MA,Ikonomidis I,Papadimitriou CA

    更新日期:2010-09-01 00:00:00

  • Infliximab therapy restores adiponectin expression in perivascular adipose tissue and improves endothelial nitric oxide-mediated vasodilation in mice with type 1 diabetes.

    abstract::Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM by reducing adiponectin (Ad) synthesis and therefore impairing Ad-mediated activity in the contiguous blood vessel system. We evaluated whether in vivo treatment with the...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2016.08.007

    authors: Nacci C,Leo V,De Benedictis L,Potenza MA,Sgarra L,De Salvia MA,Quon MJ,Montagnani M

    更新日期:2016-12-01 00:00:00

  • Characterization of four different effects elicited by H2O2 in rat aorta.

    abstract::Four main vascular effects of hydrogen peroxide (H2O2) were studied in intact and rubbed aortic rings from WKY rats. In rings partially precontracted with phenylephrine: 1-30 microM H2O2 induced an increase of tone, 100 microM H2O2 produced a transient contraction followed by a fast-developing endothelium-independent ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.06.001

    authors: Gil-Longo J,González-Vázquez C

    更新日期:2005-08-01 00:00:00

  • Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure.

    abstract::We characterized vascular reactivity to endothelin-1 (ET-1) in mesenteric vessels from DOCA-salt hypertensive and SHAM control mice and assessed the effect that endothelial-derived vasodilators have on ET-1-induced vasoconstriction. Changes in the diameter of unpressurized small mesenteric arteries and veins (100- to ...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.vph.2005.02.014

    authors: Pérez-Rivera AA,Fink GD,Galligan JJ

    更新日期:2005-06-01 00:00:00

  • Role of altered coagulation-fibrinolytic system in the pathophysiology of diabetic retinopathy.

    abstract::The implications of altered coagulation-fibrinolytic system in the pathophysiology of several vascular disorders, such as stroke and myocardial infarction, have been well researched upon and established. However, its role in the progression of diabetic retinopathy has not been explored much. Since a decade, it is know...

    journal_title:Vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.vph.2017.03.005

    authors: Behl T,Velpandian T,Kotwani A

    更新日期:2017-05-01 00:00:00