Abstract:
BACKGROUND:Platelets play crucial roles in the development of arterial thrombosis and other pathophysiologies leading to clinical ischemic events. Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis. The purposes of the study are to determine whether atherosclerotic plaque growth or stability is regulated by physiological doses of testosterone via its receptor, and to further investigate the possible mechanisms of inflammatory reaction. METHODS AND RESULTS:We prepared models of castrated male rabbits. Pathological sections of aorta were performed hematoxylin-eosin (HE) staining and Masson's trichrome staining. Total plasma testosterone was measured using ADVIA Centaur Immunoassay System (Bayer, Germany). Serum TNF alpha and IL 6 were assayed using radio-immunoassay kit and serum sICAM-1 and MMP 2 were measured using ELISA kit. Our results showed that castration significantly lowered plasma testosterone levels, whereas testosterone replacement at a dose of 6 mg/kg/two-week restored circulating testosterone to physiological levels, without being altered by treatment with flutamide (a testosterone receptor inhibitor). Testosterone undecanoate replacement reduced the plaque area and the aortic intimal thickness, whereas the fibrous cap thickness and collagen contents increased in castrated rabbits. However, the presence of flutamide increased the plaque area and the aortic intimal thickness, whereas the fibrous cap thickness and collagen contents decreased in castrated rabbits again. Moreover, the levels of serum TNF alpha, IL 6, sICAM and MMP 2 increased in cholesterol-rich diet rabbits as compared with standard diet rabbits. Castration caused increases in the levels of serum TNF alpha, IL6, sICAM and MMP 2 in castrated rabbits as compared with sham-operated rabbits. Treatment of testosterone undecanoate reduced the levels of serum TNF alpha, IL 6, sICAM and MMP 2 in castrated rabbits, while the presence of flutamide increased the levels of serum TNF alpha, IL 6, sICAM and MMP 2 again. CONCLUSION:Replacement of physiological testosterone regulates atherosclerotic plaque growth and stability via its receptor in castrated rabbits, which is probably related to their influence on inflammatory reaction.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
Li S,Li X,Li Ydoi
10.1016/j.vph.2008.03.004subject
Has Abstractpub_date
2008-07-01 00:00:00pages
14-8issue
1eissn
1537-1891issn
1879-3649pii
S1537-1891(08)00040-2journal_volume
49pub_type
杂志文章abstract::The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 or phytate): 1. Inhibits induced calcification in cultured aortic valve interstitial cells (VIC) as an in vitro model of aortic valve stenosis and 2. Whether inhibition is different in VIC obtaine...
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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doi:10.1016/j.vph.2007.03.004
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2016.08.001
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journal_title:Vascular pharmacology
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doi:10.1016/s1537-1891(02)00174-x
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journal_title:Vascular pharmacology
pub_type: 杂志文章
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journal_title:Vascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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doi:10.1016/j.vph.2014.01.003
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journal_title:Vascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2015.10.010
更新日期:2016-06-01 00:00:00
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journal_title:Vascular pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.vph.2018.08.011
更新日期:2019-01-01 00:00:00
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2010.03.002
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pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1016/j.vph.2019.03.002
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2006.11.004
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2019.01.005
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2006.01.002
更新日期:2006-05-01 00:00:00
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2015.02.001
更新日期:2015-04-01 00:00:00
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2006.10.011
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Vascular pharmacology
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pub_type: 杂志文章
doi:10.1016/j.vph.2019.106601
更新日期:2020-01-01 00:00:00
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2009.07.001
更新日期:2009-10-01 00:00:00
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journal_title:Vascular pharmacology
pub_type: 杂志文章
doi:10.1016/j.vph.2005.06.001
更新日期:2005-08-01 00:00:00