Abstract:
BACKGROUND:Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS:We studied 27 women treated with paclitaxel-containing combinations for breast or ovarian cancer. The control group was represented by 10 women with carcinoma of the uterine cervix who received low doses of weekly cisplatin as radiation sensitizer. We measured endothelial-dependent flow-mediated dilatation (FMD) and nitrate-mediated dilatation (NMD) of the right brachial artery by ultrasonography, as well as levels of the inflammatory cytokines TNF-alpha and IL-6 before and after chemotherapy. RESULTS:Patients who received paclitaxel and an anthracycline had the most marked reduction in both FMD (p=0.005) and NMD (p=0.027). A significant reduction in FMD was also observed in patients treated with weekly paclitaxel (p=0.045), whereas NMD was not affected (p=0.421). Although TNF-alpha and IL-6 levels were different among chemotherapy groups after treatment, no significant differences were observed between levels of both markers before and after chemotherapy. CONCLUSION:Treatment with paclitaxel-containing combinations impairs endothelial function in vivo but endothelial function deterioration is not related to the serum levels of inflammation markers.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
Vassilakopoulou M,Mountzios G,Papamechael C,Protogerou AD,Aznaouridis K,Katsichti P,Venetsanou K,Dimopoulos MA,Ikonomidis I,Papadimitriou CAdoi
10.1016/j.vph.2010.05.002subject
Has Abstractpub_date
2010-09-01 00:00:00pages
115-21issue
3-4eissn
1537-1891issn
1879-3649pii
S1537-1891(10)00089-3journal_volume
53pub_type
杂志文章abstract::We investigated the regulation of the epithelial sodium channel (ENaC) in human bone marrow endothelial cells (HBMEC) responding to mineralocorticoid hormones and other accessory effectors. The message for both the mineralocorticoid receptor (MCR) and the alpha subunit of ENaC was expressed in HBMEC as predicted bands...
journal_title:Vascular pharmacology
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abstract:BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...
journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.vph.2010.03.003
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abstract::We investigated the effects of epinephrine and dopamine on retinal blood vessels in streptozotocin (STZ, 80 mg/kg, i.p.)-treated rats and age-matched control rats to determine whether diabetes mellitus alters the retinal vascular responses to circulating catecholamines. Experiments were performed 6-8 weeks after treat...
journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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doi:10.1016/j.vph.2014.04.003
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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journal_title:Vascular pharmacology
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