SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification.

abstract：:There is evidence that dihydropyridine calcium antagonists (DHP) play a beneficial role during the development of atherosclerosis. Since antioxidative properties of this substance class may be important, we investigated the antioxidative potency of the DHP prototype calcium channel antagonist nifedipine, the long acti...

journal_title：Vascular pharmacology

authors： Berkels R,Breitenbach T,Bartels H,Taubert D,Rosenkranz A,Klaus W,Roesen R

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Platelets play crucial roles in the development of arterial thrombosis and other pathophysiologies leading to clinical ischemic events. Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis. The purposes of the study are to determine whether atherosclerotic pl...

journal_title：Vascular pharmacology

authors： Li S,Li X,Li Y

更新日期：2008-07-01 00:00:00

abstract：:Poorly controlled diabetes in pregnancy, characterized by hypo- and hyperglycemia, is associated with adverse outcomes. We hypothesized that aberrant glucose levels affect vascular function in pregnancy. The effects of glucose concentration on constriction and endothelium-dependent relaxation in uterine arteries of no...

journal_title：Vascular pharmacology

authors： Chirayath HH,Wareing M,Taggart MJ,Baker PN

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population w...

journal_title：Vascular pharmacology

authors： Hollstein T,Vogt A,Grenkowitz T,Stojakovic T,März W,Laufs U,Bölükbasi B,Steinhagen-Thiessen E,Scharnagl H,Kassner U

更新日期：2019-05-01 00:00:00

abstract：:Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

journal_title：Vascular pharmacology

authors： Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

更新日期：2020-01-01 00:00:00

abstract：:Recent studies evidence that peroxynitrite is spontaneously formed when nitric oxide (NO) and superoxide coexist and suggest that it is likely to be involved in the destruction of the pancreatic beta cells. We examined whether drugs that inhibit nitric oxide synthase (NOS) or scavenge peroxynitrite could abrogate STZ-...

journal_title：Vascular pharmacology

authors： Rao VS,Santos FA,Silva RM,Teixiera MG

更新日期：2002-03-01 00:00:00

abstract：:Propranolol is a non-selective beta-adrenergic receptor blocker used in the treatment of cardiovascular diseases and migraine prophylaxis. Although it has been shown that propranolol dilates the peripheral arteries of rat, its action in the central nervous system vasculature has not been investigated. In this study, t...

journal_title：Vascular pharmacology

authors： Cekic EG,Soydan G,Guler S,Babaoglu MO,Tuncer M

更新日期：2013-04-01 00:00:00

abstract：:In addition to its role as a vasoconstrictor, angiotensin II also acts as a potent growth factor by activating several tyrosine kinases, including Jak2. Interestingly, Jak2 has been linked to similar cardiovascular pathologies as have been previously linked to the renin-angiotensin system. Identifying the downstream t...

journal_title：Vascular pharmacology

authors： Wallace TA,Xia SL,Sayeski PP

更新日期：2005-11-01 00:00:00

abstract：:Endothelial cell dysfunction is considered to be an early event which subsequently leads to vascular wall disorders. Ultrastructural studies indicate that the endothelial cell changes involve membrane damage, increased permeability, swelling and necrosis. The endothelial cell loss of function could be as a result of c...

journal_title：Vascular pharmacology

authors： Tesfamariam B,DeFelice AF

更新日期：2007-04-01 00:00:00

abstract：:Spontaneous variation in blood pressure is defined as 'blood pressure variability' (BPV). Sinoaortic denervation (SAD) is characterized by BPV without sustained hypertension. In the present study, we investigated whether BPV could be related to vascular β-adrenoceptor desensitization in rats. Three days after surgery ...

journal_title：Vascular pharmacology

authors： Rocha ML,Silva BR,Lunardi CN,Ramalho LN,Bendhack LM

更新日期：2016-07-01 00:00:00

abstract：:While brain-derived neurotrophic factor (BDNF) was previously reported to induce relaxation of conduit artery, whether the BDNF/TrkB (tropomyosin-related kinase) pathway is involved in the tone control of resistance arteries is not known. This study investigated TrkB receptors levels/localization and the vasomotor eff...

journal_title：Vascular pharmacology

authors： Totoson P,Pedard M,Marie C,Demougeot C

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Acetylsalicylic acid (ASA) represents the basis of pharmacological therapy for cardiovascular prevention. However, several patients are excluded from the benefits of ASA for hypersensitivity problems, and controversies still exist on their management. The aim of present study was to evaluate the safety and e...

journal_title：Vascular pharmacology

authors： Verdoia M,Barbieri L,Schaffer A,Nardin M,Suryapranata H,De Luca G

更新日期：2016-05-01 00:00:00

abstract：:tert-Butyl hydroperoxide (t-BOOH), a membrane permeant oxidant, elicits enhanced vasoconstriction of perfused kidney and mesenteric arterial beds isolated from DOCA-salt-induced hypertensive rats. We hypothesize that enhanced vasoconstriction to t-BOOH during DOCA-salt hypertension involves free radical species and de...

journal_title：Vascular pharmacology

authors： Awe SO,Tsakadze NL,D'Souza SE,Adeagbo AS

更新日期：2003-01-01 00:00:00

abstract：:Bemiparin is a low molecular weight heparin (LMWH) indicated for the acute treatment of deep vein thrombosis with or without pulmonary embolism, for the prophylaxis of venous thromboembolism in surgical and non-surgical patients and for the prevention of clotting in the extracorporeal circuit during hemodialysis. Due ...

journal_title：Vascular pharmacology

authors： Ciccone MM,Cortese F,Corbo F,Corrales NE,Al-Momen AK,Silva A,Zito A,Pinto M,Gesualdo M,Scicchitano P

更新日期：2014-07-01 00:00:00

abstract：:Activation of ATP-sensitive K+ channels (K ATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal K ATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial K ATP channel blocker on cardiac fun...

journal_title：Vascular pharmacology

authors： Gok S,Vural K,Sekuri C,Onur R,Tezcan A,Izanli A

更新日期：2006-04-01 00:00:00

abstract：:Platelet adhesion to subendothelial types I and III collagens exposed upon vascular injury plays a crucial role in hemostasis and thrombosis. We previously identified a KOGEOGPK sequence (O for hydroxyproline) within type III collagen interacting with platelets, and demonstrated a strong inhibitory effect of the KOGEO...

journal_title：Vascular pharmacology

authors： Maurice P,Pires V,Amant C,Kauskot A,Da Nascimento S,Sonnet P,Rochette J,Legrand C,Fauvel-Lafeve F,Bonnefoy A

更新日期：2006-01-01 00:00:00

abstract：:The sulfur-containing amino acid, taurine, has been shown to ameliorate the vascular disorders. We examined the effects of taurine ingestion on intimal thickening following balloon injury. Balloon injury was induced in the left common carotid artery of Wistar rats. Taurine (3% (w/v)) was mixed in the drinking water fr...

journal_title：Vascular pharmacology

authors： Murakami S,Sakurai T,Toda Y,Morito A,Sakono M,Fukuda N

更新日期：2010-09-01 00:00:00

abstract：:We investigated the effects of epinephrine and dopamine on retinal blood vessels in streptozotocin (STZ, 80 mg/kg, i.p.)-treated rats and age-matched control rats to determine whether diabetes mellitus alters the retinal vascular responses to circulating catecholamines. Experiments were performed 6-8 weeks after treat...

journal_title：Vascular pharmacology

authors： Nakazawa T,Sato A,Mori A,Saito M,Sakamoto K,Nakahara T,Ishii K

更新日期：2008-08-01 00:00:00

abstract：:Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

journal_title：Vascular pharmacology

authors： Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

更新日期：2007-08-01 00:00:00

abstract：:Cardiovascular diseases are the major challenge to modern medicine. Intervention to cardiovascular cells is crucial for treatment of the diseases. Here we report a novel intervention to vascular smooth muscle (VSM) cells by optogenetics. Channelrhodopsin in a tandem with YFP was selectively expressed in smooth muscle ...

journal_title：Vascular pharmacology

authors： Wu Y,Li SS,Jin X,Cui N,Zhang S,Jiang C

更新日期：2015-08-01 00:00:00

abstract：:The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic-reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of contractile function. Additionally, the A3AR may attenuate vascular dysfunction and improve long-term outcome from myocardial in...

journal_title：Vascular pharmacology

authors： Headrick JP,Peart J

更新日期：2005-04-01 00:00:00

abstract：:Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that PGE2 receptor signaling modulates angiotensin II (Ang II)-induced hypertension, but the interact...

journal_title：Vascular pharmacology

authors： Kraemer MP,Choi H,Reese J,Lamb FS,Breyer RM

更新日期：2016-09-01 00:00:00

abstract：:Sixty-seven male patients with hypercholesterolemia, divided into three groups according to apolipoprotein E phenotype (33 with apoE3/ 3 phenotype, E3 group; 23 with 2/2 or 2/3, E2+ group; 11 with 4/4 or 4/3, E4+ group), received daily 20-40 mg of fluvastatin for 12 weeks. The levels of triglyceride (TG), cholesterol ...

journal_title：Vascular pharmacology

authors： Dergunov AD,Perova NV,Visvikis S,Siest G

更新日期：2003-12-01 00:00:00

abstract：:Small GTPase Rap1 has been extensively studied in vitro and shown to regulate multiple basic cellular processes. Until recently, the best studied aspect of Rap1 function in endothelial cells involved its role in regulation of cell-cell junction formation and remodeling. These in vitro studies have increased understand...

journal_title：Vascular pharmacology

authors： Chrzanowska-Wodnicka M

更新日期：2010-07-01 00:00:00

abstract：:To investigate the vasorelaxant effect of fasudil mesylate (FM) in vivo and in vitro. The relaxation effect of FM was studied using cerebral vasospasm (CVS) model in vivo and isolated aortic rings in vitro. FM (0.35, 1.2, 3.5 mg·kg⁻¹) increased cerebrovascular flow (CVF) and femoral blood flow (FBF) dose-dependently i...

journal_title：Vascular pharmacology

authors： Li Q,Chen Y,Sun L,Fu G,Guo L

更新日期：2011-11-01 00:00:00

abstract：:Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

journal_title：Vascular pharmacology

authors： Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

更新日期：2018-11-01 00:00:00

abstract：:A large number of studies utilize animal models to investigate therapeutic angiogenesis. However, the lack of a standardized experimental model leaves the comparison of different studies problematic. To establish a reference model of prolonged moderate tissue ischemia, we created unilateral hind limb ischemia in athym...

journal_title：Vascular pharmacology

authors： Yang Z,von Ballmoos MW,Diehm N,Baumgartner I,Kalka C,Di Santo S

更新日期：2009-10-01 00:00:00

abstract：:Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apo...

journal_title：Vascular pharmacology

authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Malý J,Kramer HJ,Dvorák P,Cervenka L

更新日期：2009-08-01 00:00:00

abstract：AIM:Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against cardiovascular diseases including atherosclerosis. The safe dose of selenium in the organism is very narrow, limiting the supplementation of selenium in diet. The aim of this study is to explore whet...

journal_title：Vascular pharmacology

authors： Zhu ML,Wang G,Wang H,Guo YM,Song P,Xu J,Li P,Wang S,Yang L

更新日期：2019-04-01 00:00:00

abstract：:Unresolved endoplasmic reticulum (ER) stress, with the subsequent persistent activation of the unfolded protein response (UPR) is a well-recognized mechanism of endothelial cell apoptosis with a major impact on the integrity of the endothelium during the course of cardiovascular diseases. As in other cell types, Ca(2+...

journal_title：Vascular pharmacology

authors： Ampem PT,Smedlund K,Vazquez G

更新日期：2016-01-01 00:00:00