当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Acute hyperglycemia in uterine arteries from pregnant, but not non-pregnant mice, enhances endothelium-dependent relaxation.

Acute hyperglycemia in uterine arteries from pregnant, but not non-pregnant mice, enhances endothelium-dependent relaxation.

Abstract：

:Poorly controlled diabetes in pregnancy, characterized by hypo- and hyperglycemia, is associated with adverse outcomes. We hypothesized that aberrant glucose levels affect vascular function in pregnancy. The effects of glucose concentration on constriction and endothelium-dependent relaxation in uterine arteries of normal C57BL/6 mice were examined. Ex-vivo arteries from 18 pregnant and 14 non-pregnant mice were mounted on a wire myograph, constricted with phenylephrine and relaxed with incremental doses of acetylcholine, in physiological saline solution containing 5 mmol/L glucose. Arteries were then exposed to solutions with 2, 5, 8 or 12 mmol/L glucose for 30 min and constriction/relaxation repeated. On altering glucose concentrations to 2, 8 or 12 mmol/L, maximal constriction was increased in arteries from pregnant but not from non-pregnant mice (paired t-test, p<0.05). Endothelium-dependent relaxation was enhanced at 12 mmol/L glucose in arteries from pregnant (two-way ANOVA, p<0.01), but not from non-pregnant mice. Endothelium-dependent relaxation in the uterine artery was pre-dominantly mediated by a non-nitric oxide/non-prostanoid mechanism, with a smaller contribution from nitric oxide, and no prostanoid-mediated relaxation. In summary, acute changes in glucose concentration alter both constriction and endothelium-dependent relaxation in uterine arteries of normal pregnant mice; these effects are unique to pregnancy.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Chirayath HH,Wareing M,Taggart MJ,Baker PN

doi

10.1016/j.vph.2006.09.001

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

137-43

issue

2

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(06)00587-8

journal_volume

46

pub_type

杂志文章

相关文献

VASCULAR PHARMACOLOGY文献大全
  • Optogenetic approach for functional assays of the cardiovascular system by light activation of the vascular smooth muscle.

    abstract：:Cardiovascular diseases are the major challenge to modern medicine. Intervention to cardiovascular cells is crucial for treatment of the diseases. Here we report a novel intervention to vascular smooth muscle (VSM) cells by optogenetics. Channelrhodopsin in a tandem with YFP was selectively expressed in smooth muscle ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.03.006

    authors： Wu Y,Li SS,Jin X,Cui N,Zhang S,Jiang C

    更新日期：2015-08-01 00:00:00

  • Role of altered coagulation-fibrinolytic system in the pathophysiology of diabetic retinopathy.

    abstract：:The implications of altered coagulation-fibrinolytic system in the pathophysiology of several vascular disorders, such as stroke and myocardial infarction, have been well researched upon and established. However, its role in the progression of diabetic retinopathy has not been explored much. Since a decade, it is know...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2017.03.005

    authors： Behl T,Velpandian T,Kotwani A

    更新日期：2017-05-01 00:00:00

  • The kinetics of angiotensin-I metabolism in human carotid atheroma: An emerging role for angiotensin (1-7).

    abstract：AIM:Local levels of angiotensin peptides depend on their rates of production and degradation, which induce proatherogenic or atheroprotective effects. Here, we reveal the kinetics of Angiotensin-I metabolism in paired early and advanced atherosclerotic lesions. METHODS:Lesions were spiked with labeled Ang-I* and super...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.08.001

    authors： Nehme A,Marcelo P,Nasser R,Kobeissy F,Bricca G,Zibara K

    更新日期：2016-10-01 00:00:00

  • "Fishing" for endothelial microRNA functions and dysfunction.

    abstract：:MicroRNAs (e.g., miRNAs), endogenously expressed small non-coding RNAs, control gene expression by regulating target messenger RNA at post-transcriptional level. Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. The zebrafish (Danio rerio) system is a ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2011.08.224

    authors： Santoro MM

    更新日期：2011-10-01 00:00:00

  • Anti-inflammatory influence of P-selectin on human mononuclear cells.

    abstract：:The purpose of this study was to determine if P-selectin, an adhesion molecule involved in the transendothelial movement of leukocytes, might also have a direct influence on the function of cells that come into contact with it. Human peripheral blood mononuclear cells were incubated on immobilized P-selectin or a cont...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.11.002

    authors： Sloan CL,Sloan GJ,Cannon JG

    更新日期：2006-03-01 00:00:00

  • Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling.

    abstract：BACKGROUND:Immunosuppressive agents are at the forefront of preventing organ rejection after transplantation. However, their effects on vascular smooth muscle cell-mediated intimal hyperplasia that occurs in post-transplant coronary artery disease are less well known. METHODS AND RESULTS:We investigated the in vitro e...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2004.10.002

    authors： Hafizi S,Mordi VN,Andersson KM,Chester AH,Yacoub MH

    更新日期：2004-05-01 00:00:00

  • Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell migration through preventing the activation of MMP-2 and FAK via inhibiting ERK and PI3K/AKT signaling pathways.

    abstract：:Angiogenesis has become an attractive target for the treatment of certain diseases such as cancer and rheumatoid arthritis. Our previous studies demonstrated that the saponin fraction from Gleditsia sinensis fruits had anti-angiogenic potential, and Gleditsiosides B (GB) was probably the main active constituent. In th...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.09.006

    authors： Tong B,Lu D,Wei Z,Wang T,Xia Y,Dai Y

    更新日期：2013-01-01 00:00:00

  • Pharmacogenomics of cholesterol-lowering therapy.

    abstract：:The prevention of cardiovascular disease is critically dependent on lipid-lowering therapy, including 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), cholesterol absorption inhibitors, bile acid resins, fibrates, and nicotinic acid. Although these drugs are generally well tolerate...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2005.07.012

    authors： Schmitz G,Langmann T

    更新日期：2006-02-01 00:00:00

  • Tert-butyl hydroperoxide-mediated vascular responses in DOCA-salt hypertensive rats.

    abstract：:tert-Butyl hydroperoxide (t-BOOH), a membrane permeant oxidant, elicits enhanced vasoconstriction of perfused kidney and mesenteric arterial beds isolated from DOCA-salt-induced hypertensive rats. We hypothesize that enhanced vasoconstriction to t-BOOH during DOCA-salt hypertension involves free radical species and de...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(02)00309-9

    authors： Awe SO,Tsakadze NL,D'Souza SE,Adeagbo AS

    更新日期：2003-01-01 00:00:00

  • Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with familial combined hyperlipidemia and/or metabolic syndrome.

    abstract：OBJECTIVE:In patients with familial combined hyperlipidemia (FCHL), without metabolic syndrome (MS), occurrence of non-alcoholic fatty liver disease (NAFLD) is related to a specific pro-inflammatory profile, influenced by genetic traits, involved in oxidative stress and adipokine secretion. Among FCHL or MS patients, h...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.04.004

    authors： Santilli F,Blardi P,Scapellato C,Bocchia M,Guazzi G,Terzuoli L,Tabucchi A,Silvietti A,Lucani B,Gioffrè WR,Scarpini F,Fazio F,Davì G,Puccetti L

    更新日期：2015-09-01 00:00:00

  • CRISPR links to long noncoding RNA function in mice: A practical approach.

    abstract：:Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered regularly interspaced short palindromic repeats (CRISPR) editing h...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2019.02.004

    authors： Miano JM,Long X,Lyu Q

    更新日期：2019-03-01 00:00:00

  • Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events.

    abstract：:Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during early development. Upon exposure to glucocorticoids, the fetus develops hypertension, and the of...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2016.02.002

    authors： Anwar MA,Saleh AI,Al Olabi R,Al Shehabi TS,Eid AH

    更新日期：2016-07-01 00:00:00

  • Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.

    abstract：:Unresolved endoplasmic reticulum (ER) stress, with the subsequent persistent activation of the unfolded protein response (UPR) is a well-recognized mechanism of endothelial cell apoptosis with a major impact on the integrity of the endothelium during the course of cardiovascular diseases. As in other cell types, Ca(2+...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.07.011

    authors： Ampem PT,Smedlund K,Vazquez G

    更新日期：2016-01-01 00:00:00

  • Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

    abstract：:Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.10.001

    authors： Sangartit W,Pakdeechote P,Kukongviriyapan V,Donpunha W,Shibahara S,Kukongviriyapan U

    更新日期：2016-12-01 00:00:00

  • Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.

    abstract：:Endothelial cell dysfunction may play an important role in the development of various vascular diseases, including atherosclerosis. Here we investigated whether lithium chloride (LiCl), an inhibitor of glycogen synthase kinase-3β (GSK-3β), could counteract atherosclerosis induced by a high-fat diet in ApoE⁻/⁻ mice. Te...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.09.004

    authors： Choi SE,Jang HJ,Kang Y,Jung JG,Han SJ,Kim HJ,Kim DJ,Lee KW

    更新日期：2010-11-01 00:00:00

  • Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.

    abstract：:The present study was undertaken to investigate endothelial function and epoxyeicosatrienoic acids (EETs), which is a cytochrome P-450 monooxygenase (CYP) metabolite and one of the candidates as an endothelium-derived hyperpolarizing factor (EDHF) in the renal artery isolated from short-term hypercholesterolemic rabbi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.03.005

    authors： Taniguchi J,Honda H,Shibusawa Y,Iwata T,Notoya Y

    更新日期：2005-06-01 00:00:00

  • Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.

    abstract：:Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alp...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106577

    authors： Kamau F,Strijdom H,Mwangi P,Blackhurst D,Imperial E,Salie R

    更新日期：2019-10-01 00:00:00

  • Pharmacogenetics and cardiac ion channels.

    abstract：:Ion channels control electrical excitability in living cells. In mammalian heart, the opposing actions of Na(+) and Ca(2+) ion influx, and K(+) ion efflux, through cardiac ion channels determine the morphology and duration of action potentials in cardiac myocytes, thus controlling the heartbeat. The last decade has se...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2005.07.013

    authors： Roepke TK,Abbott GW

    更新日期：2006-02-01 00:00:00

  • Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature.

    abstract：:Although the vasorelaxing effects of testosterone (T) and various androgen metabolites have been observed in a variety of blood vessels and species, previous studies have not systematically compared the vasorelaxing effects of androgen metabolites in different vascular beds within the same species. Therefore, we studi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.01.008

    authors： Perusquía M,Espinoza J,Montaño LM,Stallone JN

    更新日期：2012-03-01 00:00:00

  • Call for a reference model of chronic hind limb ischemia to investigate therapeutic angiogenesis.

    abstract：:A large number of studies utilize animal models to investigate therapeutic angiogenesis. However, the lack of a standardized experimental model leaves the comparison of different studies problematic. To establish a reference model of prolonged moderate tissue ischemia, we created unilateral hind limb ischemia in athym...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2009.07.001

    authors： Yang Z,von Ballmoos MW,Diehm N,Baumgartner I,Kalka C,Di Santo S

    更新日期：2009-10-01 00:00:00

  • PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges.

    abstract：:Hypercholesterolemia, is a prominent risk factor for cardiovascular disease (CVD). Undestanding of the biochemical mechanisms that regulate the expression of the low density lipoproteins receptor (LDLR) and the hepatic clearance of LDL cholesterol (LDL-C) paved the way to the statin therapy as the gold standard for CV...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.05.011

    authors： Norata GD,Tibolla G,Catapano AL

    更新日期：2014-08-01 00:00:00

  • Na(+)/H(+) exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2(+) mobilization.

    abstract：:The objective of this study was to determine the mechanism by which Na(+)/H(+) exchanger (NHE) inhibitors induce vasodilatation. The NHE inhibitors, 5-(N,N-dimethyl)-amiloride (DMA), cariporide, and amiloride, evoked endothelium-dependent relaxation in rat aortas with ED50 values of 16, 89, and 148μM, respectively, an...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.11.004

    authors： Sasahara T,Yayama K,Matsuzaki T,Tsutsui M,Okamoto H

    更新日期：2013-04-01 00:00:00

  • Contractile effect of ghrelin on isolated guinea-pig renal arteries.

    abstract：:Ghrelin, a 28-amino acid peptide, known to exist in both acylated and des-acylated varieties, was identified as the first endogenous ligand of growth hormone secretagogue receptor in 1999. Various arteries are known to express ghrelin receptors, but the direct action of ghrelin on blood vessels has been unclear. In th...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2007.03.004

    authors： Dimitrova DZ,Mihov DN,Wang R,Hristov KL,Rizov LI,Bolton TB,Duridanova DB

    更新日期：2007-07-01 00:00:00

  • Treatment with PCSK9 inhibitors reduces atherogenic VLDL remnants in a real-world study.

    abstract：BACKGROUND:Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population w...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.03.002

    authors： Hollstein T,Vogt A,Grenkowitz T,Stojakovic T,März W,Laufs U,Bölükbasi B,Steinhagen-Thiessen E,Scharnagl H,Kassner U

    更新日期：2019-05-01 00:00:00

  • Differential effects of ET(A) and ET(B) receptor antagonism on oxidative stress in type 2 diabetes.

    abstract：:Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2007.05.006

    authors： Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

    更新日期：2007-08-01 00:00:00

  • Macro- and microvascular disease in systemic sclerosis.

    abstract：:Vasculopathy is common in patients with connective tissue disease and can be directly implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune multiorgan connective tissue disorder characterized by fibrosis of the skin and visceral organs and vascular disease. Micro- and macro-vessels are a ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2015.05.015

    authors： Kavian N,Batteux F

    更新日期：2015-08-01 00:00:00

  • Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis.

    abstract：:Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stabl...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.06.014

    authors： Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

    更新日期：2019-01-01 00:00:00

  • PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells.

    abstract：:Increasing evidences support that PGC-1α participates in regulating endothelial homeostasis, in part by mediating endothelial nitric oxide (NO) synthase (eNOS) activity and NO production. However, the molecular mechanisms by which PGC-1α regulates eNOS activity are not completely understood. In the present study, we i...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.05.005

    authors： Li J,Geng XY,Cong XL

    更新日期：2016-08-01 00:00:00

  • Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases.

    abstract：:Propionyl-l-carnitine (PLC) is a natural short-chain derivative of l-carnitine (LC), a natural amino acid that plays an important role in fatty acid metabolism. Recent studies suggest that PLC has vascular protective effects. Because of the importance of endothelial nitric oxide synthase (eNOS) and its product, antiat...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2013.07.001

    authors： Ning WH,Zhao K

    更新日期：2013-09-01 00:00:00

  • Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.

    abstract：:To investigate mechanisms of protective effects of fenofibrate on the diabetic kidney, male Wistar rats were divided into control, untreated diabetes, and fenofibrate-treated (32 mg kg(-1) d(-1), 8 weeks) diabetes groups. Diabetes induced by streptozotocin (25 mg/kg) and a high-fat diet was characterized by the disord...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.01.004

    authors： Chen LL,Zhang JY,Wang BP

    更新日期：2006-05-01 00:00:00