当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats.

Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats.

Abstract：

:Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apocynin on the development of hypertension. Systolic blood pressure (SBP) was monitored from 30 to 99 days of age in TGR and in normotensive Hannover Sprague-Dawley (HanSD) rats. At the end of the experiment, urinary protein and 8-isoprostane excretion were determined and angiotensin II (ANG II) and malondialdehyde (MDA) levels were measured in kidney and cardiac tissues. Cardiac hypertrophy was assessed as the ratio of left heart ventricle weight to tibia length (LVW/TL). Although tempol and apocynin treatment in TGR significantly decreased 8-isoprostane excretion and MAD tissue concentrations as compared with untreated TGR, it did not alter the course of SBP, LVW/TL ratio, proteinuria or ANG II levels that were enhanced as compared with HanSD rats. Our data suggest that the development of hypertension in TGR is clearly ANG II-dependent but the contribution of oxidative stress to the development of hypertension in this model appears to be negligible.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Malý J,Kramer HJ,Dvorák P,Cervenka L

doi

10.1016/j.vph.2009.06.001

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

175-81

issue

2-3

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(09)00072-X

journal_volume

51

pub_type

杂志文章

相关文献

VASCULAR PHARMACOLOGY文献大全
  • Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats.

    abstract：:Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injecti...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2017.09.007

    authors： Fioretti AC,Ogihara CA,Cafarchio EM,Venancio DP,de Almeida RL,Antonio BB,Sato MA

    更新日期：2017-12-01 00:00:00

  • Thyroid hormone and chronically unloaded hearts.

    abstract：:The heart is subjected to chronic mechanical unloading during prolonged spaceflight and microgravity. The heart in patients with end-stage heart failure is also unloaded in prolonged duration after left ventricular assist devices (LVAD) are implanted. Heterotopic heart transplantation in rats is an established model o...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2009.10.004

    authors： Ito K,Kagaya Y,Shimokawa H

    更新日期：2010-03-01 00:00:00

  • Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins.

    abstract：:Impaired endothelial function is recognised as one of the earliest events of atherogenesis. Endothelium-dependent vasomotion has been the principal method to assess endothelial function. In this article, we will discuss the clinical value of the different techniques to evaluate endothelium-dependent vasomotion. To dat...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2005.01.009

    authors： Asselbergs FW,van der Harst P,Jessurun GA,Tio RA,van Gilst WH

    更新日期：2005-02-01 00:00:00

  • Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?

    abstract：:Autoimmune rheumatic diseases are characterised by systemic inflammation and complex immunopathology, with an increased risk of cardiovascular disease, initiated by endothelial dysfunction in a chronic inflammatory environment. Endothelial microparticles (EMPs) are released into the circulation from activated endothel...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2016.05.016

    authors： McCarthy EM,Wilkinson FL,Parker B,Alexander MY

    更新日期：2016-11-01 00:00:00

  • Different antioxidative potencies of dihydropyridine calcium channel modulators in various models.

    abstract：:There is evidence that dihydropyridine calcium antagonists (DHP) play a beneficial role during the development of atherosclerosis. Since antioxidative properties of this substance class may be important, we investigated the antioxidative potency of the DHP prototype calcium channel antagonist nifedipine, the long acti...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2004.11.003

    authors： Berkels R,Breitenbach T,Bartels H,Taubert D,Rosenkranz A,Klaus W,Roesen R

    更新日期：2005-03-01 00:00:00

  • Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature.

    abstract：:Although the vasorelaxing effects of testosterone (T) and various androgen metabolites have been observed in a variety of blood vessels and species, previous studies have not systematically compared the vasorelaxing effects of androgen metabolites in different vascular beds within the same species. Therefore, we studi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.01.008

    authors： Perusquía M,Espinoza J,Montaño LM,Stallone JN

    更新日期：2012-03-01 00:00:00

  • Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts.

    abstract：:Activation of ATP-sensitive K+ channels (K ATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal K ATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial K ATP channel blocker on cardiac fun...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.11.006

    authors： Gok S,Vural K,Sekuri C,Onur R,Tezcan A,Izanli A

    更新日期：2006-04-01 00:00:00

  • Platelet reactivity in patients with impaired renal function receiving dual antiplatelet therapy with clopidogrel or ticagrelor.

    abstract：BACKGROUND:Suboptimal platelet inhibition still represents an important challenge, especially for patients undergoing percutaneous coronary interventions (PCI). Chronic kidney disease (CKD) is a common comorbidity of patients with coronary artery disease, and may potentially influence platelet reactivity. So far only f...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.10.006

    authors： Barbieri L,Pergolini P,Verdoia M,Rolla R,Nardin M,Marino P,Bellomo G,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

    更新日期：2016-04-01 00:00:00

  • Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca(2+) stores and inhibition of capacitative calcium entry.

    abstract：:Despite a large number of studies, the mechanism by which 3',5'-cyclic monophosphate (cAMP) induces vasorelaxation is not fully understood. The comparison between results obtained in different vessels or species has often been the source of conflicting reports. In order to shed more light onto this mechanism, we studi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.08.007

    authors： Cuíñas A,Elíes J,Orallo F,Campos-Toimil M

    更新日期：2013-01-01 00:00:00

  • Effect of Semecarpus anacardium nut extract on ECM and proteases in mammary carcinoma rats.

    abstract：:The early stages of invasion are characterized by the extracellular proteolysis and the accumulation of specialized extracellular matrix (ECM) scaffold, that are responsible for the development of vascular bed, endothelial cell proliferation and invasion of tumour cells. The ground substance of provisional matrix cons...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.12.004

    authors： Mathivadhani P,Shanthi P,Sachdanandam P

    更新日期：2007-06-01 00:00:00

  • Treatment of experimental immune complex glomerulonephritis by sodium alginate.

    abstract：:We have studied the therapeutic efficacy of the sodium alginate in experimental immune complex glomerulonephritis. Bovine serum albumin (BSA) nephritis was induced in rats by a subcutaneous immunization and daily intravenous administration of BSA. Sodium alginate at two different doses (25 and 50 mg/kg) was administer...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.03.002

    authors： Mirshafiey A,Borzooy Z,Abhari RS,Razavi A,Tavangar M,Rehm BH

    更新日期：2005-06-01 00:00:00

  • Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.

    abstract：:To investigate mechanisms of protective effects of fenofibrate on the diabetic kidney, male Wistar rats were divided into control, untreated diabetes, and fenofibrate-treated (32 mg kg(-1) d(-1), 8 weeks) diabetes groups. Diabetes induced by streptozotocin (25 mg/kg) and a high-fat diet was characterized by the disord...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.01.004

    authors： Chen LL,Zhang JY,Wang BP

    更新日期：2006-05-01 00:00:00

  • The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries.

    abstract：:There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2008.11.002

    authors： Montes FR,Cabrera M,Delgadillo A,Salgar C,Echeverri D

    更新日期：2009-03-01 00:00:00

  • Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition.

    abstract：AIM:Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against cardiovascular diseases including atherosclerosis. The safe dose of selenium in the organism is very narrow, limiting the supplementation of selenium in diet. The aim of this study is to explore whet...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.01.005

    authors： Zhu ML,Wang G,Wang H,Guo YM,Song P,Xu J,Li P,Wang S,Yang L

    更新日期：2019-04-01 00:00:00

  • Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.

    abstract：:Endothelial cell dysfunction may play an important role in the development of various vascular diseases, including atherosclerosis. Here we investigated whether lithium chloride (LiCl), an inhibitor of glycogen synthase kinase-3β (GSK-3β), could counteract atherosclerosis induced by a high-fat diet in ApoE⁻/⁻ mice. Te...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.09.004

    authors： Choi SE,Jang HJ,Kang Y,Jung JG,Han SJ,Kim HJ,Kim DJ,Lee KW

    更新日期：2010-11-01 00:00:00

  • Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.

    abstract：:Peroxisome proliferator-activated receptors (PPAR)alpha, gamma and beta/delta belong to the nuclear receptor family of ligand-activated transcription factors. PPARs heterodimerize with the retinoid X receptor (RXR) and then act as transcription factors to modulate the function of many target genes. PPARalpha, gamma an...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2005.11.014

    authors： Touyz RM,Schiffrin EL

    更新日期：2006-07-01 00:00:00

  • Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia.

    abstract：:The present study was designed to investigate the roles of enhanced arginase activity due to up-regulated arginases and the decreased hydroxyarginine for accelerating intimal hyperplasia with hyperglycemia. Thirteen weeks after injection of alloxan or physiological saline, endothelial denudation of the carotid artery ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2007.08.001

    authors： Ishizaka M,Nagai A,Iwanaga M,Imamura M,Azuma H

    更新日期：2007-11-01 00:00:00

  • Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.

    abstract：:Arterial hypertension is a condition associated with endothelial dysfunction, accompanied by an imbalance in the production of reactive oxygen species (ROS) and NO. The aim of this study was to investigate and elucidate the possible mechanisms of sildenafil, a selective phosphodiesterase-5 inhibitor, actions on endoth...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106601

    authors： Leal MAS,Aires R,Pandolfi T,Marques VB,Campagnaro BP,Pereira TMC,Meyrelles SS,Campos-Toimil M,Vasquez EC

    更新日期：2020-01-01 00:00:00

  • Blood pressure variability provokes vascular β-adrenoceptor desensitization in rats.

    abstract：:Spontaneous variation in blood pressure is defined as 'blood pressure variability' (BPV). Sinoaortic denervation (SAD) is characterized by BPV without sustained hypertension. In the present study, we investigated whether BPV could be related to vascular β-adrenoceptor desensitization in rats. Three days after surgery ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.05.007

    authors： Rocha ML,Silva BR,Lunardi CN,Ramalho LN,Bendhack LM

    更新日期：2016-07-01 00:00:00

  • Call for a reference model of chronic hind limb ischemia to investigate therapeutic angiogenesis.

    abstract：:A large number of studies utilize animal models to investigate therapeutic angiogenesis. However, the lack of a standardized experimental model leaves the comparison of different studies problematic. To establish a reference model of prolonged moderate tissue ischemia, we created unilateral hind limb ischemia in athym...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2009.07.001

    authors： Yang Z,von Ballmoos MW,Diehm N,Baumgartner I,Kalka C,Di Santo S

    更新日期：2009-10-01 00:00:00

  • Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production.

    abstract：:LIGHT is known to act as a novel mediator for atherogenesis. Furthermore, it has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells. However, it is not known if emodin exerts anti-atherogenic effects in the human monocyte, THP-1, following treatment with LIGHT. I...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.03.002

    authors： Heo SK,Yun HJ,Noh EK,Park SD

    更新日期：2010-07-01 00:00:00

  • Lipoic acid decreases exhaled nitric oxide concentrations in anesthetized endotoxemic rats.

    abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.08.005

    authors： De Marco VG,Bosanquet JP,Rawlani VR,Skimming JW

    更新日期：2005-12-01 00:00:00

  • The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.

    abstract：:Successful drug delivery to the central nervous system (CNS) is highly dependent on DMPK as well as physicochemical properties and it is therefore important to characterise these properties and take them into account when designing chemical lead series that act at CNS targets. Since the drug discovery/development proc...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(02)00203-3

    authors： Lundquist S,Renftel M

    更新日期：2002-06-01 00:00:00

  • Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF-κB signaling pathway in vascular smooth muscle cells.

    abstract：:Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascular smooth muscle cells (VSMCs) are involved in As. Hyperhomocysteinemia (HHcy) is an independent risk factor for As. The present study was designed to test our hypothesi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106613

    authors： Chen Y,Su X,Qin Q,Yu Y,Jia M,Kong L,Zhang H,Li H

    更新日期：2020-01-01 00:00:00

  • Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop.

    abstract：BACKGROUND:Vascular calcification (VC) is associated with the high morbidity and mortality of cardiovascular diseases in dialysis patients and is a process in which vascular smooth muscle cells (VSMCs) actively differentiate into osteoblast-like cells. Reticulocalbin-2 (RCN2) is involved in the process of osteogenic di...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2020.106821

    authors： Zhao J,Liu Z,Chang Z

    更新日期：2021-02-01 00:00:00

  • Mechanisms of endothelial cell protection by hydroxycinnamic acids.

    abstract：:An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as the...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.10.006

    authors： Fuentes E,Palomo I

    更新日期：2014-12-01 00:00:00

  • Ex vivo microangioCT: Advances in microvascular imaging.

    abstract：:Therapeutic modulation of angiogenesis is believed to be a prospective powerful treatment strategy to modulate the microcirculation and therefore help millions of patients with cardiovascular and cancer diseases. The often-frustrating results from late-stage clinical studies indicate an urgent need for improved assess...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.09.003

    authors： Hlushchuk R,Haberthür D,Djonov V

    更新日期：2019-01-01 00:00:00

  • A novel method to isolate retinal and brain microvessels from individual rats: Microscopic and molecular biological characterization and application in hyperglycemic animals.

    abstract：:Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction proced...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2018.07.001

    authors： Li Y,Lapina N,Weinzierl N,Bonde L,Boedtkjer E,Schubert R,Moshage H,Wohlfart P,Schilling L

    更新日期：2018-11-01 00:00:00

  • Paclitaxel chemotherapy and vascular toxicity as assessed by flow-mediated and nitrate-mediated vasodilatation.

    abstract：BACKGROUND:Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS:We studied 27 women treated with paclitaxel-containing combinations...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.05.002

    authors： Vassilakopoulou M,Mountzios G,Papamechael C,Protogerou AD,Aznaouridis K,Katsichti P,Venetsanou K,Dimopoulos MA,Ikonomidis I,Papadimitriou CA

    更新日期：2010-09-01 00:00:00

  • Aldosterone signaling modifies capillary formation by human bone marrow endothelial cells.

    abstract：:We investigated the regulation of the epithelial sodium channel (ENaC) in human bone marrow endothelial cells (HBMEC) responding to mineralocorticoid hormones and other accessory effectors. The message for both the mineralocorticoid receptor (MCR) and the alpha subunit of ENaC was expressed in HBMEC as predicted bands...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2003.08.003

    authors： Chen W,Valamanesh F,Mirshahi T,Soria J,Tang R,Agarwal MK,Mirshahi M

    更新日期：2004-01-01 00:00:00