Abstract：
:Autoimmune rheumatic diseases are characterised by systemic inflammation and complex immunopathology, with an increased risk of cardiovascular disease, initiated by endothelial dysfunction in a chronic inflammatory environment. Endothelial microparticles (EMPs) are released into the circulation from activated endothelial cells and may therefore, reflect disease severity, vascular and endothelial dysfunction, that could influence disease pathogenesis via autocrine/paracrine signalling. The exact function of EMPs in rheumatic disease remains unknown, and this has initiated research to elucidate EMP composition and function, which may be determined by the mode of endothelial activation and the micro environment. To date, EMPs are thought to play a role in angiogenesis, thrombosis and inflammation by transferring specific proteins and microRNAs (miRs) to target cells. Here, we review the mechanisms underlying the generation and composition of EMPs and the clinical and experimental studies describing the involvement of EMPs in rheumatic diseases, since we have previously shown endothelial dysfunction and an elevated risk of cardiovascular disease are characteristics in systemic lupus erythematosus. We will also discuss the potential of EMPs as future biomarkers of cardiovascular risk in these diseases.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
McCarthy EM,Wilkinson FL,Parker B,Alexander MYdoi
10.1016/j.vph.2016.05.016subject
Has Abstractpub_date
2016-11-01 00:00:00pages
71-76eissn
1537-1891issn
1879-3649pii
S1537-1891(15)30125-7journal_volume
86pub_type
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
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journal_title：Vascular pharmacology
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journal_title：Vascular pharmacology
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.vph.2015.02.018
更新日期：2015-04-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2006.05.006
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1537-1891(02)00300-2
更新日期：2002-08-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2015.02.001
更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.vph.2003.09.002
更新日期：2003-12-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.02.014
更新日期：2005-06-01 00:00:00
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journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2005.02.012
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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abstract：:Since the discovery of the importance of nitric oxide (NO) to the human body three decades ago, numerous laboratory and clinical studies have been done to explore its potential therapeutic actions on many organs. In the cardiovascular system, NO works as a volatile signaling molecule regulating the vascular permeabili...
journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
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journal_title：Vascular pharmacology
pub_type： 杂志文章
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journal_title：Vascular pharmacology
pub_type： 杂志文章,评审
doi：10.1016/s1537-1891(02)00121-0
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.06.001
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2008.11.002
更新日期：2009-03-01 00:00:00
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journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2004.10.002
更新日期：2004-05-01 00:00:00
abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...
journal_title：Vascular pharmacology
pub_type： 杂志文章
doi：10.1016/j.vph.2005.08.005
更新日期：2005-12-01 00:00:00
abstract：:The implications of altered coagulation-fibrinolytic system in the pathophysiology of several vascular disorders, such as stroke and myocardial infarction, have been well researched upon and established. However, its role in the progression of diabetic retinopathy has not been explored much. Since a decade, it is know...
journal_title：Vascular pharmacology
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doi：10.1016/j.vph.2017.03.005
更新日期：2017-05-01 00:00:00
