Abstract：
BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2) between 9 and 11 kPa over 180 min). At the baseline point and after 180 min of mechanical ventilation, a neutrophil count, luminol-dependent chemiluminescence of the neutrophils stimulated with opsonized zymosan (OZ) or PMA (phorbol myristate acetate), and the hydrogen peroxide production of the cells upon the PMA stimulation were measured. Serum cortisol levels were additionally determined. RESULTS:In both studied groups, a significant neutrophilia after 180 min of mechanical ventilation was observed (P<.05). Neither chemiluminescence nor hydrogen peroxide production of peripheral neutrophils was changed (P>.05). CONCLUSIONS:Hypercapnia lasting for 180 min did not affect the oxidative metabolism of circulating neutrophils but a rise in a neutrophil count was observed in the mechanically ventilated rabbit.
journal_name
Vascul Pharmacoljournal_title
Vascular pharmacologyauthors
Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz Mdoi
10.1016/s1537-1891(02)00338-5keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
119-25issue
2eissn
1537-1891issn
1879-3649pii
S1537189102003385journal_volume
40pub_type
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