当前位置： SCI文献检索 > VASCULAR PHARMACOLOGY期刊下所有文献 > Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats.

Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats.

Abstract：

:Our previous studies in heterozygous Ren-2 transgenic rats (TGR) have shown that early treatment with selective endothelin (ET)(A) receptor blockade is superior to nonselective ET(A/B) receptor blockade. The aim of this study was to evaluate the role of the ET system in male heterozygous TGR with established hypertension (late-onset treatment). TGR and control Hannover Sprague-Dawley (HanSD) rats were fed a high-salt diet and were treated concomitantly with the nonselective ET(A/B) receptor blocker bosentan or the selective ET(A) receptor blocker atrasentan from day 52 of age on. Survival rate was partly increased by bosentan and fully normalized with atrasentan. Bosentan transiently decreased blood pressure (BP), whereas atrasentan significantly reduced BP as early as one week after the start of the treatment. This effect persisted for the whole experimental period. Atrasentan also substantially reduced cardiac hypertrophy, proteinuria, glomerulosclerosis and left ventricle ET-1 content. Bosentan improved and atrasentan almost restored podocyte architecture and reversed changes in podocyte phenotype represented by the expression of CD 10, desmin and vimentin. Our results demonstrate that selective ET(A) receptor blockade has more favorable effects than nonselective ET(A/B) receptor blockade and, unlike observed in homozygous TGR, ET(A) receptor blockade has similar effects in heterozygous rats with established hypertension as in young animals with developing hypertension.

journal_name

Vascul Pharmacol

journal_title

Vascular pharmacology

authors

Vernerová Z,Kramer HJ,Bäcker A,Cervenka L,Opocenský M,Husková Z,Vanourková Z,Eis V,Chábová VC,Tesar V,Malý J,Vanecková I

doi

10.1016/j.vph.2008.01.009

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

165-73

issue

4-6

eissn

1537-1891

issn

1879-3649

pii

S1537-1891(08)00020-7

journal_volume

48

pub_type

杂志文章

相关文献

VASCULAR PHARMACOLOGY文献大全
  • Systemic inflammatory response syndromes in the era of interventional cardiology.

    abstract：:Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophys...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.04.003

    authors： Gorla R,Erbel R,Eagle KA,Bossone E

    更新日期：2018-04-12 00:00:00

  • Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts.

    abstract：:Activation of ATP-sensitive K+ channels (K ATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal K ATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial K ATP channel blocker on cardiac fun...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.11.006

    authors： Gok S,Vural K,Sekuri C,Onur R,Tezcan A,Izanli A

    更新日期：2006-04-01 00:00:00

  • β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

    abstract：:β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2014.04.003

    authors： Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

    更新日期：2014-05-01 00:00:00

  • Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice.

    abstract：:Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.05.001

    authors： Roth L,Van der Donckt C,Emini Veseli B,Van Dam D,De Deyn PP,Martinet W,Herman AG,De Meyer GRY

    更新日期：2019-01-01 00:00:00

  • SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification.

    abstract：:The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 or phytate): 1. Inhibits induced calcification in cultured aortic valve interstitial cells (VIC) as an in vitro model of aortic valve stenosis and 2. Whether inhibition is different in VIC obtaine...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2019.106583

    authors： Zabirnyk A,Ferrer MD,Bogdanova M,Pérez MM,Salcedo C,Kaljusto ML,Kvitting JP,Stensløkken KO,Perelló J,Vaage J

    更新日期：2019-01-01 00:00:00

  • Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.

    abstract：:Unresolved endoplasmic reticulum (ER) stress, with the subsequent persistent activation of the unfolded protein response (UPR) is a well-recognized mechanism of endothelial cell apoptosis with a major impact on the integrity of the endothelium during the course of cardiovascular diseases. As in other cell types, Ca(2+...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.07.011

    authors： Ampem PT,Smedlund K,Vazquez G

    更新日期：2016-01-01 00:00:00

  • Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

    abstract：:Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2016.10.001

    authors： Sangartit W,Pakdeechote P,Kukongviriyapan V,Donpunha W,Shibahara S,Kukongviriyapan U

    更新日期：2016-12-01 00:00:00

  • Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.

    abstract：BACKGROUND:Dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE(-/-)) mice, and examined its effects on endothelial function. METHODS AND ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.08.011

    authors： Salim HM,Fukuda D,Higashikuni Y,Tanaka K,Hirata Y,Yagi S,Soeki T,Shimabukuro M,Sata M

    更新日期：2016-04-01 00:00:00

  • Regulation of angiogenesis by a small GTPase Rap1.

    abstract：:Small GTPase Rap1 has been extensively studied in vitro and shown to regulate multiple basic cellular processes. Until recently, the best studied aspect of Rap1 function in endothelial cells involved its role in regulation of cell-cell junction formation and remodeling. These in vitro studies have increased understand...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2010.03.003

    authors： Chrzanowska-Wodnicka M

    更新日期：2010-07-01 00:00:00

  • Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: sodium nitroprusside and a new ruthenium complex.

    abstract：:We studied the mechanisms involved in the relaxation induced by nitric oxide (NO) donors, ruthenium complex ([Ru(terpy)(bdq)NO(+)](3+)-TERPY) and sodium nitroprusside (SNP) in denuded rat aorta. Both NO donors induced vascular relaxation independent of the agonist used in the pre-contraction. [Ru(terpy)(bdq)NO(+)](3+)...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.10.002

    authors： Bonaventura D,de Lima RG,Vercesi JA,da Silva RS,Bendhack LM

    更新日期：2007-03-01 00:00:00

  • Detection and implications of potassium channel alterations.

    abstract：:Potassium channel dysfunction plays a role in the pathogenesis of a number of vascular diseases including pulmonary and systemic hypertension, diabetes, and complications of atherosclerosis. Two types of K+ channels that are known to be prevalent and contribute significantly to the repolarization of vascular smooth mu...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1537-1891(02)00121-0

    authors： Korovkina VP,England SK

    更新日期：2002-01-01 00:00:00

  • Lipoic acid decreases exhaled nitric oxide concentrations in anesthetized endotoxemic rats.

    abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.08.005

    authors： De Marco VG,Bosanquet JP,Rawlani VR,Skimming JW

    更新日期：2005-12-01 00:00:00

  • B cells treated with CTB-p210 acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient mice.

    abstract：OBJECTIVE:Intranasal immunization with a fusion protein of the ApoB100-derived peptide p210 and the cholera toxin B subunit (CTB-p210) has previously been shown to induce mucosal tolerance and reduce atherosclerosis development, but the exact mode of action remains to be elucidated. Recent studies have indicated an imp...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2018.09.002

    authors： Rattik S,Mantani PT,Yao Mattisson I,Ljungcrantz I,Sundius L,Björkbacka H,Terrinoni M,Lebens M,Holmgren J,Nilsson J,Wigren M,Nordin Fredrikson G

    更新日期：2018-12-01 00:00:00

  • Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis.

    abstract：:Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stabl...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2018.06.014

    authors： Perrotta P,Emini Veseli B,Van der Veken B,Roth L,Martinet W,De Meyer GRY

    更新日期：2019-01-01 00:00:00

  • Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca(2+) stores and inhibition of capacitative calcium entry.

    abstract：:Despite a large number of studies, the mechanism by which 3',5'-cyclic monophosphate (cAMP) induces vasorelaxation is not fully understood. The comparison between results obtained in different vessels or species has often been the source of conflicting reports. In order to shed more light onto this mechanism, we studi...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.08.007

    authors： Cuíñas A,Elíes J,Orallo F,Campos-Toimil M

    更新日期：2013-01-01 00:00:00

  • Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide.

    abstract：:Since the discovery of the importance of nitric oxide (NO) to the human body three decades ago, numerous laboratory and clinical studies have been done to explore its potential therapeutic actions on many organs. In the cardiovascular system, NO works as a volatile signaling molecule regulating the vascular permeabili...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2014.08.001

    authors： Ma S,Ma CC

    更新日期：2014-11-01 00:00:00

  • Na(+)/H(+) exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2(+) mobilization.

    abstract：:The objective of this study was to determine the mechanism by which Na(+)/H(+) exchanger (NHE) inhibitors induce vasodilatation. The NHE inhibitors, 5-(N,N-dimethyl)-amiloride (DMA), cariporide, and amiloride, evoked endothelium-dependent relaxation in rat aortas with ED50 values of 16, 89, and 148μM, respectively, an...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2012.11.004

    authors： Sasahara T,Yayama K,Matsuzaki T,Tsutsui M,Okamoto H

    更新日期：2013-04-01 00:00:00

  • Role of altered coagulation-fibrinolytic system in the pathophysiology of diabetic retinopathy.

    abstract：:The implications of altered coagulation-fibrinolytic system in the pathophysiology of several vascular disorders, such as stroke and myocardial infarction, have been well researched upon and established. However, its role in the progression of diabetic retinopathy has not been explored much. Since a decade, it is know...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2017.03.005

    authors： Behl T,Velpandian T,Kotwani A

    更新日期：2017-05-01 00:00:00

  • Macro- and microvascular disease in systemic sclerosis.

    abstract：:Vasculopathy is common in patients with connective tissue disease and can be directly implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune multiorgan connective tissue disorder characterized by fibrosis of the skin and visceral organs and vascular disease. Micro- and macro-vessels are a ...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2015.05.015

    authors： Kavian N,Batteux F

    更新日期：2015-08-01 00:00:00

  • Treatment of experimental immune complex glomerulonephritis by sodium alginate.

    abstract：:We have studied the therapeutic efficacy of the sodium alginate in experimental immune complex glomerulonephritis. Bovine serum albumin (BSA) nephritis was induced in rats by a subcutaneous immunization and daily intravenous administration of BSA. Sodium alginate at two different doses (25 and 50 mg/kg) was administer...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2005.03.002

    authors： Mirshafiey A,Borzooy Z,Abhari RS,Razavi A,Tavangar M,Rehm BH

    更新日期：2005-06-01 00:00:00

  • "ApoptomiRs" in vascular cells: their role in physiological and pathological angiogenesis.

    abstract：:MicroRNAs (miRNAs) have emerged as crucial players regulating the magnitude of gene expression in a variety of organisms. This class of short (22 nucleotides) noncoding RNA molecules have been shown to participate in almost every cellular process investigated so far, and their deregulation is observed in different hum...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.vph.2011.07.004

    authors： Quintavalle C,Garofalo M,Croce CM,Condorelli G

    更新日期：2011-10-01 00:00:00

  • Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells.

    abstract：BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2008.09.001

    authors： Star GP,Giovinazzo M,Langleben D

    更新日期：2009-01-01 00:00:00

  • Contractile effect of ghrelin on isolated guinea-pig renal arteries.

    abstract：:Ghrelin, a 28-amino acid peptide, known to exist in both acylated and des-acylated varieties, was identified as the first endogenous ligand of growth hormone secretagogue receptor in 1999. Various arteries are known to express ghrelin receptors, but the direct action of ghrelin on blood vessels has been unclear. In th...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2007.03.004

    authors： Dimitrova DZ,Mihov DN,Wang R,Hristov KL,Rizov LI,Bolton TB,Duridanova DB

    更新日期：2007-07-01 00:00:00

  • Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids.

    abstract：:Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor sub...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.06.017

    authors： de Souza Rossignoli P,Yamamoto FZ,Pereira OC,Chies AB

    更新日期：2015-09-01 00:00:00

  • Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.

    abstract：:Endothelial cell dysfunction may play an important role in the development of various vascular diseases, including atherosclerosis. Here we investigated whether lithium chloride (LiCl), an inhibitor of glycogen synthase kinase-3β (GSK-3β), could counteract atherosclerosis induced by a high-fat diet in ApoE⁻/⁻ mice. Te...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2010.09.004

    authors： Choi SE,Jang HJ,Kang Y,Jung JG,Han SJ,Kim HJ,Kim DJ,Lee KW

    更新日期：2010-11-01 00:00:00

  • Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.

    abstract：:Recent studies evidence that peroxynitrite is spontaneously formed when nitric oxide (NO) and superoxide coexist and suggest that it is likely to be involved in the destruction of the pancreatic beta cells. We examined whether drugs that inhibit nitric oxide synthase (NOS) or scavenge peroxynitrite could abrogate STZ-...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1537-1891(02)00212-4

    authors： Rao VS,Santos FA,Silva RM,Teixiera MG

    更新日期：2002-03-01 00:00:00

  • Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.

    abstract：:To investigate mechanisms of protective effects of fenofibrate on the diabetic kidney, male Wistar rats were divided into control, untreated diabetes, and fenofibrate-treated (32 mg kg(-1) d(-1), 8 weeks) diabetes groups. Diabetes induced by streptozotocin (25 mg/kg) and a high-fat diet was characterized by the disord...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.01.004

    authors： Chen LL,Zhang JY,Wang BP

    更新日期：2006-05-01 00:00:00

  • Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.

    abstract：RATIONALE:We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. METHODS:Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC a...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2006.05.006

    authors： Beckles DL,Mascareno E,Siddiqui MA

    更新日期：2006-12-01 00:00:00

  • Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.

    abstract：:This study examined the effects of a novel orally active 14,15-epoxyeicosatrienoic acid analog (EET-A) on blood pressure (BP) and myocardial infarct size (IS) in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats during sustained phase of hypertension. Between days 31 and 35 after clip placement the rats were tre...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2015.08.013

    authors： Alánová P,Husková Z,Kopkan L,Sporková A,Jíchová Š,Neckář J,Imig JD,Klevstig M,Kolář F,Rami Reddy N,Falck JR,Sadowski J,Nishiyama A,Kramer HJ,Melenovský V,Červenková L,Kujal P,Vernerová Z,Červenka L

    更新日期：2015-10-01 00:00:00

  • Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia.

    abstract：:The present study investigates the potential of ozagrel, a thromboxane A2 (TXA2) synthase inhibitor, in bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water maze (MWM) test was employed on 7th day p...

    journal_title：Vascular pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.vph.2020.106827

    authors： Bhatia P,Kaur G,Singh N

    更新日期：2020-12-17 00:00:00