Spectrum of immune-mediated necrotizing myopathies and their treatments.

abstract：:The spondyloarthropathies are diseases influenced by genetic predisposition and, to a varying extent, infectious triggers. A causal role for bacterial infections is most clear for reactive arthritis. Recent insights into arthritogenic components of bacteria may set the stage for a better understanding of disease patho...

journal_title：Current opinion in rheumatology

authors： Pacheco-Tena C,Zhang X,Stone M,Burgos-Vargas R,Inman RD

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Much has been documented in recent years on the possible involvement of angiogenesis in osteoarthritis. An understanding of the various regulatory mechanisms controlling blood vessel growth in the joint should lead to novel therapeutics, which selectively inhibit undesirable angiogenesis. Here, we sum...

journal_title：Current opinion in rheumatology

authors： Ashraf S,Walsh DA

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy. RECENT FINDINGS:Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscl...

journal_title：Current opinion in rheumatology

authors： Mammen AL

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a risk-stratified and evidence-based management for subsets of systemic sclerosis (SSc) patients in the first five years from disease onset. RECENT FINDINGS:Cardiopulmonary disease remains the primary cause of mortality in SSc patients. Morbidity and mortality in SSc-associated p...

journal_title：Current opinion in rheumatology

authors： Roofeh D,Khanna D

更新日期：2020-05-01 00:00:00

abstract：:With the opportunity for long-term follow-up, it has been appreciated that disease severity may vary considerably in patients with Wegener's granulomatosis, polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Although combined therapy with cyclophosphamide and glucocorticoids continues to be th...

journal_title：Current opinion in rheumatology

authors： Langford CA,Sneller MC

更新日期：1997-01-01 00:00:00

abstract：:In hip replacement, prophylaxis of thromboembolism with warfarin to 1.5 times control with respect to prothrombin time remains efficacious. Further reduction of the dosage has not met with success. Confirmatory studies on the usefulness of adjusted-dose heparin and low molecular weight heparin continue. Promising new ...

journal_title：Current opinion in rheumatology

authors： Yen D

更新日期：1992-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...

journal_title：Current opinion in rheumatology

authors： Boland P,Heath J,Sandigursky S

更新日期：2020-01-01 00:00:00

abstract：:Eosinophilic infiltration into skeletal muscle, although rare, has been described in a diverse group of conditions. It most commonly occurs in parasitic infection as focal eosinophilic myositis but can be a feature of systemic hypereosinophilic conditions such as eosinophilia-myalgia syndrome and idiopathic hypereosin...

journal_title：Current opinion in rheumatology

authors： Pickering MC,Walport MJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent progress in the understanding of various aspects of renal transport of urate. RECENT FINDINGS:Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. The mo...

journal_title：Current opinion in rheumatology

authors： Anzai N,Kanai Y,Endou H

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses genomic investigations in ankylosing spondylitis (AS) beyond genome-wide association (GWA) studies, but prior to this, genetic variants achieving genome-wide significance will be summarized highlighting key pathways contributing to disease pathogenesis. RECENT FINDINGS:Evidence...

journal_title：Current opinion in rheumatology

authors： O'Rielly DD,Uddin M,Rahman P

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00

abstract：:The emergence of various therapeutic possibilities in the field of osteoarthritis has strongly prompted clinicians to conduct studies to evaluate the symptomatic as well as the potential chondromodulating effects of these treatments. For this purpose, some authors recently proposed guidelines with regard not only to t...

journal_title：Current opinion in rheumatology

authors： Dougados M

更新日期：1995-03-01 00:00:00

abstract：:The eosinophilia-myalgia syndrome, which is associated with the ingestion of L-tryptophan that contained products, occurred as an epidemic in the United States in 1989. Eosinophilia-myalgia syndrome is similar in many ways to the toxic-oil syndrome, which occurred in Spain in 1981, and to diffuse fasciitis with eosino...

journal_title：Current opinion in rheumatology

authors： Silver RM

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To review and interpret the recently published data on hyperuricemia and cardiovascular disease to present an opinion on the nature of link between serum uric acid concentration and the risk for cardiovascular outcomes, and to comment on its implications for clinical practice. RECENT FINDINGS:Evidenc...

journal_title：Current opinion in rheumatology

authors： Krishnan E,Sokolove J

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

journal_title：Current opinion in rheumatology

authors： Asquith M,Rosenbaum JT

更新日期：2016-07-01 00:00:00

abstract：:Psoriatic arthritis is an inflammatory arthropathy associated with psoriasis and is classified as a seronegative spondyloarthropathy. It occurs in approximately 5% to 7% of patients with psoriasis. The etiopathogenesis of psoriatic arthritis is not well known, but interaction among genetic, immunologic, and environmen...

journal_title：Current opinion in rheumatology

authors： Espinoza LR,Cuéllar ML,Silveira LH

更新日期：1992-08-01 00:00:00

abstract：:Shoulder injuries are common in the athletic population. Injuries can be a result of repetitive overhead use or from direct trauma. Common injury sites include the rotator cuff, glenohumeral joint, acromioclavicular joint, biceps tendon, scapulothoracic articulation, and sternoclavicular joint. The identification, phy...

journal_title：Current opinion in rheumatology

authors： Ong BC,Sekiya JK,Rodosky MW

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...

journal_title：Current opinion in rheumatology

authors： Yelin E

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will highlight recent advances functionally linking the gut microbiome with mucosal and systemic immune cell activation underlying autoimmunity. RECENT FINDINGS:Dynamic interactions between the gut microbiome and environmental cues (including diet and medicines) shape the effector potenti...

journal_title：Current opinion in rheumatology

authors： Longman RS,Littman DR

更新日期：2015-07-01 00:00:00

abstract：:A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoim...

journal_title：Current opinion in rheumatology

authors： Parker PM,Openshaw H,Forman SJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:IgG4-related disease (IgG4-RD) is a recently described fibroinflammatory condition that can affect nearly any organ. Our knowledge of this condition--its manifestations, diagnosis, pathogenesis and treatment--is expanding rapidly. RECENT FINDINGS:This review highlights the most recent developments in...

journal_title：Current opinion in rheumatology

authors： Wallace ZS,Stone JH

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, with typical skin manifestations of dermatomyositis but little or no evidence of myositis. This review focuses on updates on epidemiology, clinical manifestations, and autoantibody profiles in patients with CADM. RECE...

journal_title：Current opinion in rheumatology

authors： Sato S,Kuwana M

更新日期：2010-11-01 00:00:00

abstract：:Current advances in the study of hypertrophic osteoarthropathy are discussed. An update of the classification of hypertrophic osteoarthropathy is given in which the POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is included among the associated diseases. Cyanotic heart disea...

journal_title：Current opinion in rheumatology

authors： Martínez-Lavín M

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides an update on the recent findings on autoantibodies to modified proteins in rheumatoid arthritis (RA). RECENT FINDINGS:In the past few years, the knowledge on the autoantibodies to citrullinated antigens has expanded considerably. More specifically, it is now clear that many diff...

journal_title：Current opinion in rheumatology

authors： Toes RE,Huizinga TJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review advances in the understanding of potentially causal relationships between gout, hyperuricemia and comorbidities. RECENT FINDINGS:Observational studies reveal 4-5 comorbidity clusters in gout patients. There tend to be gout alone, gout with chronic kidney disease and gout with other metaboli...

journal_title：Current opinion in rheumatology

authors： Sumpter NA,Saag KG,Reynolds RJ,Merriman TR

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immu...

journal_title：Current opinion in rheumatology

authors： Weyand CM,Yang Z,Goronzy JJ

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent efficacy and safety data comparing methotrexate (MTX) and leflunomide (LEF) monotherapy, in combination with biologic therapies and in combination with each other. RECENT FINDINGS:MTX is the 'anchor drug' in all rheumatoid arthritis treatment strategies. Patients with contraindic...

journal_title：Current opinion in rheumatology

authors： Singer O,Gibofsky A

更新日期：2011-05-01 00:00:00

abstract：:Systemic lupus erythematosus and Sjögren syndrome remain elusive in the description of their underlying etiologic causes and pathogenic mechanisms. Although underlying genetic predisposition appears to contribute to both diseases based on twin and other genetic studies, additional factors must play a role. Over the de...

journal_title：Current opinion in rheumatology

authors： James JA,Harley JB,Scofield RH

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to evaluate recent trials and studies of different types of physical activity programs for individuals with chronic arthritis and to discuss recommendations and findings from systematic reviews of physical activity interventions. RECENT FINDINGS:Recent randomized control...

journal_title：Current opinion in rheumatology

authors： Callahan LF

更新日期：2009-03-01 00:00:00

abstract：:Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed self-antigens. Autoantigens in systemic lupus erythematosus are highly diverse in terms of structure and location in control cells, but become clust...

journal_title：Current opinion in rheumatology

authors： White S,Rosen A

更新日期：2003-09-01 00:00:00