Abstract:
PURPOSE OF REVIEW:To review advances in the understanding of potentially causal relationships between gout, hyperuricemia and comorbidities. RECENT FINDINGS:Observational studies reveal 4-5 comorbidity clusters in gout patients. There tend to be gout alone, gout with chronic kidney disease and gout with other metabolic comorbidities. However, heterogeneous study populations and confounding make inference difficult for causal relationships. Mendelian randomization leverages genetic information as an instrumental variable to indicate putatively causal relationships between traits of epidemiological interest. Thus far, Mendelian randomization has not indicated widespread causal relationships of serum urate for comorbid traits. However, BMI has a small causal effect on serum urate, which may partially explain the increased prevalence of metabolic syndrome and cardiovascular disease among those with gout and hyperuricemia. There is a lack of robust and sufficiently powered Mendelian randomization studies for many serum urate-associated traits, such as hypertension. No adequately powered studies have been completed for gout and its comorbidities. SUMMARY:Although observational studies indicate putative causal effects of serum urate on comorbidities, Mendelian randomization studies suggest that serum urate does not have a causal role on the various tested comorbidities. There remains work to be done in clarifying the causal role of gout per se on the same traits.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Sumpter NA,Saag KG,Reynolds RJ,Merriman TRdoi
10.1097/BOR.0000000000000691subject
Has Abstractpub_date
2020-03-01 00:00:00pages
126-133issue
2eissn
1040-8711issn
1531-6963pii
00002281-202003000-00003journal_volume
32pub_type
杂志文章,评审abstract::This study reviews articles published in 2000 and 2001 about occupational physical activities as risk factors for osteoarthritis (OA) of the knee and hip. Six studies were identified in MEDLINE and EMBASE; five case-control studies and one cross-sectional study. Criteria for OA were: (on the waiting list for) joint re...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200203000-00002
更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:It is an understatement to say that drug approvals in systemic lupus erythematosus (SLE), lupus nephritis, and Sjogren's syndrome have lagged far behind those in other autoimmune diseases, such as rheumatoid arthritis and psoriatic arthritis. Reasons for this are multiple and include the molecular and...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/BOR.0000000000000754
更新日期:2020-11-01 00:00:00
abstract::Tumor necrosis factor-alpha, acting through its receptors expressed on all cells of the body, is a key mediator of inflammation and immunity. However, its overproduction may also lead to pathologic changes. The latter situation occurs often in chronic inflammatory diseases such as rheumatoid arthritis. The concept sug...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200305000-00014
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abstract:PURPOSE OF REVIEW:This review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs). RECENT FINDINGS:Autoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define tw...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000335
更新日期:2016-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328363eb08
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000245722.10136.6d
更新日期:2006-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328349c3b1
更新日期:2011-09-01 00:00:00
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journal_title:Current opinion in rheumatology
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doi:10.1097/00002281-200211000-00008
更新日期:2002-11-01 00:00:00
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000387
更新日期:2017-07-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282f01625
更新日期:2007-11-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:2011-05-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000172799.03379.86
更新日期:2005-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-08-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200307000-00009
更新日期:2003-07-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000265
更新日期:2016-05-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200105000-00010
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200205000-00018
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199112000-00010
更新日期:1991-12-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200109000-00005
更新日期:2001-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000598
更新日期:2019-05-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328341137d
更新日期:2011-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32835b13e1
更新日期:2013-01-01 00:00:00