Myositis associated with graft-versus-host disease.

abstract：PURPOSE OF REVIEW:To review the recent efficacy and safety data comparing methotrexate (MTX) and leflunomide (LEF) monotherapy, in combination with biologic therapies and in combination with each other. RECENT FINDINGS:MTX is the 'anchor drug' in all rheumatoid arthritis treatment strategies. Patients with contraindic...

journal_title：Current opinion in rheumatology

authors： Singer O,Gibofsky A

更新日期：2011-05-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather than a focal disorder of synovial joints. RECENT FINDINGS:Inflammation was seen as the key component promoting synovitis as well as progression of cartilage and ...

journal_title：Current opinion in rheumatology

authors： Malemud CJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on the new interleukin-1 (IL-1) cytokine family members in inflammatory diseases with focus on recent findings concerning the family members IL-36, IL-37, and IL-38 and their different expression patterns. RECENT FINDINGS:The IL-1 cytokines are known to be involved in m...

journal_title：Current opinion in rheumatology

authors： Hahn M,Frey S,Hueber AJ

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile dermatomyositis is a rare chronic inflammatory disease that primarily affects the muscles and skin. Immunosuppressive therapy has played a very important role in reducing mortality rates and morbidity. The review focuses on the spectrum of medications currently used in the treatment of juveni...

journal_title：Current opinion in rheumatology

authors： Stringer E,Feldman BM

更新日期：2006-09-01 00:00:00

abstract：:In the United States, Lyme disease is the most common arthropod-borne infection. The majority of cases are reported from the Northeast, the Midwest, and California, which are areas with established foci of Borrelia burgdorferi. Advances in the understanding of the epidemiology of Ixodes ticks, the established vector f...

journal_title：Current opinion in rheumatology

authors： Evans J

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

journal_title：Current opinion in rheumatology

authors： Asquith M,Rosenbaum JT

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...

journal_title：Current opinion in rheumatology

authors： Yelin E

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Wound healing is a normal physiological response to tissue injury which can occur in any organ. Mechanisms that orchestrate wound healing in different organs are surprisingly generic, involving generation of fibroblasts and myofibroblasts by differentiation processes that require extensive alterations...

journal_title：Current opinion in rheumatology

authors： Mann J,Mann DA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review pharmacologic and nonpharmacologic therapies in the treatment of systemic sclerosis (SSc) from 2011 to 2014 through a systematic review. RECENT FINDINGS:Our systematic review identifies randomized controlled trials, meta-analyses, systematic reviews, case series, and observational studies w...

journal_title：Current opinion in rheumatology

authors： Young A,Khanna D

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections play a role in the pathogenesis of autoimmune diseases (AID). Several bacterial and viral pathogens play a double role, as both inducers and inhibitors of AID. In this review, we will present current evidence and discuss different aspects of this notion. RECENT FINDINGS:Infectors that both...

journal_title：Current opinion in rheumatology

authors： Shamriz O,Shoenfeld Y

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Rheumatoid arthritis (RA) is a systemic, autoimmune disease resulting in the destruction of affected joints. Even though current therapies with biologics such as tumor necrosis factor-alpha blockers yield significant improvement for the patients, the disease is not curable yet. Therefore, we need nove...

journal_title：Current opinion in rheumatology

authors： Jüngel A,Ospelt C,Gay S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Myositis, or idiopathic inflammatory myopathy, is an overarching concept that includes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome. Glucocorticoids are still considered the mainstay of treatment of myositis but some patients require add-on immuno...

journal_title：Current opinion in rheumatology

authors： Pipitone N,Salvarani C

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review and interpret the recently published data on hyperuricemia and cardiovascular disease to present an opinion on the nature of link between serum uric acid concentration and the risk for cardiovascular outcomes, and to comment on its implications for clinical practice. RECENT FINDINGS:Evidenc...

journal_title：Current opinion in rheumatology

authors： Krishnan E,Sokolove J

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Raynaud phenomenon is the earliest and most common clinical manifestations of scleroderma (systemic sclerosis). Therefore, Raynaud phenomenon offers the best window into the investigation of the early steps in the pathogenesis of systemic sclerosis. This review focuses on the differential diagnosis of...

journal_title：Current opinion in rheumatology

authors： Kahaleh MB

更新日期：2004-11-01 00:00:00

abstract：:Recent studies have revealed the important role of streptococci in the etiology of Behçet's disease. Among patients with Behçet's disease, there is a high incidence of a history of streptococcal infections. Certain antigens of streptococci induced not only cutaneous, delayed-type hypersensitivity, but also systemic at...

journal_title：Current opinion in rheumatology

authors： Mizushima Y

更新日期：1991-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Although osteoarthritis (OA) has received a paucity of attention from researchers in terms of drug development, there have been some significant findings relevant to clinical issues in OA that are summarized in this review. RECENT FINDINGS:Recent osteoarthritis research has focused on synovial, subch...

journal_title：Current opinion in rheumatology

authors： Kalunian KC

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the central role of pain in osteoarthritis, until recently, relatively little attention was paid to the osteoarthritis pain experience, including the features of osteoarthritis pain that are most important to people living with this disease. The focus of this review is on recent advances in ou...

journal_title：Current opinion in rheumatology

authors： Hawker GA

更新日期：2009-09-01 00:00:00

abstract：:Significant advances were made this year in the understanding of serum amyloid A isotypes and in the definition of different amyloid light-chain proteins. Increasing numbers of hereditary amyloid-related transthyretin mutations have been reported (more than 30 to date). Two new hereditary amyloid proteins in several d...

journal_title：Current opinion in rheumatology

authors： Cohen AS

更新日期：1994-01-01 00:00:00

abstract：:The evolution of total knee replacement designs and techniques has made possible predictable and long-lasting pain relief in the treatment of knee arthritis. Excellent long-term results have been obtained with cemented knee replacement, with or without preservation of the posterior cruciate ligament. Attempts to achie...

journal_title：Current opinion in rheumatology

authors： Buly RL,Sculco TP

更新日期：1995-03-01 00:00:00

abstract：:With the opportunity for long-term follow-up, it has been appreciated that disease severity may vary considerably in patients with Wegener's granulomatosis, polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Although combined therapy with cyclophosphamide and glucocorticoids continues to be th...

journal_title：Current opinion in rheumatology

authors： Langford CA,Sneller MC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs...

journal_title：Current opinion in rheumatology

authors： Ansboro S,Roelofs AJ,De Bari C

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the emergence, clinical features, pathogenesis, and treatment of acute chikungunya (CHIK) fever and chronic CHIK arthritis. RECENT FINDINGS:Since 2004, CHIK, an arboviral infection, has spread throughout the world, infecting millions of people. The illness occurs in two phases: an acute vir...

journal_title：Current opinion in rheumatology

authors： Sutaria RB,Amaral JK,Schoen RT

更新日期：2018-05-01 00:00:00

abstract：:The first part of this article draws together descriptive studies on the direct medical costs of osteoporosis. The second part is devoted to economic evaluation of 1) osteoporosis treatment on the basis of clinical criteria and 2) preventive strategies, some of them including bone mineral density screening. These anal...

journal_title：Current opinion in rheumatology

authors： Joel ME,Le Gales C

更新日期：1998-07-01 00:00:00

abstract：:Due to our increasing knowledge of mechanisms underlying pathogenic events in autoimmune rheumatic diseases, biologic agents have been further explored and tested in open and controlled clinical trials. Based on the results of placebo-controlled trials, monoclonal antibodies to CD4+ T cells have been found ineffective...

journal_title：Current opinion in rheumatology

authors： Kalden JR,Manger B

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Much has been documented in recent years on the possible involvement of angiogenesis in osteoarthritis. An understanding of the various regulatory mechanisms controlling blood vessel growth in the joint should lead to novel therapeutics, which selectively inhibit undesirable angiogenesis. Here, we sum...

journal_title：Current opinion in rheumatology

authors： Ashraf S,Walsh DA

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Current treatment of ankylosing spondylitis such as non-steroidal anti-inflammatory drugs and tumor necrosis factor (TNF)-blockers have shown a good efficacy on sign and symptoms. However, it is less clear whether and how structural damage, determined mainly by new bone formation, can be prevented. Re...

journal_title：Current opinion in rheumatology

authors： Sieper J

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight recent evidence regarding the contribution of traditional and nontraditional [e.g. inflammatory markers, rheumatoid arthritis (RA) features] risk factors toward the excess cardiovascular risk in RA. RECENT FINDINGS:The impact of traditional risk factors on the development of cardiovascul...

journal_title：Current opinion in rheumatology

authors： Gabriel SE,Crowson CS

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis. RECENT FINDINGS:Highlights include further elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/peptide antibody generation, including identification of putative citrul...

journal_title：Current opinion in rheumatology

authors： Cooles FA,Isaacs JD

更新日期：2011-05-01 00:00:00

abstract：:HLA-B27 is virtually absent in most of the sub-Saharan Africa populations, and ankylosing spondylitis is rare; only a few patients have been reported from central and southern Africa. HLA-B27 was present in only one of 17 patients (6%). The disease shows clinical features that are similar to those observed in white HL...

journal_title：Current opinion in rheumatology

authors： Mijiyawa M,Oniankitan O,Khan MA

更新日期：2000-07-01 00:00:00