The novel interleukin-1 cytokine family members in inflammatory diseases.

abstract：PURPOSE OF REVIEW:Antisynthetase syndrome (ASyS) is an acquired myopathy characterized by the presence of myositis-specific autoantibodies directed against tRNA-synthetases. ASyS is potentially life threatening due to lung involvement and treatment remains a challenge to date. With symptoms not limited to muscles but a...

journal_title：Current opinion in rheumatology

authors： Gallay L,Gayed C,Hervier B

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...

journal_title：Current opinion in rheumatology

authors： Clarke JT,Werth VP

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Axial spondyloarthritis (AxSpA) is a distinct clinical entity with characteristic clinical and radiographic features; however, a multitude of other metabolic, infectious and inflammatory disorders mimic it both clinically and radiographically. RECENT FINDINGS:We present in this review article recent ...

journal_title：Current opinion in rheumatology

authors： Merjanah S,Igoe A,Magrey M

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis. RECENT FINDINGS:Highlights include further elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/peptide antibody generation, including identification of putative citrul...

journal_title：Current opinion in rheumatology

authors： Cooles FA,Isaacs JD

更新日期：2011-05-01 00:00:00

abstract：:Methotrexate has become a standard therapy for the treatment of rheumatoid arthritis. This review summarizes the recent literature on low-dose methotrexate in the rheumatologic illnesses. The effect of methotrexate on in vivo rheumatoid factor production and suppression of ex vivo leukotriene B4 generation is reviewed...

journal_title：Current opinion in rheumatology

authors： Grosflam J,Weinblatt ME

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent evidence on cutaneous manifestations of lupus, with a focus on evidence for pediatric patients. RECENT FINDINGS:Cutaneous manifestations of SLE are common and may precede signs or symptoms of systemic disease. Early recognition and initiation of therapy improves quality of life by re...

journal_title：Current opinion in rheumatology

authors： Arkin LM,Nguyen C,Klein-Gitelman M

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature on the association of infection with early arthritis, and to discuss the possible role of such infections with respect to the development of chronic rheumatic complications. RECENT FINDINGS:Viral infections are frequently associated with arthritis. Alphaviruses belo...

journal_title：Current opinion in rheumatology

authors： Leirisalo-Repo M

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a s...

journal_title：Current opinion in rheumatology

authors： Nishi H,Mayadas TN

更新日期：2019-03-01 00:00:00

abstract：:The recent literature pertaining to tumors of articular structures and bone is reviewed. In pigmented villonodular synovitis, the bone resorptive cell is a macrophage polykaryon rather than an osteoclast. Complete arthroscopic synovectomy was successful in most diffuse articular forms of the disease. The early synovia...

journal_title：Current opinion in rheumatology

authors： Abraham JH 3rd,Canoso JJ

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Exercise was established as an integral part of the nonpharmacological treatment of fibromyalgia approximately 20 years ago. Since then many studies have investigated the effects of exercise-either alone or in combination with other interventions. This review will discuss the benefits of exercise alon...

journal_title：Current opinion in rheumatology

authors： Gowans SE,deHueck A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Incorporation of the patients' perspective in clinical research is critical to ensure that outcomes measured reflect those, which matter most to patients. This review summarizes recent efforts to include the patients' perspective in the development of outcome measures and the importance of encouraging...

journal_title：Current opinion in rheumatology

authors： Hsiao B,Fraenkel L

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses genomic investigations in ankylosing spondylitis (AS) beyond genome-wide association (GWA) studies, but prior to this, genetic variants achieving genome-wide significance will be summarized highlighting key pathways contributing to disease pathogenesis. RECENT FINDINGS:Evidence...

journal_title：Current opinion in rheumatology

authors： O'Rielly DD,Uddin M,Rahman P

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Raynaud phenomenon is the earliest and most common clinical manifestations of scleroderma (systemic sclerosis). Therefore, Raynaud phenomenon offers the best window into the investigation of the early steps in the pathogenesis of systemic sclerosis. This review focuses on the differential diagnosis of...

journal_title：Current opinion in rheumatology

authors： Kahaleh MB

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis guidelines do not usually provide specific recommendations regarding what medication is most appropriate for individual patients. Generic oral bisphosphonates are often considered first-line treatment for osteoporosis, but treatment duration is limited, based on potential long-term safety...

journal_title：Current opinion in rheumatology

authors： Cosman F

更新日期：2018-07-01 00:00:00

abstract：:Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed self-antigens. Autoantigens in systemic lupus erythematosus are highly diverse in terms of structure and location in control cells, but become clust...

journal_title：Current opinion in rheumatology

authors： White S,Rosen A

更新日期：2003-09-01 00:00:00

abstract：:This article reviews evidence that subchondral bone plays a role in the degeneration of cartilage in osteoarthrosis. Whether the bony changes precede the cartilage degeneration remains unproven but may best be considered necessary for progression of the disease. Epidemiologic studies clearly show increasing subchondra...

journal_title：Current opinion in rheumatology

authors： Burr DB

更新日期：1998-05-01 00:00:00

abstract：:Although there are excellent rationales for the use of biologic agents, no published novel therapeutic strategy in patients with early or late rheumatoid arthritis has thus far been proven in controlled clinical studies to prevent or retard cartilage destruction. Although T-cell-specific therapies in chronic rheumatoi...

journal_title：Current opinion in rheumatology

authors： Häuselmann HJ

更新日期：1997-05-01 00:00:00

abstract：:Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...

journal_title：Current opinion in rheumatology

authors： McCune WJ,Vallance DK,Lynch JP 3rd

更新日期：1994-05-01 00:00:00

abstract：:Information detailing the socioeconomic impact of the vasculitides on society has been difficult to obtain. Recent published studies provide preliminary information suggesting that the impact of systemic vasculitis may be significant and far greater than previously anticipated. A rough estimate of expenditures for vas...

journal_title：Current opinion in rheumatology

authors： Cotch MF

更新日期：2000-01-01 00:00:00

abstract：:Assessment of children and adults with rheumatic diseases, both in clinical practice and controlled clinical trials in rheumatology, has traditionally focused on the measurement of disease activity. More recently emphasis has been placed on the need to incorporate estimates of physical, social, and mental functioning ...

journal_title：Current opinion in rheumatology

authors： Duffy CM,Duffy KN

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：:All industrialized nations are facing a crisis in health care financing. Rising expectations coupled with increasing specialization and technologic capacities have forced health care payers to examine their assumptions and to seek data on the outcomes of medical interventions. Clinical investigators who have been taug...

journal_title：Current opinion in rheumatology

authors： Stucki G,Liang MH

更新日期：1994-03-01 00:00:00

abstract：SUMMARY:Relapsing polychondritis is a unique, rare autoimmune disorder in which the cartilaginous tissues are the primary targets of destruction but the immune damage can spread to involve noncartilaginous tissues like the kidney, blood vessels, and so forth. The manifestations of the disease can take many different fo...

journal_title：Current opinion in rheumatology

authors： Kent PD,Michet CJ Jr,Luthra HS

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Microscopic polyangiitis is defined within the context of primary systemic vasculitis. The presentation and management of renal involvement in microscopic polyangiitis is discussed, with emphasis on prognosis and outcomes. Potential roles of newer therapies are reviewed. RECENT FINDINGS:The histologi...

journal_title：Current opinion in rheumatology

authors： Jayne D

更新日期：2008-01-01 00:00:00

abstract：:Ankylosing spondylitis and IgA nephropathy share some immunologic features, eg, elevated serum IgA and IgA-immune complex levels. These entities are frequently found as being associated. IgA and IgA immune complex catabolism involves asialoglycoprotein receptors and specific IgA Fc receptors (FcalphaR or CD89) on tiss...

journal_title：Current opinion in rheumatology

authors： Montenegro V,Monteiro RC

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs). RECENT FINDINGS:Autoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define tw...

journal_title：Current opinion in rheumatology

authors： Pinal-Fernandez I,Mammen AL

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the new therapeutic opportunities offered by the combination of biological drugs, mainly Rituximab, with direct-acting antiviral agents (DAAs). RECENT FINDINGS:Hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients with mixed cryoglobuline...

journal_title：Current opinion in rheumatology

authors： Roccatello D,Fenoglio R,Sciascia S

更新日期：2019-09-01 00:00:00

abstract：:Connective tissue diseases (CTDs) frequently present with one or only a few symptoms, which does not allow prompt diagnosis. Raynaud's phenomenon is one of those symptoms. However, only a minority of patients who present with Raynaud's phenomenon develop a CTD. Prognostic factors for the future development of CTD in s...

journal_title：Current opinion in rheumatology

authors： Kallenberg CG

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...

journal_title：Current opinion in rheumatology

authors： Yelin E

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review and interpret the recently published data on hyperuricemia and cardiovascular disease to present an opinion on the nature of link between serum uric acid concentration and the risk for cardiovascular outcomes, and to comment on its implications for clinical practice. RECENT FINDINGS:Evidenc...

journal_title：Current opinion in rheumatology

authors： Krishnan E,Sokolove J

更新日期：2011-03-01 00:00:00