Pathophysiology of rheumatoid arthritis.

abstract：PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...

journal_title：Current opinion in rheumatology

authors： Clarke JT,Werth VP

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review radiographic and MRI developments in measuring osteoarthritis progression in the tibiofemoral compartment of the knee. RECENT FINDINGS:Standardized techniques for measuring joint space width in the medial tibiofemoral compartment, using standardized radiographic protocols, have become accep...

journal_title：Current opinion in rheumatology

authors： Hunter DJ,Le Graverand MP,Eckstein F

更新日期：2009-03-01 00:00:00

abstract：:The concept suggesting the involvement of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by several clinical trials targeting TNF-alpha. In addition to reduction of pain and swelling, a dramatic effect of TNF blocking therapies on t...

journal_title：Current opinion in rheumatology

authors： Graninger WB,Smolen JS

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections play a role in the pathogenesis of autoimmune diseases (AID). Several bacterial and viral pathogens play a double role, as both inducers and inhibitors of AID. In this review, we will present current evidence and discuss different aspects of this notion. RECENT FINDINGS:Infectors that both...

journal_title：Current opinion in rheumatology

authors： Shamriz O,Shoenfeld Y

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Cryoglobulinemic vasculitis is an immune-complex-mediated systemic vasculitis involving small-medium-sized vessels. A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic...

journal_title：Current opinion in rheumatology

authors： Ferri C,Mascia MT

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Although 6 years have elapsed since the initial report describing the presence of microchimeric cells in affected tissues from patients with systemic sclerosis, a mechanism by which these cells might contribute to the pathogenesis of the disease is still unknown. This article reviews the published lit...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Artlett CM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article critically reviews the advances in medical management of giant cell arteritis (GCA) and Takayasu arteritis (TAK) with a focus on recent developments in targeted biologic therapy. RECENT FINDINGS:The role of biologics in the treatment of large vessel vasculitis (LVV) is expanding. TNFα in...

journal_title：Current opinion in rheumatology

authors： Koster MJ,Matteson EL,Warrington KJ

更新日期：2016-05-01 00:00:00

abstract：:Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...

journal_title：Current opinion in rheumatology

authors： McCune WJ,Vallance DK,Lynch JP 3rd

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines thresholds for treatment of traditional cardiovascular disease (CVD) risk factors among patients with rheumatoid arthritis (RA) and whether RA-specific treatment modulates cardiovascular risk. RECENT FINDINGS:There are substantial data demonstrating an increased CVD risk among pa...

journal_title：Current opinion in rheumatology

authors： Barbhaiya M,Solomon DH

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Takayasu arteritis remains a therapeutic challenge. In spite of current treatments, progression of vascular lesions is observed frequently. The purpose of this article is to describe advances in therapeutic strategies for Takayasu arteritis. RECENT FINDINGS:Immunosuppressive agents including methotre...

journal_title：Current opinion in rheumatology

authors： Liang P,Hoffman GS

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Exercise was established as an integral part of the nonpharmacological treatment of fibromyalgia approximately 20 years ago. Since then many studies have investigated the effects of exercise-either alone or in combination with other interventions. This review will discuss the benefits of exercise alon...

journal_title：Current opinion in rheumatology

authors： Gowans SE,deHueck A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The spectrum of periodic fever syndromes (PFS)/autoinflammation diseases is continuously expanding. This review provides an overview of the primary research and an update on the main clinical developments in these disorders published in the past 12-18 months. RECENT FINDINGS:IL-1β is pivotal to the p...

journal_title：Current opinion in rheumatology

authors： Savic S,Dickie LJ,Battellino M,McDermott MF

更新日期：2012-01-01 00:00:00

abstract：:A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoim...

journal_title：Current opinion in rheumatology

authors： Parker PM,Openshaw H,Forman SJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary fibrosis is a devastating disease that affects millions of people worldwide. Among the most common forms of lung fibrosis are idiopathic pulmonary fibrosis (IPF) and scleroderma-related interstitial lung disease (SSc-ILD). Despite a wealth of literature regarding each of these diseases, stud...

journal_title：Current opinion in rheumatology

authors： Murray LA,Rubinowitz A,Herzog EL

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:Signal transduction pathways are the intracellular mechanism by which cells respond and adapt to environmental stress. Understanding the critical networks in diseases like rheumatoid arthritis can potentially identify novel therapeutic targets. RECENT FINDINGS:Dissecting the complex pathways involved in rheuma...

journal_title：Current opinion in rheumatology

authors： Sweeney SE,Firestein GS

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus is characterized by the production of antinuclear autoantibodies and dysfunction of T-cells, B-cells, and dendritic cells. Here, we review newly recognized genetic factors and mechanisms that underlie abnormal intracellular signal processing and intercellular communication...

journal_title：Current opinion in rheumatology

authors： Perl A,Fernandez DR,Telarico T,Doherty E,Francis L,Phillips PE

更新日期：2009-09-01 00:00:00

abstract：:Diffuse alveolar hemorrhage (DAH) is a rare yet serious and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as antineutrophil cyt...

journal_title：Current opinion in rheumatology

authors： Specks U

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with rheumatoid arthritis and other inflammatory arthritides treated with tumor necrosis factor inhibitors frequently undergo orthopedic procedures. These patients may be at risk for serious postoperative infections as antitumor necrosis factor agents may be associated with impaired immunity ...

journal_title：Current opinion in rheumatology

authors： Pappas DA,Giles JT

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on the new interleukin-1 (IL-1) cytokine family members in inflammatory diseases with focus on recent findings concerning the family members IL-36, IL-37, and IL-38 and their different expression patterns. RECENT FINDINGS:The IL-1 cytokines are known to be involved in m...

journal_title：Current opinion in rheumatology

authors： Hahn M,Frey S,Hueber AJ

更新日期：2017-03-01 00:00:00

abstract：:Recent studies have revealed the important role of streptococci in the etiology of Behçet's disease. Among patients with Behçet's disease, there is a high incidence of a history of streptococcal infections. Certain antigens of streptococci induced not only cutaneous, delayed-type hypersensitivity, but also systemic at...

journal_title：Current opinion in rheumatology

authors： Mizushima Y

更新日期：1991-02-01 00:00:00

abstract：:Myositis-overlap syndromes are characterized by a heterogeneous group of clinical syndromes of which many are closely linked with specific autoantibodies. Clinical and laboratory-based research into this fascinating group of syndromes have given us clues in elucidating the role of immunogenetic, environmental influenc...

journal_title：Current opinion in rheumatology

authors： Ioannou Y,Sultan S,Isenberg DA

更新日期：1999-11-01 00:00:00

abstract：:Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensu...

journal_title：Current opinion in rheumatology

authors： Seibold JR

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease. RECENT FINDINGS:Ongoing research in murine, canine and human models of sterile bone inflammation has solidif...

journal_title：Current opinion in rheumatology

authors： Sharma M,Ferguson PJ

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer. Given concerns focused on this issue, we present a review of this important topic. RECENT FINDINGS:In non-Hodgkin lymphoma (NHL), a several-fold increased risk is seen in SLE versus the ge...

journal_title：Current opinion in rheumatology

authors： Bernatsky S,Kale M,Ramsey-Goldman R,Gordon C,Clarke AE

更新日期：2012-03-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

journal_title：Current opinion in rheumatology

authors： Asquith M,Rosenbaum JT

更新日期：2016-07-01 00:00:00

abstract：:Recent advances in renal osteodystrophy deal with the pathogenesis of the disease, in particular in early renal failure, with the mechanisms of skeletal resistance to parathyroid hormone, with the potential role of iron, and with increased knowledge of adynamic bone disease. For the control of phosphatemia, aluminum-c...

journal_title：Current opinion in rheumatology

authors： Bardin T

更新日期：1992-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the central role of pain in osteoarthritis, until recently, relatively little attention was paid to the osteoarthritis pain experience, including the features of osteoarthritis pain that are most important to people living with this disease. The focus of this review is on recent advances in ou...

journal_title：Current opinion in rheumatology

authors： Hawker GA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the present state of efforts at registry implementation which exist internationally. These efforts are contrasted with those in the USA. RECENT FINDINGS:The implications of the different data which are derived from diverse registry sources are discussed. The need for long-term ...

journal_title：Current opinion in rheumatology

authors： Kremer JM,Gibofsky A,Greenberg JD

更新日期：2008-03-01 00:00:00

abstract：:Major changes have taken place in the diagnosis and treatment of rotator cuff tears. It seems that magnetic resonance imaging alone as a diagnostic tool is still not sensitive enough, particularly in the diagnosis of partial tears. Arthrography and arthroscopy are still considered essential for an accurate preoperativ...

journal_title：Current opinion in rheumatology

authors： Uhthoff HK

更新日期：1996-03-01 00:00:00