The role of drug and disease registries in rheumatic disease epidemiology.

abstract：PURPOSE OF REVIEW:To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease. RECENT FINDINGS:Ongoing research in murine, canine and human models of sterile bone inflammation has solidif...

journal_title：Current opinion in rheumatology

authors： Sharma M,Ferguson PJ

更新日期：2013-09-01 00:00:00

abstract：:Longitudinal studies of large cohorts of patients with Raynaud's Phenomenon have addressed the predictors of developing a secondary disease. New insights have been reported into the pathogenesis of Raynaud's phenomenon and the consequences of ischemia. Studies have suggested that more than one defect may cause Raynaud...

journal_title：Current opinion in rheumatology

authors： Wigley FM

更新日期：1996-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of this review is to provide an update on exercise and clinical assessment in the idiopathic inflammatory myopathies. RECENT FINDINGS:Polymyositis, dermatomyositis and inclusion body myositis are rare conditions with muscle weakness as a common prominent feature. Earlier, these patients...

journal_title：Current opinion in rheumatology

authors： Alexanderson H,Lundberg IE

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the current evidence on the management of primary and secondary central nervous system (CNS) vasculitis. RECENT FINDINGS:Two recent retrospective cohort studies have described the treatment and outcomes of patients with adult primary central nervous system vasculitis (PCNSV). ...

journal_title：Current opinion in rheumatology

authors： Salvarani C,Pipitone N,Hunder GG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the new therapeutic opportunities offered by the combination of biological drugs, mainly Rituximab, with direct-acting antiviral agents (DAAs). RECENT FINDINGS:Hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients with mixed cryoglobuline...

journal_title：Current opinion in rheumatology

authors： Roccatello D,Fenoglio R,Sciascia S

更新日期：2019-09-01 00:00:00

abstract：:Work originating in the 1940s led to the characterization of a rare, chronic inflammatory disorder with a unique predilection for the cornea and vestibuloauditory apparatus, now called Cogan's syndrome (CS) after the ophthalmologist who first described it. CS occurs primarily in young adults and typically presents wit...

journal_title：Current opinion in rheumatology

authors： St Clair EW,McCallum RM

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic peria...

journal_title：Current opinion in rheumatology

authors： Vaglio A,Pipitone N,Salvarani C

更新日期：2011-01-01 00:00:00

abstract：:In this review, we address current concepts and recent experimental results that relate to heterogeneity in the physiologic, biochemical, and morphologic properties of mammalian skeletal muscle fibers. Recent data reinforce some of these current concepts while questioning others. The biochemical bases of the concepts ...

journal_title：Current opinion in rheumatology

authors： Talmadge RJ,Roy RR,Edgerton VR

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent advancements in diagnostic and therapeutic approaches to inclusion body myositis (IBM). RECENT FINDINGS:Our understanding of the implications of anti-cytosolic 5'-nucleotidase 1A autoantibody status in IBM and other diseases is increasing. Muscle imaging using magnetic resonance te...

journal_title：Current opinion in rheumatology

authors： Lilleker JB

更新日期：2018-11-01 00:00:00

abstract：:Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensu...

journal_title：Current opinion in rheumatology

authors： Seibold JR

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Parasitic worms have evolved strategies to manipulate the host immune system, some of which may lead to a reduction in inflammation. Characterisation of the ways in which these organisms mediate an anti-inflammatory response and identification of parasite-derived molecules involved in immune modulatio...

journal_title：Current opinion in rheumatology

authors： Cooke A

更新日期：2012-07-01 00:00:00

abstract：:Tumor necrosis factor-alpha, acting through its receptors expressed on all cells of the body, is a key mediator of inflammation and immunity. However, its overproduction may also lead to pathologic changes. The latter situation occurs often in chronic inflammatory diseases such as rheumatoid arthritis. The concept sug...

journal_title：Current opinion in rheumatology

authors： Ziolkowska M,Maslinski W

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to evaluate the relationship between infection with SARS-CoV-2 and autoimmunity. RECENT FINDINGS:Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome (SARS) associated coronavirus 2 (SARS-CoV-2). Although most of the infect...

journal_title：Current opinion in rheumatology

authors： Liu Y,Sawalha AH,Lu Q

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To critically appraise the literature related to the pathophysiology of rheumatoid arthritis (RA) focusing on the contribution of synovial tissue pathology (synovitis) in determining diverse clinical outcome/therapeutic response. RECENT FINDINGS:RA synovitis is highly heterogeneous with diverse cellu...

journal_title：Current opinion in rheumatology

authors： Pitzalis C,Kelly S,Humby F

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Exercise was established as an integral part of the nonpharmacological treatment of fibromyalgia approximately 20 years ago. Since then many studies have investigated the effects of exercise-either alone or in combination with other interventions. This review will discuss the benefits of exercise alon...

journal_title：Current opinion in rheumatology

authors： Gowans SE,deHueck A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy. RECENT FINDINGS:Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscl...

journal_title：Current opinion in rheumatology

authors： Mammen AL

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism. RECENT FINDINGS:The Wnt/beta-catenin signaling pat...

journal_title：Current opinion in rheumatology

authors： Johnson ML,Kamel MA

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will explore two new aspects of the involvement of viruses in multiple sclerosis pathogenesis. The first aspect is the complex interactions between viruses. The second aspect is the proposal of a mechanism by which autoreactive T cells are able to escape thymic selection and potentially re...

journal_title：Current opinion in rheumatology

authors： Cusick MF,Libbey JE,Fujinami RS

更新日期：2013-07-01 00:00:00

abstract：:This study reviews articles published in 2000 and 2001 about occupational physical activities as risk factors for osteoarthritis (OA) of the knee and hip. Six studies were identified in MEDLINE and EMBASE; five case-control studies and one cross-sectional study. Criteria for OA were: (on the waiting list for) joint re...

journal_title：Current opinion in rheumatology

authors： Schouten JS,de Bie RA,Swaen G

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Arthritogenic alphaviruses are globally distributed mosquito-borne RNA viruses causing epidemics of polyarthritis/arthralgia, with disease emerging or reemerging and increasingly being reported in travelers. This article summarizes the current knowledge of these diseases, focusing on recent developmen...

journal_title：Current opinion in rheumatology

authors： Suhrbier A,La Linn M

更新日期：2004-07-01 00:00:00

abstract：:There has been a renewed interest in the use of low doses of prednisone in the treatment of early rheumatoid arthritis. This is because it has been conclusively shown that low doses of prednisone retard bone damage, and physicians use prednisone because it helps control tender and swollen joints. Two studies appeared ...

journal_title：Current opinion in rheumatology

authors： Conn DL,Lim SS

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with articular and extra-articular manifestations. Remission, a state of absence of clinical and imaging signs of disease activity over time, is the goal of management. This review addresses the concept of minimal disease activity (MD...

journal_title：Current opinion in rheumatology

authors： Deodhar AA,Kumthekar A,Dubreuil M

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature on the association of infection with early arthritis, and to discuss the possible role of such infections with respect to the development of chronic rheumatic complications. RECENT FINDINGS:Viral infections are frequently associated with arthritis. Alphaviruses belo...

journal_title：Current opinion in rheumatology

authors： Leirisalo-Repo M

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent evidence for infection rates in patients with systemic vasculitides, the role of specific infectious agents in the pathogenesis of vasculitis and recent breakthroughs in the treatment of virus-associated vasculitides. RECENT FINDINGS:In well designed recent studies, infections were f...

journal_title：Current opinion in rheumatology

authors： Thomas K,Vassilopoulos D

更新日期：2017-01-01 00:00:00

abstract：:Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderl...

journal_title：Current opinion in rheumatology

authors： Jaovisidha K,Rosenthal AK

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Provide an update of studies published in last 2 years on the outcomes and therapies in childhood-onset systemic lupus erythematous (cSLE). RECENT FINDINGS:Additional evidence has been provided about the benefits of universal hydroxychloroquine in SLE patients, although antimalarial maculopathy may b...

journal_title：Current opinion in rheumatology

authors： Rodriguez-Smith J,Brunner HI

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered. This rev...

journal_title：Current opinion in rheumatology

authors： Walker UA,Warnatz K

更新日期：2006-07-01 00:00:00

abstract：:Major changes have taken place in the diagnosis and treatment of rotator cuff tears. It seems that magnetic resonance imaging alone as a diagnostic tool is still not sensitive enough, particularly in the diagnosis of partial tears. Arthrography and arthroscopy are still considered essential for an accurate preoperativ...

journal_title：Current opinion in rheumatology

authors： Uhthoff HK

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile dermatomyositis is a rare chronic inflammatory disease that primarily affects the muscles and skin. Immunosuppressive therapy has played a very important role in reducing mortality rates and morbidity. The review focuses on the spectrum of medications currently used in the treatment of juveni...

journal_title：Current opinion in rheumatology

authors： Stringer E,Feldman BM

更新日期：2006-09-01 00:00:00