Abstract:
PURPOSE OF REVIEW:The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism. RECENT FINDINGS:The Wnt/beta-catenin signaling pathway has been shown to play a major role in bone cell differentiation, proliferation and apoptosis. It is a critical component of bone mass regulation and required for bone to respond to mechanical loading. The pathway is tightly regulated by a number of modulator proteins. Mutations in pathway components that result in aberrant regulation are involved in a number of bone diseases. SUMMARY:Understanding the role that the Wnt signaling pathways play in the regulation of bone metabolism offers great promise for the developmental of new paradigms and pharmaceutical strategies for the treatment of various diseases such as osteoporosis, rheumatoid arthritis and osteoarthritis. Progress in this regard has already been made.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Johnson ML,Kamel MAdoi
10.1097/BOR.0b013e32816e06f9subject
Has Abstractpub_date
2007-07-01 00:00:00pages
376-82issue
4eissn
1040-8711issn
1531-6963pii
00002281-200707000-00011journal_volume
19pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This review will explore two new aspects of the involvement of viruses in multiple sclerosis pathogenesis. The first aspect is the complex interactions between viruses. The second aspect is the proposal of a mechanism by which autoreactive T cells are able to escape thymic selection and potentially re...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328362004d
更新日期:2013-07-01 00:00:00
abstract::In the last few years, several novel strategies have been proposed for the treatment of rheumatoid arthritis (RA). Among them, gene therapy is considered a promising concept bearing the potential of highly specific targeting of relevant pathomechanisms. Early studies using gene transfer focused mainly on studying dise...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200005000-00008
更新日期:2000-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Since their discovery over 15 years ago, intensive research has focused on the presence, phenotype and function of FOXP3(+) regulatory T cells (Treg) in autoimmune diseases such as rheumatoid arthritis (RA). The questions of whether Treg deficiencies underlie autoimmune pathology and whether or how Tr...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32835d0ee4
更新日期:2013-03-01 00:00:00
abstract::The spectrum of clinical descriptions and clinicopathologic studies on patients with primary and secondary forms of antiphospholipid antibody syndrome continues to widen. Some differences exist for patients with lupus compared with those with Sjogren's syndrome. Some new thoughts regarding pathogenetic mechanisms and ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199305050-00007
更新日期:1993-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on recent evidence pointing to the importance of inflammatory factors in the onset and progression of age-related muscle wasting, also known as sarcopenia, and discusses critical areas of uncertainty within the literature that require further development in order to identify novel ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000245722.10136.6d
更新日期:2006-11-01 00:00:00
abstract::Ankylosing spondylitis and IgA nephropathy share some immunologic features, eg, elevated serum IgA and IgA-immune complex levels. These entities are frequently found as being associated. IgA and IgA immune complex catabolism involves asialoglycoprotein receptors and specific IgA Fc receptors (FcalphaR or CD89) on tiss...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199907000-00007
更新日期:1999-07-01 00:00:00
abstract::Longitudinal studies of large cohorts of patients with Raynaud's Phenomenon have addressed the predictors of developing a secondary disease. New insights have been reported into the pathogenesis of Raynaud's phenomenon and the consequences of ischemia. Studies have suggested that more than one defect may cause Raynaud...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract:PURPOSE OF THIS REVIEW:Gene expression profiling is emerging as a promising methodology in pediatric rheumatology research. There is considerable interest in using this technology as the basis for diagnostic assays. This review will summarize the new knowledge. RECENT FINDINGS:Most gene expression studies of children ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000171212.42252.d1
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study is to review the evidence and recent developments leading to novel therapeutics in scleroderma. RECENT FINDINGS:Recent advances have been made in understanding the key pathogenetic aspects of scleroderma, and these have led to potential targeted therapeutic agents for the ma...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328337c3d6
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS). RECENT FINDINGS:Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum u...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32833645e8
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Rheumatoid arthritis (RA) is a systemic, autoimmune disease resulting in the destruction of affected joints. Even though current therapies with biologics such as tumor necrosis factor-alpha blockers yield significant improvement for the patients, the disease is not curable yet. Therefore, we need nove...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283389641
更新日期:2010-05-01 00:00:00
abstract::Raloxifene, a selective estrogen receptor modulator, is currently used for both prevention and treatment of postmenopausal osteoporosis. Recent data from the MORE (Multiple Outcomes of Raloxifene Evaluation) trial have evaluated health-related quality of life, 1-year clinical vertebral fracture reduction, and the corr...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200207000-00017
更新日期:2002-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer. Given concerns focused on this issue, we present a review of this important topic. RECENT FINDINGS:In non-Hodgkin lymphoma (NHL), a several-fold increased risk is seen in SLE versus the ge...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32834ff258
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This article critically reviews the advances in medical management of giant cell arteritis (GCA) and Takayasu arteritis (TAK) with a focus on recent developments in targeted biologic therapy. RECENT FINDINGS:The role of biologics in the treatment of large vessel vasculitis (LVV) is expanding. TNFα in...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000265
更新日期:2016-05-01 00:00:00
abstract::Tumor necrosis factor-alpha, acting through its receptors expressed on all cells of the body, is a key mediator of inflammation and immunity. However, its overproduction may also lead to pathologic changes. The latter situation occurs often in chronic inflammatory diseases such as rheumatoid arthritis. The concept sug...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200305000-00014
更新日期:2003-05-01 00:00:00
abstract::Assessment of children and adults with rheumatic diseases, both in clinical practice and controlled clinical trials in rheumatology, has traditionally focused on the measurement of disease activity. More recently emphasis has been placed on the need to incorporate estimates of physical, social, and mental functioning ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199709000-00011
更新日期:1997-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review advances in the understanding of potentially causal relationships between gout, hyperuricemia and comorbidities. RECENT FINDINGS:Observational studies reveal 4-5 comorbidity clusters in gout patients. There tend to be gout alone, gout with chronic kidney disease and gout with other metaboli...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000691
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic peria...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328341137d
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The identification of the genetic variants that mediate the risk for susceptibility and severity of rheumatoid arthritis will allow the development of new drug targets and also increase the ability to predict disease course. Technical and methodologic progress has fueled the advances in this field. R...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000160780.13012.be
更新日期:2005-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The production of autoantibodies against nuclear antigens is the hallmark of systemic lupus erythematosus. Among the large number of autoantibodies known, only a limited number appear to be clinically important. The various autoantibodies have different clinical significance in lupus patients. In this...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000135452.62800.8f
更新日期:2004-09-01 00:00:00
abstract::Advances in molecular biologic techniques and the availability of novel immunologic reagents have allowed new approaches to understanding the pathogenesis of human autoimmune diseases, including the idiopathic inflammatory myopathies. Indirect evidence that autoreactive T cells mediate muscle inflammation in the human...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199511000-00007
更新日期:1995-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Two diseases associated with chronic kidney disease (CKD) have benefited from advances in the past year which are of great importance for rheumatologists: renal osteodystrophy, which is now clearly associated with vascular calcification and cardiovascular death, and nephogenic systemic fibrosis, which...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32831ca5c5
更新日期:2009-01-01 00:00:00
abstract::Acute bacterial arthritis continues to be a common occurrence, and despite improved treatment regimens, the prognosis has not improved significantly over the past 20 years. During the past year, the emergence of unique predisposing factors for bacterial arthritis, including prosthetic joints and HIV infection, were em...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199407000-00008
更新日期:1994-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis. RECENT FINDINGS:Fine-mapping studies in the major histocompatibility complex region in Caucasia...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/BOR.0000000000000652
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and v...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200405000-00021
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review addresses diagnostic methods for crystalline arthritis including synovial fluid analysis, ultrasound, and dual energy CT scan (DECT). RECENT FINDINGS:There are new technologies on the horizon to improve the ease, sensitivity, and specificity of synovial fluid analysis. Raman spectr...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000582
更新日期:2019-03-01 00:00:00
abstract::Nitric oxide (NO) and prostaglandin E2 (PGE2) are two pleiotropic inflammatory mediators overproduced in arthritis-affected joints. The inducible isoform of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are found both in the synovial tissue and in the cartilage. Their expression is regulated by catabolic cyt...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199905000-00009
更新日期:1999-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Glucocorticoids are used in the treatment of most rheumatic diseases, and are used chronically in up to 50% of cases of rheumatoid arthritis. The frequency of their use has in the past been incompletely supported by trial evidence of their benefit and by incomplete understanding of their mechanisms of...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32805e87d0
更新日期:2007-05-01 00:00:00
abstract::HLA-B27 is virtually absent in most of the sub-Saharan Africa populations, and ankylosing spondylitis is rare; only a few patients have been reported from central and southern Africa. HLA-B27 was present in only one of 17 patients (6%). The disease shows clinical features that are similar to those observed in white HL...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200007000-00008
更新日期:2000-07-01 00:00:00
abstract::This article describes the magnitude, extent, and economic consequences of some of the more common, work-related musculoskeletal disorders. In addition, it provides a brief historic overview of the state-federal vocational rehabilitation program in the United States. It identifies and considers a constellation of risk...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199803000-00010
更新日期:1998-03-01 00:00:00